기업체 화학물질관리 우수사례

박재범,Park, Jae-Beom 환경보전협회 2007 환경정보 Vol.29 No.367

불량한 치조제에서의 임플랜트 시술증례

박재범,안상헌,정수일,조병완,안재진,Park, Jae-Bum,Ahn, Sang-Hun,Cheung, Soo-Il,Jo, Byung-Woan,Ahn, Jae-Jin 대한악안면성형재건외과학회 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.1

The most critical factor in determining which type of implant to be used would be the available bone of the patient. Usually a minimum of 5mm in the bone width and 8mm in the bone height is necessary to ensure primary implant stability and maintain the integrity of bone contact surface. Placement of implant is limited by the several anatomic strutures such as maxillary sinus, floor of the nose, inferior alveolar neurovascular bundle and nasopalatine foramen, etc. When severe resorption of alveolar ridge is encountered, implant placement would be a problematic procedure. A number of techniques to improve the poor anatomic situations have been proposed. This article reports 4 cases of patients using surgical procedures such as blade implant technique, cortical split technique in the anterior maxillary area, sinus lifting and lateral repositioning of inferior alveolar nerve, We treated dental implant candidates with unfavorable alveolar ridge utilizing various surgical techniques, resulted in successful rehabilitation of edentulous ridge.

Pin-to-plate Type 대기압 PECVD 방법을 이용해 성장된 다중벽 탄소나노튜브의 전계방출 특성연구

박재범,경세진,염근영,Park Jae-Beom,Kyung Se-Jin,Yeom Geun-Young 한국진공학회 2006 Applied Science and Convergence Technology Vol.15 No.4

본 연구에서는 전계 방출소자로 사용하기 위한 탄소나노튜브의 합성 방법으로, pin to plate type의 대기압 플라즈마 소스를 사용한 AP-PECVD(Atmosphere pressure plasma enhanced chemical vapor deposition)를 이용하였으며, 이를 통하여 대기압에서 성장된 탄소나노튜브의 구조적 및 전기적 특성을 연구하였다. 유리 / 크롬 / 니켈을 기판으로 사용하여 $400{\sim}500^{\circ}C$ 변화 영역에서 탄소나노튜브를 성장시킨 결과 다중벽 탄소나노튜브가 얻어짐을 알 수 있었다. $500^{\circ}C$에서 성장시킨 탄소나노튜브의 경우 FT-Raman을 이용한 분석 결과 $I_D / I_G$ ratio 가 0.772 임을 관찰하였으며 TEM으로 분석결과, 내부의 그래파이트층은 15 - 20 층, 내부 직경은 10-15nm, 외부 직경은 30 - 40nm 이고, 각 층간의 간격은 0.3nm 임을 알 수 있었다. 또한 전계 방출 문턱전압은 $2.92V/{\mu}m$ 이고, FED 에서 요구되는 $1mA/cm^2$의 방출전류밀도는 $5.325V /{\mu}m$의 문턱전압 값을 가지는 것을 관찰하였다. In this study, carbon nanotubes (CNTs) were grown on glass substrates coated with Ni/Cr by an atmospheric pressure plasma enhanced chemical vapor deposition(AP-PECVD) and their structural and electrical characteristics were investigated as a possible application to the field emitter of field emission display (FED) devices. The substrate temperature ($400{\sim}500^{\circ}C$) were varied and the grown CNTs were multi wall CNTs (at $500^{\circ}C$, 15 - 20 layers of graphene sheets, distance of each layer : 0.3nm, inner diameter: 10 - 15nm, outer diameter: 30 - 40nm). The ratio of defective carbon peak to graphite carbon peak of the CNTs grown at $500^{\circ}C$ (C measured by fourier transform(FT)-Raman was 0.772 $I_D / I_G$ ratio. When field emission properties were measured, the turn-on field was $2.92V/{\mu}m$ and the emission field at $1mA/cm^2$ was $5.325V /{\mu}m$.

Performance of a Prototype CsI Detector for the Low-Energy LAMPS System by Using Different Gamma-Ray Sources

박재범,홍병식,이한슬,Gyunghwan BAK,Jeonghyeok PARK,문동호 한국물리학회 2017 새물리 Vol.67 No.6

A Large-Acceptance Multipurpose Spectrometer (LAMPS) will be essential for studying nuclear symmetry energy at the rare isotope beam facility, RAON, in Korea. According to the conceptual design of the LAMPS, a Si-CsI detector system will be used for identifying the charged particles produced in nuclear collisions. The CsI detector will be used particularly for the measurement of photons. In this work, the prototype CsI detector was tested using radioactive gamma sources, and the simulations using the GEANT4 simulation toolkit were performed. The energy resolutions estimated from the full width at half maximum (FWHM) of the energy spectra were found to be 8.4 and 7.9\%, respectively, for the 1.17- and the 1.33-MeV gamma-rays from the $^{60}$Co source

수소 환원기체와 (hfac)Cu(3,3-dimethyl-1-butene) 증착원을 이용한 Pulsed MOCVD로 Cu seed layer 증착 특성에 미치는 영향에 관한 연구

박재범,이진형,이재갑,Park Jaebum,Lee Jinhyung,Lee Jaegab 한국재료학회 2004 한국재료학회지 Vol.14 No.9

Pulsed metalorganic chemical vapor deposition (MOCVD) of conformal copper seed layers, for the electrodeposition Cu films, has been achieved by an alternating supply of a Cu(I) source and $H_2$ reactant at the deposition temperatures from 50 to $100^{\circ}C$. The Cu thickness increased proportionally to the number of cycles, and the growth rate was in the range from 3.5 to $8.2{\AA}/cycle$, showing the ability to control the nano-scale thickness. As-deposited films show highly smooth surfaces even for films thicker than 100 nm. In addition about a $90\%$ step coverage was obtained inside trenches, with an aspect ratio greater than 30:1. $H_2$, introduced as a reactant gas, can play an active role in achieving highly conformal coating, with increased grain sizes.

세계변화에 주목하라 - 중국 전기자동차 질주의 영향

박재범,Park, Jae-Beom 대한석유협회 2016 석유와 에너지 Vol.301 No.-

도장 부서 남성 근로자들의 피부 질환

박재범,이경종,장재연,정호근,Park, Jae-Beom,Lee, Kyung-Jong,Jang, Jae-Yeon,Chung, Ho-Keun 대한예방의학회 1997 Journal of Preventive Medicine and Public Health Vol.30 No.4

Painting is risky work to occupational skin disease. This research was carried out to investigate the prevalence of occupational skin diseases in painting department of a shipyard company in June 1996. Dermatological examination, self-administered questionnaire survey were conducted. Exposed group(n=379) was selected randomly in painting department and control of group(n=151) was selected in those who had not exposed to paints or solvents. The prevalence of contact dermatitis(11.9%) is significantly elevated compared with control of group(2.6%), and odds ratio(OR) is 4.95 (95% confidence interval[CI]: 1.75-14.02). The prevalence of Tinea pedis, the most common skin disease, in exposure group is 48.0%, and its odds ratio(OR) is significantly elevated compared with control group (OR:3.18, 95% CI: 2.06-4.90). Pompholyx is also significantly elevated in prevalence(11.9%) and OR(OR:6.64, 95% CI:2.03-21.69). There were no difference in the prevalence of contact dermatitis, Tinea pedis, and pompholyx by use of personal protective equipments(PPE), job categories, and duration of employment in painting department. In exposure group, 71.1% suffer from contact dermatitis improved in vacation or holiday and 68.9% of them had lesion on exposed area, it suggest that contact dermatitis in exposed group is related to their work. In conclusion, workers in painting department have high risks of contact dermatitis, Tinea pedis, and pompholyx. A health policy should be provided to prevent skin disease among painting department. 직업성 피부 질환을 일으키는 주요 작업 공정의 하나인 도장작업자들의 피부 질환의 실태를 파악하기 위하여 모 조선업체 도장 부서의 남자 근로자 379명을 폭로군으로, 같은 회사 비도장부서에서 근무하고 유기용제를 취급한 경력이 없는 근로자 151명을 대조군으로 선정하여 피부과 전문의의 진료와 설문 조사를 통하여 아래와 같은 결과를 얻었다. 피부과적 진찰 결과 도장부서 근로자들이 이환되어 있는 가장 흔한 피부질환은 족부 백선으로 폭로군의 유병률은 48.0%였으며 대조군에 비하여 이환될 비차비가 3.18로 통계학적으로 유의한 차이를 보였다. 접촉성 피부염과 한포진의 유병률도 각각 11.9%, 11.9%로 대조군보다 유의하게 높았으며 질병에 이환될 비차비가 4.95, 6.64로 통계학적으로 유의한 차이를 보였다. 이외에도 비특이적 습진, 자극성 피부염, 모낭염, 두드러기 등과 같은 피부 질환이 관찰되었으나 대조군과 유의한 차이는 없었다. 접촉 피부염 소견을 보이는 폭로군 중 71.1%가 피부 증상이 휴일이나 휴가시에 호전된다고 응답하였고, 68.9%가 옷이나 보호구에 가려지지 않는 노출부위에 피부 병변이 발생한다고 응답하여 접촉 피부염이 작업과 관계가 있음을 시사하였다. 근로자들의 보호구 착용률은 비교적 양호한 편이었지만 보호구 착용과 피부질환과는 연관성이 없어서 보호구 착용이 피부질환의 예방에 큰 효과가 없는 것으로 나타났다. 대조군과 유의한 차이를 보인 접촉 피부염, 한포진, 족부 백선의 유병률을 수행직무별로 스프레이군, 터치업군, 혼합군, 전처리군으로 구분하여 비교한 결과 유의한 차이를 보이지 않아 피부 질환의 위험도는 수행직무에 따라서는 큰 차이가 없음을 보여주었다. 도장 부서 근무 년수에 따른 비교에서도 근무 년수가 증가함에 따라 유병률이 증가하는 소견을 보이지 않았는데 근무 기간에 길어질수록 피부 저항이 증가되며, 피부반응이 둔해지며, 숙련된 작업으로 접촉물질에 대한 노출이 감소되기 때문이라고 판단된다. 이상과 같이 조선업체 도장부서 근로자들에게서 접촉 피부염, 한포진, 족부 백선 등 작업과 연관된 질병을 발견할 수 있었다. 앞으로 도장 부서 근로자들의 피부 병변을 예방하기 위한 대책 마련이 시급하다고 생각한다.

Purification and Characterization of Malate Synthase from Acinetobacter calcoaceticus Grown on Malonate

박재범,채호준,김유삼,Park, Jae-Bum,Chae, Ho-Zoon,Kim, Yu-Sam 생화학분자생물학회 1986 한국생화학회지 Vol.19 No.3

Malonate를 유일한 탄소 및 에너지원으로 이용하는 배지에서 Acinetobacter calcoaceticus를 배양했을 때 malate synthase가 유도된다는 사실을 확인하였다. 이 미생물로부터 DEAE-Sephacel ion exchange chromatography, oxalate-Sepharose 4B affinity chromatography, hydroxyapatite chromatography를 이용하여 malate synthase를 분리 정제하였고, disc polyacrylamide gel electrophoresis를 수행한 결과 하나의 단백질 띠로 나타났다. 그 최적 pH는 8.0이였으며, 정제한 malate synthase가 관여하는 반응은 기질인 glyoxylate나 acetyl CoA에 대해 전형적인 Michaelis-Menten kinetics에 부합했다 Lineweaver-Burk plot을 이용하여 $K_m$과 $V_{max}$를 정한 결과 acetyl CoA에 대해서는 $1.5{\times}10^{-5}\;M$과 $1\;{\mu}mol/min/mg$ protein이였고 glyoxylate에 대해서는 $3.5{\times}10^{-5}\;M$과 $0.8\;{\mu}mol/min/mg$ protein 이었다. Oxalate와 glyoxylate는 competitive inhibitor였으며 $K_i$ 값은 각각 $4{\times}10^{-5}\;M$, $1.4{\times}10^{-4}\;M$이었다. Pyruvate, succinate, malonate 그리고 tartrate도 효소활성을 억제하였다. Pseudomonas fluorescens의 malate synthase를 항원으로 하여 만들어진 항체는 Acinetobacter calcoaceticus 의 malate synthase활성을 저해 하지 않았다. 이러한 사실로 미루어 분류상 유사한 두 미생물의 malate synthase는 면역학적으로 많은 차이가 있음을 알았다. Malate synthase (EC 4.1.3.2) was induced in Acinetobacter calcoaceticus grown on malonate as a sole carbon source. The enzyme was purified by the combined methods of DEAE-Sephacel anion exchange chromatography, oxalate Sepharose 4B affinity chromatography and hydroxyapatite chromatography in an electrophoretically homogeneous form. The molecular size of the enzyme was estimated to be 75,000 dalton consisted of a single polypeptide. Optimum pH for the enzyme was about 8.0. The rate of acetyl group incorporation on variable concentraions of the substrate into malate was well fitted to a typical Michaelis-Menten kinetics. From the Lineweaver-Burk plot, $K_m$ and $V_{max}$ for acetyl-CoA were $1.5{\times}10^{-5}\;M$ and $1\;{\mu}mol/min/mg$ respectively and those for glyoxylate were $3.5{\times}10^{-5}\;M$ and $0.8\;{\mu}mol/min/mg$ respectively. The activity of this enzyme was inhibited by oxalate with $K_i$, $4{\times}10^{-5}\;M$ and by glycolate with $K_i$, $1.4{\times}10^{-4}\;M$ competitively. Pyruvate, succinate, malonate and tartrate also inhibited the enzyme activity. Antibody prepared against malate synthase from Pseudomonas fluorescens did not cross-react with the enzyme from Acinetobacter, suggesting that the enzyme isolated from two different bacteria are immunologocally different.

생지황(生地黃)이 강제수영부하시험에서 HPA Axis System과 Catecholaminergic System에 미치는 영향

박재범,이태희,Park, Jae-Beom,Lee, Tae-Hee 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.1

Object : The effects of Rehmanniae Radix(RR) on HPA Axis system and Catecholaminergic system was investigated. Methods : we performed the Forced Swimming Test(FST). Also the expression of Corticotropin -Releasing Factor(CRF), c-Fos and Tyrosine Hydorxylase(TH) was measured by immunohistochemical method at Paraventricular Nucleus(PVN), Locus Coeruleus(LC) and Ventral Tegmental Area(VTA). Results : 1. The duration of immobility in the Forced Swimming Test was significantly decreased in the Rehmanniae Radix 400 mg/kg groups in comparison with the control group(p<0.05). 2. Comparing to the control group, CRF expression was significantly decreased in the Rehmanniae Radix 400 mg/kg treated group in comparison with the control group(p<0.01). 3. c-Fos expression was significantly decreased at PVN in the Rehmanniae Radix 100 mg/kg treated group in comparison with the control group(p<0.01). 4. TH expression was significantly increased at LC in the Rehmanniae Radix 100 mg/kg and 400 mg/kg treated group in comparison with the control group(p<0.001). 5. TH expression was significantly decreased at VTA in the Rehmanniae Radix 100 mg/kg and 400 mg/kg treated group in comparison with the control group(p<0.001). Conclusion : According to the results, it can be considered that Rehmanniae Radix has antidepressant effect by showing the reduction of immobility in FST through the decreased expression of CRF, c-Fos in PVN and TH in VTA.

낙동강 중소하천 홍수예경보시스템 구축을 위한 한계강우량 산정과 적용

박재범,신동수,박무종,강봉권,신현석,Park,Jae Beom,Shin,Dong Soo,Park,Moo Jong,Kang,Bong Gwon,Shin,Hyun Suk 한국방재학회 2013 한국방재학회논문집 Vol.13 No.2

본 연구에서는 중소하천 홍수경보시스템 구축을 위한 소유역기반 한계강우량 산정 방법론을 제안하였다. 소유역 말단 하천단면에서 위험유량에 해당하는 한계강우량을 초과하는 강우가 발생하면 위험상황이 발생하고 하천재해에 대응하고 대처하기 위한 경보를 발령한다. 관측강우량과 유역의 수문학적반응특성을 기반으로 하는 한계강우량은 소유역 말단에서 위험상황을 발생하는 유량에 해당하는 특정 지속시간 동안의 총강우량을 의미한다. 지형분석도구인 ArcGIS 기반 Hec-GeoHMS를 이용하여 낙동강유역을 2,268개 소유역으로 분할 후 Hec-HMS모형을 구축하였으며 이를 이용하여 선행토양함수조건과 초기손실 시나리오에 따른 한계강우량을 산정하였다. An procedure for the definition of rainfall threshold value is illustrated in order to develop optimal flood forecasting and warnings systems for small river basins. Threshold overcoming could produce a danger situation in river sites and trigger the prevention and emergency system alert. Rainfall threshold values is based both on the quantitative rainfall observed and the hydrological response of the small river basin. Threshold values specify the rainfall amount for a given duration that generates a danger discharge in a outlet`s cross section and are estimated by hydrological modeling for several scenarios(e.g, Soil Moisture conditions, Initial Abstraction). Nakdong River basin is separated to 2,268 small river basins by using Hec-GeoHMS, rainfall threshold for small river basins are presented for several scenarios.