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이수희,박이안,( Ma Jinxuan ),( Xu Mengcan ),이우걸 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
Calcium and phosphate ions are major ingredients for human bone tissue. Therefore, calcium phosphate ceramics possess excellent biocompatibility compared to other type of biomaterials. In this study, we investigated surface modification for poly(ε-caprolactone) (PCL) and poly-L-lactide (PLLA) using calcium-containing ceramic films. The surface hydrophilicity was quantified in terms of contact angle measurements. Morphological changes of coating surface was observed using a SEM. The analysis of the chemical state was conducted using FT-IR. The biocompatibility of the films was evaluated in vitro cell assays. <sup>**</sup>This research was supported by the Ministry of Trade, Industry and Energy(MOTIE), KOREA, through the Education Program for Creative and Industrial Convergence. (Grant Number N0000717)
Acceleration of bone tissue regeneration using naturally derived Dendropanax extract
이수희,박이안,( Ma Jinxuan ),( Xu Mengcan ),이우걸 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
Korean Dendropanax is a plant that grows wild in Korea. According to earlier reports, it is known to have various therapeutic effects, such as antioxidant, anticancer, and inhibitory of liver damage. In this study, we examined the effects of Dendropanax extract on bone tissue regeneration. The analysis on the components of the extract were conducted using HPLC. Dendropanax extract was supplemented in culture medium and performed cell assays to inspect stability and effects on cellular responses using osteoblastic MG63 cells. Our results illustrated that the dendropanax extract has positive effects on bone regeneration. <sup>**</sup>This research was supported by the Ministry of Trade, Industry and Energy(MOTIE), KOREA, through the Education Program for Creative and Industrial Convergence. (Grant Number N0000717)
Preparation of lecithin nanoemulsion for drug delivery applications
박진우,마진쉬엔,박이안,이우걸 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Nanoemulsion is newly developing delivery system for drugs and bioactive agents. Nanoemulsion is consisting of heterogeneous systems such as continuous and dispersed phases. This technique can be utilized also for cosmetic purposes. Drugs immiscible in continuous phase can be entrapped in dispersed phase. In this investigation, we examined the effects of the preparation conditions including drug concentration, types of surfactant, and process conditions including mixing rate on the nanoemulsion formulation. The properties of nanoemulsion will be analyzed using scanning electron microscope, Fourier-transform infrared spectroscope, and zeta potential. The drug release kinetics was analyzed using high performance liquid chromatograph. The biological function of the nanoemulsion will be evaluated using fibroblast cell proliferation.
Improvement of Osteoconductivity of Biodegradable PLCL Bone Cement
박진우,김정헌,박이안,임예람,홍재윤,이우걸 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Human bone-related disease, such as osteoporosis and arthritis, is continuously increasing problem in elderly population. This illness is caused due to the lack of calcium arising from demineralization of bone tissue and brings about serious deterioration of physical structure of bone. In this investigation, we synthesized PLCL(5:5) via copolymerization of lactide and caprolactone monomers. highly porous PLCL scaffolds combined with ceramic particles were fabricated to use as bone cement possessing improved physical and biological properties. Various properties including mechanical strength, chemical state, hydrophilicity, and water uptake were examined using SEM, EDX, and FT-IR. The biological property of the scaffold was evaluated with regard to proliferation of osteoblastic sarcoma cells. Results demonstrate that both mechanical and biological functionality were significantly improved, suggesting the developed scaffold can be potentially applied for the preparation of bone grafts.
Formulation of Calcium Phosphate Ceramic Particles for Bone Replacement
임예람,김정헌,박이안,조가은,서종휘,남지현,이우걸 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Recently, the growth of the elderly population increases the number of patients suffering from osteoporosis. Accordingly, it becomes an immediate need to develop bone grafts for bone replacement. Human bone is composed of 35% organic components, 45% inorganic components, and 20% moisture. Among them, the inorganic component accounts for a large proportion of calcium and phosphate as well as trace elements, such as magnesium, fluorine, sodium, and zinc. In this study, we synthesized phosphate-based inorganic ceramic particles with various chemical states for the use of bone substitutes. The chemical composition, size, surface charge, and degradation pattern are evaluated using SEM, FTIR, zeta potential, and EDX. Biocompatibility of these ceramic particles were examined via cell assays using osteoblastic MG63 cells.