인두 뒤 공간으로 자란 미만성 갑상선종

박성희,김은경<SUP>1<,SUP>,Sung Hee Park,and Eun-Kyung Kim,<SUP>1<,SUP> 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.4

When there is a large goiter, it usually grows downward to the lower anterior neck it rarely grows upward to the retropharyngeal space. We report a 73-year-old woman with a palpable neck mass that was shown to be a diffuse goiter extending into the retropharyngeal space. The mass was well-demonstrated on CT scan. (Korean J Endocrine Surg 2008;8:269-271)

혼합 가우시안 모델과 민쉬프트 필터를 이용한 깊이 맵 부호화 전처리 기법

박성희,유지상,Park, Sung-Hee,Yoo, Ji-Sang 한국정보통신학회 2011 한국정보통신학회논문지 Vol.15 No.5

본 논문에서는 깊이 맵(depth map)에 대한 효율적인 부호화를 위하여 전처리 기법을 제안한다. 현재 3차원 비디오 부호화(3D video coding : 3DVC)에 대한 표준화가 진행 중에 있지만 아직 깊이 맵의 부호화 방법에 대한 표준은 확정되지 않은 상태이다. 제안하는 기법에서는 먼저 입력된 깊이 맵의 히스토그램 분포를 가우시안 혼합모델(Gaussian mixture model : GMM) 기반의 EM(expectation maximization) 군집화 기법을 이용하여 분리한다. 분리된 히스토그램을 기반으로 깊이 맵을 여러 개의 레이어로 분리하게 된다. 분리된 각각의 레이어에서 배경과 객체의 포함여부에 따라 다른 조건의 민쉬프트 필터(mean shift filter)를 적용한다. 결과적으로 영상내의 각 영역 경계는 최대한 살리면서 영역내의 화소 값에 대해서는 평균 연산을 취하여 부호화시 효율을 극대화 하고자 하였다. 다양한 실험영상에 대하여 제안한 기법을 적용한 깊이 맵을 부호화하여 비트율(bit rate)이 감소하고 부호화 시간도 다소 줄어드는 것을 확인 할 수 있었다. In this paper, we propose a new pre-processing algorithm applied to depth map to improve the coding efficiency. Now, 3DV/FTV group in the MPEG is working for standard of 3DVC(3D video coding), but compression method for depth map images are not confirmed yet. In the proposed algorithm, after dividing the histogram distribution of a given depth map by EM clustering method based on GMM, we classify the depth map into several layered images. Then, we apply different mean shift filter to each classified image according to the existence of background or foreground in it. In other words, we try to maximize the coding efficiency while keeping the boundary of each object and taking average operation toward inner field of the boundary. The experiments are performed with many test images and the results show that the proposed algorithm achieves bits reduction of 19% ~ 20% and computation time is also reduced.

화학요법을 받고 있는 암환아의 구토 및 식이양상

박성희,Park Sung Hee 한국아동간호학회 1997 Child Health Nursing Research Vol.3 No.1

The incidence of chemothrapy related among pediatric cancer patient was 90.1%. Adequate oral intake and nutrition have been shown to be important. These consideration prompted the decision to survey by means of a questionaire. The questionaire were included nausea-vomiting peak time, causing factor, coping method, education need, diet pattern change and food preference. Results are fellow 1. Almost(90.1%) pediatric cancer patient experienced nausea-vomiting during chemotherapy and required coping method or reducing method. 2 . The food preference form were Identified. Those were fluid form, cold and small amout and frequentry eating form. The patients preferred noodles, chickens, soap, juice. The results of the survey indicate that nasea-vomiting relief nursing intervention are required pediatric cancer patient received chemotherapy. Health care personnels recognize the pediatric cancer patient's diet pattern and encourage the nutritional counselling. The care of patient should be multidisciplinary team approach and the nurse occupies a key position with in this team, which includes the pediatrician, nutrionist.

Fact constellation 스키마와 트리 기반 XML 모델을 적용한 실험실 레벨의 단백질 데이터 통합 기법

박성희,이영화,류근호,Park, Sung-Hee,Li, Rong-Hua,Ryu, Keun-Ho 한국정보처리학회 2004 정보처리학회논문지D Vol.11 No.3

유전자 및 단백질간의 복잡한 상호작용에 의해 기능이 결정되는 생명정보 데이터의 특성으로 인하여 생명정보 데이터 분석을 위해서는 이질적인 데이터를 통합적으로 분석할 수 있는 통합시스템이 요구된다. 따라서 이 논문에서는 생물학 실험실 레벨에서 단백질 구조 관련 데이터를 통합할 수 있도록 XML 모델기반에 웨어하우스 미디에이터 통합시스템을 제안한다. 제안 시스템은 fact constellation 모델을 기반하여 이질적인 소스에 대한 통합 모델링을 진행하고 통합 스키마를 XML 스키마로 변환하여 유지한다. 또한 통합 데이터베이스에 포함된 소스 데이터의 변경 및 출처에 대한 추적 관리를 위해 데이터의 점진적 갱신방법과 서열에 대한 버전관리를 이용한다. 실제로 이 시스템을 단백질 구조(PDB), 서열(Swiss-Prot)과 도메인 분류데이터(CATH) 통합에 적용한 통합 모델링 과정을 보여준다. With the explosion of bioinformatics data such proteins and genes, biologists need a integrated system to analyze and organize large datasets that interact with heterogeneous types of biological data. In this paper, we propose a integration system based on a mediated data warehouse architecture using a XML model in order to combine protein related data at biology laboratories. A fact constellation model in this system is used at a common model for integration and an integrated schema it translated to a XML schema. In addition, to track source changes and provenance of data in an integrated database employ incremental update and management of sequence version. This paper shows modeling of integration for protein structures, sequences and classification of structures using the proposed system.

수종의 한국산 야생식물에서의 항암효과 검색

박성희,조성지,이인선,이정옥,김종원,이인자,Park, Sung-Hee,Cho, Sung-Ji,Rhee, In-Sun,Lee, Chong-Ock,Kim, Chong-Won,Rhee, In-Ja 한국생약학회 1996 생약학회지 Vol.27 No.4

The objective of this reseach is to find new antitumoral substances from natural products. Several of natural products have been used as food that were isolated into hexane(Hex.) and/or ethylacetate(EtOAc) extracts. we have tested cytotoxicities of these plants against human solid tumor cells. The cytotoxic activity of these plants were tested using Sulforhodamin B(SRB) assay. Hexane extracts of Chrysanthemum sinense, Allium tubersum. Beta vulgaris, Ixeris dentata have revealed cytotoxicities against five human solid tumor cells, and its cytotoxicities of each cell line were $10-100\;{\mu}l/ml$ ED50 (Effective dose that cause 50% inhibition of cell growth in vitro)

간호대학생의 감성지능, 유머감각, 자아탄력성이 대학생활적응에 미치는 영향

박성희(Sung Hee Park1),변은경(Eun Kyung Byun) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.10

본 연구는 간호대학생의 대학생활적응에 영향을 미치는 요인을 파악하고, 대학생활적응 향상을 위한 중재방안의 기초자료를 제공하기 위하여 시도되었다. 연구대상자는 B시의 간호대학생으로 자료수집은 2017년 5월 8일부터 5월 12일까지였고, 최종 408부를 분석하였다. 수집된 자료는 SPSS/WIN 21.0 프로그램을 이용하여 실수, 백분율, 평균과 표준편차, 일원분산분석, 피어슨 상관계수, 다중회귀분석으로 분석하였다. 연구결과 연구대상자의 대학생활적응은 3.24±.49점으로 나타났다. 일반적 특성에 따른 대학생활적응의 차이는 학년(t=2.687, p<.001), 연령(F=3.187, p=.042), 성적(F=18.551, p<.001), 전공만족(F=61.347, p<.001), 교우관계(F=28.273, p<.001)에서 유의한 차이를 나타냈다. 연구대상자의 감성지능, 유머감각, 자아탄력성, 대학생활적응과의 상관관계에서 대학생활적응은 감성지능(r=.421, p<.001), 유머감각(r=.360, p<.001), 자아탄력성(r=.418, p<.001)과 정적 상관관계를 나타냈다. 연구대상자의 대학생활적응에 영향을 미치는 요인은 학년(t=-5.241, p<.001), 성적(t=3.833), p<.001), 전공만족(t=6.768, p<.001), 교우관계(t=2.923, p=.014), 감성지능(t=2.674, p=.008), 자아탄력성(t=4.345, p<.001)으로 나타났고, 설명력은 41.7%로 나타났다. 본 연구 결과를 통하여 간호대학생의 대학생활적응에 영향을 미치는 다양한 요인의 확인하고, 대학생활 적응을 향상시킬 수 있는 중재가 필요하다. This study was conducted to investigate the factors influencing adjustment to college life by nursing college students. Data were collected from 408 nursing students in B city from May 8, 2017 to May 12 and analyzed by ANOVA, Pearson"s correlation coefficient, and multiple regression using SPSS/WIN 21.0. The degree of adjustment to college life by nursing students was 3.24±.49. There were significant differencesin adjustment to college life with respect to grade(t=2.687, p<0.001), age(F=3.187, p=0.042), academic grade(F=18.551, p<0.001), satisfaction withmajor(F=61.347, p<0.001), and relationship with colleagues (F=28.273, p<0.001). There were positive correlations between adjustment to college life and emotional intelligence(r=0.421, p<0.001), humor sense(r=0.360, p<0.001), and ego resilience(r=0.418, p<0.001). Regression analysis showed 41.7% of variance in nursing student"s adjustment to college life was causedby grade, academic scores, satisfaction withmajor, relationship with colleagues, emotional intelligence, and ego resilience. These results indicated that it is necessary to determine the various factors affecting adjustment to college life and increase adjustment to college life amongnursing students.

SVM 모델을 이용한 3차원 패치 기반 단백질 상호작용 사이트 예측기법

박성희,Park, Sung-Hee,Hansen, Bjorn 한국정보처리학회 2012 정보처리학회논문지D Vol.19 No.1

모노머 단백질의 상호작용 사이트 예측은 기능을 알지 못하는 단백질에 대해서 이것과 상호작용하는 단백질로부터 기능을 예측하거나 단백질 도킹을 위한 검색 공간의 감소에 중요한 역할을 한다. 그러나 상호작용사이트 예측은 대부분 단백질 상호작용이 세포 내에서 순간적 반응에 일어나는 약한 상호작용으로 실험에 의한 3차원 결정 구조 식별의 어려움이 따르며 이로 인해 3차원의 복합체 데이터가 제한적으로 양산된다. 이 논문에서는 모노머 단백질의 3차원 패치 계산을 통하여 구조가 알려진 복합체의 상호작용사이트와 비상호작용사이트에 대한 패치 속성을 추출하고 이를 기반으로 Support Vector Machine (SVM) 분류기법을 이용한 예측 모델 개발을 제시한다. 타겟 클래스의 데이터 불균형 문제 해결을 위해 under-sampling 기법을 이용한다. 사용된 패치속성은 2차 구조 요소와 아미노산 구성으로부터 총 9개가 추출된다. 147개의 단백질 복합체에 대해서 10 fold cross validation을 통해서 다양한 분류모델의 성능 평가를 하였다. 평가한 분류 모델 중 SVM은 92.7%의 높은 정확성을 보이고 이를 이용하여 분류 모델을 개발하였다. Predication of protein interaction sites for monomer structures can reduce the search space for protein docking and has been regarded as very significant for predicting unknown functions of proteins from their interacting proteins whose functions are known. In the other hand, the prediction of interaction sites has been limited in crystallizing weakly interacting complexes which are transient and do not form the complexes stable enough for obtaining experimental structures by crystallization or even NMR for the most important protein-protein interactions. This work reports the calculation of 3D surface patches of complex structures and their properties and a machine learning approach to build a predictive model for the 3D surface patches in interaction and non-interaction sites using support vector machine. To overcome classification problems for class imbalanced data, we employed an under-sampling technique. 9 properties of the patches were calculated from amino acid compositions and secondary structure elements. With 10 fold cross validation, the predictive model built from SVM achieved an accuracy of 92.7% for classification of 3D patches in interaction and non-interaction sites from 147 complexes.

설소대의 크기와 운동이 발음에 미치는 영향

박성희,손우성,김용덕,신상훈,김욱규,정인교,권순복,Park, Seong-Hee,Son, Woo-Sung,Kim, Yong-Deok,Shin, Sang-Hun,Kim, Uk-Kyu,Chung, In-Kyo,Kwon, Soon-Bok 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.6

Purpose : The objective of this study is to ascertain whether the positive exists among the frenum length, the tongue movement and the speech and to present the normal range of tongue movement and guidelines for the choice of surgery, observation if necessary. Materials and Methods : 180 patients were evaluated. We divided 180 patients into 6 group by age. Each group was separated as follows; the age of 2.5-4, 5-6, 7-9, 10-12, 16-18. We measured the frenal length, the range of tongue motion and evaluated the speech so that we really questioned about the positive relationship between the tongue-tie and speech. We let the patient exercise the protrusive both(right, left) laterotrusive superior movement of the tongue. During these movements, we measured the distance between the vermilion border and the tongue tip. We also measured the distance from the tongue tip to the point contacting the upper lip with dorsum of the tongue during the maximal protrusive movement of the tongue. Three linear measurement of the anterior, inferior segment of the tongue including the lingual frenum, are made. These measurements are as follows: 1. Distance A. Free anterior portion of the tongue from the point of frenular insertion to the tongue tip. 2. Distance B. The distance from the initiating point of the lingual frenum to the point connecting the two sublingual carundcles to the lingual frenum perpendicularly. 3. Distance C. The distance from the point contacting the line crossing the sublingual caruncles with the lingual frenum to the terminating point of the lingual frenum. We transform three linear measures into a statistical ratio, A/(A-B+C), representing the length of the free portion of the tongue compared with the total sublingual dimensions. In addition, we assessed the speech through Picture Consonant Articulation Test(PCAT) and tried to find out the relationship between the length of the lingual frenum and speech. Conclusion : As people are born, they have small and restricted tongue. As people grow old, tongue motions are more liberate, and unrestricted and they can speak so freely. Therefore we suggest that until age 5, oral and maxillofacial surgeons postpone the surgery if not urgent, evaluate the maximal lingual motions and PCAT according to this article and observe their changes.

한국인 성인성 치주염 환자에서 16S rRNA 분석을 이용한 치은연하치태 세균 분포도 조사

박성희,김소영,최성호,채중규,김종관,조규성,Park, Seong-Hee,Kim, So-Young,Choi, Seong-Ho,Chai, Jung-Kiu,Kim, Chong-Kwan,Cho, Kyoo-Sung 대한치주과학회 1998 Journal of Periodontal & Implant Science Vol.28 No.4

The 16S rRNA analyzing method is a bacterial identification method that is useful in identifying bacteria which is difficult to do by other means. The following 7 types of bacteria which are Treponema, A. actinomycetemcomitans, P. gingivalis, Fusobacterium, B. forsythus, P. intermedia, P. micros were evaluated in order to study their distribution among patients with adult periodontitis. The 16S rRNA analyzing method was used to compare bacterial distribution among 3 groups. Subgingival plaque acquired from the affected sites(pocket depth ${\geq}6mm$) of 29 patients with adult periodontitis were grouped as the experimental group while plaque from the non-affected sites(pocket depth ${\leq}3mm$) were grouped as control 2 and finally plaque acquired from students with healthy periodontal tissues were grouped as control 1. The results are as follows ; 1. The distribution of Treponema was 12.5% for control 1, 21.4% for control 2 and 75.4% for the experimental group. For A. actinomycetemcomitans the distribution was 0.5%, 19.0%, 44.4% in respect to the order of groups mentioned above. P.gingivalis showed 10.5%, 43.1%, 94.0% distribution, Fusobacterium 33.0%, 48.3%, 81.0% distribution, B. forsythus 9.5%, 17.2%, 65.9% distribution, P. intermedia 1.0%, 12.1%, 26.3% distribution and finally P. micros 5.0%, 19.0%, 48.7% respectively. In all 7 types of bacteria, the experimental group showed higher bacterial distribution compared to the other two groups with statistically significant difference. 2. In the case of Treponema, A. actinomycetemcomitans, gingivalis,Fusobacterium, B. forsythus, P. intermedia, P. micros showed significant difference between control 1 and 2. These results suggest that the 16S rRNA analyzing method which was applied on Koreans for the first time could be utilized and useful in finding potential pathogens of periodontal disease.

A Study on Carrier Injection and Trapping by the High Field for MOS(Metal-$Al_2O_3$-p Si$) Structure

박성희,성만영,Park, Sung Hee,Sung, Man Young The Institute of Electronics and Information Engin 1987 전자공학회논문지 Vol.24 No.1

This study is carrier out to investigate the carrier injection and the characteristics of trapping for the CVD deposited Al2O3 film on Si substrates. Samples used are metal -Al2O3-Si Structure in which metal field plates are used with Aluminium or God. Canier injection and trapping, which result in flat band voltalge shift, occur at fields as low as 1~2 MV/cm. An approximate method is proposed for computing the location of the centroid of the trapped electrons in this paper. Results show that carriers are trapped near the injecting interface at fields less than about 5MV/cm. Because of continued charging, a steady state can not be reached. Therefore the unique I-V curve is obtained when the traps are initially empty. By utilization of applied voltage on each point of the fresh device sample, it is measured the I-V surves for two polarities of applied voltage. The current densities observed in the Al2O3 films are much larger than those obtained in SiO2.