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증례 : 소화기 ; 췌장미부 종양으로 오인된 부비장 결핵 1예
박성후 ( Seong Hu Park ),이동건 ( Dong Gun Lee ),최정문 ( Jeong Mun Choi ),서종훈 ( Jong Hun Seo ),양미진 ( Mi Jin Yang ),임대관 ( Dae Kwan Lim ),이상호 ( Sang Ho Lee ) 대한내과학회 2010 대한내과학회지 Vol.79 No.1
저자들은 33세 남자 환자에서 비장 경색을 동반한 췌장 미부 종양으로 오인된 부비장 및 비장 결핵을 경험하였기에 문헌고찰과 함께 보고하고자 한다. Abdominal tuberculosis usually affects the gastrointestinal tract, peritoneum, lymph nodes, liver or spleen. Tuberculosis of the spleen is uncommon, except when associated with miliary dissemination. We report a case of a 33-year-old man with tuberculosis of the accessory spleen, which was originally suspected to be a distal pancreatic tumor. He was admitted with a history of left upper quadrant abdominal pain for 3 months. Computed tomography imaging of the abdomen revealed a 4.5 cm sized poorly defined hypodense mass in the distal pancreas and showed multiple focal hypodense lesions in the enlarged spleen. We performed distal pancreatectomy and splenectomy under the preoperative expectation of a distal pancreatic tumor. Microscopic examination of the specimens revealed accessory splenic tuberculosis associated with splenic tuberculosis. Following this, he was treated with appropriate antituberculosis drugs and was discharged without any complications. (Korean J Med 79:53-56, 2010)
박성후 ( Seong Hu Park ),이승근 ( Seong Geun Lee ),김상미 ( Sang Mi Kim ),김근태 ( Gun Tae Kim ),백승훈 ( Seung Hoon Baek ),박영은 ( Young Eun Park ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.1
SLE 환자에서 발생한 림프절 병증은 다양한 조직학적 소견을 보일 수 있으며 악성 림프종의 감별 진단을 위해 주의 깊은 평가를 요한다. SLE 환자에서 발생한 림프절병증에서 캐슬만병이 진단된 예가 많지 않고 그 경과에 대해 충분히 알려 지지 않았으므로 이에 저자들은 SLE 환자에서 발생한 유리체혈관형의 다중심성 캐슬만병 1예를 경험하였기에 경과 및 치료, 예후 등을 보고하는 바이다. Castleman`s disease is a rare atypical lymphoproliferative disorder. Although HHV-8 has been reported to be a cause of Castleman`s disease, the etiology and pathogenesis of the disease remains mostly unknown. We experienced a 51- year-old female patient who was concurrently diagnosed with Castleman`s disease and systemic lupus erythematosus. Castleman`s disease has been rarely reported in patients with systemic lupus erythematosus. Thus, we report the case and briefly discuss relevant articles.
IL-15에 의한 류마티스관절염 환자 활막 섬유모세포에서의 SDF-1 유도
박영은 ( Young Eun Park ),김성일 ( Sung Il Kim ),박성후 ( Seong Hu Park ),백승훈 ( Seung Hoon Baek ),오혜좌 ( Hye Jwa Oh ),허양미 ( Yang Mi Heo ),조미라 ( Mi La Cho ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.3
Objective: Interleukin-15 (IL-15) recruits and activates synovial T cells, and IL-15 plays an important role in amplifying and perpetuating inflammation in the pathogenesis of rheumatoid arthritis (RA). Stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant for memory T cells in the inflamed RA synovium. This study investigated the effect of IL-15 on SDF-1 production in RA fibroblast-like synoviocytes (FLS). Methods: The expressions of IL-15 and SDF-1 were determined from the synovium of patients with RA and osteoarthritis (OA) by performing immunohistochemistry. The expressions of SDF-1 was measured from the RA FLS that were cultured with IL-15 and IL-17 by real-time RT-PCR and ELISA. The SDF-1 expression was also measured, via ELISA, from the RA FLS stimulated by IL-15 together with the inhibitors of such intracellular signal molecules as phosphatidylinositol 3-kinase (PI 3-kinase, LY294002), STAT3 (AG490), MAP Kinase (PD98059), NF-κB (parthenolide) and activator protein 1 (AP-1, curcumin). Results: IL-15 and SDF-1 were mainly expressed in the RA synovium compared to that of the OA synovium. IL-15 increased the SDF-1 expressions and it, and had an additive effect with IL-17 on the SDF-1 expressions in the cultured RA FLS. The IL-15 induced increase of the SDF-1 expression in the cultured RA FLS was blocked by the inhibitors of PI 3-kinase, NF-κB and AP-1. Conclusion: The SDF-1 expression was increased in the RA synovium and it was up-regulated by IL-15 in the RA FLS through the PI 3-kinase, NF-κB, and AP-1 pathways. These results imply that the IL-15 induced increase of the SDF-1 expressions may be involved in the immunopathogenesis of RA.
류마티스관절염에 동반된 만성 골수성 백혈병 환자에서 Imatinib Mesylate 효과 보고 1예
전혜경 ( Hye Kyung Jeon ),박영은 ( Young Eun Park ),김성일 ( Sung Il Kim ),박성후 ( Seong Hu Park ),백승훈 ( Seung Hoon Baek ),이정욱 ( Joung Wook Lee ),하동우 ( Dong Woo Ha ),이혜원 ( Hye Won Lee ),정주섭 ( Joo Seop Chung ),이승 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.2
Rheumatoid arthritis is associated with an increased risk of hematological malignancy as a result of the RA itself or its treatment. We report here on an unusual case of a 55-year-old female with long-standing rheumatoid arthritis and who was treated with low dose methotrexate and hydrochloroquine. She was diagnosed with chronic myelogenous leukemia that manifested with severe thrombocytosis and basophilia, and this was treated with imatinib mesylate. After 6 months, she achieved a complete cytogenetic response of the CML and a complete resolution of all the RA symptoms without DMARDs.