http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
일측 전정기관 손상 흰쥐에서 전정안구반사와 내측전정신경핵의 c-Fos 단백질발현에 대한 전정기관의 전기자극 효과
박병림,황호룡,이문영,김민선,Park Byung-Rim,Hwang Ho-Ryong,Lee Moon-Yong,Kim Min-Sun 대한약리학회 1997 The Korean Journal of Physiology & Pharmacology Vol.1 No.3
Unilateral labyrinthectorny (ULX) causes autonomic symptoms, ocular and postural asymmetries, which disappear over tune in the process of equilibrium recovery known as vestibular compensation. In the present study in order to elucidate mechanisms responsible for the effects of electrical stimulation on vestibular compensation and investigate the relationship between vestibular compensation and c-Fos expression in the medial vestibular nuclei following ULX, we measured spontaneous nystagmus, eye movement induced by sinusoidal rotation and c-Fos expression or to 72 hs after ULX in Sprague-Dawley rats. Experimental animals were divided into two groups: ULX group with ULX only, and electrical stimulation (ES) group with electrical stimulation of $-2{\sim}-5V$, 1.0ms, 100 Hz to the lesioned vestibular system for 4 hs/day. Spontaneous nystagmus following ULX disappeared by 72 hs in ULX group and 36 hs in ES group. In eye movement induced by sinusoidal rotation, normal pattern of eye movement by rotation toward the lesioned side was recovered 24 hs after ULX at rotation of 0.1 Hz and 6 hs after at 0.2 Hz, 0.5 Hz in ULX group. In ES group, the eye movement recovered after 12 hs at 0.1 Hz, 6 hs at 0.2 Hz, and 4 hs at 0.5 Hz. Directional Preponderance which represents the symmetry of bilateral vestibular functions showed significantly early recovery in ES group compared with that of ULX group. Expression or c-Fos immunoreactive cells in the bilateral medial vestibular nuclei was severely asymmetrical till 36 hs in ULX group, and then it became a symmetry and disappeared after 72 hs. However, ES group showed the symmetry of c-Fos expression after 6 hs, which was significantly early recovery in 25 group. All these findings suggest that electrical stimulation ameliorates recovery of vestibuloocular reflex following ULX by the restoration of the balance of the resting activity between bilateral medial vestibular nuclei. In addition, c-Fos expression in the medial vestibular nuclei could be used as a marker of vestibular compensation since c-Fos expression is closely related to the course of recovery following ULX.
양측 전정절제(前庭切除) 가묘(家猫)의 경안구반사(頸眼球反射)
박병림,박철순,Park, Byung-Rim,Park, Chul-Soon 대한생리학회 1988 대한생리학회지 Vol.22 No.1
The effect of cervical proprioceptors on the control of eye movement and body posture was examined in unanesthetized labyrinthine intact and bilateral labyrinthectomized cats. Cervico-ocular reflex(COR) was elicited by stimulation of the cervical proprioceptors by means of sinusoidal rotation of head or body in the darkness. The following results were obtained: 1) In labyrinthine intact cats, sinusoidal rotation of the whole body elicited compensatory eye movement(vestibulo-ocular reflex: VOR); the direction of eye movement was opposite to the direction of head rotation. 2) Anticompensatory eye movement was observed by sinusoidal rotation of the body with head fixed in labyrinthine intact cats; the direction of eye movement was the same as the direction of head rotation. 3) Compensatory eye movement was observed by sinusoidal rotation of the head with body fixed or sinusoidal rotation of the body with head fixed in both acute and chronic bilateral labyrinthectomized cats. These results suggest that the cervical proprioceptors are important in the control of ocular movement and posture in the bilateral labyrintectomized cats, although they are questionable in labyrinthine intact cats.
메틸수은에 의해 손상된 희소돌기아교세포에 대한 allopurinol의 영향
박승택(Seung Taeck Park),박병림(Byung Rim Park),정연태(Yeun Tai Chung) 대한체질인류학회 1996 대한체질인류학회지 Vol.9 No.2
희간추림. 수온의 신경독성에 대한 기천을 규명하기 위하여 소의 뇌조직으로부터 분리, 배양된 희소돌기아교세포를 methylmercuric chloride(MMC)에 노출시킨 후 MMC에 의해 유도된 신경독성효과를 측정하고, 또한 MMC 에 의하여 유도된 신경독성에 대한 항산화제인 allopurinol 의 방어효과를 MTT 분석법에 의하여 조사하였다. 소의 뇌로부터 분리, 배양된 희소돌기아교세포를 35㎛ MMC에서 24시간 동안 노출시킨 결과 MMC는 약 50%의 세포생존율을 감소시켰으며, 또한 allopurinol 은 MMC에 의하여 중재원 신경독성을 유의하게 방어하였다. 위의 결과로부터 산소자유기는 MMC의 독성효과에 관여하고 있으며 allopurinol과 같은 항산화제가 MMC의 독성방어에 효과적인 것으로 나타났다.
시각 장애우와 청각 장애우에서 두점식별력과 격자해상능을 이용한 촉각인지능평가
박진희 ( Jin Hee Park ),유현광 ( Hyun Kwang Ryoo ),김나리 ( Na Ri Kim ),최명애 ( Myoung Ae Choi ),김민선 ( Min Sun Kim ),박병림 ( Byung Rim Park ),강대임 ( Dae Im Kang ) 한국감성과학회 2011 감성과학 Vol.14 No.4
시각장애우와 청각장애우에서 상실된 감각기능을 대체할 목적으로 촉각제시장치를 이용할 경우 효과적으로 촉각을 제시하기 위하여 대조군, 시각장애군, 청각장애군, 합병증성 시각장애군에서 신체 부위에 따른 촉각인 지능을 컴퍼스와 JVP dome을 이용하여 각각 두점식별력과 격자해상능을 측정하였다. 컴퍼스를 이용한 두점식 별력은 대조군에서 손가락이 가장 높은 민감도를 보였으나 남녀의 차이는 보이지 않았다. 시각장애군과 청각장애군은 대조군과 비교하여 손가락에서는 차이를 보이지 않았으나 팔과 다리 부위에서는 낮은 민감도를 보였다. JVP dome을 이용한 격자해상능은 대조군에서 다섯 손가락 모두에서 상호간의 차이를 보이지 않았으며, 또한 남녀의 차이도 보이지 않았다. 시각장애군은 대조군과 비교하여 다섯 손가락 모두에서 높은 민감도를 보였으며, 청각장애군은 대조군과 차이를 보이지 않았다. 그러나 합병증성 시각장애군은 대조군 및 시각장애군과 비교하여 두점식별력 및 격자해상능에서 모두 낮은 민감도를 보였다. 이상의 연구결과는 촉각제시장치를 이용할 경우 자극 부위와 방법을 고려해야 하며, 감각상실의 원인 질환에 따라 촉각인지능에 차이가 있음을 시사한다. Tactile acuity was assessed in groups of control, blind, deaf, and blind caused by complication to investigate the effective tactile stimuli on tactile sensory substitution studies when tactile display is applied to persons with sensory loss of vision or hearing. Two-point discrimination and grating resolution were assessed by compass and JVP dome, respectively, in the hand, arm, neck, lumbar, and knee. In two-point discrimination by compass, control group showed the highest sensitivity in fingers among assessed body areas but did not show any significant difference between male and female. Blind group and deaf group compared to control group did not show any significant difference in fingers but showed lower sensitivity in arm and knee. In grating resolution by JVP dome, control group did not show any significant difference among five fingers as well as between male and female. Blind group showed higher sensitivity in five fingers compared to control group, but deaf group did not show any significant difference from control group. Blind caused by complication group showed lower sensitivity in two-point discrimination and grating resolution compared to control group and blind group. These results suggest that the body area and method of tactile stimulation, and difference in tactile acuity depending on underlying disease of sensory loss should be considered when tactile display is applied for sensory substitution.
인체 전기 신호 계측을 위한 pre-amplifier의 제작
박종환 ( Jong Hwan Park ),천우영 ( Woo Young Chun ),박형준 ( Hyung Jun Park ),박병림 ( Byung Lim Park ) 한국감성과학회 1997 연차 학술대회 논문집 Vol.1997 No.-
In this study, the pre-amplifiers were manufac-tured, which correspinds with the properties of signal source, For measuring the EMG, EEG, ECG and EOG``s signal, which are generated at human body, the pre-amplifiers were manufactured in this study which was corresponding with the propertiies of each signal source. So as to do, the bandwidth of filters and the amplitude of amplifiers were adaptively adjusted, according to signal source. Then, the usefulness was represented by showing the measured examples.
가토(家兎)에 있어서 전정반규관(前庭半規管)의 외안사근(外眼斜筋)에 관(對)한 흥분적(興奮的) 작용(作用)에 관(關)한 연구(硏究)
김재협,박병림,길원식,Kim, Jeh-Hyub,Park, Byung-Rim,Gill, Won-Sik 대한생리학회 1982 대한생리학회지 Vol.16 No.1
The present experiment was carried out to elucidate interrelation between the vestibular canals and the extraocular oblique muscles. In urethane anesthetized rabbits, excitatory or inhibitory effect of the canal was produced by three different methods; selective electrical stimulation of the ampullary nerve, bidirectional (ampullofugal or ampullopetal) lymphatic fluid flow, and rapid freezing of the canal. Changes of isometric tension as well as electro-myographic activity of the oblique muscles were recorded in the ipsilateral and contralateral eyes, by means of a polygraphic recorder, and the following results were obtained. 1) Electrical stimulation of a unilateral vertical or horizontal nerve caused contraction of superior oblique muscle and relaxation of inferior oblique muscle in the ipsilateral eye, and contraction of inferior oblique muscle and relaxation of superior oblique muscle in the contralateral eye. 2) Ampullofugal flow in a vertical canal and ampullopetal flow in a horizontal canal caused the oblique muscle responses which were identical to those responses produced by the electrical stimulation of the same canal nerve. 3) Rapid freezing of a vertical canal elicited the oblique muscle responses which were opposite to those caused by electrical stimulation of the same canal nerve. From the above experimental results, functional interrelation between the individual vestibular canal and bilateral extraocular oblique muscles were better elucidated. When these results were compared to those reported by previous investigators (Utzumi, Suzuki et al.), some important discrepancies were found between them. We ascribed such discrepancies to experimental errors of the previous investigators, since their results reflected theoretical contradictions in terms of vestibular eye movements.