순환성분 추출을 위한 EMD와 HP 필터의 비교분석: 한국의 거시 경제 지표에의 응용

박민정,성병찬,Park, Minjeong,Seong, Byeongchan 한국통계학회 2014 응용통계연구 Vol.27 No.3

본 논문에서는 시간-진동수 영역에서 시계열을 여러 구성 성분으로 분해하는 방법인 경험적모드분해법(Empirical Mode Decomposition)을 소개하고, 이를 이용하여 한국의 주요 거시 경제 지표를 대상으로 순환변동과 추세 성분을 추출하고 예측에 활용한다. 그 효율성을 살펴보기 위하여, 추출된 구성 성분들의 변동성, 동행성, 지속성, 인과성, 비정상성 및 예측력을 계산하고, 가장 보편적으로 널리 사용되고 있는 Hodrick-Prescott 필터에 의한 결과와 비교한다. We introduce the empirical model decomposition (EMD) to decompose a time series into a set of components in the time-frequency domain. By using EMD, we also extract cycle and trend components from major Korean macroeconomic indices and forecast the indices with the components combined. In order to evaluate their efficiencies, we investigate volatility, autocorrelation, persistence, Granger causality, nonstationarity, and forecasting performance. They are then compared with those by Hodrick-Prescott filter which is the most commonly used method.

졸-겔법에 의한 나노크기 Au 미립자 분산 TiO₂ 박막의 특성

박민정,구세나,이경석,문종수,Park, Min-Jung,Koo, Se-Na,Lee, Kyoung-Seok,Mun, Chong-Soo 한국세라믹학회 2006 한국세라믹학회지 Vol.43 No.2

Nano-size Au particle doped $TiO_2$ films were prepared with $Ti(OC_3H_7^i)_4$, polyvinylpyrrolidone(PVP), $HAuCl_4$ and $C_3H_7OH$ etc. by sol-gel method. $TiO_2$ gel films were obtained by the dip-coating method on the $SiO_2$ glass substrates, and then heat-treated at $700^{\circ}C$ for 10 min. The thickness of $TiO_2$ films were $0.7\~1.8\;{\mu}m$. It was found that the thickness of films prepared from PVP containing solution was about $2\~8$ times higher values than that of thin films without PVP. The size of Au particles doped in the films were about $350\~750\;nm$. Nano-size Au particle dispersed $TiO_2$ films showed high absorption peak at visible region 450nm, which made them good candidates for non-linear optical materials and photo-catalytic materials. The contact angle of $TiO_2$ film for water was $12.5^{\circ}$, and therefore it is clear that $TiO_2$ films have very high hydrophilic properties and the self-cleaning effects.

퇴행성 슬관절염 환자에 대한 슬관절방(膝關節方) 1호(號)의 제형변화 유효성 임상연구

박민정,서진우,성인형,김남옥,성수민,정애경,신대희,박쾌환,Park, Min-Jung,Seo, Jin-Woo,Sung, In-Hyung,Kim, Nam-Ok,Sung, Su-Min,Chung, Ae-Kyung,Shin, Dae-Hee,Park, Koae-Hwan 대한한의학방제학회 2005 大韓韓醫學方劑學會誌 Vol.13 No.2

Objective: This study is designed to compare the effects of Sulguanjul-Bang No.1 on osteoarthritis in knee joint according to formulation. Methods: 47 patients with symptomatic osteoarthritis of the knee joint were enrolled in a open clinical trial. The 47 patients were devided into two groups at random and taken Sulguanjul-bang No.1 with decoction type, suspension type respectively for8 weeks. After 8-week treatment period, the following parameters were analyzed ; Visual analogue Scale(VAS), Lysholm index score, patients' global assessment. Results: Sulguanjul-bang No.1 treatment led to significant improvement in the pain and symptoms of osteoarthritis as determined by all efficacy measures. After 8 weeks of therapy, there was significant improvement in VAS, Lysholm index and patients' global assessment. But there is no significant difference between two groups. Conclusions: Sulguanjul-bang No.1 was very beneficial pain relief effect and functional improvement irrespect of formulation, decoction type or suspension type.

마이크로데이터 공표를 위한 통계적 노출제어 방법론 고찰

박민정,김항준,Park, Min-Jeong,Kim, Hang J. 한국통계학회 2016 응용통계연구 Vol.29 No.6

학술 연구나 정책 입안 등을 위한 심층적 자료 활용의 확대는 동시에 개별 정보 노출에 대한 염려도 증가시킨다. 때문에 최근 이십여 년 간 통계적 노출제어(정보보호) 분야에서 많은 논문들이 발표되었다. 본 논문은 그러한 연구 내용들을 정리하여 국내 통계인들과 기관들에게 소개하고자 한다. 주요 내용으로 국소통합이나 잡음추가와 같은 전통적인 매스킹 기법 뿐만 아니라, 온라인 자료 분석 시스템에서의 정보보호 처리, 차등정보보호를 통한 노출제어 및 재현자료를 활용한 정보보호 대안 모색에 대해 다룬다. 또한 각각의 주제에 대한 방법론 소개와 함께 활용 사례 및 장단점을 논의하였다. 본 논문이 실제적인 통계적 노출제어 문제를 고민하는 통계인들에게 도움이 되기를 바란다. The increasing demand from researchers and policy makers for microdata has also increased related privacy and security concerns. During the past two decades, a large volume of literature on statistical disclosure control (SDC) has been published in international journals. This review paper introduces relatively recent SDC approaches to the communities of Korean statisticians and statistical agencies. In addition to the traditional masking techniques (such as microaggregation and noise addition), we introduce an online analytic system, differential privacy, and synthetic data. For each approach, the application example (with pros and cons, as well as methodology) is highlighted, so that the paper can assist statical agencies that seek a practical SDC approach.

한.양방 협진의 진료협력수준 측정도구개발 및 타당도 연구

박민정,최병희,백윤희,박정혜,Park, Minjung,Choi, Byunghee,Baek, Yun Hui,Park, Jeong Hye 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.1

Objective : The purpose of this study is to present the desirable model for the promotion of care coordination between Korean Medicine and Western Medicine and develope the instrument to measure the level of coordination. Moreover, we verified the validity and reliability of the developed Instrument. Method : In this study, We developed the 16 items regarding care coordination in Korean Medicine and Western Medicine by literature review and expert interviews. In addition, we verified the validity and reliability of the instrument as a methodological research. Results : We developed two factors such as 'Inter-professional activities' and 'Organizational support' as the instrument to measure the level of care coordination, and each of seven, eight total of 15 measurement items are listed. Conclusion : Since the legal permission, the level and type of care coordination and the effects of them are needed to be checked. So, the measurement instrument driven by this study has a political signification in healthcare system specially in these times. In addition, by utilizing this instrument, we propose to perform a variety of future studies on the levels of healthcare coordination and related outcomes.

경제활동인구조사 자료를 위한 다중대체 방식 연구

박민정,배윤종,김정연,Park, Min-Jeong,Bae, Yoonjong,Kim, Joungyoun 한국통계학회 2021 응용통계연구 Vol.34 No.5

경제활동인구조사는 고용 관련 통계를 생성하는 국가조사로서, 국민의 경활상태(취업/실업/비경활)를 파악하는 것이 주요 목적이다. 정확한 통계를 내기 위해 무응답률을 낮추는 것이 중요하고, 이미 발생한 무응답을 보완하기 위한 방법으로 무응답 대체가 가능하다. 경제활동인구조사는 응답 방식이 순차적 흐름을 따라가기 때문에 구조적인 무응답이 존재한다. 또한 전체 가구원내 무응답 항목이 하나라도 있으면 해당 가족 구성원 전체를 무응답 처리하기에 최종 자료에는 항목 무응답이 아닌 단위 무응답만 존재한다는 특징이 있다. 본 연구에서는 구조적 무응답 이해 및 연계자료를 통한 과거 자료의 활용 등을 통해 기존의 방법보다 효과적인 무응답 대체 모형을 제시하고자 한다. 대체 모형의 성능을 일치도/비일치도를 기반으로 평가한다. 이를 위해, 2019년 11월 경제활동인구조사 자료를 기반으로 모의실험을 실시한다. 총 59,996명의 응답자 중 일부를 랜덤하게 선택한 뒤, 경활상태를 판정하는데 결정적인 설명변수 6개와 경활상태를 무응답 처리한다. 기존 무응답 대체 모형에서 사용하였던 설명 변수 이외에 산업변수와 종사상지위 변수를 추가함으로써 모형을 개선한다. 이는 과거자료의 연계 및 활용을 가정한 것으로, 기존의 모형모다 성능이 향상되는 것을 확인한다. 또한, 경활상태별 무응답자 수에 대한 다양한 시나리오를 고려한다. The Korean Economically Active Population Survey (KEAPS) is a national survey that produces employment-related statistics. The main purpose of the survey is to find out the economic activity status (employed/ unemployed/ non-employed) of the people. KEAPS has a unique characteristics caused by the survey method. In this study, through understanding of structural non-response and utilization of past data, we would like to present an improved imputation model. The performance of the proposed model is compared with the existing model through simulation. The performance of the imputation models is evaluated based on the degree of mathing/nonmatching rates. For this, we employ the KEAPS data in November 2019. For the randomly selected ones among the total 59,996 respondents, the six explanatory variables, which are critical in determining the economic activity states, are treated as non-response. The proposed model includes industry variable and job status variable in addition to the explanatory variables used in the precedent research. This is based on the linkage and utilization of past data. The simulation results confirm that the proposed model with additional variables outperforms the existing model in the precedent research. In addition, we consider various scenarios for the number of non-responders by the economic activity status.

The Effect of Topiramate on Hippocampal Neuronal Death and Expression of Glutamate Receptor in Kainate-induced Status Epilepticus Model

박민정,하세운,배혜란,김상호,Park Min-Jeong,Ha Se-Un,Bae Hae-Rahn,Kim Sang-Ho Korean Society of Life Science 2005 생명과학회지 Vol.15 No.3

신경흥분독성과 간질발작발현은 glutamate 수용체활성과 연관이 있다고 알려져 있다. a-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA), kainate 수용체에 대한 glutamate 활성을 포함하는 다양한 기전을 가진 항전간제인 Topiramate는 신경보호작용을 가진다는 증거가 제시되어 Topiramate가 간질발작 후 해마의 glutamate 수용체 발현에 미치는 효과를 관찰하였다. 흰쥐에 kainate를 복강 내 주사하여 간질중첩증을 유발시킨 후 Topiramate를 1주일 주사하였다 Apop tag in situ detection kit를 이용하여 세포손상을 관찰한 결과 kainate 유발 간질중첩증 1주일 후 해마의 CA1, CA3에서 심각한 세포사를 보였으나, Topiramte 처리 군에서는 세포사가 현저히 감소하였다. 간질중첩증 이후 NMDA 수용체 아형 1,2a, 2b 발현이 현저히 증가했으나 Topiramate 처치에 의해 NMDA수용체의 발현에는 뚜렷한 변화가 없었다. AMPA수용체에서는 GluR1이 간질중첩증 이후 현저히 상향 조정되었고 GluR2는 현저히 하향조정 되었다 Topiramate 1주일 처리 시 간질중첩증으로 인해 변화된 CluR1과 GluR2의 발현이 역전되었다. 결론적으로 Topiramate는 간질중침증에 의한 CluR1/CluR2 발현비의 증가로 유발되는 흥분성 신경세포사를 억제시킴으로써 신경보호작용이 있는 것으로 보인다. Excitotoxicity and epileptogenesis have often been associated with glutamate receptor activation. Accumulating evidences indicates that topiramate (TPM), an antiepileptic drug with multiple mechanisms of action has neuroprotective activity. We explored the neuroprotective effect of TPM on the status epilepticus (SE)-induced hippocampal neuronal death. After development of SE by kainite injection (15 mg/Kg), rats were treated with TPM (10mg/kg) for 1 week. The neuronal death was detected by Apop tag in situ detection kit, and the expression levels of glutamate receptors were semi-quantitatively analyzed by immunoblot. Kainate-induced SE caused a significant neuronal death and cell loss in CAI and CA3 regions of hippocampus at 1 week. However, treatment of TPM for 1 week after SE markedly reduced hippocampal neuronal death. The expression of N-methyl-D-aspartate (NMDA) receptor subunit 1, was increased by SE, but was not affected by 1 week treatment of TPM. The expressions of NMDA receptor subunit 2a and 2b were not changed by either SE or TPM. As for ${\alpha}-amino-3-hydroxy-5-methyl-4-isoxazole-propionate$ (AMPA) glutamate receptors (GluR), kainate-induced SE markedly up-regulated GluR1 expression but down-regulated GluR2 expression, leading to increased formation of $Ca^{2+}$ permeable GluR2- lacking AMPA receptors. TPM administration for 1 week attenuated SE-induced expression of both the up-regulation of GluR1 and down-regulation of GluR2, reversing the ratio of GluR1/GluR2 to the control value. In conclusion, TPM protects neuronal cell death against glutamate induced excitotoxicity in kainate-induced SE model, supporting the potential of TPM as a neuroprotective agent.

위천공 수술 후 발생한 난치성 딸꾹질을 호소하는 환자 치험 1례

박민정,손정화,우지명,조기호,정우상,문상관,Park, Minjeong,Son, Jeonghwa,Woo, Ji Myoug,Cho, Ki-ho,Jung, Woo-sang,Moon, Sang-kwan 대한중풍순환신경학회 2016 대한중풍.순환신경학회지 Vol.17 No.1

■ Objectives The purpose of this clinical study is to evaluate the effect of Korean Medical Treatment on a 71 years old Korean male with Intractable hiccup for 40 years after gastric perforation operation. ■ Methods He was treated with acupuncture, electroacupuncture, moxibustion and herbal medicine, Jakyakgamcho-tang and Banhasasim-tang. We evaluated the improvement by frequency of hiccup and NRS of hiccup. ■ Results Hiccup disappeared at sixth day of treatment and NRS of hiccup also decreased.. ■ Conclusion Korean medical treatment may be effective in treating intractable hiccup

적외선체열촬영을 통한 편측 경항상지통환자의 임상적 고찰

박민정,이경윤,조원영,박쾌환,Park, Min-jung,Lee, Kyung-yun,Cho, Won-young,Park, Koae-hwan 대한침구의학회 2004 대한침구의학회지 Vol.21 No.2

Objectives : We studied to discover the patterns of DITI of the patients having a both neck and upper extremity pain on one side without any nerve root compression sign and the history of cervical disc herniation. Method : We selected 26 patients as an experimental group, who had visited for a both neck and upper extremity pain on one side without any nerve root compression sign, at the department of acupunture and moxibustion in Conmaul oriental medical hospital, during 2001. 01. - 2003. 09. And 31 normal adults were selected as a control group, not having any neck or arm pain and any history of cervical disease. We analyzed the segmental temperature statistically with t-test. Results & Conclusion : There was a significant change of temperatures in the scapula, posterior brachium, lateral forearm and dorsal hand area. And the experimental group showed cold spot and disruption of normal thermographic shape that were usually shown on the cervical sprain.

실손형 민간보험의 비급여 보장축소가 한방의료이용에 미친 영향

박민정,고성규,Park, Minjung,Ko, Seong-Gyu 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.3

Objective : Private health insurance coverage in Korean medicine has been reduced since October 2009 for preventing unnecessary utilization. The aim of this study is to identify how private health insurance coverage reduction affects on the Korean medicine utilization. Method : We analyzed the Korea Health Panel data from 2008 to 2012. Panel negative binominal regression model was used to analyze the relationship between private health insurance coverage reduction and utilization of outpatient service. Panel tobit regression analysis was used to identify the relationship between private health insurance coverage reduction and health expenditure of outpatient service. Results : Private health insurance coverage reduction significantly dropped both utilization and health expenditure of outpatient service by 9%, 9.22% respectively. In addition, therapeutic utilization significantly decreased up to 10%. Conclusion : Private health insurance coverage reduction seems to have an effect to reduce both utilization and the health expenditure of Korean medicine outpatient service. This effect was more noticeable in the therapeutic utilization. Thus, more elaborate policy will be needed to prevent unnecessary utilization of Korean medicine.