Downregulation of SETD5 Suppresses the Tumorigenicity of Hepatocellular Carcinoma Cells

박미진,Byul Moon,김종환,Seung-Jin Park,Seon-Kyu Kim,Kihyun Park,김재훈,김선영,Jeong-Hoon Kim,김정애 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.8

Hepatocellular carcinoma (HCC) is an aggressive and incurable cancer. Although understanding of the molecular pathogenesis of HCC has greatly advanced, therapeutic options for the disease remain limited. In this study, we demonstrated that SETD5 expression is positively associated with poor prognosis of HCC and that SETD5 depletion decreased HCC cell proliferation and invasion while inducing cell death. Transcriptome analysis revealed that SETD5 loss downregulated the interferon-mediated inflammatory response in HCC cells. In addition, SETD5 depletion downregulated the expression of a critical glycolysis gene, PKM (pyruvate kinase M1/2), and decreased glycolysis activity in HCC cells. Finally, SETD5 knockdown inhibited tumor growth in xenograft mouse models. These results collectively suggest that SETD5 is involved in the tumorigenic features of HCC cells and that targeting SETD5 may suppress HCC progression.

생활속의 건강상식

박미진,Park, Mi-Jin 사단법인 한국당뇨협회 2007 당뇨 Vol.206 No.-

사회경제적 위치와 유방암 수술 후 총 사망위험과의 관련성

박미진,정우진,이선미,박종혁,장후선,Park, Mi-Jin,Chung, Woo-Jin,Lee, Sun-Mi,Park, Jong-Hyock,Chang, Hoo-Sun 대한예방의학회 2010 예방의학회지 Vol.43 No.4

Objectives: This study aims to evaluate and explain the socioeconomic inequalities of all-cause mortality after breast cancer surgery in South Korea. Methods: This population based study included all 8868 females who underwent radical mastectomy for breast cancer between January 2002 and June 2003. Follow-up for mortality continued from January 2002 to June 2006. The patients were divided into 4 socioeconomic classes according to their socioeconomic status as defined by the National Health Insurance contribution rate. The relationship between socioeconomic status and all-cause mortality after breast cancer surgery was assessed using the Cox proportional hazards model with adjusting for age, the Charlson’s index score, emergency hospitalization, the type of hospital and the hospital ownership. Results: Those in the lowest socioeconomic status group had a significantly higher hazard ratio of 2.09 (95% CI =1.50 - 2.91) compared with those in the highest socioeconomic group after controlling for all the identifiable confounding variables. For allcause mortality after radical mastectomy, all the other income groups showed significantly higher 3-year mortality rates than did the highest income group. Conclusions: The socioeconomic status of breast cancer patients should be considered as an independent prognostic factor that affects all-cause mortality after radical mastectomy, and this is possibly due to a delayed diagnosis, limited access or minimal treatment leading to higher mortality. This study may provide tangible support to intensify surveillance and treatment for breast cancer among low socioeconomic class women.

Corrigendum to: Downregulation of SETD5 Suppresses the Tumorigenicity of Hepatocellular Carcinoma Cells

박미진,Byul Moon,김종환,Seung-Jin Park,Seon-Kyu Kim,Kihyun Park,김재훈,김선영,김정훈,Jung-Ae Kim 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.10

융기된 영상의 골격선 추출에 의한 에지 보정 알고리듬

박미진,양영일,박중조,Park, Mi-Jin,Yang, Yeong-Il,Park, Jung-Jo 대한전자공학회 2001 電子工學會論文誌-SP (Signal processing) Vol.38 No.6

본 논문에서는 에지 영상의 정보를 잃지 않으며 인접한 에지를 연결하는 에지 보정 알고리듬을 제안하였다. 제안된 에지 보정 알고리듬은 두 단계로 구성되어 있다. 첫 단계는 에지 영상을 반복적으로 융기시켜 융기 영상을 얻는 단계이며, 두 번째 단계는 골격선 추출 알고리듬을 이용하며 융기된 영상으로부터 에지 영상을 추출하는 단계로 이루어져 있다. 실험 결과는 제안된 방법이 다른 방법에 비해 원래의 에지 영상의 정보를 왜곡시키지 않으면서 인접한 에지를 잘 연결함을 보여준다. In this paper, we propose the edge compensation algorithm which connects the adjacent edges without losing the information of the skeletons on the edge image. The proposed edge compensation algorithm is composed of succeeding two steps. In the first step, the uplifted image is obtained by uplifting the edge image repeatedly. The next step is to extract the edge image from the uplifted image using the skeleton extraction algorithm. Experimental results show that the proposed method connects the adjacent edges without the distortion of the original edge information compared to the traditional method.

지역사회 아웃리치 실천기술의 구성요소에 대한 사회복지사의 인식 탐색 연구

박미진(Park, Mi Jin) 한국지역사회학회 2017 지역사회연구 Vol.25 No.2

This study examines the effects of individual factors (age, gender, education, certificate level, working experiences, reeducation), organizational factors, community outreach experience on needs of community outreach practice skills among social workers in community welfare centers. 526 social workers who work at the community welfare centers in Busan responded by mail survey. The data were used to analyze by the SPSS 23.0 software. The results of analysis are as follows. First, exploratory factor analysis showed four sections: community understanding skills, clients engagement skills, community intervention skills, and marketing and report skills. Second, higher education level, certificate level, and organizational factor, greater community outreach experiences are significantly predictive of higher community outreach skills need among respondents. Lastly, the implications of the findings and offer suggestions are discussed for further research.

위기취약 대상자 발굴을 위한 사회복지사의 지역사회 아웃리치 실천 기술 경험에 관한 질적 연구

박미진(Park, Mi Jin),김진(Kim, Jin) 한국지역사회학회 2018 지역사회연구 Vol.26 No.3

본 연구의 목적은 지역사회복지관 사회복지사들이 지역사회 아웃리치를 어떻게 경험하고 있고, 이를 위해 사용하는 실천기술들이 무엇인지를 이해하고자 하는 것이다. 연구참여자는 지역사회 아웃리치 경험이 있는 지역사회 복지관에 근무하는 사회복지사 15명을 대상으로 하였다. 자료수집방법은 심층면접을 통해 이루어졌고, 질적연구방법중 Giorgi의 현상학적 분석방법을 활용하였다. 분석결과, 지역사회 아웃리치 실천과 기술에 대한 경험은 74개의 의미단위, 12개의 드러난 주제, 7개의 본질적 주제로 범주화되었다. 본질적 주제는 지역사회 아웃리치 개념, 필요성, 지역사회 아웃리치 장애요소, 지역사회 아웃리치 대상자, 지역사회 아웃리치 실천기술에 대한 개별적 접근 (클라이언트와 관계맺기, 동기부여하기), 조직적 접근(기관차원에서 정기적으로 하기, 기관정책 차원에서 체계마련하기), 지역적 접근(지역주민과 함께 하기, 지역사회 기관들과 함께 하기)으로 구분하였다. 또한 사회복지사들의 실천경험토대 지역사회 아웃리치 인식, 장애물, 기술 구조화를 제시하였다. 마지막으로 사회복지사들의 지역사회 아웃리치에 대한 개입과 실천방법에 대한 함의에 대해 논의하였다. The purpose of this study was to understand how social workers in community welfare centers use their community outreach skills. This study used Giorgi phenomenological methodology to in-depth interview 15 social workers. The essential meaning of the phenomenon of community outreach, as experienced by social workers in community welfare centers is analysed. The interviews referenced 74 meaning units, 12 revelatory themes and seven core themes. Core themes identified four: community outreach concepts(meaning of community outreach, going to the clients), necessity of community outreach, clients’ type of community outreach, obstacles of community outreach. Community outreach practice skills fell into three themes: individual approach(relationships with clients centered, motivating clients), organizational approach(approaching with regulary, with a system at the agency level), and community aprroach(being with community citizens, being with commingy agencies). Finally, this study discussed some of the implications of community outreach practice for social workers in community welfare centers.

대학생의 성격 5요인과 삶의 만족간의 관계에서 진로결정자기효능감의 매개효과

박미진(Park Mee Jin),김진희(Kim Jin Hee) 학습자중심교과교육학회 2015 학습자중심교과교육연구 Vol.15 No.11

본 연구는 대학생의 성격 5요인과 삶의 만족의 관계에서 진로결정자기효능감의 매개효과를 검증하는 것을 목적으로 하였다. 이를 위해 충청남도에 위치한 4년제 대 학 2곳에 재학 중인 대학생 323명을 표집하였다. 상관분석 결과, 성격 5요인(개방성, 성실성, 외향성, 사교성, 정서안정성), 진로결정자기효능감, 삶의 만족은 모두 유의한 정적 상관이 있는 것으로 나타났다. 또한 진로결정자기효능감은 대학생의 성격 5요 인과 삶의 만족 간에서 5요인(개방성, 성실성, 외향성, 사교성, 정서안정성) 모두 유 의한 매개효과를 보이는 것으로 나타났다. 연구의 결과를 토대로 시사점, 한계 및 제언을 논의하였다. The purpose of this study is to examine the mediation effect of the career decision-making self-efficacy on the relationships between big five personality factors and life satisfaction of university students. This analysis is utilized with data from 323 college students from two universities in Chungnam. The results of this article show significant positive correlation among big five personality factors(openness, conscientiousness, extroversions, agreeableness, emotional stability), career decision-making self-efficacy, and life satisfaction. The mediation effects of career decision-making self-efficacy are also significant in the relationship between big five personality factors(openness, conscientiousness, extroversions, agreeableness, emotional stability) and life satisfaction. Based on these findings, this study ends with discussion of the results, imitations, and suggestions for further research.

고등학생의 여가생활과 진로결정의 관계

박미진(Park, Mee-Jin),김진희(Kim, Jin-Hee) 한국진로교육학회 2003 진로교육연구 Vol.16 No.1

층간소음의 환경적 특성에 관한 연구

박미진(Park Mi Jin) 한국주거환경학회 2016 주거환경(한국주거환경학회논문집) Vol.14 No.1

In an apartment house, which is a representative housing form and occupies over 57% of all the houses in Korea, floor noise between households is continuously occurring due to the structure to share the floor and wall with a neighboring household. According to the Ministry of Environment, civil complaints about floor noise had constantly increased to 16,370 from 2012 to 2014. So the importance of solving floor noise problems is becoming bigger and bigger. After the revision of Housing Act, it appears that floor noise problem in newly built houses would be solved gradually. But floor noise problems in apartment houses built before the enactment of floor noise-related law in 2005 cannot be fully solved through revision of law and there is a need to develop related technology. Therefore, this study quantitatively evaluated floor noise reduction performance in a multiplex house depending on the kinds of materials, thickness and construction location in order to research environmental characteristics of floor noise in a multiplex house, which was built before 2005 and needs to be remodeled, and to evaluate if reduction performance of floor noise materials is possible. For this study, reduction performance was measured by comparing and analyzing test cases depending on the kinds of floor noise materials in the lower bottom of the multiplex house, thickness and construction location, and reduction performance in the upper slab was measured, based on the results of the lower slab in the multiplex house.