팔라듐 합금 수소 분리막의 전처리에 관한 연구

박동건(Dong-Gun Park),김형주(Hyung-Ju Kim),김효진(Hyo Jin Kim),김동원(Dong-Won Kim) 한국표면공학회 2012 한국표면공학회지 Vol.45 No.6

A Pd-based hydrogen membranes for hydrogen purification and separation need high hydrogen perm-selectivity. The surface roughness of the support is important to coat the pinholes free and thin-film membrane over it. Also, The pinholes drastically decreased the hydrogen perm-selectivity of the Pd-based composite membrane. In order to remove the pinholes, we introduced various surface pre-treatment such as alumina powder packing, nickel electro-plating and micro-polishing pre-treatment. Especially, the micro-polishing pretreatment was very effective in roughness leveling off the surface of the porous nickel support, and it almost completely plugged the pores. Fine Ni particles filled surface pinholes with could form open structure at the interface of Pd alloy coating and Ni support by their diffusion to the membrane and resintering. In this study, a 4 μm surface pore-free Pd-Cu-Ni ternary alloy membrane on a porous nickel substrate was successfully prepared by micro-polishing, high temperature sputtering and Cu-reflow process. And H₂ permeation and N₂ leak tests showed that the Pd-Cu-Ni ternary alloy hydrogen membrane achieved both high permeability of 13.2 ml·cm<SUP>?2</SUP>·min<SUP>-1</SUP>·atm<SUP>-1</SUP> permation flux and infinite selectivity.

이중 로듐 층을 갖는 멤스 프로브 팁의 특성

박동건(Dong-Gun Park),박용준(Yong Joon Park),임슬기(Seul-Ki Lim),김일(Il Kim),신상훈(Sanghun Shin),조현철(Hyun Chul Cho),박승필(SeungPil Park),김동원(Dong-Won Kim) 한국표면공학회 2012 한국표면공학회지 Vol.45 No.2

Probe tip, which should have not only superior electrical characteristics but also good abrasion resistance for numerous contacts with semiconductor pads to confirm their availability, is essential for MEMS probe card. To obtain good durability of probe tip, it needs thick and crack-free rhodium layer on the tip. However, when the rhodium thickness deposited by electroplating increased, unwanted cracks by high internal stress led to serious problem of MEMS probe tip. This article reported the method of thick Rh deposition with Au buffer layer on the probe tip to overcome the problem of high internal stress and studied mechanical and electrical properties of that. MEMS probe tip with double-Rh layer had good contact resistance and durability during long term touch downs.

스퍼터 공정변수가 팔라듐 합금 수소분리막의 특성에 미치는 영향

한재윤(Jae-Yun Han),주새롬(Sae-Rom Joo),이준형(Jun-Hyong Lee),박동건(Dong-Gun Park),김동원(Dong-Won Kim) 한국표면공학회 2013 한국표면공학회지 Vol.46 No.6

It is generally recognized that thin Pd-Cu alloy films fabricated by sputtering show a wide range of microstructures and properties, both of which are highly dependent on the sputtering conditions. In view of this, the present study aims to investigate the relationship between the performance of hydrogen separation membranes and the microstructure of Pd alloy films depending on sputtering deposition conditions such as substrate temperature, working pressure, and DC power. We fabricated thin and dense Pd-Cu alloy membranes by the micro-polishing of porous Ni support, an advanced Pd-Cu sputtered multi-deposition under the conditions of high substrate temperature / low working pressure / high DC power, and a followed by Cu-reflow heattreatment. The result of a hydrogen permeation test indicated that the selectivity for H₂/N₂ was infinite because of the void-free and dense surface of the Pd alloy membranes, and the hydrogen permeability was 10.5 ml·cm-2<SUP></SUP>·min<SUP>-1</SUP>·atm<SUP>-1</SUP> for a 6 μm membrane thickness.

Helicobacter pylori 제균이 위장 전정부 점막의 세포증식능과 apoptosis 에 미치는 영향

이구(Goo Lee),최석진(Suk Jin Choi),최영환(Young Hwan Choi),박동건(Dong Gun Park),서완다(Wan Da Seo),서정일(Jeong Il Suh),양창헌(Chang Heon Yang),이창우(Chang Woo Lee),장태정(Tae Jung Jang),김정란(Jung Ran Kim) 대한내과학회 1999 대한내과학회지 Vol.57 No.3

N/A Helicobacter pylori (H. pylori) is the principle cause of type B gastritis and peptic ulcer disease and has been classified as group I carcinogen for gastric cancer. H. pylori may affect the normal balance between gastric cell proliferation and epithelial cell death, thus interfering with the maintenance of gastric mucosal integrity. The aim of this study was to investigate the effect of H. pylori on cell proliferation and apoptosis according to the effect of eradication of H. pylori. Methods : The subjects were 45 patients who had undergone diagnostic gastroduodenoscopy; 11 with gastritis, seven with gastric ulcer and 27 duodenal ulcer. H. pylori infection was assessed by H&E and immunohistochemical stain with anti-H. pylori polyclonal antibody and rapid urease test. Acute and chronic inflammation, apoptosis and intestinal metaplasia were scored according to the updated Sydney system. Gastric epithelial cell proliferation was assessed by immunohostochemical method using Ki-67 monoclonal antibody. In situ apoptosis was detected with in situ terminal deoxyribonucleotide transferase (TdT)-mediated dUTP nick end labeling. Results : Acute and chronic inflammation, intestinal metaplasia, Ki-67 labeling index, and apoptosis were significantly higher in H. pylori infected persons (n=45) than in uninfected persons (n=5)(p<0.05). Acute and chronic inflammation, intestinal metaplasia, Ki-67 labeling index and apoptosis in H. pylori eradicated group (n=25) significantly decreased after eradication therapy (p<0.05), but no significant differences of them was observed in H. pylori non-eradicated goup (n=20) after eradication therapy. Ki-67 labeling index was significantly correlated with acute inflammation, chronic inflammation and apoptosis (p<0.05). Apoptosis was significantly correlated with acute and chronic inflammation (p<0.05). Conclusion : In eradicated group, epithelial apoptosis and proliferation closely associated with gastric carcinogenesis are stabilized after treatment, which suggests H. pylori eradication therapymay preven the early step of gastric carcinogenesis. (Korean J Med 57:288-297, 1999)

Penfluridol 투여후 추체외로증상의 출현빈도에 대한 연구

박동건,이정남 朝鮮大學校 附設 醫學硏究所 1986 The Medical Journal of Chosun University Vol.11 No.1

In order to evaluate the frequency of extrapyramidal symptoms induced by long-acting oral antipsychotics, Penfluridal, 48 chronic schizophrenics were subjected in this study. Schizophrenic patients were divided into group A(N=26, 1 week neuroleptics washout periord) and group B (N-22, neuroleptics nonwashout period). Penfluridol of 20 to 100㎎ was administered, racing of exfrapyramidal symptoms was measured by the Rating Scale for Extrapyramidal Symptoms designed by Chien and Dimascio at the interval of 1,2,3,4,5, and 6 week. The results are as follows. 1. Dropout rate due to severe extrapyramidal symptoms was noticed in 6 out of the 48 cases(12.5%). 2. Most common period of occurence of extrapyramidal symptoms in group A is revealed at the 6th week(33.3%) and that in group B is noted at the 3rd week(40.9%) 3. To control extrapyramidal symptoms, when benztropine mesylate was administered orally, the mean days of administration in group A were 21.22±8.45 and those in group B were 11.63±2.50. This difference of mean days between group A and B was highly significant(P < 0.005). In. conclusion, to minimize extrapyramidal symptoms, it is recommended to start the regimen with drug washout period in converting previous antipsychotics medication into penfluridol.

국민 학교 학동의 성장에 관한 연구 : Urban, Suburban and Rural Area

박동건,유기환,홍영숙,손창성,독고영창 고려대학교 의과대학 1992 고려대 의대 잡지 Vol.29 No.2

It is well known that physical growth and development of children are influenced by many factors genetic, nutritional, socioeconomic, emotional and cultural factors. The present study was carried out for 3103 primary school children from 6 to 12 years of age exploring the difference of growth and development in urban, suburban and rural area. All the children were measured physique skinfold thickness, Kaup index, and Rohler index for evaluation of physical growth. The results obtained were as follows. 1. In this study. all the physical measurements, Kaup index, fat area, and muscle area among calculated values from physical measurements were increased by age, but Rohler index was decreased by age. 2. Male was predominant on physique and calculated values, except for fat area and skinfold thickness. 3. Children who are living urban area was predominant on physique than another area.

뇌출혈이 합병된 감염성 심내막염 1례

박동건,이재욱,권삼,이동철,강승완 동국대학교 경주대학 1997 東國論集 Vol.16 No.2

감염성심내막염에 의한 신경계 합병증은 색전성 뇌경색, 색전성 뇌출혈, 두개내 패혈성 동맥류, 뇌농양, 뇌막염등 다양한데 항생제 요법의 발달과 판막치환술에도 불구하고 그 빈도는 감소되지 않고 있다. 이 중 두개내 패혈성 동맥류의 파열에 의한 뇌출혈은 사망률이 80%로 치명적일 수 있어 조기 발견 및 적절한 치료가 필요하다. 저자들은 두통, 열감, 근육통 등의 증상으로 내원하여 감염성 심내막염으로 진단받고, 항생제 치료로 임상증세의 호전중에 심한 두통과 전신적 발작이 있은 후 갑자기 발생한 두개내 뇌출혈을 심장초음파 및 뇌 컴퓨터 단층촬영을 통하여 진단, 경험하였기에 문헌고찰과 함께 보고하는 바이다. The complications of infective endocarditis may involve any organ system ie, cardia, neurologic, vascular, dermatologic, and kidney. Extracardiac complications are usually caused by either embolization of vegetations or deposition of immune complexes. Neurologic complications remain a significant problem in bacterial endocarditis and have been reported to occur in up to 20% to 40% of cases of infective endocarditis. The various types of central nervous system disease seen in patients with infective endocarditis are cerebral embolism (with infarction or with intracerebral hemorrhage), intracranial mycotic aneurysm, seizures, brain abscess, meningitis, mental change, psychiatric disorder. Mycotic aneurysms are uncommon but not rare and are an important cause of local or systemic sepsis and acute hemorrhage following aneurysmal rupture. Cerebral mycotic aneurysms have been noted in 2∼10% of cases of bacterial endocarditis and account for 2.5∼6.2% of all intracerebral aneurysms. We have experienced a case of neurologic complication due to infective endocarditis in a 23 year-old female patient, who admitted to our hospital because of fever, chill, headache, myalgia. This case was diagnosed by echocardiography, brain computed tomography. The patient died of sudden intracerebral hemorrhage in the 53th hospital day despite intensive medical treatment. We report one case of intracerebral hemorrhage complicated with infective endocarditis.

소아 급성 호흡기 감염증성에서의 Cefminox(Meicelin^(�))의 치료 효과

박동건,유기환,김순겸 최신의학사 1993 最新醫學 Vol.36 No.6

한국대학생의 음주양태와 생물정신사회적 요인의 상호관계

이창인,김학렬,박동건 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

연구목적 및 방법 : 본 연구는 한국 남자 대학생의 음주양태와 생물학적, 심리사회적 요소의 연관성을 알아보기 위해, 약4개월에 걸쳐 조선대학교 의과대학 의학과 학생 750명중 예비조사 결과 선정된 94명의 남학생을 대상으로 음주양태에 대한 설문지, 생활사건척도, 사회지지척도, 내-외 통제척도, 성격차원검사, 상태-특성 불안척도, 간이정신진단검사, 에탄올 삽포검사를 통해 다음의 결과를 얻었다. 결 과 : 1) 소량음주군과 과량음주군(이후 두 군으로 칭함)의 가족력 비교결과 소량음주군의 가족에서 음주후 급성 신체반응 민감자가 많았다(p〈.005). 2) 소량음주군에서 음주후 급성 신체반응이 많았으며(p〈.005). 과량음주군에서 음주후 심리적 유쾌감이 높았으며(p〈.005). 심리적 불쾌감은 차이가 없었다. 3) 성격, 심리, 환경적 특성비교에서 과량음주군이 성격차원검사의 외향성 척도가 높고(p〈.01). 사회 지지척도상 물질적 지지도가 높았다(p〈.01). 4) 에탄올 삽포검사상 15분, 30분, 60분후 모두 소량음주군의 양성반응율이 높았다(p 〈.005). 5) 한국형 알코올 사용척도(AUI) 하위요인을 비교한 결과 요인 1, 2, 4는 α=0.005 수준에서, 요인 3는 α=0.01 수준에서 과량음주군이 높았다. 6) 두 군의 음주양태 비교에서 소량음주군은 유사 비음주자. 숭화형 음주자가 많았고, 과량음주군은 일과성 사교음주자, 자제형 사교음주자, 습관적 과음자, 충동적 폭음자가 많았다(p〈.005). 두 군의 음주 양상의 차이는 과량음주군은 음주 의존도, 음주기간, 일일 음주성향, 음주선호, 술의 돗수, 막걸리, 소주 및 맥주의 평균 주량과 최대 주량, 맥주의 한 모금에 마시는 양은 α=0.01 수준에서 높으며, 소량음주자는 술을 마시는 두 모금사이의 시간이 유의하게 길었다(p〈.005). 7) 두 군의 사회인구학적 변인의 비교에서 과량음주군의 흡연율이 상대적으로 높았고(p〈.01), 가족들의 주거지를 보면 과량음주군은 대도시 출신이 많은 반면 소량음주군은 시골 출신이 많았으며(p〈.05), 동거 가족수는 소량음주군이 많은 편이었다(p〈.05). 그외의 다른 사회인구학적인 변인에서 과량음주군은 부모의 학력이 모두 높았고(p〈.05), 부모의 부부사이가 나쁜 편이었다(p〈.05). 결 론 : 알코올중독의 원인론과 그 특성에 대한 이해를 돕기 위해 비교적 균일하며 병적인 음주행태가 시작되는 대학생 집단에서 과량음주군과 소량음주군으로 나누어 비교했는데, 현저한 차이를 보이는 것은 ALDH 활성도 결핍과 강력히 연관된 것으로 추정되는 급성 신체(홍조)반응과 에탄올 삽포검사의 양성율의 차이였고 심리사회적인 측면은 다소의 차이가 있었으나 구체적인 해석에 어려움이 있었다. Objects and Methods : In order to evaluate the relationships between drinking habits and biological and psychosocial characteristics, the authors administrated the questionnaires about drinking patterns and acute physiological and psychological responses after drinking, several psychological scales and ethanol patch test to 94 male medical students in Chosun University. Results : 1) Low consumer group had significantly more severe physiological respondents after drinking in family members than high consumer group(p<0.05). 2) Low consumer group has significantly more severe acute physiological responses(p<0.005) and high consumer group revealed more positive psychological responses after drinking(p<0.05). But there was no difference in the degree of negative psychological responses between two group. 3) High consumer group had significantly more extroversion tendency(p<0.1) and received more financial support from family than low consumer group(p<0.1). 4) In the results of ethanol patch test, low consumer group showed more positive skin reaction in three test occasions than high consumer group (p<0.005). 5) Also the high consumer group revealed higher scores in factor 1, 2, 4(α=0.005), and 3(α=0.01) in comparison of factors of Korean Alcohol Use Inventory. 6) In comparison of drinking habits, low consumer group revealed higher incidence of nearly non-drinkers and sublimatory drinkers. But there were more casual social drinkers, sel-controlled social drinkers, impulsive-binge drinkers, and habitual-excessive drinkers in high consumer group(p<0.05). And in drinking patterns, the items of dependence and duration of drinking, daily drinking disposition, preferential beverage, average and maximum drinking amount of each liquor, and magnitude of sips taken were higher in high consumer group. Only one item of interval between sips was longer in low consumer group(o<.005). 7) In comparison of sociodemographic variables, there were more students who were smokers(p<0.1), from larger cities and small family(P<0.5), and whose parents were well educated(P<0.5) but had worse marital relationship(P<0.5) in high consumer group. Conclusion : For better explanation of the etiology and characteristics of alcoholism, we investigated the differences in various aspects between low alcohol consumers and high alcohol consumer in college students. The most evident differences lied in the degree of acute physiological reaction and positive rates of ethanol patch test that strongly suggested the relations with the activity of ALDH. Some differences in psychosocial aspects between two groups were noticed but could not appropriately be explained at this time.

한약에 의해 유발된 급성 간질성 신염 2례

김덕윤,박동건,김응석,강영모,양창헌,이정호,이동철,이영현,김정란 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

간질성 신염은 신장의 간질을 선택적으로 침범하는 염증성 질환으로 여러가지 원인에 의해 유발되며, 이 중 약물에 의한 경우는 각종 항생제, 비스테로이드성 진통제, 항경련제, 이뇨제, 면역억제제등에 의한 증례들이 보고되고 있다. 현재 각종 질환-특히 만성질환-의 치료에서 한약이 차지하는 비중이 적지 않으나, 그 각각의 성분들이 유발할 수 있는 부작용들에 대한 연구는 거의 없는 실정이다. 저자들은 관절염 치료를 위해 중국산 한약을 복용한 후 복통, 피로감 및 육안적 혈뇨를 주소로 내원한 두 환자에서, 단백뇨와 신기능 장애를 보여 시행한 신조직 생검상 급성 간질성 신염에 합당한 병리학적 소견을 보이고, 한약 복용 중지 후 급속한 회복을 보여, 한약에 의해 유발된 것으로 사료되는 급성 간질성 신염 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Acute interstitial nephritis is a disease characterized by renal interstitial inflammatory cell infiltration and acute renal functional deterioration. This is caused mainly by antibiotics, NSAID and diuretics such as thiazide, but cases induced by herb medication are rare. We experienced two cases of acute interstitial nephritis after treatment with herb medication. One 71-year-old female patient and the other 60-year-old female were admitted to the hospital because of general weakness and gross hematuria. Microscopic hematuria, pyuria, and proteinuria were presented. After definitive diagnosis with a renal biopsy, we noted rapid recovery of renal function by drug withdrawal and steroid therapy. We report these cases with a review of the referenced literatures. Key Words : Herb medication, Acute Interstitial nephritis.