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RISS 인기검색어
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하범만 ( Ha Beomman ),박대화 ( Park Dae Wha ),이도형 ( Lee Do-hyeong ) 국군의무사령부 2017 대한군진의학학술지 Vol.48 No.1
Objectives: The aim of this study was to estimate the prevalence and clinical characteristics of patients with complex regional pain syndrome(CRPS) among ROK army servicemen. Methods: A total subjects of 72 patients who have been diagnosis with CRPS at the Armed Forced Hospitals from year 2011 to 2015. As for the data, socio-demographic characteristics (age, rank, educational level, body mass index), durations among enrollment, 1st symptoms and medically discharges, characteristics of CRPS(symptoms, sign, criteria of medically discharge) were investigated. Results: 1.5-6.5 per 100, 000 ROK army servicemen were medically discharges due to CRPS. 60 patients(81.8%) had CRPS type 1, and Crush injury(58.1%) was common cause of CRPS patients. 43 patients(60.8%) had pain on right side, and lower extremities(78.4%) was more commonly affected than upper extremities(18.9%). The mean duration between enrollment and 1st CRPS symptom, between 1st CRPS symptom and medically discharge were 29.4 weeks and 37.6 weeks, respectively. Most common symptoms and signs were abnormal vasomotor include temperature asymmetry and skin color change Conclusions: Earlier diagnosis is important in CRPS, and suspicion of CRPS is more important. It is necessary for miliary doctors to educate the contents of CRPS during education program at Armed Forced Medical School.
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초치료 만성 B형간염 환자에서 엔테카비어의 장기 치료 효과 및 그 예측인자
김범희 ( Beom Hee Kim ),윤범용 ( Beom Yong Yoon ),박대화 ( Dae Wha Park ),이엄석 ( Eaum Seok Lee ),김석현 ( Seok Hyun Kim ),이병석 ( Byung Seok Lee ),이헌영 ( Heon Young Lee ) 대한내과학회 2010 대한내과학회지 Vol.85 No.2
목적: 초치료 만성 B형간염 환자들에서 엔테카비어의 치료 효과와 그 예측인자에 대해 분석하였다. 방법: 2007년 3월부터 2011년 5월까지 과거 항바이러스제 치료 경험이 없는 만성 B형간염 환자로서 엔테카비어 0.5 mg을 매일 최소 48주 이상 복용한 환자 77명을 후향적으로 조사하였다. 엔테카비어 투여 중 혈청 HBV DNA치가 116 copies/mL 이하로 감소하여 검출되지 않는 경우인 바이러스 반응과 혈청 ALT치의 정상화되는 경우인 생화학적 반응, HBeAg의 혈청 소실과 혈청전환을 각각 평가하였다. 결과: 치료 12, 24, 48, 96, 144주에 대한 누적 바이러스 반응률은 각각 59.7%, 82%, 88.3%, 89.6%, 93.1%였다; 누적 생화학적 반응률은 각각 51.9%, 74%, 84.4%, 94.8%, 98.3%였다; HBeAg의 누적 혈청 소실률은 10.5%, 18.4%, 28.9%, 36.8, 47.4%였다; 누적 HBeAg 혈청 전환율은 7.9%, 18.4%, 21.1%, 28.9%, 39.5%였다. 다변량 분석을 시행한 결과 혈청 HBV DNA 음전과 관련된 독립적 예측인자는 기저 HBeAg 음성(p = 0.006)과 치료 12주 후 바이러스 반응인 초기 바이러스 반응(p = 0.027)이었다. 또한 HBeAg 혈청 소실과 관련된 독립적 예측인자도 초기 바이러스 반응(p = 0.001)이었다. 결론: 엔테카비어는 초치료 만성 B형간염 환자에서 뛰어난 생화학적 반응과 바이러스 반응을 보였다. 초기 바이러스 반응은 혈청 HBV DNA 음전과 HBeAg 혈청 소실을 예측할 수 있는 독립적 인자로 확인되어 치료 중 초기 바이러스 반응이 엔테카비어의 장기적인 치료 반응을 예측하는 데 유용할 것으로 생각된다. Background/Aims: The aims of this study were to characterize the treatment response to entecavir and to examine factors affecting that response. Methods: A total of 77 nucleoside-na?ve patients with chronic hepatitis B who had received entecavir (0.5 mg daily) for at least 48 weeks were consecutively enrolled between March 2007 and March 2011. The rates of virological response (hepatitis B virus [HBV] DNA < 116 copies/mL), biochemical response (alanine aminotransferase ≤ upper limit of normal), hepatitis B e antigen (HBeAg) loss, and seroconversion were retrospectively analyzed. Results: The cumulative rates of virological response at 12, 24, 48, 96, and 144 weeks were 59.7%, 82%, 88.3%, 89.6%, and 93.1%, respectively; biochemical response rates were 51.9%, 74%, 84.4%, 94.8%, and 98.3%, respectively; HBeAg loss rates were 10.5%, 18.4%, 28.9%, 36.8%, and 47.4%, respectively; and HBeAg seroconversion rates were 7.9%, 18.4%, 21.1%, 28.9%, and 39.5%, respectively. In multivariate analysis, independent predictors associated with HBV DNA polymerase chain reaction (PCR) negativity were the absence of HBeAg at baseline (p = 0.006) and early virological response (HBV DNA < 2,000 copies/mL after 12 weeks of therapy; p = 0.027). In univariate analysis, early virological response was an independent factor predicting HBeAg loss (p = 0.001). Conclusions: Entecavir induced excellent biochemical and virological responses in nucleoside-na?ve patients with chronic hepatitis B. Early virological response was an independent factor predicting HBV PCR negativity and HBeAg loss, and can be used to predict long-term treatment response to entecavir. (Korean J Med 2013;85:157-166)
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