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미세다공성 Biphasic calcium phosphate ceramics의 골이식 대체재로서의 기본특성에 대한 비교연구
박광범,박진우,안현욱,양동준,최석규,장일성,여신일,서조영,Park, Kwang-Bum,Park, Jin-Woo,Ahn, Hyun-Uk,Yang, Dong-Jun,Choi, Seok-Kyu,Jang, II-Sung,Yeo, Shin-Il,Suh, Jo-Young 대한치주과학회 2006 Journal of Periodontal & Implant Science Vol.36 No.4
Objective : The purpose of this study was to evaluate the physicochemical properties and cytocompatibility of microporous, spherical biphasic calcium phosphate(BCP) ceramics with a 60/40 $hydroxyapatite/{\beta}$ -tricalcium phosphate weight ratio for application as a bone graft substitute. Materials and Methods : Microporous, spherical BCP granules(MGSB) were prepared and their basic characteristics were compared with commercially available BCP(MBCP; Biomatlante, France) and deproteinized bovine bone mineral(Bio-Oss; GBistlich-Pharma, Switzerland, BBP; Oscotec. Korea), Their physicochemical properties were evaluated by scanning electron microscopy, X-ray diffractometry, Fourier-transform infrared spectroscopy, inductively coupled plasma atomic emission spectrometer, and Brunauer-Emmett-Teller method. Cell viability and proliferation of MC3T3-El cells on different graft materials were evaluated. Results : MGSB granules showed a chemical composition and crystallinity similar with those in MBCP, they showed surface structure characteristic of three dimensionally, well-interconnected micropores. The results of MTT assay showed increases in cell viablity with increasing incubation times. At 4d of incubation, MGSB, MBCP and BBP showed similar values in optical density, but Bio-Oss exhibited significantly lower optical density compared to other bone substitutes(p <0,05). MGSB showed significantly greater cell number compared to other bone substitutes at 3, 5, and 7d of incubation(p <0,05), which were similar with those in polystyrene culture plates. Conclusion: These results indicated the suitable physicochemical properties of MGSB granules for application as an effective bone graft substitute. which provided compatible environment for osteoblast cell growth. However, further detailed studies are needed to confirm its biological effects on bone formation in vivo.
박광범(Kwang-Bum Park) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.11
비교적 짧은 역사를 지니고 있는 미국과 호주에서도 조차 역사유산, 문화유산에 대한 보존 및 재사용에 대한 중요성을 크게 인식하고 이를 보존, 활용하는 데에 매우 체계적이고 현실적인 방안을 모색하여 이를 실천하고 있다. 반면, 반만년이란 오랜 역사를 지니고 있는 우리나라의 경우, 소중한 건축유산을 어떻게 보존하고 다시 사용해야 하는지에 대한 복원 시스템 및 활용방안에 대해 명확한 기준들이 매우 부족한 것이 현실이다. 본 논문은 이렇게 역사가 짧고 따라서 역사, 문화유산이 그리 많지 않을 것 같은 호주, 미국을 대상으로 이 나라에서의 이들 유산에 대한 보존 및 활용방안이 어떻게 이루어지고 있는 지를 사례를 통하여 그의 제도와 시스템을 면밀히 조사, 분석하고자 하였다. 이를 통하여 지금까지 재개발에 의해 한순 간에 사라져 갔던 우리들의 옛 건축, 구도심 환경, 특히 현재의 건축물들에 대한 인식 제고와 일괄적인 재건축에서 벗어나 역사와 함께 건축적 환경이 지속될 수 있는 건축물 및 도시환경의 가이드라인을 제시하고자 하였다. Even though the United States and Australia have a relatively short history, the preservation and reuse of their historical heritage and cultural heritage are considered to be very important. In the case of Korea, which has a long historical heritage, there is a lack of development and restoration systems and there are no clear guidelines on how to preserve and reuse these precious legacies. In this study, we examine and analyze through examples how the historic buildings have been preserved and reused in Australia and the United States, which have a shorter history than our own. Also, we suggest that the raising of awareness of the historicity associated with the existing architecture and that of the architectural environment following its full-scale reconstruction will enable them be considered historical heritages with the passing of time.