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Design, Syntheses, and Conformational Study of Angiogenesis Inhibitors
박경수,백동하,임동열,박상돈,김민영,박영선,김양미,Park, Gyeong Su,Baek, Dong Ha,Im, Dong Yeol,Park, Sang Don,Kim, Min Yeong,Park, Yeong Seon,Kim, Yang Mi Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.9
Since anti-angiogenesis could lead to the suppression of tumor growth, angiogenesis inhibitors have received particular attention for their therapeutic potential. In this study, two angiogenic inhibitors using the bioactive sequence from the kring le 5, AK1(KLYDY), AK2(KLWDF) were designed and synthesized. We have investigated their solution structures using NMR spectroscopy and their activities as angiogenesis inhibitors. AK2 has an intramolecular hydrogen bon d between the side chain amino proton of Lys1 and the carboxyl oxygen of Asp4 with a N ${\cdot}{\cdot}{\cdot}$O distance of $3.27\AA$, while AK1 shows more flexible structures than AK2. Indole ring in Trp is much bigger than the phenyl ring in Tyr and may have good face-to-edge interaction enforcing more rigid and constrained conformational features of AK2. Because of this relatively stable structure, Trp3 in AK2 may have better hydrophobic interaction with Phe5 than Tyr3 in AK1 if two adjacent aromatic groups are located in hydrophobic pocket of receptor. Since AK2 shows the similar anti-angiogenic activities to AK1, we are also able to confirm that the activity of AK1 is irrelevant to the Tyr phosphorylation. More rigid drug with higher activities can be provided by the mimetic approaches. For the further development of the angiogenesis inhibitors, these conformational studies on our lead peptides will be helpful in design of peptidomimetics.
마이크로 컴퓨터를 이용한 기본표준자료(基本標準資料) 개발
박경수,Park, Gyeong-Su 대한인간공학회 1985 大韓人間工學會誌 Vol.4 No.1
This research developes a microcomputer program for MSD which is one of the most widely llsed predetermined time standards. The program is written in BASIC and designed mainly for desk-top or portable microcomputer to facilitate the development of standard times for time study analysis. A simple case is illustrated to show the program running procedure.
박경수,이동하,Park, Gyeong-Su,Lee, Dong-Ha 대한인간공학회 1985 大韓人間工學會誌 Vol.4 No.2
This article developes a cost-effective on-line measurement system of R - R intervals in ECG. The system is composed of a R peak detector, a timer and an Apple II computer (a 6502 microprocessor and memories). The system measures the R - R intervals in msec and stores them in a disk, for off-line analysis. A circuit diagram of the R peak detector and programs for controlling the microprocessor are presented.
Recent Transmission Electron Microscopy in Materials Analysis
박경수,홍순구,신도다이스케,Park, Gyeong-Su,Hong, Soon-Ku,Shindo, Daisuke Korean Society of Electron Microscopy 1996 Applied microscopy Vol.26 No.2
투과전자현미경을 이용한 최근의 재료 분석기술에 대해 일본 토호쿠대학의 ASMA (Atomic Scale Morphology Analysis) 연구실에서 얻은 실험결과를 중심으로 설명하였다. 현재 토호쿠대학에서 가동 중에 있는 가속전압 1250 kV의 초고압 투과전자현미경은 분해능이 약 0.1nm이며, 이 전자현미경으로부터 얻은 고분해능상은 대형컴퓨터를 이용한 시뮤레이션에 의해 해석 할 수 있음을 나타내었다. 또한, 이러한 뛰어난 고분해능 특성을 가진 초고압 투과전자현미경과 최근 재료 분야의 전자현미경 시료 제작기술의 하나로서 크게 주목받고 있는 초박절편법 (Ultramicrotomy)을 이용한 헤마타이트 미립자의 내부구조 해석 결과를 나타내었다. 새로운 전자현미경 분석기법을 위한 주변장비의 눈에 띄는 발달중의 하나로서 전자현미경상을 디지탈 형태로 기록하고, 이를 효과적인 화상처리 기법으로 해석할 수 있는 Imaging Plate (IP)를 주목할 수 있다. 본 논문에서는 IP의 응용 예로서 IP를 이용하여 기록한 고분해능 전자현미경상과 전자 회절패턴의 정량해석 결과에 대해 나타내었다. 에너지분산 X-선 검출기를 이용한 새로운 분석기법의 예로서 전자 채널링 효과를 이용한 ALCHEMI법을 Ni-Al-Mn계 화합물에 대한 실험결과와 함께 나타내었다. 또한, 전자에너지 손실 분광 분석법을 이용한 최근 분석 결과로서 여러 구리 화합물의 전자구조 차이에 따른 구리의 $L_{23}$ 가장자리 피이크 변화를 나타내었다. 새로운 전자현미경법인 에너지 필터를 사용하여 $Al_{0.5}In_{0.5}As$의 전자회절 패턴의 백그라운드를 제거한 결과를 에너지 필터를 사용하지 않은 $Al_{0.5}In_{0.5}As$의 전자회절 패턴과 비교하여 나타내었다.
머리의 자세를 추적하기 위한 효율적인 카메라 보정 방법에 관한 연구
박경수,임창주,이경태,Park, Gyeong-Su,Im, Chang-Ju,Lee, Gyeong-Tae 대한인간공학회 2000 大韓人間工學會誌 Vol.19 No.1
The aim of this study is to develop and evaluate an efficient camera calibration method for vision-based head tracking. Tracking head movements is important in the design of an eye-controlled human/computer interface. A vision-based head tracking system was proposed to allow the user's head movements in the design of the eye-controlled human/computer interface. We proposed an efficient camera calibration method to track the 3D position and orientation of the user's head accurately. We also evaluated the performance of the proposed method. The experimental error analysis results showed that the proposed method can provide more accurate and stable pose (i.e. position and orientation) of the camera than the conventional direct linear transformation method which has been used in camera calibration. The results of this study can be applied to the tracking head movements related to the eye-controlled human/computer interface and the virtual reality technology.