간융기성병변의 (肝隆起性病變) 내시경적 (內視鏡適) 관찰

문영명,강진경,박인서,최흥재 ( Young Myoung Moon,Jin Kyung Kang,In Suh Park,Heung Jai Choi ) 대한소화기학회 1980 대한소화기학회지 Vol.12 No.2

Since the excellent gastric fiderscopy and direct vision diopsy has decome available in medical practice, the detaction and differential diagnosis of the elevated lesions of stomach has decome easy and more accurate. The differential diagnosis, however, is still impossible without operation in some cases. In this paper we present the anzlysis of 410 patients with elevated lesion in stomach studied at the Department of Internal Medicine, Yonsei University College of Medicine. The results are as follows. 1 The age distridution of patients was btween 18 and 76 years old with the highest incidence in 6th decade. The ratio of male to female was adout 2:1. 2. The diseases producing elevated lesions were variolar form erosions in 145 cases, protruding carcinomas in 115 cases, b nign gastric polyps in 81 cases and sudmucosal tumor or extrinsic pressure effect in 69 cases. Among 69 cases with submucosal tumor or extrinsic pressure effect 6 cases were confirmed to submucosal tumor, 21 cases to extrinsic pressure effect and 42 cases were undetermined. 3. The gastric erosions were multiple in 75.2Fo and the polyps were multiple only in 14.5F.. 4. The size of lesions.' The diameters of lesions of variolar erosions were under 1cm in 90. 3 In protruding cancers 52. 2/o of them had 4-6cm in diameter, 24. 3% had 2-4cm and 16. 5Zo had the diameter over 6cm. Benign gastric polyps had the diameter below 1cm ia 73.6io 44.99o of submucosal tumors or extrinsic mass effects had the diameter of 4-6cm, 39, g io hBd 2 4Cm Slld 11 6 Zo hRd OVC1' 6Cm, 1CBSC of submucosal tumors had less than 1cm in diameter, 2 cases had 1-2cm, 2cases had 2-4cm and 1 case had 4-6cm. Extrinsic pressure effect had 2-4cm in diameter in 17 cases, 4 6cm in 19 cases, and over 6cm in 6case 5. The sites of lesions.' The erosions and benign polyps were mostly located at gastric antrum, the protruding cancer were on the mid and lower parts of stomach. The submucosal tumor or extrinsic pressure effects were located on mid and upper part. Two cases of submucosal tmors were located on upper body, 3 cases on mid and lower body and one on antrum. The extrinsic pressure effects were on upper body in 12 cases, mid and lower body in 6 cases and antrum in 3cases.

상부소화관의 (上部消化管) 반복내시경검사예에 (反復內視鏡檢査例) 대한 관찰

문영명,강진경,박인서,최흥재 ( Young Myoung Moon,Jin Kyung Dang,In suh Park,Heung Jae Choi ) 대한소화기학회 1980 대한소화기학회지 Vol.12 No.1

The advances of upper gastrointestinal endoscopy in recent years have facilitated the ebservation on the conditions inside the esophagus, stomach and duodenum, and the diagnos- tic value of the endoscopic examination on various diseases has improved markedly. In some cases it is difficult in five the accurate diagnosis with single study and the repetitions are required for accurate diagnosis. Sometimes it is necessary to observe the change of lesions for proper management. We performed 6829 times of upper gastrointestinal endoscopy during the period from January, 1969 to August 15, 1978 in 6396 cases. Among them 316 cases had the endoscopic cxaminations twice or more. The results were as follow: The age distribution of 31() cases were from the age of 19 to 77 and the most of them e ere between 4th and 6th decades. The ratio of male to female was 3. 9: 1. 2. The cases had endoscopic examinations twice were 247 patients, thrice 42, four times 15, five times 6, six times 4 seven times 1 and nine times l. 3. The confirmed diagnoses of 31g cases were benign gastric ulcer in ]54 cases, gastritis in 5g cases, gastric cancer in 4g cases, duodenal ulcer in 26 cases and others in 44 cases. The numbers of patients having two diseases in each were 13 cases. 4. The reasons of repetition of endoscopy were followings as follow-up study in 285 times, uncertain diagnosis in 72 times, continuation of symptoms in 37 times, inadequate study of previous examination in 21 times, annual check in 20 times and pseudopositive result of X-ray in one time. 5. Endoscopy were repeated within one week from previous study in 72 times, 1-2 weeks in 89 times, 2-3 weeks in 51 times, 3-4 weeks in 30 times, 1-2 months in 47 times, 2-3 months in 21 times, 3-6 months in 36 times, 6-l3 months in 28 times, 1-2 years in 3z times, .2-3 years in 15 times and over 3 years from previous examination in 12 times. 6. Confirmed diagnosis were made with the first examinations in 245 cases, second in 60 cases, third in 6 cases and 4th in 2 cases. The diagnosis could not be made definitely in three cases even with the repetition of examinations. 7. In follow-up studies, the lesions were improved over moderate degree in 148 times out of 178 examinations of gastric ulcer, and 18 times out of 27 examinations of duodenal ulcer. In gastritis only g times showed improved lesions from 25 examinations. The gastric cancer recurred in 6 cases out of 20 after operation and the lesion was improved in one case out of 8 cases after chemotherapy without operation. 8. To confirm the lesions the endoscopic examinations were repeated 72 times and we could confirm the lesions in 68 times, but in 4 times the lesions could not be confirmed with repeated endoscopic examination. G. The patients with the benign gastric ulcer were diagr.osed to benign ulcer definitely with first examination in most cases, but 21 cases needed to be differentiated from malignant lesions at first examination and 12 cases were diagnosed to malignant ulcer at first exami- nations. 10. To get definite diagnosis the gastroscopy was repeated 20 times in gastric cancer. Among them 10 cases showed negative results in biopsy which were converted to positive with repeated biopsy in 4 cases, but in 6 cases the results of hiopsy in repeated study were negative whiche were confirmed to cancer after surgery. In 5 cases of gastric cancer the lesions looked like benign but in biopsy specimen malignant cells were seen which had repeated examination for confirmation. The remaining 5 cases had inadequate study at first but were confirmed at second examinations. Li. The reasons of unsatisfactory examinations in 21 cases were as follow: too much blood in stomach in 7 cases, food particle in stomach in 5 cases, examiner's carelessness in 3 cases, patients uncooperation in 2 cases, poor selection of instrument, poor expansion of stomach, barium coating and drug coating on stomach mucosa were one case in each.

복부 결핵성 임파선염에서의 초음파유도 흡침생검의 역할

문영명(Young Myoung Moon),김기황(Ki Whang Kim),김경희(Kyung Hee Kim),김응(Eung Kim),김복성(Bock Seong Kim),곽승민(Seung Min Kwack) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2

N/A Tuberculous lymphadenitis within the abdomen is uncommon, and diagnosis is difficult because symptoms are vague, signs nonspecific, and clinical tests often not conclusive. It may mimic a large variety of conditions including lymphoma or metastasis. Recenty we had experienced 4 cases of tuberculous lymphadenitis in the abdomen. Th diagnosis was obtained by ultrasonogrpahy guided fine needle aspiration biopsy, which was less invasive procedure than laparotomy. The clinical suspicions and the extent of the disease were made by abdominal ultrasonogroaphy and computerized tomography. Histologic examination showed granulomas in 2 of 4 cases, and acid-fast bacilli in 3 of 4 cases. All the patients received antituberculous chemotherapy with prompt clinical improvement.

심포지움 : 21세기 간학의 전망 - 임상분야에 있어서 -

문영명 ( Young Myoung Moon ) 대한내과학회 1999 대한내과학회 추계학술대회 Vol.57 No.-

회장 장중첩증을 수반한 염증성 섬유양 용종

문영명(Young Myoung Moon),김경희(Kyung Hee Kim),이관식(Kwan Sik Lee),이희대(Hee Dae Lee),박형근(Hyung Geun Park),김동수(Dong Soo Kim),정현주(Hyeon Joo Jeong),김기황(Gee Hwang Kim) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.1

Inflammatory fibroid polyp is a polypoid lesion composed of fibrous tissues and blood vessels, originating in the submucosa of the gastrointestinal tract. It is seen mostly in the stomach and rarely, along the small bowel and colon. Complications which produced intussusception are rare. Recently we experienced a case of inflammatory fibroid po]yp of the ileum which produced intussusception. A 53 year old female patient was referred for evaluation of vomiting and diffuse abdominal pain of 6 days' duration. Ultrasonography revealed a 3.5 cm sized round hypoechoic mass in the lower abdomen associated with a target lesion, centrally echogenic with echopoor wheel in the adjacent area which suggested a mass with intussusception and a emergency exploratory laparotomy was performed. On operation findings, the intussusception was formed by the tumor and its size was approximately 8 cm. It was found at a distance about 80 cm from the ileocecal valve in the ileum. Segmental resection of ileum and end-to-end anastomosis were performed. The sectioned mass revealed yellow-gray color and showed a homogenous necrotizing lesion. Microscopically it was revealed to be an inflammatory fibroid polyp. The patient was discharged on the 12th hospital day with improved symptoms.

위점막 Ca++ 이 백서의 손상된 위점막 재생에 미치는 영향

문영명(Young Myoung Moon),함기백(Ki Baik Hahm),이상인(Sang In Lee),정재복(Jae Bock Chung),전재윤(Jae Yoon Chon),강진경(Jin Kyung Kang),박인서(In Suh Park),최흥재(Heung Jai Choi) 대한내과학회 1988 대한내과학회지 Vol.35 No.1

N/A A study was undertaken to investigate the influence of luminal Ca++ on the integrity of normal mucosa and the recovery process of damaged mucosa in rat stomachs using a perfusion system. The results were as follows: 1) The exposure of the stomach to EDTA at concentrations over 50mM significantly reduced the potential difference (PDimV). 2) Perfusion of the stomach with 5mM Ca++ led to a rapid recovery of the PD, which was reduced by preperfusion with 250mM EDTA. 3) An application of 50~9~o and 100% ethanol caused a rapid reduction of the ID and an addition of 5mM Ca++ significantly enhanced the recovery process of the damaged gastric mucosa. 4) An application of 0.4 M NaC1 and 1 M NaC1 also caused a prompt decrease of the PD and after an addition of 5mM CaC1 the reduced PD was increased to a near initial level. 5) The PD changes were well correlated with the microscopical changes of the resected stomach. In conclusion, luminal Ca+ seems to play an important role in maintaining the integrity of normal gastric mucosa and accelerating the recovery process of damaged gastric mucosa in rats.

한국인 만성 B형간염 환자에 대한 텔비부딘의 효능 및 안전성

문영명 ( Young Myoung Moon ),황성규 ( Seong Gyu Hwang ),김부성 ( Boo Sung Kim ),임규성 ( Kyu Sung Rim ),조몽 ( Mong Cho ),김동준 ( Dong Joon Kim ),한준열 ( Joon Yeol Han ),김영석 ( Young Seok Kim ),최호순 ( Ho Soon Choi ),안상훈 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.4

직시하생검용 (直視下生檢用) 위 (胃) Fiberscope 으로 절편채취한 (切片採取) 위석 (胃石) 2예

문영명(Young Myoung Moon),김창규(Chang Kyu Kim),박인서(In Suh Park),최흥재(Heung Jai Choi) 대한소화기학회 1972 대한소화기학회지 Vol.4 No.2

we have presented two cases of bezoa associated with beign gastric ulcer. Diagnosis was made by raentgenological and fibergastroscopic examinations and fragments of bezoar were taken by biopsy forcep incorporated with fibergastroscope under direct vision for microscopic examination. In one patient 54 year-old male, an egg-sized bezoar was found on roetgenological and endoscopic examinations, and it was confirmed as phytobezoarb by microscopic examination of the secimen taken by biopsy forsep under direct vision. The formation of phytobezoar in this case seemed to be related to to ingestion of large amount of the vegetable (herb medicine). In follow up study after treatment with antacid and diet thrapy for two inonths, the bezoar disappeared and the ulcer was healed completely. In the other patient, 31-year-old male, roentgenolgical and endoscopic examinations also revealed an egg-sized bezoar, but failed to confirm its components by microscopic examination which only showed amorphous, structureless findings.

한국 간암의 현황

문영명 ( Young Myoung Moon ) 대한간암연구회 1999 대한간암연구회 학술심포지엄 Vol.- No.-

만성위염 환자에서 위액내의 Calcium 이온 농도에 관한 연구

박영숙(Young Sook Park),문영명(Young Myoung Moon),김경희(Kyung Hee Kim),박인서(In Suh Park),최흥재(Heung Jai Choi),김경환(Kyung Hwan Kim) 대한내과학회 1989 대한내과학회지 Vol.36 No.6

N/A It was reported that ionized calciun in the Gl tract stimutates the parietal cells and induces gastric secretions. It also plays a role in preventing stress ulcers and in the functional and anatomical recovery of mucosal damage. This study was undertaken to investigate the relation-ship between gastric juice calcium, serum calcium, gastric juice pH and pathologic change on 103 patients with chronic gastritis. The results were as follows: 1) The mean value of the calcium concentration of gastric juice was 0.55 mM and 79% of the patients were within the range of 0.35 to 0.68 mM. 2) The calcium concentration of gastric juice of patients with atrophic change was significantly lower than that of patients with deffuse superficial gastritis. 3) The concentration of calcium of gastric juice of patients with intestinal metaplasia was lower than that of patients wihtout intestinal metaplasia. 4) No relation was found between the calcium concentration of gastric juice and the activity of chronic gastritis. 5) An inverse relation tended to be observed between the calcium concentration of gastric juice and gastric juice pH. 6) No correlation was found between the calcium concentration of gastric juice and serum calcium concentration. 7) The serum calcium concentration had no correlation with the gastric juice pH. In conclusion, the calcium concentration of gastric juice may be related to the histologic change in patients with chronic gastritis and it plays an important role in the recovery process of damaged gastric mucosa.