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기관지천식 환자에서 말초 혈액 단핵구와 기관지폐포 세척액 세포의 IL - 4 유전자 표현
이상무(Sang Moo Lee),문승혁(Seung Hyuk Moon),김경호(Kyung Ho Kim),임건일(Gune Il Lim),정성환(Seong Whan Jeong),김현태(Hyeon Tae Kim),어수택(Soo Taek Uh),김용훈(Yong Hoon Kim),박춘식(Choon Sik Park) 대한내과학회 1996 대한내과학회지 Vol.50 No.1
N/A Objectives: Type 2 CD4+ lymphocytes are presumed to have an important role in develompent of allergic inflammation. We measured m-RNA expressions of interleukin 4 in peripheral blood mononuclear cells and bronchoalveolar lavage cells to investigate the difference of interleukin 4 gene expression in the patients with atopic and nonatopic bronchial asthma, normal subjects and patients with other lung disease. Methods: Total RNA was obtained from peripheral blood mononuclear cells and bronchoalveolar lavage cells by acid-guanidium thiocyanate-phenol-chloroform method. The presence of interleukin 4 m-RNA was identified by RNA reverse transcription/polymerase chain reaction. Southern blot or DNA dot blot was applied to confirm the interleukin 4 gene products. Results: Interleukin 4 Gene products in peripheral blood mononuclear cells were detected in 90.9% (10/11) of the patients with bronchial asthrna and in 75%(9/12) of non-asthmatic control subjects. Interleukin 4 gene product in bronchoalveolar lavage cells was positive in one case of bronchial asthma. Conclusion: Interleukin 4 m-RNAs were constitutionally expressed in peripheral blood mononuclear cells of normal controls as well as in those of the patients with bronchial asthma
Proinflammatory Cytokines과 TGF-beta가 섬유모세포의 증식에 미치는 영향
김철 ( Chul Kim ),박춘식 ( Choon Sik Park ),김미호 ( Mi Ho Kim ),장헌수 ( Hun Soo Chang ),정일엽 ( Il Yup Chung ),기신영 ( Shin Young Ki ),어수택 ( Soo Taek Uh ),문승혁 ( Seung Hyuk Moon ),김용훈 ( Yong Hoon Kim ),이희발 ( Hi Bal 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.4
만성 C형 간염 환자에서 인터페론 치료 후 발생한 간질성 폐렴 1예
김홍수,이문호,김선주,서문정,정호석,박상흠,정일권,오종용,전진,문승혁 대한소화기학회 1999 대한소화기학회지 Vol.34 No.5
Interferon has been effective in treatment of viral hepatitis. However, side effects have been reported and they are related to dosage and frequency of administration. The common side effects are flu-like symptoms such as general myalgia, fever, arthralgia, headache, leukopenia and thrombocytopenia. Interstitial pneumonitis after interferon therapy are reported rarely and those are related to high dosage and long term therapy. We report a rare case of interstitial pneumonitis developed shortly after low dose interferon therapy with a review of the literatures.