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Gemcitabine 투여 후 발생한 방사선 회귀 피부, 근육염
노희선 ( Hee Sun No ),임희환 ( Hee Hwan Lim ),김정훈 ( Jung Hoon Kim ),조장현 ( Jang Hyun Cho ),허정권 ( Jeong Kwon Huh ),조성인 ( Sung In Cho ),유지영 ( Ji Young Yoo ),김철현 ( Cheol Hyeon Kim ),이재철 ( Jae Cheol Lee ) 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.2
A radiation recall reaction refers to an inflammatory reaction at previous irradiated areas subsequent to the administration of a variety of pharmacological agents. The skin is the major site of radiation recall reactons with the muscle and internal organs being less commonly affected. These reactions usually occur days to weeks after exposure to the causative agents. We report a case of gemcitabine-induced radiation recall dermato-myositis the developed in a female patient with a metastatic non-small cell lung cancer. She had received a palliative radiation therapy of 3900 cGy to the metastatic lesion on the femur shaft prior to chemotherapy. The pain, swelling and erythema of the left thigh resolved after the cessation of gemcitabine and the use of a systemic steroid. (Tuberc Respir Dis 2006; 61: 167-170)
증례 : 소화기 ; 대장내시경 후 발생한 피하기종, 기종격동 및 기복증
허정권 ( Jung Kwon Huh ),노희선 ( Hee Sun No ),임희완 ( Hee Hwan Lim ),김정훈 ( Jung Hoon Kim ),김유철 ( You Cheoul Kim ),김철현 ( Cheol Hyeon Kim ),이재철 ( Jae Cheol Lee ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5S
Colonoscopy is an essential tool to investigate and to manage intraluminal lesions of the colon and has been considered safe although a perforation as a complication of this procedure is often associated with serious morbidity. A 56-year-old woman had a colonoscopic biopsy for a suspicion of colon cancer. After the procedure, the patient complained of neck swelling and abdominal distension and pain. A chest X-ray and abdominal computed tomography scan showed subcutaneous emphysema, pneumomedistinum and pneumoperitoneum. If the colon perforates into the retroperitoneum, air can travel to the mediastinum and subcutaneous tissue as the fascial planes of the cervical soft tissues are in continuity with those of the mediastinum and through the diaphragmatic hiatus with the retorperitoneal soft tissue space. We report here a rare case of subcutaneous emphysema, pneumomediastinum and pneumoperitoneum that developed after a colonoscopic biopsy. (Korean J Med 77:S1153-S1156, 2009)
왕고들빼기 선향과 야생종의 수확시기별 일반성분 및 생리활성
권혜정(Hye-Jeong Kwon),정은경(Eun-Kyoung Jeong),정혜정(Hye-Jeong Jeong),김시창(Si-Chang Kim),허남기(Nam-Kee Heo),노희선(Hee-Sun No) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.3
왕고들빼기 신품종 선향과 야생종의 수확시기별 일반성분, 무기질, 항산화, 항당뇨, 항염 효과를 측정하였다. 수분 함량은 6월 수확된 선향 잎이 90.5%로 가장 높았으며, 8월 수확된 야생종에서 단백질은 4.8%, 조섬유는 2.7%로 가장 높았다. 칼륨은 선향과 야생종 잎에서 626~684 mg/100 g으로 수확시기별 큰 차이가 없었다. 칼슘은 8월 수확 선향 잎에서 350 mg/100 g으로 가장 높았다. 인은 8월 수확 야생종에서 123 mg/100 g으로 가장 높았다. 6월 수확된 야생종 잎에서 총 폴리페놀은 59.8 mg/g, 총 플라보노이드는 125.8 mg/g으로 가장 높았다. DPPH radical 소거 활성은 6월 수확된 선향과 야생종 잎의 에탄올 추출물에서 약 94%로 가장 높았다. α-Amylase 저해 활성은 7월에 수확된 선향 잎의 물 추출물에서 94.8%로 가장 높았다. NO 생성 저해 활성은 6월 수확된 선향과 야생종 잎의 에탄올 추출물에서 각각 14.3, 16.8 μM로 LPS 단독처리에 비해 NO 생성 저해 효과를 보였다. 따라서 선향 잎은 야생종에 비해 칼슘 함량과 α-amylase 저해 활성이 높았으며, 이러한 선향 잎의 영양?기능성을 활용한 다양한 가공품 개발이 가능할 것으로 보인다. We investigated the effect of harvesting time on the proximate compositions and biological activities of Lactuca indica L. Seonhyang and wild species. The highest moisture content (91%) was obtained from Seonhyang harvested in June. The wild species harvested in August showed the highest crude protein (4.8%) and crude fiber contents (2.7%). Potassium contents were 626∼684 mg/100 g, and no significant difference in harvesting time was observed between Seonhyang and wild species. Calcium and phosphate contents of Seonhyang leaves harvested in August were highest (350 mg/100 g and 123 mg/100 g, respectively). The highest total polyphenol and total flavonoid contents were observed for wild species harvested in June (60 mg/g and 126 mg/g, respectively). Ethanol extracts of Seonhyang and wild species leaves harvested in June showed the highest DPPH radical scavenging activity (95%). α-Amylase inhibitory activity was highest (94.8%) in water extract of Seonhyang leaves harvested in July. Nitric oxide production inhibitory activity was 14.3 μM in ethanol extracts of Seonhyang and 16.8 μM in ethanol extracts of wild species harvested in June. Calcium content and α-amylase inhibitory activity of Seonhyang leaves were greater than those of wild species leaves. These results suggest that Seonhyang leaf can be used to develop processed foods.