암석과 광물의 대자율

노현정(Hyun-jung Noh),유용재(Yongjae Yu) 대한지질학회 2015 대한지질학회 학술대회 Vol.2015 No.10

지질학계 신진여성과학기술인 양성과 역량강화 : 현황과 과제

노현정(Hyun-jung Noh) 대한지질학회 2015 대한지질학회 학술대회 Vol.2015 No.10

觀復菴 金崇謙의 次韻詩 작법과 운용의 실제

노현정(Noh Hyun Jung) 대동한문학회 2020 大東漢文學 Vol.63 No.-

이 논문은 觀復菴 金崇謙(1682~1700)의 차운시의 내용적･형식적 특성을 알아보고 더불어 관복암의 차운시의 특징에 대하여 살펴보고자 한다. 관복암은 조선후기 시인으로 어렸을 때부터 부친 農巖과 숙부 三淵으로 부터 시를 배웠다. 농암과 삼연뿐만 아니라 杜甫･尤庵 宋時烈･揖翠軒 朴誾 등 당대의 학자들을 배우며 그들의 시를 차운하였다. 觀復菴詩稿 에 나오는 차운시는 총 17題로 오언율시, 칠언절구, 칠언율시로 이루어져 있다. 이들을 각각 원운시와 차운시의 내용을 비교분석하고 평측의 법칙을 어떤 식으로 적용했는가에 대해서 살펴보았다. 오언율시는 三淵 金昌翕의 시, 칠언율시는 簡齋 陳與義의 시, 칠언절구는 農巖 金昌協, 柳下 洪世泰의 시를 들여다보았는데, 이들의 시는 전체적으로 다음과 같은 특징을 가지고 있다. 관복암은 어려운 시어는 사용하지 않으면서도 풍경이나 감정을 자신만의 느낌으로 잘 묘사하였다. 또한 대부분의 시가 도치 없이 차례로 번역되어 시를 처음 읽는 사람들이 어렵지 않게 읽을 수 있다는 특징이 있다. 이는 초학자적인 면모를 보이지만 그 속에서 그만의 의경을 잘 지켜나가려고 노력하였다. 또, 형식적인 측면에서 살펴보면, 관복암은 나름대로 평측을 지키려고 노력하였음을 알 수 있다. 초학자의 학시 과정에 있어서 차운시는 유용하다. 시를 쓰는 방법이나 부친과 숙부로부터 시를 배워 활용한 것을 관복암은 잘 보여주고 있다. 그가 길지 않은 생애동안 자신만의 시적세계를 가지고 그 속에서 배움을 활용하여 실질적인 차운시에 적용했다는 점은 주목할 만하다. 하지만 그가 부친과 숙부의 시어를 가져다 썼으나 같은 의경이라고 해도 맛을 달리할 수 있는지는 조금 더 생각해볼 필요가 있다. 본고는 관복암의 차운시를 통해 평측의 법칙과 관복암의 차운시의 특징을 알아보는 데에 집중하였다. 이러한 연구는 차운시를 분석하고 글자를 놓는 방법을 이해하는 데에 도움이 될 것이다. This paper will examine the contents and formal characteristics of Chaun-si(次韻詩) in Kim Sung gyeom(金崇謙, 1682~1700) and also examine the characteristics of Chaun-si(次韻詩) in Gwanbokam(觀復菴). Gwanbokam(觀復菴) was a poet in the late Joseon Dynasty and learned poetry from his father Nongam(農巖) and uncle Samyeon(三淵). Not only Nongam(農巖) and Samyeon(三淵), but also Dufu(杜甫) and U-am(尤庵) Song Si-yeol(宋時烈) and Eup-chwi-heon(揖翠軒) Park-Eun(朴誾) scholars of the time and learned their poems. Chaun-si(次韻詩) in Gwanbokamsigo(觀復菴詩稿) has a total of 17 titles, consisting of 5 words Yulshi(律詩), 7 words jeolgu(絶句), and 7 words Yulshi(律詩). We compared and analyzed the contents of Wonwoon-si(元韻詩) and Chaun-si(次韻詩) respectively, and looked at how the law of pyeong-cheug(平仄) was applied. The 5 words Yulshi(律詩) looked at the poems of Kim Chang Heup(金 昌翕), the 7 words Yulshi(律詩) looked at the poems of Gan-je(簡齋) Jin-Yeoui(陳與義), and the 7 words jeolgu(絶句) looked at the poems of Nongam(農巖) Kim Chang Hyeop(金昌協) and Yu-ha(柳下) Hong Se-tae (洪世泰). Their poetry as a whole has the following characteristics. Gwanbokam(觀復菴) portrayed the scenery or emotions with its own feelings without using difficult poetic words. This seems to be a beginner, but within it, he tried to keep his will. Also, from a formal point of view, it can be seen that Gwanbokam(觀復菴) tried to protect its own pyeongcheug( 平仄). Chaun-si(次韻詩) is useful for beginners academic courses. Gwanbokam (觀復菴) shows how to write poetry and how to learn and use poetry from father and uncle. It is noteworthy that he took his own poetic world and applied learning to practical poetry in his not long life. However, although he wrote the poetic words of his father and uncle, it is necessary to think a little bit more about whether the taste is different even if they are the same mind. This paper focused on finding out the laws of pyeong-cheug(平仄) and the characteristics of Gwanbokam(觀復菴)’s Chaun-si(次韻詩) through Gwanbokam(觀復菴)’s Chaun-si(次韻詩). These studies will help you to analyze the rhyme and understand how to place letters.

만성폐쇄성폐질환 환자들의 질병 인식과 치료 경험

노현정(Noh, Hyun Jung),김수현(Kim, Su Hyun),정우정(Joung, Woo Joung) 기본간호학회 2020 기본간호학회지 Vol.27 No.2

Purpose: The purpose of this study was to explore patients’ awareness and treatment experiences with Chronic Obstructive Pulmonary Disease (COPD) through in-depth interviews. The objective was to develop data to support patients in the successful management of their illness. Methods: Purposeful sampling was used to collect information-rich cases and participants were recruited at a university hospital in Daegu, South Korea. Data collection was done through face to face in-depth individual interviews with 10 patients with COPD from November 2016 to December 2018. Interview began with open-ended questions and each interview lasted on average one hour. All interviews were audio-taped and transcribed verbatim and transcripts were analyzed using qualitative thematic analysis. The findings were verified by the participants. Results: Four themes emerged from data analysis: ‘Feeling like the disease is not my disease,’ ‘Terminology spills like a flood,’ ‘Negligent daily disease-management with relief,’ and ‘Relying on health professionals and family members hoping for healing’. Conclusion: Participants do not have a clear understanding of their illness nor feel that they are principal agents of their health and illness for treatment and disease management; instead, they depend mainly on their family members and doctors. The findings elucidated the need for increasing patients’ awareness of the illness. Nurses should develop educational support programs to help COPD patients improve their awareness of their illness and successfully manage their treatment.

인터넷 기반 중재프로그램을 통한 성인 당뇨 환자의 HbA1c 중재효과: 메타분석

정창숙 ( Chang Suk Jung ),노현정 ( Hyun Jung Noh ),구민정 ( Min Jeong Gu ),김이영 ( Yi Young Kim ),이순영 ( Soon Young Lee ) 한국보건정보통계학회(구 한국보건통계학회) 2018 보건정보통계학회지 Vol.43 No.4

목적: 본 연구의 목적은 메타분석을 이용하여 2000년 이후 국내외 당뇨병을 가진 성인을 대상으로 수행된 인터넷 기반 중재 프로그램의 효과를 검증하고 실무 적용의 타당성을 확인하기 위함이다. 방법: 2000년 1월부터 2015년 12월까지 시행된 연구 중 국내외 학술지에 게재된 연구 논문을 대상으로 체계적 검토를 시행하였으며, 이중 분석 대상 기준에 적합한 최종 9편의 논문을 선정하였다. 자료 분석은 Internet-based Intervention의 실험군과 대조군에 따른 효과성을 파악하기 위하여 오픈 소스 통계 소프트웨어인 R 3.5.0을 사용하여 분석하였다. 결과: 분석 결과 성인 당뇨 환자의 HbA1c 조절을 위한 인터넷 기반 중재 프로그램의 효과 크기에 관한 연구는 국외 8편, 국내 1편이었다. 연구에 사용된 중재는 Internet-based Management가 7편(77.8%)으로 가장 많았고, Internet-based Education이 2편(22.2%)이었으며, 중재 프로그램 적용기간은 6개월이 4편(33.4%)으로 가장 많았다. 선행연구와의 중재 효과 비교에서는 모바일 전용 중재에서의 HbA1c 조절에 대한 가중평균 차이(WMD -0.20%, 95% CI: -0.43-0.03; p = 0.09)의 효과는 통계적으로 유의하지 않았으며, 모바일과 인터넷을 기반으로 한 중재를 통합했을 경우 가중평균 차이(WMD 0.54%, 95% CI: 0.72-0.37; p<0.001)의 효과를 나타냈다. 본 연구의 메타분석 결과에서도 인터넷을 기반으로 한 중재활동에서 통계적으로 유의한 효과를 보였다. 중재기간에 따른 효과 크기 분석 결과에서는 약 89%인 8편에서 3개월, 6개월, 12개월 모두 인터넷을 기반으로 한 중재활동 시행 시, 실험군에서 높은 효과를 보였으나, 중재 지속 기간의 증가에 따라 중재 효과는 감소하는 경향을 나타내었다. 결론: 본 연구의 결과에서는 인터넷 기반 중재 프로그램의 효과를 확인할 수 있었으며, 이는 인터넷을 기반으로 한 중재활동이 성인의 대표적 만성질환인 당뇨관리를 위한 HbA1c 및 혈당조절에 효과적임을 의미한다. 이와 함께 만성질환인 당뇨의 꾸준한 관리를 위한 인터넷 중재 프로그램의 활용 방안에 대한 연구와 중재활동의 구체적인 지침, 프로토콜 수립의 필요성이 제기된다. Objectives: This study aimed to verify the effectiveness of Internet-based intervention programs for adults with diabetes by conducting a meta-analysis of studies conducted since 2000. Methods: We conducted a systematic review of research papers published in domestic and overseas journals from January 2000 to December 2015, and selected 9 papers that met the analysis criteria. Data analysis was performed using the open source statistical software R 3.5.0, to analyze the effectiveness of Internet-based interventions on experimental and control groups. Results: The analysis showed that intervention programs for controlling HbA1c levels in adult patients with diabetes most commonly comprised 7 sessions on Internet-based management (77.8%), and the most common frequency of application of intervention programs was 4 session in 6 months (33.4%). The present meta-analysis revealed statistically significant effects of Internet-based intervention activities (SMD=0.92, 95% CI 0.45-1.40). The analysis of the effect size according to the intervention period showed that the 3-month, 6-month, and 12-month interventions reported in eight studies (89%) had a high effect on the Internet-based intervention group. Conclusions: The results of this study confirm the effectiveness of Internet-based intervention programs for adult patients with diabetes. The need for research on the utilization of Internet-based intervention programs for the steady management of diabetes, a chronic disease; for the development of specific guidelines for intervention activities; and for establishing appropriate protocols are acknowledged.

데이터마이닝 기반의 코로나 시대 여행 트렌드 변화 분석 : 제주 지역을 중심으로

고주원(Ju-won Ko),김지연(Ji-yeon Kim),노현정(Hyun-jung Noh),정유진(Yu-jin Jung),한유림(Yu-rim Han),김근형(Keun-hyung Kim) 한국정보통신학회 2023 한국정보통신학회 종합학술대회 논문집 Vol.27 No.1

코로나 팬데믹으로 인해 새로운 형태의 여행들이 생겨나고, 선호하는 여행방식 또한 변화하면서 팬데믹 전후 여행 트렌드 변화 연구의 중요성이 높아지고 있다. 이에 본 연구는 소셜 데이터 연관어 분석을 통해 ‘팬데믹 회복 후에 제주여행에 대한 선호도가 증가하며 관광객이 증가할 것이다’라는 가설이 옳은지 검증하고자 한다. 이러한 가설을 검증하며 팬데믹 전후 여행지에 대한 변화와 함께 이들의 여행 선호도 및 취향의 변화를 파악할 수 있다. 결과적으로 제주도의 관광 산업을 위한 마케팅 및 정책 방향성 등 실질적인 제언을 제공할 수 있다. As new types of travel are created due to the corona pandemic and preferred travel methods are also changing, the importance of research on changes in travel trends before and after the pandemic is increasing. Therefore, this study aims to verify whether the hypothesis that ‘after the pandemic recovery, the preference for Jeju travel will increase and the number of tourists will increase’ is correct through analysis of social data. By verifying these hypotheses, it is possible to identify changes in their travel preferences and tastes along with changes in travel destinations before and after the pandemic. As a result, practical suggestions such as marketing and policy direction for Jeju Islands tourism industry can be provided.

CJ-11555의 안전성 약리실험

최재묵(Jae Mook Choi),이성학(Sung Hak Lee),김일환(Il Hwan Kim),박지은(Jie Eun Park),김덕열(Deog Yeor Kim),노현정(Hyun Jung Noh),김택로(Taekrho Kim),최광도(Do-Gwang Choi),김영훈(Young Hoon Kim),김진완(Jin Wan Kim),장준환(Joon Hwan Jan 한국독성학회 2004 Toxicological Research Vol.20 No.2

Safety pharmacological properties of CJ-11555, an anti-cirrhotic agent, were investigated in experimental animals and in vitro test system. CJ-11555 had no effects on normal body temperature in rats, motor coordination, chemoshock induced by pentetrazol, electric shock induced by electric shocker and writhing syndromes in mice at dose levels of 100, 300 and 1,000 mg/kg. CJ-11555 inhibited intestinal activity and prolonged hexobarbital-induced sleeping time in mice at the dose level of 1,000 mg/kg. CJ-11555 affected on general activity and behaviour tests in SD rats, such as<br/> lacrimation, ptosis, piloerection, decreased body tone, abnormal dispersion within the cage, diarrhoea, red colored faeces, slight hypothermia and decreased grooming, at the dose level of 1,000mg/kg in rats. CJ-11555 was effected on cardiovascular and respiratory system in anesthetized beagle dogs, such as tachycardia, increase of mean blood pressure and decrease of PR interval, decrease of respiratory rate and minute volume, at dose levels of 10 and <br/> 30mg/kg. However, these effects were also observed in vehicle treated anesthetized beagle dogs. In in vitro experiments, CJ-<br/> 11555 inhibited agonists (histamine, acetyl-choline or BaCl2) induced contraction of isolated guinea-pig at the concentration of 30x10-6 M. CJ-11555 was weekly inhibited hERG channel current at concentrations of 10 and 30x10-6 M, and IC50 was estimated to be higher than 30x10-6 M. Based on these results, it was concluded that CJ-11555 affected on cardiovascular and respiratory system, general activity and behaviour and hexobarbital-induced sleeping time at the dose level of 1,000 mg/kg and contraction of the smooth muscle and hERG channel current at the concentration of 30x10-6 M.

CJ-11555의 Sprague-Dawely 랫드를 이용한 단회 및 4주 반복경구투여 독성시험

김일환(Il-Hwan Kim),이성학(Sung-Hak Lee),최재묵(Jae-Mook Choi),박지은(Jie-Eun Park),김덕열(Deog-Yeor Kim),노현정(Hyun-Jung Noh),김택로(Taek-Rho Kim),이상호(Sang-Ho Lee),김영훈(Young-Hoon Kim),김진완(Jin-Wan Kim),장준환(Jun-Hwan Chang 한국독성학회 2004 Toxicological Research Vol.20 No.1

This study was to investigate single and repeated-dose toxicities of CJ-11555, an anticirrhotic agent, in Sprague-Dawley (SD) rats. In single-dose oral toxicity study, the test article were administered once by gavage to males and females at dose levels of 0 and 2,000 mg/kg. No dead animals and abnormal necropsy findings were found in control and CJ-11555 treated group. Therefore, the approximate lethal dose of CJ-11555 was considered to be higher than 2,000 mg/kg in rats. In the 4-week repeated oral toxicity study, the test article was administered once daily by gavage to<br/> male and female rats at dose levels of 0, 10, 50 and 200 mg/kg/day for 4-weeks. In clinical signs, yellow-colored urine and yellow hair coat were observed in the 50 and 200 mg/kg male and female<br/> groups. In hematology, erythrocyte count and hemoglobin were significantly decreased in the 200mg/kg male and female groups. In serum biochemistry, total cholesterol was significantly increased and aspartate aminotransferase (AST) was significantly decreased in the 50 or 200 mg/kg male and female groups. In histopathological examinations, centrilobular hepatocellular hypertrophy in the liver, congestion and pigmentation in the spleen, hyaline droplets in the kidney were observed in the 50 and 200 mg/kg male and female groups. In toxicokinetic study, CJ-11555 was dose-dependent in systemic exposure and showed better absorption in female with minimum accumulation after multidosing. Based on these results, it was concluded that the 4-week repeated oral dose of CJ-11555 resulted in the suppression of AST activity and centrilobular hepatocellular hypertrophy in both sexes at a dose level of 50 or 200 mg/kg/day. The target organ was estimated to be liver, spleen and male's kidney. The no-observed-adverse-effect level (NOAEL) for CJ-11555 in rats following gavage for at least 4-week is 10 mg/kg/day.

CJ-11555의 안전성 약리실험

최재묵(Jae-Mook Choi),이성학(Sung-Hak Lee),김일환(Il-Hwan Kim),박지은(Jie-Eun Park),김덕열(Deog-Yeor Kim),노현정(Hyun-Jung Noh),김택로(Taekrho Kim),최광도(Do-Gwang Choi),김영훈(Young-Hoon Kim),김진완(Jin-Wan Kim),장준환(Joon-Hwan Jan 한국독성학회 2004 Toxicological Research Vol.20 No.1

Safety pharmacological properties of CJ-11555, an anti-cirrhotic agent, were investigated in experimental animals and in vitro test system. CJ-11555 had no effects on normal body temperature in rats, motor coordination, chemoshock induced by pentetrazol, electric shock induced by electric shocker and writhing syndromes in mice at dose levels of 100, 300 and 1,000 mg/kg. CJ-11555 inhibited intestinal activity and prolonged hexobarbital-induced sleeping time in mice at the dose level of 1,000 mg/kg. CJ-11555 affected on general activity and behaviour tests in SD rats, such as lacrimation, ptosis, piloerection, decreased body tone, abnormal dispersion within the cage, diarrhoea, red colored faeces, slight hypothermia and decreased grooming, at the dose level of 1,000<br/> mg/kg in rats. CJ-11555 was effected on cardiovascular and respiratory system in anesthetized beagle dogs, such as tachycardia, increase of mean blood pressure and decrease of PR interval, decrease of respiratory rate and minute volume, at dose levels of 10 and 30 mg/kg. However, these effects were also observed in vehicle treated anesthetized beagle dogs. In in vitro experiments, CJ-11555 inhibited agonists (histamine, acetyl-choline or BaCl2) induced contraction of isolated guinea-pig at the concentration of 30×10-6 M. CJ-11555 was weekly inhibited hERG channel current at concentrations of 10 and 30×10-6 M, and IC50 was estimated to be higher than 30×10-6 M. Based on these results, it was concluded that CJ-11555 affected on cardiovascular and respiratory system, general activity and behaviour and hexobarbital-induced sleeping time at the dose level of 1,000 mg/kg and contraction of the smooth muscle and hERG channel current at the concentration of 30×10-6 M.

이차성 부갑상선 기능 항진증을 가진 복막투석 환자에서 경구 칼시트리올 치료 반응에 관여하는 요인

강신욱(Shin Wook Kang),최규헌(Kyu Hun Choi),이호영(Ho Yung Lee),한대석(Dae Suk Han),신석균(Sug Kyun Shin),하성규(Sung Kyu Ha),노현진(Hyun Jin Noh),송현용(Hyun Yong Song),노현정(Hyun Jung Roh),유태현(Tae Hyun Yoo),황재하(Jae Ha Hwang) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.1

N/A Calcitriol therapy is an important treatment for the prevention and control of secondary hyperparathyroidism in continuous ambulatory peritoneal dialysis (CAPD) patients. However, this often has been limited by the associated hypercalcemia and hyperphosphatemia due to increase in intestinal calcium and phosphorus absorption. Many studies reported that these limitations could be avoided by changing routes, frequency and dose of calcitriol treatment. But, there are still controversy about each methods and the results on the PTH response to conventional calcitriol treatment in CAPD patients. This study was performed to evaluate the factors affecting the response to oral calcitriol in CAPD patients. A retrospective study was done in 92 CAPD patients with secondary hyperparathyroidism(intact PTH level >200pg/ml) on oral calcitriol treatment. After baseline study of serum calcium, phosphorus, alkaline phosphatase, BUN, creatinine and intact PTH, calcitriol therapy was begun via oral rou- te, daily. Serum calcium, phosphorus, alkaline phosphatase, BUN, creatinine, intact FI'H and other bio- chemical markers were checked at 3 month, 6 month after treatment. Parathyroid gland ultrasonography was performed to detect parathyroid hypertrophy and nodule and to measure the diameter of parathymid gland. All the patients were divided into two groups according to percent reduetion of i-PTH(initial PTH PTH after 3, 6 months)×100/initial PTH(%),△PTH during oral calcitriol therapy for 3 and 6 months(group I ; △PTH >30%, group II ; △PTH <30%). Result: 1) All 92 patients(mean age 46.5 11.3yr, M: F 45: 47, mean CAPD duration 51.3 39.4 months) were administered oral calcitriol, daily. Mean calcitriol dose during 3 month was 0.43 0.22μg and during 6month 0.43 0.24μg. 2) After 3-month treament, there were significant differences in initial i-PTH, the diameter of parathyroid gland, initial phosphorus, intial total alkaline phosphatase and duration of CAPD between group I and II(406.7±196.5 vs. 871.0±478Apglml, 6.2±2.6 vs. 13.1±5.2mm, 5.0±1.3 vs. 5.7±1.3mg/dl, 93.7±4L1 vs. 171.9±137.6IU/L, 40.1±34.9 vs. 73.5±37.8months, p< 0.05, respectively). 4) After 6-month treament, there were significant differences in initial i-PTH, the diameter of parathyroid gland, intial total alkaline phosphatase and duration of CAPD between group I and II(474.1±266.6 vs. 889.7±485.4pg/ml, 6.4±2.7 vs. 14.5±5.1mm, 107.9±80.1 vs. 180.7±121.5IU/L, 40.5± 32.9 vs. 81.8±35.3months, p<0.05, respectively). 5) The significant negative correlation was shown between △PTH and the duration of peritoneal dialysis, the diameter of parathyroid gland, initial PTH level and PTH response during 3-month and 6-month oral calcitriol treatment. The response to oral calcitriol was poor when i-PTH level more than 500pg/ml(kappa 0.429, p value <0.01), the diameter of parathyroid gland more than 10.0mm(kappa 0.641, p value<0.01), the duration of CAPD more than 55months(kappa 0.524, p value< 0.01). These data suggested that initial i-PTH level, the diameter of parathyroid gland size and the duration of CAPD were independent risk factors of the poor response to oral calcitriol therapy in CAPD patients with secondary hyperparathyroidism.