익산 미륵사지 출토 납제품의 납동위원소비 분석 고찰

노지현,히라오 요시미츠,김규호,노기환,No, Ji-Hyun,Hirao, Yoshimitsu,Kim, Gyu-Ho,Noh, Gi-Hwan 국립문화재연구소 2009 保存科學硏究 Vol.30 No.-

Mireuk temple site is located in Iksan, on the North Jeolla province in Korea, and confirmed tiles, potteries, metals, glasses and other materials that are remaining between Baekje Kingdom and Joseon period after excavations. It is also detected that production and supply of the materials in this era were started inside the country(domestic) at that time. This is important information for the understanding of the production and circulation systems. In this study, lead isotope ratios of 18 samples includedlead glass, crucibles and glazed rafter tiles excavated from Mireuk Temple Site of Baekje era were analyzed for the provenance study of raw glass material supply and distribution of glass products. The results of lead isotope ratio analysis have shown that all raw materials were located in the distribution area of Baekje region and also confirmed to be accord with the previous research results. As comparing the lead isotope ratios of glass and glass materials excavated from Mireuk Temple Site with Miyajidake tomb from Fukuoka Prefecture in Japan, it is found that the same raw materials were used for glass production. It means that there is the active connection between Mireuk temple site and Miyajidake and that these areas are sharing the same materials at the same period. It also shown that artifacts excavated from Miyajidake were strongly influenced from Baekje culture. And it is estimated that there is a possibility of the use ofsame materials whether the supplies of them are from a specific place of Baekje or not

노후공동주택의 효율적인 주차장확대 리모델링 시공을 위한 BIM 설계기법의 적용사례 연구

노지현(Noh Ji-Hyun),민병직(Min Byung-Jik),김인기(Kim In-Ki),남상철(Nam Sang-Chul) 대한건축학회 2010 대한건축학회논문집 Vol.26 No.6

The amount of old apartment complexes are increasing rapidly by supplying large quantity of their construction since mid-1980s. By growing number of old apartment complexes that need to be remodeled, not only studies about this issue are necessary, but a study about parking area issue in the old apartment complexes is also necessary for its importance and practical point. The purpose of this research is to be available as a basic material for parking area expansion plan. Through a couple of completed cases, we confirmed the characters of parking area expansion plan and find factor from the cases. After that we revised the factors through some of uncompleted cases. A result through the analysis, simply we divided by inner factor and outer factor, and classified by its items. Inner factors are present land condition and requirements of the inhabitants. Outer factors are economical efficiency and architectural building codes.

갑상선 기능 저하증과 동반된 거대 난소 종양

노지현 ( Ji Hyun Noh ),고승희 ( Seung Hee Goh ),심의섭 ( Ey Sup Shim ),고재환 ( Jae Whoan Koh ),김용봉 ( Yong Bong Kim ),최석구 ( Suk Koo Choi ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.4

In adult women, hypothyroidism has significant effect on reproduction. Hypothyroidism is associated with oligomenorrhea, amenorrhea, anovulation, hypermenorrhea, menorrhagia, infertility, spontaneous abortion, stillbirth or preterm delivery. It can cause

앙금 생성 반응을 이용한 화학반응속도 측정 실험의 분석과 Small-Scale Chemistry를 적용한 실험 개발

박국태,노지현,김동진,유란영,노윤미,김묘경,이상권,Park, Kuk-Tae,Noh, Ji-Hyun,Kim, Dong-Jin,Ryu, Ran-Yeong,Noh, Yun-Mi,Kim, Myo-Kyung,Lee, Sang Kwon 대한화학회 2008 대한화학회지 Vol.52 No.3

이 연구의 목적은 고등학교 과학 교과서에 제시된 앙금 생성 반응을 이용한 화학반응속도 측정 실 험으로 small-scale chemistry (SSC)를 적용한 실험을 개발하고자 하는 것이다. 연구를 위해서 고등학교 10종 과 학 교과서에 제시된 화학반응속도에 미치는 농도와 온도의 영향에 대한 실험 방법을 반응 생성물 확인 방법 에 따라 분류하고, 과학 교과서에 가장 많이 제시되어 있는 앙금 생성 반응을 이용한 화학반응속도 측정 실험 을 교과서 실험 방법에 따라 수행하였다. 그리고 실험 과정에서 나타나는 문제점들을 분석해서 앙금 생성 반 응을 이용한 화학반응속도 측정 실험에 SSC를 적용한 실험을 개발하였다. 연구 결과에 의하면, 과학 교과서 에 제시된 앙금 생성 반응을 이용한 화학반응속도 측정 실험에는 반응 용액들의 혼합 방법에 대한 번거로움, X자가 보이지 않는 시점의 애매모호함, 실험 결과 수집의 시간 지연, 유독한 이산화황 기체의 발생, 물중탕 장 치 조작의 불편함, 그리고 반응 온도 통제의 어려움 등의 문제점들이 있었다. 또한, 실험 결과들의 재현성이 부 족하였다. 이러한 문제점들은 앙금 생성 반응을 이용한 화학반응속도 측정 실험에 SSC를 적용하여 개발한 실 험으로 해결할 수 있었다. SSC를 적용한 실험에서는 A4 용지 반응판에 실험의 순서를 명시하여 실험 방법을 명확하게 할 수 있었으며, 홈판과 스템 피펫을 사용하여 반응시간을 단축하여 실험 결과들을 연속적으로 얻을 수 있었다. 또한, 유독한 이산화황 기체의 발생량을 1/7 정도로 줄일 수 있었으며, X자가 보이지 않는 시점도 뚜렷하게 관찰할 수 있었다. 그리고 30분 내에 화학반응속도에 미치는 농도와 온도의 영향에 대한 두 실험을 간편하고 재현성 있게 수행할 수 있었다. 또한, 수업시간 중 실험 결과들을 해석하고 토의할 수 있는 시간을 확보할 수 있어, 고등학생들이 화학반응속도에 미치는 농도와 온도의 영향에 대한 과학적인 개념을 형성하는 데 도움을 줄 것으로 기대된다. The purpose of this study was to understand the experiment for measuring chemical reaction rate by precipitate formation and to develop experiments applying small-scale chemistry. For this study, the experimental method for measuring the effect of concentration and temperature on chemical reaction rates presented in the 10 high school science textbooks were classified by their experimental methods of confirming production. Subsequently, problems observed in carrying out the experiments for measuring chemical reaction rates by precipitate formation frequently presented in the 10 high school science textbooks were analyzed. Experiments applying small-scale chemistry were developed measuring chemical reaction rate by precipitate formation. According to the result of this study, there were some problems in the experimental method of precipitate formation for measuring chemical reaction rates presented in the high school science textbooks. Those problems in the science textbook experiments were insufficient specification of mixing methods of reaction solutions, obscurity of knowing when the character letter X disappeared, time delay in collecting the experimental data, formation of hazardous sulfur dioxide, uneasiness of fixing water bath container, controlling the reaction temperature, and low reproducibility. Those problems were solved by developing experiments applying smallscale chemistry. Presenting the procedure of mixing reaction solutions on the A4 reaction paper sheet made the experimental procedure clearly, using well plates and stem pipette shortened the reaction time and made it possible to continuously collect the experimental data. Furthermore, the quantity of hazardous sulfur dioxide was reduced 1/7 times and the time when the character letter X disappeared could be observed clearly. Since experiments for measuring the effect of concentration and temperature on chemical reaction rates could be performed in 30 minutes, the developing experiments applying SSC would help students understand the scientific concepts on the effect of concentration and temperature on chemical reaction rates with enough time for experimental data analysis and discussion.

자궁내막증과 progesterone receptor gene polymorphism (PROGINS)과의 연관성에 관한 연구

김윤진(Yun Jin Kim),노지현(Ji Hyun Noh),고재환(Jae Whoan Koh),김용봉(Yong Bong Kim) 대한의학유전학회 2007 대한의학유전학회지 Vol.4 No.2

목적 : 자궁내막증은 유전적 연관성이 명확히 규명되지 않은 에스트로겐 의존성 질환이다. 그 연관성에 대하여 명확히 밝혀진 것은 없으나 일부 유전적 연구 결과들을 살펴보면 자궁내막증이 프로게스테론 수용체 유전자의 특정 다형성 부위와 연관되어 있음을 알 수 있다. 본 연구는 프로게스테론 수용체 유전자의 다형성(PROGINS)을 분석하여 자궁내막증 환자와 대조군에 차이가 있는지를 알고자 고안되었다. 방법 : 수술 및 병리조직 소견에서 자궁내막증을 확진받은 100명의 환자와 건강검진을 시행 받은 일반 인구군 110명을 대상으로 하였다. 대상 환자들의 말초 혈액에서 DNA를 추출한 후 프로게스테론 수용체의 유전자 다형성 검사를 PCR-SSP (Sequence specific primer)방법으로 시행하였고 자궁내막증 환자군과 건강대조군에 있어서 특정 유전자 다형성의 빈도에 차이가 있는지 x² 검정을 통하여 통계 분석하였다. 결과 : 자궁내막증군과 대조군에서 각각 1명에서만 PROGINS 다형성 양상이 T1/T2 이형접합자로 확인이 되었고 나머지 개체에서는 모두 T1/T1 동형접합자임이 확인되었다. 결론 : 자궁내막증과 프로게스테론 수용체의 유전자 다형성(PROGINS)간의 연관성은 밝혀지지 않았으나 대규모의 연구 및 다른 유전자의 연구가 자궁내막증이 병인을 규명하는데 유용할 것으로 생각된다. Purpose: Endometriosis is a steroid dependent disease with a particular genetic background but the location of possible genomic aberrations are still poorly clarified. This study was designed to investigate the associations between the polymorphism of the progesterone receptor gene (PROGINS) and endometriosis. Methods : 100 women with surgically diagnosed and histologically confirmed endometriosis were enrolled as a patient population and a total of 110 female centre subjects undergoing health examination were enrolled as control population. DNA extraction and polymerase chain reaction (PCR) were used to genotype women for the presence of the PROGINS polymorphism in peripheral blood samples. The x2-test was used to compare genotype distributions between endometriosis and controls. Results: T1/T2 heterozygote was found to be one patient in each group, and the rest of the subjects were all T1/T1 homozygotes. There was no difference in the genotype distribution between the endometriosis group and the control group. Conclusion: These results suggest that the progesterone receptor gene PROGINS is not associated with the risk for endometriosis.

원발성 난관암

고희은 ( Hee Eun Ko ),노지현 ( Ji Hyun Noh ),강윤경 ( Yun Kyung Kang ),고승희 ( Seung Hee Goh ),고재환 ( Jae Whoan Koh ),김용봉 ( Yong Bong Kim ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.1

Primary carcinoma of the fallopian tube is very rare and accounts for less than 1% of all gynecologic malignancies. Nonspecific symptoms are presented, so primary carcinoma of the fallopian tube was confirmed postoperatively on the basis of the pathologic

자궁각 병합임신 환자에서 KCL 주입을 통한 선택적 태아감축술 시행 후 성공적으로 만삭분만에 이른

김미선 ( Mi Seon Kim ),이지원 ( Ji Won Lee ),정명철 ( Myung Chul Jung ),최희정 ( Hee Jeong Choi ),김용봉 ( Yong Bong Kim ),문명진 ( Myoung Jin Moon ),박병규 ( Byung Kyoo Park ),노지현 ( Ji Hyun Noh ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.12

Heterotopic pregnancy is defined as simultaneous intrauterine and ectopic pregnancy. Natural occurrence rate is very low occuring 1/30,000. However, with the use of assisted reproductive technology (ART), the risk increases up to 1/7,000. It is important to continuously monitor the patient using ultrasonography after ART for early detection of heterotopic pregnancy. Treatment options include surgical and medical interventions for the maintenance of intrauterine pregnancy. This is a case of full-term birth following selective fetal reduction using potassium chloride in a heterotopic pregnancy along with relevant literature review.

임산부에서 부신절제술 후 잔여 선종인한 일차성 고알도스테론증

박선욱 ( Sun Wook Park ),고행일 ( Haeng Il Koh ),노지현 ( Ji Hyun Noh ),김문철 ( Mun Cheol Kim ),이혜경 ( Hye Kyung Lee ),박상현 ( Sang Hyun Park ),나현희 ( Hyun Hee Na ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.3

Primary aldosteronism is present in approximately 1 percent of hypertensive patients, and is rarely associated with pregnancy. We report a case of unilateral aldosterone producing adenoma in a pregnant woman. A 29-year-old woman was referred to with hypertension and proteinuria at 14 weeks` gestation. She had known that she had unilateral aldosterone producing adenoma for 18 months and refused medical or surgical treatment. She was prescribed antihypertensive medication and preformed laparoscopic adrenalectomy in left adrenal gland at 22 weeks` gestation. After adrenalectomy, her blood pressure was normal. At 29 weeks` gestation, she complained headache, and her blood pressure was 200/100 mmHg with pitting edema. We thought preeclampsia and performed cesarean section. After the baby was delivered, she had uncontrolled hypertension, hypokalemia with persistent proteinuria. We checked plasma renin activitity, aldoterone and abdminopelvic computed tomography. We found remnant left adrenal adenoma and perfomed laparoscopic operation. After reoperation, her blood pressure was normal and no proteinuria.

자궁내막증에서 aromatase의 발현과 임상적 중등도와의 연관성

이일한 ( Il Han Lee ),김동호 ( Dong Ho Kim ),노지현 ( Ji Hyun Noh ),고재환 ( Jae Whoan Koh ),김용봉 ( Yong Bong Kim ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.4

목적: 본 연구는 자궁내막증 조직, eutopic endometrium 및 정상 자궁내막조직에서의 aromatase 발현율 차이를 알아보고 aromatase 발현군과 비발현군 간의 임상적 중증도의 차이를 알아보고자 시행되었다. 연구 방법: 자궁내막증으로 진단되어 수술을 시행 받은 78명의 환자와 그 중에서 eutopic endometrium의 채취가 가능했던 14명의 환자를 실험군으로 하였고 난소 낭종이나 기능성 자궁 출혈로 소파술 및 자궁 절제술을 시행받은 30명의 환자를 대조군으로 하였다. 각각의 동결 절편한 조직들에서 aromatase를 이용한 면역조직화학염색을 시행하여 aromatase의 발현 정도를 비교하였고 발현 여부에 따라 환자군의 임상 증상, 검사실 소견, 수술 소견을 나누어 비교 분석하였다. 결과: Aromatase는 총 78명의 자궁내막증 조직에서 46명 (59.0%)이 발현 되었다. 이는 eutopic endometrium의 발현율보다 유의하게 높았으며 (P<0.05), eutopic endometrium의 발현율 역시 정상 조직군에 비해 유의하게 높았다 (P<0.05). Aromatase 양성인 환자는 음성인 환자에 비해서 중등도의 만성 골반통 비율, CA-125 수치가 유의하게 높았고 (P<0.05), 수술 소견에서도 중증병기 (P<0.001), 양측성 자궁내막종의 존재 (P<0.05), 근종이나 선근증의 동반 정도가 유의하게 높았다 (P<0.05). 혈중 백혈구수치와 적혈구 침강속도, CA 19-9는 양성군에서 다소 높게 관찰되었으나 통계적 유의성은 보이지 않았다. 결론: 자궁내막증환자에 있어서 eutopic endometrium과 자궁내막증 조직 내의 aromatase 발현은 국소적인 에스트로겐을 형성함으로써 자궁내막증의 발생과 유지에 연관이 있는 것으로 나타났고, aromatase의 발현의 증가는 자궁내막증의 중등도 및 활성도에 중요한 영향을 미치는 것으로 나타났다. Objective: Aromatase is the key enzyme for the conversion of C19 steroids into estrogen in certain human tissues. We studied to evaluate the aromatase expression in eutopic endometirum and endometriotic lesion and its relationship to clinical and laboratory parameters. Methods: The study included 78 cases of endometriotic lesion and 14 cases of eutopic endometrium and 30 cases of normal uterine endometrium obtained through laparoscopic surgery and curettage. The frozen tissue specimens were examined by immunohistochemistry using aromatase. Clinical symptoms, laboratory findings, and operative findings were analyzed and compared in according to aromatase expression. Results: We observed positive immunohistochemical expression for aromatase in endometriotic lesion from 46/78 patients (59.0%). Aromatase expression was elevated in comparison to eutopic endometrium (5/14 patients, P=0.032) and the difference was more pronounced when eutopic endometriums from patients with endometriosis were compared with those of healthy controls (2/30 patients, P<0.001). Aromatase-positive patients had more moderate-to-severe chronic pelvic pain, higher CA-125 level significantly. Also in operative findings, severe grade endometriosis, bilateral endometriomas, and associated leiomyoma and adenomyosis were more frequent in aromatase positive patients. High values of white blood cell count, erythrocyte sedimentation rate, CA 19-9 were more frequent in aromatase positive patients notwithstanding insignificant differences. Conclusion: Unopposed local biosynthesis of estrogens by increased expression of aromatase in eutopic endometrium and endometrial tissue could be involved in the development or maintenance of endometriosis and other uterine estrogen-triggered diseases. Our findings suggest increased expression of aromatase may be related with severity, activity, and chronic pelvic pain in patients with endometriosis.

경계성 난소종양의 복강경수술 후 투관침 부위로 착상된

최자인 ( Ja In Choi ),최희정 ( Hee Jeong Choi ),노지현 ( Ji Hyun Noh ),고재환 ( Jae Whoan Koh ),김용봉 ( Yong Bong Kim ),강윤경 ( Yun Kyung Kang ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.6

Borderline tumor of ovary is epithelial proliferation without stromal invasion, first reported by Taylor in 1929. Borderline ovarian tumor occurs in younger women and is detects in early stage. Laparosocopy is alternative treatment of younger women for postoperative quality of life because it reduces postoperative adhesion. But it is limited to incomplete staging, tumor cell dissemination and recurrence. We report a case of port site implantation of mucinous borderline tumor after the laparoscopic operation; usually recurrence of borderline tumors were occurred after ten or fifteen years later, this case a direct evidence of cause of metastasis after the laparoscopic operation.