배양된 토끼 각막간질세포의 Candida albicans 에 대한 탐식능과 Acid Phosphatase 활성도 변화

노주헌(Joo Heon Roh),한영호(Young Ho Hahn),손승완(Seung Wan Sohn),안도환(Do Whan Ahn),원인건(In Gun Won) 대한안과학회 2000 대한안과학회지 Vol.41 No.2

편측 만성 안검 결막염으로 가면 ( Masquerade ) 된 피지선암 1 례

노주헌(Joo Heon Roh),손승완(Seung Wan Sohn),박세광(Seh Kwang Park) 대한안과학회 2000 대한안과학회지 Vol.41 No.2

윗눈꺼풀에서 발생된 피부뿔을 동반한 각질가시세포종

이주헌(Joo Heon Lee),노주헌(Joo Heon Roh) 대한안과학회 2022 대한안과학회지 Vol.63 No.11

목적: 윗눈꺼풀에 발생한 피부뿔이 동반된 각질가시세포종을 경험하였기에 이를 보고하고자 한다. 증례요약: 59세 여자 환자가 우측 윗눈꺼풀에 발생한 종괴를 주소로 내원하였다. 통증 없이 크기가 빠르게 커지는 양상을 보였다고하였다. 내원 당시 우안 윗눈꺼풀 중앙에 2×2×5 mm 크기의 원뿔모양 암갈색 덩이가 돌출되어 있었으며, 기저부에 7×4 mm의 융기된 결절이 관찰되었다. 진단을 위해 절제생검하였으며, 절제된 종괴는 주변 조직과 유착되어 있어 가능한 완전절제를 시행하였다. 절제된 원뿔형 종괴에서는 이상각화증과 과각화증이 관찰되었고, 결절 형태의 종괴에서는 각질마개, 각질진주, 편평상피세포의 증식이 관찰되었다. 이러한 소견으로 눈꺼풀에 발생된 피부뿔을 동반한 각질가시세포종으로 진단하였다. 결론: 눈꺼풀에 발생하는 각질가시세포종은 피부뿔을 동반하기도 하며 편평상피세포암종과 임상 및 병리학적으로 감별해야 할 질환으로써, 수술적 절제 및 조직병리검사를 고려해야 한다. Purpose: To report a case of upper eyelid keratoacanthoma with a cutaneous horn. Case summary: A 59-year-old female presented to our clinic with a rapidly growing, painless mass in the center of the right upper eyelid. A 2 × 2 × 5 mm dark brown conical hyperkeratotic mass and a 7 × 4 mm nodular, nontender mass were palpable on the right upper eyelid. The lesion was isolated from the surrounding tissues and excised completely. Histopathologically, the excised masses showed parakeratosis along with hyperkeratosis of the conical mass and the keratin plug, keratin pearls, and epithelial proliferation in the nodular mass. These findings led to a diagnosis of eyelid keratoacanthoma with a cutaneous horn. Conclusions: Eyelid keratoacanthomas may be accompanied by cutaneous horns and confused with squamous cell carcinomas. The treatment is complete excision, which should be followed by histopathological analysis.

만성 누소관염의 임상양상과 치료

박재홍,노주헌.Jae Hong Park. MD. Joo Heon Roh. MD 대한안과학회 2013 대한안과학회지 Vol.54 No.10

Purpose: To report on the clinical manifestations, species and treatments of patients with chronic canaliculitis. Methods: From August 2003 to February 2012, 77 eyes of 77 patients who were diagnosed with chronic canaliculitis at our hospital were retrospectively analyzed. Results: The mean period from the onset of symptoms to diagnosis was 4.7 months. The most common systemic disease associated with chronic canaliculitis was diabetes (18 eyes, 23%), and 13 eyes (17%) were related to punctual plug insertion. Main symptoms consisted of epiphora with discharge and pouting punctum. In the culture results of 55 eyes, streptococci, staphylococci, and actinomyces among other bacteria were identified. Seventy-two eyes (94%) were cured with one-snip punctoplasty with curettage. Conclusions: Chronic canaliculitis is rare, and the clinical aspect can be obscured by chronic conjunctivitis, thus the diagnosis is often delayed. In patients who have systemic diseases such as diabetes or past history of punctual plug insertion, chronic canaliculitis should be differentiated by observing the punctum more closely. If the diagnosis is accurate at the time, chronic canaliculitis could be easily cured by a relatively simple procedure such as one-snip punctoplasty with curettage.

윗눈꺼풀에 국한하여 발생한 신경집종 1예

양헌(Heon Yang),노주헌(Joo Heon Roh) 대한안과학회 2017 대한안과학회지 Vol.58 No.1

목적: 눈꺼풀에 국한하여 발생하는 신경집종은 매우 드문 질환이다. 저자들은 콩다래끼와 유사한 형태로 발생한 증례가 있어 이를 보고하는 바이다. 증례요약: 54세 남자가 재발된 우안 윗눈꺼풀의 종괴를 주소로 내원하였다. 과거력상 환자는 2년 전 개인 안과에서 콩다래끼로 진단받고 절개술을 시행 받은 병력이 있으며, 종괴는 절개 후 재발하여 2년 동안 통증 없이 크기가 천천히 커지는 양상을 보였다. 내원 당시 우안 윗눈꺼풀 가운데에 4 × 3 mm의 단단한 비색소성 눈꺼풀 종괴가 관찰되었으며, 신경섬유종증과 같은 전신질환은 없었다. 진단을 위해 국소마취하에 종괴를 절제 생검하였으며, 종괴는 경계가 분명하였고 주변과 잘 박리되었다. 절제된 종괴는 조직병리검사상 방추세포들이 울타리 배열의 베로케이 소체를 구성하는 모습을 보였고, 면역조직화학염색상 S-100 단백질에 대하여 미만성의 강한 양성 소견을 보였다. 이러한 소견으로 눈꺼풀에 발생한 신경집종으로 진단하였다. 결론: 눈꺼풀에 발생하는 신경집종은 매우 드물지만 콩다래끼와 유사한 양상을 보이는 경우가 있어 간과하기 쉽다. 따라서 본 증례와 같이 불완전한 절제 후 다시 느리게 자라나거나 악성 변형이 의심되는 종괴는 감별진단 시 신경집종도 고려할 필요가 있다. Purpose: To report a rare case of upper eyelid schwannoma presenting as a chalazion. Case summary: A 54-year-old male presented to our clinic with a slowly growing, painless recurred mass located in the middle area of the right upper eyelid margin. Surgical incision had been performed on a similar mass two year previous, although no histological analysis had been performed. On examination, a 4 × 3-mm-sized, firm, nonpigmented mass was palpable in the right upper eyelid, and no signs of neurofibromatosis were present elsewhere. The lesion was initially thought to be an eyelid mass, so we performed an excisional biopsy under local anesthesia. The lesion was easily isolated from the surrounding tissue and was excised completely. Histopathologically, the excised mass showed a compact arrangement of spindle cells forming palisades with Verocay bodies (Antoni A patterns). Immunohistochemistry revealed diffuse and strong S-100 protein positivity. These findings resulted in the diagnosis of eyelid schwannoma. Conclusions: Because of its rarity and solitary feature, eyelid schwannoma can be confused with chalazion. Thus, ophthalmologists should consider schwannoma in the differential diagnosis of a slowly growing, painless recurred mass or a lesion with malignant transformation after incomplete excision.

상안검에 국한되어 발생한 Merkel 세포 종양 1예

이우석,김상원,노주헌.Woo Seok Lee. MD. Sang Won Kim. MD. Joo Heon Roh. MD. PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.6

Purpose: To report a case of Merkel cell carcinoma on the left upper eyelid without metastasis and its immunohistochemical features. The carcinoma was successfully treated with excisional surgery and prophylactic radiation therapy. Case summary: A 76-year-old woman presented to the hospital complaining of a 0.6 × 0.9-cm-sized painless and purplish- red colored mass that had grown rapidly on her left upper eyelid margin over the previous two months. An excisional biopsy was performed. On immunohistochemical examination of the lesion, the tumor cells expressed immunoreactivity for synaptophysin and were negative for LAC and cytokeratin, confirming the diagnosis of Merkel cell carcinoma. Additional surgery was performed because the surgical margins were positive. No other primary or metastatic lesions were found. The patient was treated with local prophylactic irradiation and remained disease-free at her 10-month follow-up visit. J Korean Ophthalmol Soc 2012;53(6):856-860

퇴행성 눈꺼풀속말림의 수술방법에 따른 치료결과 분석

윤재문,김선아,노주헌.Jae Moon Yoon. M.D.. Sun A Kim. M.D.. Joo Heon Roh. M.D.. Ph.D 대한안과학회 2008 대한안과학회지 Vol.49 No.12

Purpose: To evaluate the long-term effectiveness of different surgical procedures according to horizontal eyelid laxity in correcting involutional entropion. Methods: This retrospective study reviewed 104 eyes of 79 patients with involutional lower eyelid entropion who underwent surgical repair. The 62 eyes with horizontal eyelid laxity were classified as group I. In 17 eyes of group I, we performed the lateral tarsal strip procedure alone (group Ia), while in 45 eyes of group I, we performed the lateral tarsal procedure and Quickert suture (group Ib). The 42 eyes without horizontal eyelid laxity were classified as group II. In 13 eyes of group II, we performed a lower eyelid retractor reinsertion procedure only (group IIa), and in 29 eyes of group II, we performed combined lower eyelid retractor reinsertion and orbicularis resection (group IIb). Results: The recurrence rate in these four surgical subsets (group Ia , group Ib, group IIa, group IIb) was 11.7%, 0%, 15.4%, and 6.9%, respectively, with an average follow-up of 11 months. Six recurrent eyelids and two overcorrected eyelids successfully underwent procedures to correct recurrent entropion and ectropion, respectively. Conclusions: The lateral tarsal strip procedure is an effective approach for achieving long-lasting correction of involutional entropion with horizontal eyelid laxity, whereas the lower eyelid retractor reinsertion procedure is an effective approach for achieving long-lasting correction for involutional entropion without horizontal eyelid laxity. Use of the Quickert suture reduced the need to repeat the lateral tarsal strip procedure and additional orbicularis resection decreased the need to repeat the lower eyelid retractor reinsertion procedure. J Korean Ophthalmol Soc 2008;49(12):1877-1887

청색고무수포모반증후군으로 인한 안구돌출 1예

김태원,정규봉,노주헌,JohnJ,Woog,Tae-Won Kim,Kyu-Bong Jung,Joo-Heon Roh,John J,Woog M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.6

Purpose: Blue rubber bleb syndrome (BRBNS) is a rare disorder characterized by multiple, distinctive cavernous hemangiomas of the skin, and gastrointestinal tract. We investigated the surgical treatment and clinical findings for multiple hemangiomas in the orbit of a patient who had BRBNS on the skin and liver. Methods: A 33-year-old white woman visited our clinic with the chief complaint of continuous exophthalmos of one year duration. She did not complain of ocular pain or decreased visual acuity. Nine years previously, her medical history showed the removal of a mass from her left arm, the result of histopathologic examination was multiple hemangiomas. Check-up for gastrointestinal lesions by colonoscopy was negative and all hematological parameters were normal. The orbital mass was surgically removed. Histopathological finding showed it to be the same as hemangioma. Results: Multiple bluish nodules on the skin, visceral hemangioma, multiple hemangiomas in orbit led to the diagnosis of BRBNS. Conclusions: Multiple hemangiomas in orbit should be suspected as BRBNS, and therefore systemic evaluation is required to consider the association with BRBNS.

누선관 낭종의 임상고찰

배성환(Seung Whan Bay),노주헌(Joo Heon Roh) 대한안과학회 2001 대한안과학회지 Vol.42 No.6

감염성 안내염의 치료에서 조기 유리체절제술과 지연 유리체절제술의 비교분석

서동석(Dong Suk Suh),노주헌(Joo Heon Roh),김신동(Shin Dong Kim) 대한안과학회 1998 대한안과학회지 Vol.39 No.10