http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Anthracycline 계 항암성 항생물질 DA-125 의 Beagle dog 에 대한 26 주 반복정맥투여독성시험
정태천(Tae Cheon Jeong),한상섭(Sang Seop Han),양중익(Jung Ick Yang),차신우(Shin Woo Cha),하창수(Chang Su Ha),노정구(Jung Koo Roh),박종일(Jong Il Park),신호철(Ho Chul Shin),김형진(Hyoung Chin Kim) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.2
This study was performed to investigate the toxicity of DA-125 in beagle dogs, an anthracycline antitumor antibiotic. The dogs were administered DA-125 i.v. at 0.0023, 0.0375, 0.15 and 0.6 ㎎/㎏/day, 6 days/week for 26 weeks. At 0.6 ㎎/㎏, all male and female dogs were either sacrificed moribundly or dead during the 26-week treatment. The dogs revealed inactivity, salivation, dark bloody discharge, swelling of the subcutaneous injection site, abscess, and ulceration in the abdominal wall and legs. At 0.15 ㎎/㎏, anorexia, salivation, and swelling of the injection site were observed. The food consumption was decreased with a statistical significance at 6 and 12 weeks treatment in males of 0.6 ㎎/㎏. At 0.0375, 0.15 and 0.6 ㎎/㎏, body weights were decreased significantly in a dose-related fashion after 17 weeks treatment. Total white blood cell counts for male dogs at 0.6 ㎎/㎏ were lower than those of control dogs after 13 weeks treatment, which appeared mainly due to decreased neutrophils. At 0.15 ㎎/㎏, testicular atrophy was found in all males by gross pathology and the testicular weights were significantly decreased when compared to those of control males. Microscopically, the testis showed moderate atrophy of the seminiferous tubules and marked decrease in number of spermatozoa in the epididymal tubules. At 0.6 ㎎/㎏, petechia or echymotic hemorrhage was observed in gastrointestinal tract, heart, lungs, and other organs at the necropsy. Marked atrophy of thymus were observed in both males and females. In addition, severe testicular atrophy was noted in all males. Microscopically, gastrointestinal tract showed hemorrhage, epithelial denudation, hypermucus secretion, and atrophy of intestinal villi. Seminiferous tubules of the atrophic testis were lined with Sertoli cells only and devoid of germ cells. Severe oligospermia or aspermia was present in the epididymal tubules. Bone marrow showed marked depletion of hemopoietic cells. In addition, marked atrophy was found in the lymphoid tissue of gastrointestinal tract, various lymph nodes, and thymus. Injection sites showed marked inflammatory response with necrosis, necrotizing vasculitis, thrombus formation, and ulceration in the skin. According to the present results, no observed effect level appeared to be 0.0375 ㎎/㎏. At 0.15 ㎎/㎏, testis was a target organ, while at 0.6 ㎎/㎏ hemopoietic tissue, gastrointestinal tract, and testis were considered to be target organs. At 0.6 ㎎/㎏ the test compound seems to inflict a damage on the blood vessels causing hemorrhage in the various organs and tissues.