사물탕(四物湯)이 혈관내피세포(血管內皮細胞)에 미치는 영향(影響)

남창규,김영균,문병순,Nam, Chang-Kyu,Kim, Young-Kyun,Moon, Byung-Soon 대한한방내과학회 1999 大韓韓方內科學會誌 Vol.20 No.1

This study is designed to investigate the effects of Samul-Tang extract on the response of lactic dehydrogenase(LDH) release, cellular activity, lipid peroxidation, DNA synthesis and the changes of total protein of bovine pulmonary artery endothelial cells(PAEC) from hydrogen peroxide$(H_2O_2)$-induced injury. The results are as follows : 1. Samul-Tang significantly decreased $H_2O_2$-induced release of LDH from injured bovine PAEC. 2. Samul-Tang significantly repressed $H_2O_2$-induced cellular activity from injured bovine PAEC. 3. Samul-Tang significantly repressed $H_2O_2$-induced lipid peroxidation from injured bovine PAEC. 4. Samul-Tang significantly stimulated DNA synthesis in bovine PAEC. 5. Samul-Tang significantly repressed $H_2O_2$-induced changes of total protein volume from injured bovine PAEC. Above results suggest that Samul-Tang can protect bovine PAEC from $H_2O_2$-induced injury. These results can be effectively applied to the prevention and cure of cardiovascular and cerebrovascular diseases.

황련해독탕(黃連解毒湯)이 가토(家兎)의 혈관긴장성조절(血管緊張性調節)에 미치는 영향(影響)

남창규,김호현,정찬길,성현제,권오율,Nam Chang-Gyu,Kim Ho-Hyun,Jeong Chan-Gil,Sung Hyun-Jea,Kwon Oh-Yul 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2

Objective : The purpose of this study was to analyze the effects of HwangRyunHaeDok-Tang and combinations of constituent herbs on the arterial contraction. Methods : In order to investigate the effects Scutellariae Radix. Coptidis Rhizoma, Phellodendri Cortex and Gardeniae Fructus, in which one of them, two of them, and all of them, were used to exam. Results : The results were summarized as follows; 1. HwangRyunHaeDok-Tang significantly inhibited the contraction of artery induced by Norepinephrine(NE). However the atonic effect was slightly blunted when the vascular endothelial cell was removed. No significant change in the atonic effect of HwangRyunHaeDok-Tang was found when $_L-NNA$ was used as a preliminary treatment. These results indicate that the vascular atonic effect by HwangRyunHaeDok-Tang is slightly dependent on the endothelial cell, and that the HwangRyunHaeDok-Tang works directly to the vascular smooth muscle in creating the vascular atonic effect. 2. The pretreatment of HwangRyunHaeDok-Tang extract significantly inhibited the contractile response to additive application of $Ca^{2+}$ in the strips which were contracted by NE in $Ca^{2+}$-free solution. 3. HwangRyunHaeDok-Tang extract increased the contraction of arterial smooth muscle induced by KCl. Therefore, it can be concluded that HwangRyunHaeDok-Tang may block the NE-receptor or receptor-operated $Ca^{2+}$ channel. 4. It was determined that Scutellariae Radix, Coptidis Rhizoma and Phellodendri Cortex among the ingredients of HwangRyunHaeDok-Tang have a vascular atonic effect. In addition, those ingredients plays a role in strengthening the atonic effect by working with other herbal medicines. Gardeniae Fructus causes the blood vessel to contract. but it does not influence the atonic effects of other herbal medicines. However Gardeniae Fructus tends to inhibit the vascular atonic effect of Phellodendri Cortex. Conclusion : Based on the above results, it can be said that HwangRyunHaeDok-Tang can be applied to cure hypertension considering those three herbs have significant effects of relaxation.

중풍(中風)에 활용(活用)된 자락요법(刺絡療法)에 대(對)한 문헌적(文獻的) 고찰(考察)

남창규,이진섭,Nam, Chang-Gyoo,Lee, Jin-Seop 대한한방내과학회 1994 大韓韓方內科學會誌 Vol.15 No.2

A Literature study was done for identifying the effects of Bloodletting on C.V.A. The major results of the study were as follows. 1. The frequency of points of Bloodletting on C.V.A. were in order Twelve well point, Ship son, Gold SalivaJade Fluid, Paekoe, Chungchung, Sugu, Sosang, Taechu, Wijung, Kwanchung, etc. 2. The frequency of meridians of Bloodletting on C.V.A. were in order Extra-point, Tongmaek-kyong, Su-gworum-Shimpo-Kyong, Susoyang-Samcho-Kyong, Sutaeum-Pye-Kyong, Choktaeyang-Panggwang-Kyong. ete. 3. The frequency of the site of points of Bloodletting on C.V.A. were in order four extremities, face, neck and head, etc. 4. The effects of Bloodletting on C.V.A. is clear away heat and alleviate pain, therapy for waking up a patient from unconsciousness, dredge the meridian passage, expel wind-evil and promote blood circulation, emergency treatment for collapse, etc, 5. The effects of Bloodletting on the early stage of C.V.A. were wake up the patient from unconsciousness by clearing away the heat and The effects of Bloodletting on sequence of C.V.A. were dredge the meridian passage, 6. The frequency of points and meridians of Bloodletting on Hemiplegia were in order Twelve well point, Kyonjong, Extra-point, Chok soyang-Tam-Kyong, etc. 7. The frequency of points and meridians of Bloodletting on Aphasia were in order Gold Saliva Jade Fluid, Amun, Extra-point, Tongmaek-Kyong, etc. 8. The frequency of points and meridians of Bloodletting on Quadriplegia were in order Ship son, Twelve well point, Koktaek, Wijung, Extra-point, Chok soyang-Tam-Kyong, etc. 9, The frequency of points and meridians of Bloodletting on Vertigo were in order Four Gods Cleverness, Tuyu. Chanjuk, Paekoe, Taeyang, Extra-point, Yang-Kyong, etc. 10. The frequency of points and meridians of Bloodletting on Headache were in order Taeyang, Paekoe, Taechu, Extra-point, Tongmaek-Kyong, Yang-Kyong, etc. 11. The points and meridians of Bloodletting on Bells palsy were Chichang, Hyopko in Yangmyong-Kyong.

사물탕(四物湯) 및 구성(構成) 약물(藥物)이 가토(家兎)의 수축혈관(收縮血管)에 미치는 영향(影響)

남창규,배성한,Nam, Chang-Gyu,Bae, Seong-Han 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1

Objectives : To analyze the effects of Samul-Tang and combinations of constituent herbs on arterial contraction. Method : In order to investigate the effects, Angelicae gigantis Radix, Cnidii Rhizoma, Rehmanniae Radix, Paeoniae Radix, in which one of them, three of them, and all of them, were used to exam. Results : Samul-Tang significantly inhibited the contraction of artery induced by PE(phenylephrine), accordingly as the concentration of Samul-Tang increased and inhibited in both with intact and removed endothelium. Among the constituent herbs of Samul-Tang, Paeoniae Radix and Paeoniae Radix-Cnidii Rhizoma combination inhibited the PE-induced contraction of artery the most. Conclusions : Samul-Tang and constituent herbs of Samul-Tang inhibit the contraction of artery.

重患者室에서 氣管內 揷管後 退院한 患者의 臨床統計 考察

南昌圭(Chang-Gyu Nam),文炳淳(Byung-Soon Moon) 대한한의학회 1996 대한한의학회지 Vol.17 No.1

뇌전산화단층촬영(CT)상 확진된 120예의 뇌졸중환자에 대한 임상적 고찰

배성한,남창규,Bae, Sung-Han,Nam, Chang-Gyu 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.1

Clinical Observation was made on 120 Cases of CVA that were confirmed through brain CT of Oriental Medical hospital of Se-Myung University from July in 1997 to June in 1998. 1. The CVA cases were classified into the following kinds : cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage(SAH), and the greatest in number among them were the cases of cerebral infarction. 2. The most cases were 50 of age in all cases, in cerebral infarction were over 70 of age. There is no significant difference in the frequency of strokes between the male and female. the ratio was 1.07 : 1. 3. The frequency of strokes seems to have no relation to month and season. 4. The course of entering hospital, most patients visited this hospital directly(not through any other hospital) within 24hours. 5. The first attack was noted in 80.8%, the recurrance attack in 19.2% and the cerebral infarction had high recurrance ratio compared with cerebral hemorrhage. 6. The average duration of hospitalization was 25.2 days. 7. The most ordinary preceding disease was hypertension. 8. The common symptoms were motor disturbance and dysphasia. 9. The most frequent location of the lesion in cerebral infarction was parietal lobe, in cerebral hemorrhage was basal ganglia. 10. According to electrocardiography findings, abnormality was noted in cerebral infarction more than cerebral hemorrhage, subarachnoid hemorrhage. 11. The hypercholesterolemia and hypertriglyceridemia were found more frequently in cerebral infarction than cerebral hemorrhage, subarachnoid hemorrhage. 12. The average time to start physical theraphy was 7.76 days after admission. 13. The most common complications were pneumonia and bed sore.

청상사화탕(淸上瀉火湯)이 토끼의 수축혈관에 미치는 영향

전성배,김이화,남창규,Jeon, Sung-Bai,Kim, Ee-Hwa,Nam, Chang-Gyu 대한약침학회 2003 Journal of pharmacopuncture Vol.6 No.3

This study was undertaken to define the effect of ChungSangSaWhaTang on the norepinephrine-induced arterial contraction and the mechanism of ChungSangSaWhaTang-induced relaxation. In order to investigate the effect of ChungSangSaWhaTang on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of ChungSangSaWhaTang-induced relaxation, ChungSangSaWhaTang extract infused into contracted arterial strips induced by norepinephrine after treatment of indomethacin, $N_{\omega}$-nitro-L-arginine, or tetraethylammonium chloride. ChungSangSaWhaTang relax arterial strip with endothelium contracted by norepinephrine, but in the strips without endothelium, ChungSangSaWhaTang-induced relaxation was significantly inhibited. The endothelium-dependent relaxation induced by ChungSangSaWhaTang was decreased by the pretreatment of $N_{\omega}$-nitro-L-arginine, but it was not observed in the strips pretreated with indomethacin or tetraethylammonium chloride. We suggest that ChungSangSaWhaTang may inhibit agonist-induced contraction through the formation of nitric oxide in the vascular endothelial cells.

Carbamazepine기인성으로 추정되는 혈소판감소증 치험 1례

김동조,허금정,남창규,Kim Dong-Jo,Heo Geum-Jeong,Nam Chang-Gyu 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.4

As the use of anticonvulsant increases in neurologic field, more studies are needed to reveal various harmful effects of this medication. Especially as for carbamazepine, thrombocytopenia may appear during administration of the medication, regardless of dosage. We, the authors, report that we diagnosed the patient as Bigiheo and Eumheohyeolheo, who was suffering from insomnia, diarrhea, papura, and serious thrombocytopenia. We presumed that the symptoms could be induced by carbamazepine, and used Samulgwibitanggamibang to treat her and obtained positive results.

주차장 램프 형식 결정 및 제원 산정에 관한 연구

권성대,김윤미,남창규,하태준,Kwon, Sung-Dae,Kim, Yoon-Mi,Nam, Chang-Kyu,Ha, Tae-Jun 대한토목학회 2013 대한토목학회논문집 Vol.33 No.5

최근 급격한 경제성장과 더불어 국민 개개인의 삶의 질이 향상되고, 자동차 보급률의 폭발적인 증가로 인해 생활권역이 급속도로 확대되는 추세이다. 2012년 12월 말 기준으로 국내 자동차등록대수는 18,871만 대로 비약적인 증가를 보이고 있으며, 행정안전부의 주민등록인구수가 5,094만 명과 비교할 때 자동차 1대당 주민등록인구수는 약 4명으로 나타나고 있는 실정이다. 이는 자동차 수요가 많아 주택단지, 산업 및 상업단지 등 주차장의 수요도 함께 증가하고 있지만, 지상의 한정된 공간으로 인하여 대부분의 주차장을 지하로 설치하고 있는 실정이다. 특히, '주차장법'에 의하면 주차장의 경사는 직선부 17%, 곡선부 14%를 초과하지 못하도록 시행하고 있지만, 운전자가 주차장 램프 주행 중 멈춰선 경우에는 운전자 안전측면에서 커다란 위험요인으로 작용하는 것으로 나타났다. 이에 본 연구에서는 주차장 램프에 대해 운전자 안전성 측면의 적합성 여부를 검토하고자 한다. 우선, 주차장 램프 형식을 곡선부와 직선부로 분류하고, 경사별, 경사거리별, 방향별, 경사거리에 따른 지점별 등을 고려하여 주행실험 후 설문조사를 통해 주차장 램프 형식 및 제원을 산정하고자 한다. 그 결과, 곡선부는 반시계방향, 최대 경사 12%를 권유하며, 직선부의 경우 최대 경사는 13~14%로 분석되어 15% 이상은 지양해야 할 것으로 사료된다. 결론적으로, 본 연구에서 제시한 주차장 램프 형식 및 제원의 제시를 통해 향후 주차장 관련 기준 정립은 물론, 주차장관련 사업 추진 시 비용 효율적인 교통안전 개선대안으로 활용될 수 있을 것으로 기대된다. Due to the rapid economic growth within the nation, the quality of life of individuals have improved dramatically. The scope of living activities of individuals have also extended, resulting in a rapidly increasing demand for automobiles. The number of vehicles registered in Korea is rapidly increasing and will reach 188.71 million as of December 2012. Compared to the registered residents of 50.94 million provided by the Ministry of Public Administration and Security, the registered population reflects about 4 people per every automobile. Due to the high demands for vehicles, the demands for parking lots in collective housing and businesses are also increasing. In reality, the current state of expansion of parking lots are underground, due to the limited available space on ground level. Specifically, the slope of a parking lot cannot exceed 17% linear slope and 14% curved slope according to the 'parking lot laws', however studies show that the driver feels at risk for safety when stopped on the parking ramp while driving in the parking lot. This study seeks to examine the suitability of parking lot ramps, concerning the safety aspects of the driver. First, the ramp type was categorized as linear or curved, then test drives were performed based on variations of slopes, slant distances, directions and points. A survey was administered to the driver after the completion of the test drive, in order to element design for an ideal ramp. In the case of curved ramp, the results of the estimate suggests a counterclockwise, slope at a maximum of 12% incline. The maximum slope for a linear ramp was analyzed to be between 13~14%, suggesting that slope greater than 15% need to be eliminated. In conclusion, it is anticipated that the element design parking ramp reported in this study will help to serve as a reference for future parking lot related guidelines, and provide cost effective traffic safety mechanisms in future parking lot businesses to follow.

곽향정기산(藿香正氣散)이 가토(家兎)의 수축혈관에 마치는 영향(影響)

선중기,김호현,남창규,구창모,Sun Jung-Ki,Kim Ho-Hyun,Nam Chang-Gyu,Koo Chang-Mo 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2

Object : This study was undertaken to define the mechanism of GwakHyangJungGiSan-induced relaxation in rabbit common carotid artery contracted by agonists. Method : In order to investigate the effect of GwakHyangJungGiSan on rabbit's contracted vascular ring detached from common carotid artery, vascular ring intact or damaged endothelium was used for the experiment using organ bath. To analyze the mechanism of GwakHyangJungGiSan-induced relaxation, GwakHyangJungGiSan extract was infused into contracted vascular ring which had been pretreated by pretreatment of indomethacin(IM), tetraethylammonium chloride(TEA), $N{\omega}-nitro-L-arginine(L-NNA)$. Result : GwakHyangJungGiSan blocks an inflow of $Ca^{2+}$ and relaxes vascular ring by the action of Nitric oxide from endothelium. Consequently when GwakHyangJungGiSan is prescribed, a rise in blood pressure by the resistance of peripheral vessel may be controlled to some extent and so it is anticipated that hypertension, a disorder of blood flow from the vascular contraction and vascular disease will be treated well.