http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김휘정 ( Hui Jung Kim ) 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.5
A key mechanism in the pathogenesis of chronic obstructive pulmonary disease is thought to be an abnormal inflammatory response in the lungs to the inhalation of toxic particles and gases, derived from tobacco smoke, air pollution, and/or occupational exposures. This review highlights the potential participation of several alternative pathogenetic processes, particularly involving the potential participation of biological and pathobiological processes related to aging, including oxidative stress and enhanced expression of markers of senescence/aging in emphysematous lungs, and the potential for enhanced tissue destruction involving alveolar cell apoptosis.
진행된 비소세포 폐암 환자에서 Concurrent Chemoradiotherapy 와 Conventional Radiotherapy의 비교
김휘정 ( Hui Jung Kim ),이동수 ( Dong Soo Lee ),송소향 ( So Hyang Song ),정수미 ( Su Mi Jung ),김영균 ( Young Kyoon Kim ),윤세철 ( Se Chul Yoon ),문화식 ( Hwa Sik Moon ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Park ) 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.3
폐암세포주에서 저용량 시스플라틴에 의해 유도된 자가포식
신정현 ( Jeong Hyun Shin ),장혜연 ( Hye Yeon Jang ),정진수 ( Jin Soo Chung ),조경화 ( Kyung Hwa Cho ),황기은 ( Ki Eun Hwang ),김소영 ( So Young Kim ),김휘정 ( Hui Jung Kim ),이삼윤 ( Sam Youn Lee ),이미경 ( Mi Kung Lee ),박순아 ( 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.1
Background: Most lung cancer patients receive systemic chemotherapy at an advanced stage disease. Cisplatin-based chemotherapy is the main regimen for treating advanced lung cancer. Recently, autophagy has become an important mechanism of cellular adaptation under starvation or cell oxidative stress. The purpose of this study was to determine whether or not autophagy can occurred in cisplatin-treated lung cancer cells. Methods: H460 cells were incubated with RPMI 1640 and treated in 5 μM or 20 μM cisplatin concentrations at specific time intervals. Cells surviving cisplatin treatment were measured and compared using an MTT cell viability assay to cells that underwent apoptosis with autophagy by nuclear staining, apoptotic or autophagic related proteins, and autophagic vacuoles. The development of acidic vascular organelles was using acridine orange staining and fluorescent expression of GFP-LC3 protein in its transfected cells was observed to evaluate autophagy. Results: Lung cancer cells treated with 5 μM cisplatin-treated were less sensitive to cell death than 20 μM cisplatin-treated cells in a time-dependent manner. Nuclear fragmentation at 5 μM was not detected, even though it was discovered at 20 μM. Poly (ADP-ribose) polymerase cleavages were not detected in 5 μM within 24 hours. Massive vacuolization in the cytoplasm of 5 μM treated cells were observed. Acridine orange stain-positive cells was increased according in time-dependence manner. The autophagosome-incorporated LC3 II protein expression was increased in 5 μM treated cells, but was not detected in 20 μM treated cells. The expression of GFP-LC3 were increased in 5 μM treated cells in a time-dependent manner. Conclusion: The induction of autophagy occurred in 5 μM dose of cisplatin-treated lung cancer cells.
하기도 감염증 치료에 대한 Azithromycin과 Erythromycin의 임상 효과 비교
김영균,김양리,이동수,김휘정,송소향,강문원,박성학 대한화학요법학회 1995 대한화학요법학회지 Vol.13 No.2
Azithromycin is a 15-membered ring macrolide derivative, azalide, and has characteristics of high tissue concentrations and prolonged terminal half-life. It was developed to compensate the weak point of erythromycin and to expand the antimicrobial spectrum. We compared once-daily azithromycin(500 mg daily for 3 days) to erythromycin(500 mg twice a day for 10 days) in the treatment of lower respiratory tract infections. Of total 18 patients in azithromycin group, 16(88.9%) resulted in clinical cure or improvement with 57.1% bacteriologic eradication. Of 20 patients in erythromycin group, 15 (75% ) showed clinical cure or improvement with 50% bacteriologic eradication. There is no statistical differences of clinical response and bacteriologic eradication between two groups(p>0.05). Azithromycin was well tolerated, but 1 patient in erythromycin group experienced severe nausea. This study shows that 3-day course of once-daily azithromycin is as effective as 10-day twice daily course of erythromycin In the treatment of patients with lower respiratory tract infection.
일란성 쌍생아에서 발견된 편측성 폐 발육부전(hypoplasis) 및 무발생(agenesis) 각 1예
김수길,정석태,박정식,김현일,김인재,김휘정,오용열,권한진,조호,오성주,엄민섭,원동준 대한내과학회 1999 대한내과학회지 Vol.56 No.3
Unilateral developmental deficiency of lung is rare. As the most of those, unilateral agenesis or Scimitar syndrome(hypogenetic lung syndrome) had been reported. We experienced that two cases of unilateral developmental deficiency of lung, which is different form each other, are found in identical twin. To our knowledge, this condition has not been reported before. We evaluated lung parenchyma and bronchus(; simple chest PA, chest CT(HRCT, 3DCT)), vasculatures(; pulmonary angiography and cardiac catheterization) and combined anomalies (;abdominal ultrasound, echocardiography, routine blood chemistry, and chromosomal study). This 31 yrs old twin female patient was confirmed as an unilateral agenesis of left upper lobe and hypoplasia of left lower lobe without combined anomalies. She's twin younger sister was confirmed as unilateral agenesis of right lung with atrial septal defect(ASD).