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노화와 일회 지구성 운동이 골격근 내 mTOR, 4E-BP1, p70S6K 및 AMPK 발현에 미치는 영향
어수주(Eo Su-Ju),권형태(Kwon Hyeong-Tae),선주상(Shan Zhou-Xiang),채정훈(Chae Jung-Hun),김효식(Kim Hyo-Sik),손희정(Son Hui-Jung),김효정(Kim Hyo-Iung),김창근(Kim Chang-Keun) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.3
We determined acute endurance exercise on mTOR signaling responses in aging skeletal muscle(soleus; SOL, extensor digitorium longus; EDL). Total 32 Sprague-Dawley rats were divided into two groups by age; young group(YG; 20wk; n=16) or old group(OG; 72wk; n=16). Each experimental group was further allocated two subgroups; Exercise(EX; n=8), Control(CON; n=8) group. All animals in exercise group performed one bout of 3hr endurance swimming exercise (30min×6bouts). The phosphorylation of mammalian target of rapamycin(mTOR) and p70 ribosomal S6 kinase(p70S6K) were significantly increased in 20wk(YG) soleus (p<.05). However, the phosphorylation of mTOR and eukaryotic initiation of factor 4E binding protein 1(4EBP1) were significantly decreased in 72wk(OG) muscles(p<.05) after endurance acute swimming exercise. The phosphorylation state of AMPK was significantly increased in 20wk(YG) muscles(p<.05) and 72wk soleus(p<.01) after exercise. The results suggest that a bout endurance exercise was increased AMPK activity but inhibited mTOR and 4E-BP1 phosphorylation in aging slow-twitch muscle.