임플란트 주위 조직 보존을 위한 임플란트 경부의 디자인에 관한 고찰

김홍준,김지환,김성태,이재훈,박영범,Kim, Hong-Jun,Kim, Jee-Hwan,Kim, Sung-Tae,Lee, Jae-Hoon,Park, Young-Bum 대한치과보철학회 2011 대한치과보철학회지 Vol.49 No.4

연구 목적: 임플란트 식립 후 변연골 흡수에 따라 임플란트 주위 연조직이 재구성되며, 이에 따라 치료의 예후 및 심미성 등에 영향을 주게 된다. 그러므로 임플란트 경부 주위 골조직 보존을 위한 임플란트 경부에 다양한 디자인이 연구되고 있다. 본 고찰의 목적은 초기 변연골 흡수의 원인과 이에 따른 임플란트 주위의 연조직 변화에 대해 고찰하고, 어떠한 임플란트 경부 디자인이 임플란트 주위 조직의 보존에 유리한 지 알아보고자 한다. 연구 재료 및 방법: Pubmed database에서 임플란트 초기 변연골 흡수의 원인과 관련된 논문과 임플란트 경부의 여러 디자인에 관한 논문을 검색하여 분석하였다. 임플란트 경부 디자인은 one piece implant, two piece implant, internal hex abutment, external hex abutment, taper joint connection, butt joint connection, scalloped design abutment, platform switching concept에 관해 검토하였다. 결과: 초기의 임플란트 주위 조직 보존에 대하여 one piece implant가 two piece implant보다 유리한 것으로 여러 임상적, 실험적 연구가 있다. Two piece implant에서는 internal hex abutment가 external hex abutment보다, taper joint connection가 butt joint connection보다 유리할 것으로 보여진다. Scalloped design abutment에 대해서는 논쟁의 여지가 있어 더 많은 연구가 필요할 것으로 판단된다. Platform switching concept은 그 원인이 명확히 밝혀지지는 않았으나 임상적, 실험적으로 초기 임플란트 주위 조직 보존에 대해 유리한 것으로 판단된다. 결론: 임플란트 경부의 디자인마다 각각의 장단점이 있고 추가적인 연구가 더 필요한 제한이 있지만 현재까지의 선행 연구들을 분석 종합해 보면 초기 임플란트 주위 조직 보존을 고려한다면 가능한 경우 one piece implant가 유리할 것으로 판단되며, 보철적인 문제나 다른 이유로 인하여 two piece implant를 고려할 경우 platform switching concept, internal connection abutment, taper joint connection을 이용하는 것이 임플란트 주위 조직 보존에 좀더 유리할 것으로 사료된다. Purpose: The peri-implant soft tissue is remodeled by the initial marginal bone resorption affecting the prognosis and esthetic result of treatment. Thus various designs on implant neck design are studied to preserve peri-implant bone. The purpose of this study is to review on the causes of initial marginal bone resorption, the configuration of peri-implant soft tissue, and the implant crestal module favorable in preserving peri-implant tissue. Materials and methods: The studies on the causes of initial marginal bone resorption and the implant crestal modules are researched and reviewed using Pubmed database. The implant crestal modules including one piece and two-piece implant, internal and external hex abutment, taper and butt joint connection, scalloped design abutment, and platform switching concept are reviewed. Results: A number of clinical and experimental studies preferred one piece implant to two-piece in preserving initial peri-implant tissue. For two piece implants, internal hex abutment and taper joint connection appear more favorable than external hex abutment and butt joint connection relatively. Controversial issues still exist on scalloped design requiring more studies on it. Although the rationale is not certain, the concept of platform switching seems favorable in preserving initial peri-implant tissue based on clinical and experimental studies. Conclusion: Each implant crestal module contains its own advantages and disadvantages with various controversial issues. In the aspect of preservation of initial peri-implant tissue, however, one-piece implant seems beneficial. In cases when two-piece implant is more appropriate due to prosthodontic concerns or any other problems, the application of platform switching concept, internal connection abutment, and taper joint connection may be favorable for the preservation of peri-implant tissues.

ISO/TC 173 장애인용 기술시스템 국제회의

김홍준,Kim, Hong-Jun 기술표준원 2004 기술표준 Vol.25 No.-

Anticariogenic activity of acanthoic acid isolated from Acanthopanax koreanum $N_{AKAI}$ against oral pathogens

김홍준,정승일,이화정,주영승,Kim, Hong-Jun,Jeong, Seung-Il,Lee, Hwa-Jung,Ju, Young-Sung 한국한의학연구원 2006 한국한의학연구원논문집 Vol.12 No.1

치면세균막내의 미생물 중 Streptococcus mutans $N_{AKAI}$는 치면세균막형성에 가장 중요한 역할을 하는 원인균으로 알려져 있으며, Streptococcus mutans $N_{AKAI}$는 치아우식을 일으키는 주요 원인균으로 주목을 받고 있다. Streptococcus mutans $N_{AKAI}$균에 항균효과를 나타내는 화합물 acanthoic acid (AA, $C_{20}H_{30}O_2$)을 Acanthopanax koreanum $N_{AKAI}$의 클로로포롬 추출물에서 각종 컬럼크로마토그래피법으로 추출분리하여 ms, 1H-NMR 그리고 13C-NMR 등을 이용하여 구조를 동정하였다. AA의 Streptococcus mutans $N_{AKAI}$에 대한 최소억제농도(MIC)와 최소살균농도(MBC)를 조사하였으며, 이 때 각각 2와 $4\:{\mu}g/mL$을 나타냈었다. 또한 다른 천연물에서 분리된 화합물인 tanshinone IIA는 8/16\;${\mu}g/mL$, 녹차의 추출물과 eucalyptoi은 $250/500\;{\mu}g/mL$이었다. 그리고 또 다른 치주질환의 원균인 Streptococcus sobrinus $N_{AKAI}$, Streptococcus sanguis $N_{AKAI}$ 및 Streptococcus gordonii $N_{AKAI}$의 최소억제 농도의 범위는 $4{\sim}32\;{\mu}g/mL$이었다. 우리의 연구결과에서 Acanthopanax koreanum $N_{AKAI}$에서 분리한 acanthoic acid 치주질환 원인균들을 억제하는 항균제로의 가능성을 확인하였다. This research was aimed to search for natural antimicrobial agents that are sefe for humans and specific for oral pathogens. Acanthoic was isolated from the chloroform fraction of methanol extract of Acanthopanax koreanum $N_{AKAI}$ and its structure were elucidated by 13-NMR, 1H-NNR and ESIMS. Antibacterial activity of acanthoic acid was investigated by the minimum inhibitory (MIC) and minimun bactericidal (MBC) concentration. MIC/MBC of acanthoic acid against Streptococcus mutans $N_{AKAI}$ causing dental caries was determined to be $2/4\;{\mu}g/mL$, which was much lower than these of other natural antimicrobial agents such as $8/16\;{\mu}g/mL$ of sangurinarine and $250/500\;{\mu}/mL$ of green tea extract, $500/600\;{\mu}g/mL$ of thymol and borneol. Acanthoic and significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus $N_{AKAI}$ and Streptococcus sanguis $N_{AKAI}$, and Streptococcus gordonii $N_{AKAI}$ in the MIC range of $4{\sim}32\;{\mu}g/mL$. My finding suggests that acanthoic acid could be employed as a potential antibacterial agent for preventing dental caries.

타이어품질개량에 대한 소고

김홍준,Kim, Hong-Jun 대한타이어공업협회 1967 타이어 고무 Vol.1 No.-

안전관리

김홍준,Kim, Hong-Jun 대한타이어공업협회 1968 타이어 고무 Vol.13 No.-

국제표준활동-APEC 자동차 대화체 회의

김홍준,Kim, Hong-Jun 기술표준원 2004 기술표준 Vol.30 No.-

자동차분야 표준화현황

김홍준,Kim, Hong-Jun 기술표준원 2006 기술표준 Vol.51 No.-

마우스 복강대식세포에서 가감공진단(加減拱辰丹)의 항염증 효과

김홍준,김영식,목지예,정승일,황성연,조정근,장선일,Kim, Hong-Jun,Kim, Young-Sik,Mok, Ji-Ye,Jeong, Seung-Il,Hwang, Sung-Yeoun,Cho, Jung-Keun,Jang, Seon-Il 대한한의학방제학회 2011 大韓韓醫學方劑學會誌 Vol.19 No.1

Objectives : In a previous study, we have shown that Gagam-Gongjin-Dan(GGD) has an inhibitory effect on the ovalbumin-induced immune responses and a hepatoprotective effect on actaminophen-induced liver injury in Balb/c Mice. However, the possible anti-inflammatory effect of GGD extract for inflammatory mediators was not reported. Therefore, the purpose of this study was to investigate an inhibitory effects of GGD extract against lipopolysaccharides(LPS) induced inflammatory mediators in mouse peritoneal macrophages. Methods : GGD extract was prepared by extracting with methanol for 7 days. The extract was freeze-dried following filtration through vacuum distillation system. Accumulated nitrite, an oxidative product of nitric oxide(NO), was measured in the culture medium by the Griess reaction. The levels of prostaglandin $E_2(PGE_2)$, interleukin-$1{\beta}$(IL-$1{\beta}$), tumor necrosis factor-${\alpha}$(TNF-${\alpha}$) were measured by enzyme-linked immunosorbent assay. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2(COX-2) were measured by Western blot analysis. Results : GGD extract (50-$400\;{\mu}g$/ml) per se had no cytotoxic effect in LPS-stimulated peritoneal macrophages. GGD extract dose-dependently reduced NO, $PGE_2$, IL-$1{\beta}$ and TNF-${\alpha}$ production and COX-2 activity caused by stimulation of LPS. The levels of iNOS and COX-2 protein expressions were markedly suppressed by the treatment with GGD extract in a dose dependent manner. Conclusions : These results suggest that GGD extract has an anti-inflammatory effect against LPS-induced inflammatory mediators in peritoneal macrophages, these properties may contribute to inflammation disease care.

상자형의 압축플랜지 휨강도 및 좌굴거동에 관한 연구

김홍준,정희효,Kim, Hong-Jun,Jung, Hee-Hyo 한국강구조학회 2011 韓國鋼構造學會 論文集 Vol.23 No.6

판의 탄성좌굴에 관해서는 이미 많은 이론적 실험적 연구가 이루어져 여러 가지 경계조건 및 하중에 대해서 좌굴응력을 결정하는데 큰 어려움이 없다. 현재 플랜지 및 웨브판에 대한 설계기준도 휨에 대한 좌굴응력을 기준으로 하고 있으며, 후좌굴강도에 안전율을 적용하여 고려하도록 하고 있다. 그러므로 본 연구는 이상적인 조건하에서 전개되는 선형좌굴이론에서 뿐만이아니라, 유한처짐을 허용하는 극한강도 설계개념에 까지 확장되어진다. 또한, 이 개념에 근거한 실험적 연구가 이루어져 단순지지 조건을 만족시킬 수 있는 보강재에 대한 현 시방규정의 적정성을 분석 검토하고자 한다. 본 연구의 결과를 토대로 세장비의 변화에 따른 강상자형의 극한강도를 결정하는 식을 제시하고자 한다. Since the elastic buckling problem of the plate has been studied both experimentally and theoretically, the buckling loads with various boundary conditions and loads can be easily determined. Currently, flange and web design specifications are based on the buckling stress and the post-buckling strength and include a safety-factor. Therefore, this study extended suchresearch to the linear buckling theory with ideal conditions and to the ultimate state with post-buckling. The current specifications are based on elastic buckling stress; and therefore, further research on the ultimate behavior of the plate is required. The ultimate strength design concept, which allows finite deflection, is used in this studyto maximize the post-buckling strength in a steel box. An empirical equation, which provides the ultimate strength of the steel box due to the change in the slenderness and optimum rigidity, are suggested based on the experiment results. Moreover, the appropriateness of the current design specifications was analyzed and discussed.

오미자(五味子)가 함유된 고제(膏劑)의 제조방법에 따른 기호도와 기능성 비교

김홍준,김영식,최고야,이금산,박경범,이승호,최영규,정승일,주영승,Kim, Hong-Jun,Kim, Young-Sik,Choi, Go-Ya,Lee, Guem-San,Park, Kyoung-Bum,Lee, Seung-Ho,Choi, Young-Kyu,Jeong, Seung-Il,Ju, Young-Sung 대한한의학방제학회 2011 大韓韓醫學方劑學會誌 Vol.19 No.1

Objectives : To further enhance the business value of domestic Schisandrae Fructus, new products composed of modified Gyeongok-go were developed. Their preferences and antioxidant behaviors were compared under different manufacturing processes. Methods : Sensory evaluation was carried out on a 7-point scale by a taste panel. Additionally, the antioxidant activities were investigated in vitro against ABTS[2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)] and DPPH(2,2-diphenyl-1-picrylhydrazyl). Results : The differences among each sample were not statistically significant in sensory evaluation. In contrast, the antioxidant properties of each sample can have up to twice effect distinction at a final concentration of 2.5 mg/ml. Conclusions : Manufacturing methods, while having smaller effect on sensory evaluation, greatly affected the antioxidant properties. As a consequence, the optimum manufacture conditions need to be established using different manufacture conditions and activity search methods.