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김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2
Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.
김현수,김성일,엄승욱,김우성,Kim Hyun-Soo,Kim Sung-Il,Eom Seung-Wook,Kim Woo-Seong 한국전기전자재료학회 2006 전기전자재료학회논문지 Vol.19 No.1
In this study, the $LiCoO_2/LiNi_{1/3}Mn_{1/3}Co_{1/3}O_2$ mixed cathode electrodes were prepared and their electrochemical performances were measured in a high cut-off voltage. As the content of $LiNi_{1/3}Mn_{1/3}Co_{1/3}O_2$ increased in a mixed cathode, the reversible specific capacity and cycleability of the electrode enhanced, but the rate capability was deteriorated. On the contrary the rate capability of the cathode enhanced, but the reversible specific capacity and cycleability were deteriorated, increasing the content of $LiCoO_2$ in the mixed cathode. The cell of $LiCoO_2/LiNi_{1/3}Mn_{1/3}Co_{1/3}O_2$ ($50:50 wt\%$) mixed cathode delivered a discharge capacity of ca. 168 mAh/g at a 0.2 C rate. The capacity of the cell decreased with the current rate and a useful capacity of ca. 152 mAh/g was obtained at a 2.0 C rate. However, the cell showed very stable cycleability: the discharge capacity of the cell after 20th charge/discharge cycling maintains ca. 163 mAh/g.
LiNi<sub>1/3</sub>Mn<sub>1/3</sub>Co<sub>1/3</sub>O<sub>2</sub>계 정극활물질을 적용한 전극 제조조건 최적화 연구
김현수,김성일,이창우,문성인,김우성,Kim Hyun-Soo,Kim Sung-Il,Lee Chang-Woo,Moon Seong-In,Kim Woo-Seong 한국전기전자재료학회 2006 전기전자재료학회논문지 Vol.19 No.2
A fabrication condition of the cathode electrode was optimized in a lithium secondary battery. The $LiNi_{1/3}Mn_{1/3}Co_{1/3}O_2$ powders were used as a cathode material. The $LiNi_{1/3}Mn_{1/3}Co_{1/3}O_2$/Li cells were prepared with a certain formulation and their cycleability and rate-capability were evaluated. Optimum electrode composition simulated from the evaluated value was 86.3: 5.6: 8.1 in mass $\%$ of active material: binder: conducting material. Discharge capacity decreased markedly as the press ratio exceeded $30\%$ during preparation of the electrode. Discharge performance at a high current rate deteriorated abruptly as the electrode thickness was over $120{\mu}m$.
Rat periodontal ligament cell에서의 RANKL mRNA의 발현
김현수,정현주,김영준,김옥수,Kim, Hyun-Soo,Chung, Hyun-Ju,Kim, Young-Joon,Kim, Ok-Su 대한치주과학회 2004 Journal of Periodontal & Implant Science Vol.34 No.2
As the periodontal ligament cells show similar phenotype with osteoblasts, periodontal ligament cells are thought to play an important role in alveolar bone remodeling. According to recent studies, receptor activation of nuclear factor $^{\kappa}B$ ligand (RANKL) and osteoprotegerin (OPG) are expressed in periodontal ligament cells during tooth movement. Also periodontal ligament cells is known to play an important role in the progression of periodontal disease. This study was designed how the expression of RANKL and OPG in periodontal ligament cells was regulated by IL-1 ${\beta}in$ the concentration of $0.01{\sim}10$ ng/ml. The results are as follows; 1. Periodontal ligament cells which stimulated by 1L-1 ${\beta}$ increased soluble RANKL synthesis by dose-dependent pattern in the concentration of $0.01{\sim}10$ ng/ml. 2. 1L-1 ${\beta}$ induced mRANKL expression in dose-dependent manner in the concentration of $0.01{\sim}5$ ng/ml. 3. mOPG expression was not to be influenced by 1L-1 ${\beta}$. These results suggested that rat periodontal ligament cells could regulate osteoclastogenesis by stimulation of production of RANKL.
김현수,김광원,김성호,성덕환,은탁,박성현,양진승,권혁빈,Kim, Hyun-Soo,Kim, Kwang-Won,Kim, Sung-Ho,Sung, Duk-Hwan,Eun, Tak,Park, Seong-Hyon,Yang, Jin-Seung,Kwon, Hyuk-Bin 대한기계학회 1993 大韓機械學會誌 Vol.33 No.10
환경오염과 차량 성능향상에 따라서 날로 강화되는 연비규제는 차량용 변속기로서 CVT 양상 보급에 대한 필요를 앞당기고 있다. CVT는 소형차를 중심으로 일부 자동차 에이커에 의해 이미 실용화되어 있으며 일본 및 구미 자동차 각 사는 CVT에 대한 자체기술을 보유하고 경쟁성 있 는 완성품 개발을 위하여 총력을 기울이고 있는 실정이다. CVT에 대한 연구개발의 추세는 동 력전달 구동요소의 특성에 따라 벨트식과 토로이달 (Torodial)식으로 구분할 수 있으며 대부분의 경우 현재 일부 실용화 개발된 벨트식 CVT가 기술완성도가 높은 반면 토로이달롤러의 각도를 연속적으로 변환시킴으로써 무단변속을 이루는 토로이달 방식은 2000년대 이후에 양산을 목표로 일본 및 영국 등에서 개발 진행주이나 새로운 재질과 제어기술개발 등의 숙제를 안고 있다. 벨 트식의 경우 금속벨트는 지난 십 수년이상 시행착오를 겪으며 CVT용으로 개발된 전문업체의 제품이 이미 특허화되어 있기 때문에 자동차 각사는 벨트와 같은 구동요소보다는 CVT 메카니즘 설계 및 제어시스템 개발에 기술력을 투입하고 있다. 따라서 국내 CVT 개발도 이와 같은 추세를 따를 것으로 기대되고 있으나 AT와 같은 완성품으로서의 상품가치를 갖기 위하여는 CVT에 대한 보다 많은 연구개발이 필요하다고 생각된다.
김현수,서일복,박세근,김정선,서정철,최선미,구성태,김이화,Kim, Hyun-Soo,Seo, Il-Bok,Park, Se-Keun,Kim, Jeong-Seon,Seo, Jung-Chul,Choi, Sun-Mi,Koo, Sung-Tae,Kim, Ee-Hwa Society for Meridian and Acupoint 2006 Korean Journal of Acupuncture Vol.23 No.1
목적 :본 연구는 collagenase로 유도된 흰쥐의 골관절염 모델에서 진범약침자극이 흰쥐 dorsolateral periaqueductal gray (DL-PAG)에서 NOS 및 nNOS 발현에 미치는 영향을 관찰하였다. 방법 : 흰쥐의 관절강내로 collagenase 용액을 주사하여 골관절염 모델을 만들고 정상군, 대조군 및 진범약침군으로 실험군을 분류한 후, nNOS(neuronal NOS)와 NOS에 대하여 미치는 영향을 nNOS immunohistochemistry와 nicotinamide adenine dinucleotide phosphate-diaphorase(NADPH-d) 검사법을 통하여 조사하였다. 결과 : 골관절염이 유발된 흰쥐의 DL-PAG 영역에서 nNOS와 NOS의 발현억제가 관찰되었으며, 진범약침군이 collagenase로 유도된 골관절염에서 감소된 nNOS와 NOS의 발현이 증가되었다. 결론 : 본 연구를 통하여 진범약침자극은 골관절염이 유발된 흰쥐의 DL-PAG에서의 nNOS와 NOS의발현에 영향을 미친다는 결과를 얻을 수 있었다.
한국인 구강암 환자에서 인유두종 바이러스의 발현율 분석
김현수,서미현,김성민,조영아,이석근,이종호,명훈,Kim, Hyun Soo,Seo, Mi Hyun,Kim, Soung Min,Cho, Young Ah,Lee, Suk Keun,Lee, Jong Ho,Myoung, Hoon 대한악안면성형재건외과학회 2013 Maxillofacial Plastic Reconstructive Surgery Vol.35 No.4
Purpose: High risk human papillomavirus (HPV) is the main source of cervical cancer, nearly up to 100%. Because there are no affordable data regarding the incidence of HPV in different sites of oral cavity, the purpose of this study is to review the previous article and to find out about the incidence and types of HPV in specific areas of oral cavity. Methods: We examined a total of 106 patients with oral cavity cancer for HPV detection. Available DNA chip (MY-HPV chip kit$^{(R)}$, Mygene Co., Korea) was used for the detection of low risk HPV types (6, 11, 34, 40, 42, 43, 44) and high risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 54, 56, 58). Patients were previously diagnosed as invasive cancer of oral cavity. Specimen used for HPV detection was extracted from the main mass during resection and were tested for HPV type, performed by a DNA chip method. Results: Histologic results showed that there were squamous cell carcinomas, mucoepidermoid carcinomas, cystadenocarcinomas, leiomyosarcoma and etc. Among HPV positive cancer, 2 patients showed positive for high risk HPV type 16, 3 patients showed positive for low risk HPV type 6 and the other 2 patients were positive for other types of HPV. Of the 7 patients with HPV positive, 4 patients were on the tongue, 3 on the lower gingiva. Conclusion: Most of the HPV positive cancers were on the tongue in our study. Cervical cancer of HPV infection is reported to be increasing in our society and because HPV infection largely spreads by sexual contact, the incidence of oral cancer with HPV infection is greatly assumed to be on the increase, simultaneously. Because the incidence of HPV on specific areas of oral cavity among oral cancer patients is not identified, more studies are ongoing.
BIM기반 자동화 데이터 수집기술을 활용한 위험지역 식별 모델
김현수,이현수,박문서,이광표,편재호,Kim, Hyun-Soo,Lee, Hyun-Soo,Park, Moon-Seo,Lee, Kwang-Pyo,Pyeon, Jae-Ho 한국건설관리학회 2010 한국건설관리학회 논문집 Vol.11 No.6
건설 산업의 재해 중 상당 부분은 작업자의 이동 중 발생한다. 건설 현장의 안전관리는 작업을 중심으로 수행되며, 이는 이동 경로에 존재하는 위험원에 대한 안전관리 수준을 상대적으로 낮게 만든다. 많은 연구자들이 위험원을 인지하는 것이 안전관리의 기본임을 제시하였다. 따라서 본 연구에서는 자동화 데이터 수집기술(Automated Data Collection)을 이용하여 작업자의 이동경로에 존재하는 위험원에 대한 안전관리자의 인지를 지원하는 모델을 개발하였다. 모델은 실시간 위치추적기술 기반의 작업자의 위치정보와 BIM을 통한 최적이동 동선의 비교를 통해 일차적으로 위험 가능 지역을 찾는다. 그리고 기존 위험지역과 작업지역을 필터링함으로써 위험 가능 지역을 폭을 좁힌다. 이를 바탕으로 안전 관리자는 위험원이 존재할 가능성이 높은 지역에 대한 정보를 제공받고, 현장의 상황에 맞는 안전관리대책을 수립할 수 있을 것이다. 본 연구에서 제시된 모델을 통해 발견하지 못한 채 남을 수 있는 위험지역을 인지함으로써 안전관리 프로세스 범위에 속하지 않는 위험원을 줄일 수 있으며, 이를 통해 건설 현장의 안전 향상에 도움을 줄 것이라 예상된다. A considerable number of construction disasters occurs on pathway. A safety management in construction sites is usually performed to prevent accidents in activity areas. This means that safety management level of hazards on pathway is relatively minified. Many researchers have introduced that a hazard identification is fundamental of safety management. Thus, algorithms for helping safety managers' hazardous area identification is developed using automated data collection technology. These algorithms primarily search potential hazardous area by comparing workers' location logs based on real-time locating system and optimal routes based on BIM. And potential hazardous areas is filtered by identified hazardous areas and activity areas. After that, safety managers are provided with information about potential hazardous areas and can establish proper safety countermeasures. This can help improving safety in construction sites.
Poly-TPD/PVK 이중 박막 정공수송층 구조의 양자점발광다이오드
김현수,이도형,김바다,황보람,김창교,Kim, Hyun Soo,Lee, Do Hyung,Kim, Bada,Hwang, Bo Ram,Kim, Chang Kyo 한국전기전자재료학회 2019 전기전자재료학회논문지 Vol.32 No.5
A poly[bis(4-butypheny)-bis(phenyl)benzidine] (poly-TPD) and poly(9-vinylcarbazole) (PVK) bilayer was employed as a hole transport layer (HTL) in solution-processed CdSe/ZnS quantum dot light-emitting diodes (QLEDs). The thickness of the PVK layer spin-coated onto the poly-TPD layer, whose thickness was fixed to 40 nm, was varied, with PVK layer thicknesses of 0 nm, 35 nm, 45 nm, and 55 nm. Because the thickness of the PVK can determine the hole transport properties of the HTL, a PVK thickness that maximizes the performance of the HTL for the QLEDs was investigated. By employing the optimized PVK thickness of 45 nm, the current efficiency of the QLED exhibited a 1.74 times improvement when compared with that of the QLED with poly-TPD based HTL without PVK. This was mainly attributed to the decrease in the energy barrier between the HTL and the quantum dot (QD) emitting layer (EML).