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이아람 ( Aram Lee ),최경호 ( Kyungho Choi ),김해중 ( Hai-Joong Kim ),이정재 ( Jeong Jae Lee ),최규연 ( Gyuyeon Choi ),김성주 ( Sungjoo Kim ),김수영 ( Su Young Kim ),조금준 ( Geumjoon Cho ),김영돈 ( Youg Don Kim ),서은숙 ( Eunsook 한국산업보건학회 2018 한국산업보건학회지 Vol.28 No.3
Objectives: This study aims to analyze manganese (Mn) concentrations in maternal and cord bloods at delivery and to estimate the Mn exposure risk for fetuses whose mothers were occupationally exposed to Mn. Materials and Methods: Forty-six pairs of maternal and cord blood samples were collected at delivery from mothers who were occupationally unexposed to Mn. Mn concentrations of blood were analyzed by graphite furnace atomic absorption spectrometer. Mn exposure levels for fetuses of female workers were estimated by simulating two working exposure scenarios. Results: The geometric mean concentration of Mn in maternal and cord blood were 27.0(1.34) ㎍/L, 46.6(1.25) ㎍/L, respectively. Transfer ratios of Mn from maternal to cord blood were 1.81±0.62, which indicated that the Mn concentrations in cord blood were higher than those in maternal blood. Mn concentrations in cord blood for the worse or general scenarios were estimated to 22.3-1,881 ㎍/L and 1.59-308 ㎍/L, respectively. The probabilities of exceeding 74 ㎍/L, which was adopted as a reference level reported in a previous study, were 95% and 44% for the two scenarios, respectively. Conclusions: Comparable levels of Mn exposure in maternal or cord blood to those in this study have shown various health effects in previous studies. This suggests that Mn exposure levels in mothers and fetuese in Korea need to be monitored and managed. In addition, female workers who are occupationally exposed to Mn should be protected from the exposure since their fetuses can be exposed to Mn at risky levels during their pregnancy.
체외수정시술 프로그램에서 황체형성호르몬의 억제와 임신율 사이의 상관 관계
김재원 ( Jae Won Kim ),정도영 ( Do Young Jung ),정소은 ( So Eun Jung ),이낙우 ( Nak Woo Lee ),김탁 ( Tak Kim ),김해중 ( Hai Joong Kim ),김선행 ( Sun Haeng Kim ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.2
목적: 체외 수정 시술 프로그램에서 후기 난포기의 황체형성호르몬의 과다 억제와 임신율 사이의 상관 관계를 알아보기 위하여 이번 연구를 시행하였다. 연구 방법: 1999년 1월부터 2002년 7월까지 고려대학교 산부인과학교실 불임클리닉에서 GnRH 효능제를 이용한 과배란 유도 실시 후 체외 수정 시술을 받았던 여성 350명 중 172 과배란유도주기를 연구 대상으로 하여, hCG 투여일의 황체형성호르몬 농도를 기준으로 황체형성호르몬 수치가 0.7mIU/mL Objective: To investigate the effect of profound LH suppression in the late follicular phase during controlled ovarian hyperstimulation (COH) on pregnancy rate. Methods: Data were collected by retrospective analysis. A total of 172 cycles of oocytes retri
정상 임신 기간 중 혈중 혈관내피 성장인자의 변화 및 혈소판 수와의 상관관계
설현주 ( Hyun Joo Seol ),이경욱 ( Kyong Wook Yi ),민주영 ( Joo Young Min ),오민정 ( Min Jeong Oh ),김해중 ( Hai Joong Kim ),이재관 ( Jae Kwan Lee ),허준용 ( Jun Yong Hur ),서호석 ( Ho Suk Saw ),박용균 ( Yong Kyun Park ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.9
목적 : 전자간증의 병리기전에 관영하는 것으로 알려진 혈관내피 성장인자 (vascular endothelial growth factor, 이하 VEGF로 약함)의 정상 임신기간동안의 혈중 변화양상을 규명하고 혈중 VEGF농도와 혈소판 수와의 상관관계를 알아보고자 하였다. 연구 방법 : 2002년 4월부터 2002년 7월까지 고려대학교 구로병원 산부인과에 내원한 33명의 정상 임산부를 대상으로 임신 초기 검사 시기 (7-8주), 모체혈청삼중표지물질 검사 Objective : The aim of the present study was to evaluate changes of vascular endothelial growth factor levels in maternal circulating blood during normal pregnancies and examine their relationship with maternal platelet counts. Methods : The 33 subjects w
임신성 고혈압의 예측지표로서 임신중기에 증가된 융모성 성선 자극호르몬의 임상적 유용성
김현수(Hyun Soo Kim),오민정(Min Jeong Oh),김해중(Hai Joong Kim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1
N/A Objective: This study was designed to evaluate whether maternal serum human chorionic gonadotropin(hCG) level measured during second trimester could be used as a predictor of pregnancy-induced hypertension. Methods: Between March 1996 and November l997, 505 pregnant women undergoing second trimester(14-22 weeks of amenorrhea) triple marker screening for neural tube defect and Down syndrome who delivered at our institution were reviewed. All samples were assayed in the same laboratory and medical records were reviewed about medical and obstetrical history. Results: Maternal serum human chorionic gonadotropin level(multiples of the median, MoM) was significantly higher in the pregnancy-induced hypertension group than in the control group. With the use of 2. l multiples of the median as a cutoff value, the sensitivity of human chorionic gonadotropin as a screening marker for development of pregnancy-induced hypertension was 38.7%, the specificity was 95.9%, positive predictive value was 38.7% and negative predictive value was 95.9%. Conlusion: We suggest that second trimester maternal serum human chorionic gonadotropin levels can be used clinically as an early predictive marker for pregnancy-induced hypertension.
조권문 ( Kweon Moon Jo ),김재원 ( Jae Won Kim ),임지은 ( Ji Eun Lim ),황종하 ( Jong Ha Hwang ),김해중 ( Hai Joong Kim ),김탁 ( Tak Kim ),이응석 ( Eung Seok Lee ),신진우 ( Jin Woo Shin ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.6
Uterine papillary serous carcinoma (UPSC) has been recognized as an aggresive tumor with early and deep myometrial invasion, frequent lympho-vascular space involvement, and a high relapse rate. It has also been shown that deep myometrial invasion cannot p
전자간증 산모와 정상임신에서 혈중 Vascular Endothelial Growth Factor와 Matrix Metalloproteinase-2에 관한 비교
이경주 ( Kyung Ju Lee ),오민정 ( Min Jeong Oh ),김해중 ( Hai Joong Kim ),김선행 ( Sun Haeng Kim ),이재관 ( Jae Kwan Lee ),허준용 ( Jun Young Hur ),서호석 ( Ho Suk Saw ),박용균 ( Yong Kyun Park ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.1
임지은 ( Ji Eun Lim ),박성훈 ( Sung Hoon Park ),조권문 ( Kwon Moon Cho ),설현주 ( Hyun Ju Sul ),김탁 ( Tak Kim ),김해중 ( Hai Joong Kim ),강재성 ( Jae Sung Kang ),라중열 ( Joong Yol Na ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.3
목적 : 쌍태임신은 불임시술의 발달과 더불어 증가하여 전체임신의 3%에 달하며 임신중의 합병증이 증가하는 고위험 임신이다. 합병증을 증가시키는 여러 위험인자 중 쌍태아간의 체중의 차이가 주산기 예후 및 모체에 끼치는 영향 등을 조사하여 임상적인 중요성을 알아보고자 하였다. 연구 방법 : 1992년부터 2001년까지 고려대학교 의료원 안산병원에서 분만한 157건의 분만을 대상으로 의무기록을 후향적으로 검토 분석하였다. 체중의 차이는 15% 미만을 보이는 Objective : The aim of this study was to determine clinical significance of weight difference in twin pregnancies. Methods : The medical records of 157 sets of twin pregnancies delivered between 1992 and 2001 were reviewed retrospectively. Birth weight di
난소의 성숙 기형종에서 기원한 비정형적 증식성 점액성 낭선종
정도영 ( Do Young Chung ),정난희 ( Nan Hui Jeong ),김재원 ( Jae Won Kim ),이낙우 ( Nak Woo Lee ),김탁 ( Tak Kim ),김해중 ( Hai Joong Kim ),신진우 ( Jin Woo Shin ),한은미 ( Eun Mee Han ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.6
The borderline tumor is not benign but has low malignant potential, which accounts for 10-15% of all ovarian tumors. The mucinous borderline tumors make up approximately 40% of all borderline tumors. About 5% of mature cystic teratomas of ovary include some with mucinous cystadenoma. The malignant transformation is occurred in about 1-3% of patients who have a mature cystic teratoma. There has been reported frequently about the malignant transformation of a mature cystic teratoma. After the first description of a patient with mucinous borderline tumor associated with a mature cystic teratoma in 1988, the borderline tumorous change of a mature cystic teratoma has been reported rarely. This report presents a patient with atypical proliferating mucinous tumor arising in a mature cystic teratoma.