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양철우(Chul Woo Yang),장윤식(Yoon Sik Chang),한치화(Chi Hwa Han),윤영석(Young Suk Yoon),박종원(Chong Won Park),김춘추(Choon Choo Kim),방병기(Byung Kee Bang),김동집(Dong Jip Kim),김학기(Hark Ki Kim) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A We reviewed 38 cases of patients with bone marrow transplantation (BMT) and the results are as follows: 1) Thirty of thirty eight patients (82%) showed nephrotoxicity: 12 cases of electrolyte imbalance (31%), 2 cases (8%) of acute renal failure (ARF), and both, 16 cases (43%). 2) Incidence of ARF in Cyclosporin A (CsA) plus antimicrobial agents (AM) group, AM group and CsA group was 60%, 33% and 16% respectively. 3) The most common incidence of electrolyte imbalance was hypokalemia (26 cases, 70%), followed by hypocalcemia (14 cases, 38%), hypophosphatemia (10 cases, 27%), hyponatremia (5 cases, 13%), and hypomagnesemia (3 cases, 8%) 4) Clinical characteristics of patients with ARF were non-oliguric (2,867±481ml/24hrs), mildly azotemic (serum Cr: 2.2±0.6mg/dl), and reversible except one expired case. 5) The increase in serum creatinine was correlated with the duration of the administration of the nephrotoxic drugs (r=0.60, p<0.05). Though the impact of the nephrotoxic drugs could not be evaluated individually, it seems that, combined use of antimicrobial agents and CsA after BMT be the major factor of ARF.