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운동수행과 고열량섭취가 동맥경직도 지표 및 염증수준에 미치는 영향
김철규(Kim, Cheol-Kyu),권영우(Kwon, Yeung-Woo),고성경(Ko, Seong-Kyeong) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.4
To investigate the effects of acute exercise and high caloric diet on the arterial stiffness, blood glucose and hs-CRP, healthy young men(22.3±1.8 yrs) were tested 3 times(0, 2, 4hr) in each cases; control(Con.) without any handling, acute stepping exercise(Exerc.) with about 80%HRR, high caloric diet(Diet) with over 2000kcal and acute exercise and high caloric diet(Exerc-Diet). Data were analyzed by repeated two way ANOVA. As arterial stiffness variables, right ankle SBP of 2, 4hr in diet group were significantly increased than baselines. Right arm PP of 2hr in Diet group and left arm PP of 2, 4hr in Cont, and Diet group were significantly increased than baselines. And, left ankle PP of 2hr in Cont, group were significantly increased than baselines, but PP of 4hr in Diet group were significantly decreased than pre-testing. Right and left ABI, left baPWV, and AIx of left arm had the main effects on the time, in which there were no significant difference between the time. As glucose and inflammation factors, glucose of had the main effects on the time, in which two hour’s glucose in Exerc. and Exerc-Diet group were significantly decrease than pre-testing. Additionally, hs-CRP had the main effects on the group, in which there were no significant difference between the groups. In conclusion, acute stepping exercise seemed to prevent arterial stiffness, however high caloric diet seemed to increase its stiffness.
김철규(Cheol-Kyu Kim),김영석(Young-Suk Kim),장현규(Hyun-Gyu Jang) 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.- No.-
용접강관의 제조에 있어 롤성형 중 발생되는 성형부하는 스탠드 수, 성형방법, 굽힘변형을 받는 소재 의 영역, 롤과 소재간 접촉상황에 영향을 받는다. 또한 소재에 가해지는 하중분포가 불명확하기 때문 에 스탠드 축의 변형과 파손을 예측하는 것은 어려운 과제이다. 따라서 본 연구에서는 고강도 유정용 강관의 성형과정에 있어 3차원 형상설계와 유한요소해석을 통 해, 스탠드별 변형량과 성형부하를 계산하였고 기존 실험식과 비교하였다. 이를 통해 성형부하를 견디는데 필요한 최소 축의 직경과 변형량을 이론적으로 계산하였고 이를 수 식화하여 소재 항복강도, 파이프 외경, 파이프 두께에 대한 스탠드 축 직경 자동계산프로그램을 개발 하였다. 이번 연구결과를 통해 고강도 후육 제품 생산시, 성형부하의 사전 예측이 가능해졌으며 이는 현재의 롤스탠드와 축 직경에서 어떤 강종에, 어떤 두께까지 성형이 가능할 것인지를 판단할 수 있는 이론적 근거를 제시하였다.
아플라톡신 4주간 반복투여에 의한 랫드 간발암 생체지표인 CYP450 1A1, p53 및 ras의 발현양상 변화
김대중(Dae Joong Kim),이범준(Beom Jun Lee),김태명(Tae Myoung Kim),이숙진(Sook Jin Lee),남상윤(Sang-Yoon Nam),홍진태(Jin Tae Hong),박철범(Cheol Beom Park),김철규(Cheol Kyu Kim),강종구(Jong-Koo Kang),윤영원(Young Won Yun) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.4
We examined the relative toxicological potency of aflatoxins using biomarkers. Aflatoxins (AFB₁, AFB₂, AFG₁) at doses 10, 50, and 250 ㎍/㎏ were administerd twice i.g. per week for 4 weeks. Blood and serum biochemical analyses and histological and immunohistochemical examinations of p53, CYP450 1A1, glutathione S-transferase placental form (GST-P) were performed and expression of ras oncogene and level of the 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OxodG) in the liver were measured. At 14 and 21 post-administration days, changes in the body weight of some aflatoxins-treated rats were found but they were not a dose-related response. There were no significant changes in organ weights and hematological values among all experimental groups. AFB₁ treatment at the dose of 250 ㎍/㎏ significantly decreased the levels of urea nitrogen and total bilirubin in serum but increased the levels of albumin, creatinine, and alanine transaminase (p<0.05). AFB₂ had no effects on blood biochemistry values but AFG₁ decreased the levels of aspartate transaminase in a dose dependent manner. The pathological lesions induced by aflatoxins in rat livers included massive vacuolar degeneration or lipidosis, centrilobular focal hepatic necrosis with inflammatory mononuclear cell infiltrations, and oval cell proliferation in the periportal areas. The severity of the damaged lesions was the most in the highest dose group of each aflatoxin B₁ treatment. The p53-positive hepatocytes were often observed at the high doses of aflatoxins. The Immuno-reactivity against CYP450 1A1 was mainly found in the centrilobular region of the liver at the high dose of AFB₁ and AFG₁. No GST-P foci in rat liver were observed in all experimental groups. The formation of 8-OxodG was not changed in the liver of rats treated with aflatoxins. The expression of ras oncogene in the rat liver by the AFB₁, AFB₂ and AFG₁ at some dosages was increased three to four folds compared to that of controls. These results suggest that CYP 450 1A1, p53, ras, GST-P and 8-OxodG as biomarkers were not useful to predict hepatocarcinogenicity of aflatoxins and develop a value of relative toxicity of aflatoxins vs AFB₁ in the present model. Further studies are needed to look for other biomarkers to predict carcinogenic potency of aflatoxins.
소의 호흡기 감염증에 대한 Danofloxacin과 Oxytetracycline의 효과 비교
이창우,김본원,김철규,조영웅,Lee Ghang-Woo,Kim Bonn-Won,Kim Cheol-Kyu,Jo Yong-Woong 한국임상수의학회 1993 한국임상수의학회지 Vol.10 No.1
A total of 108 Holstein calves with an average body weight of l19kg was studied in 4 farms in middle region of South Korea in late Autumn from November 8 to 27, 1991. Individuals were selected for treatment when they exhibited acute signs of pneumonia and had a rectal temperature of$\geq$4$0^{\circ}C$. Each animal received intramuscularly either danofloxacin at 1.25mg/kg once daily or oxytetracycline at 10mg/kg once daily for three consecutive days. The individuals which had a rectal temperature of$\geq$39.5$^{\circ}C$ at 24 hours after the third treatment received two further treatments. Treatment for three or five days with danofloxacin was very efficacious and superior to oxytetracycline in the treatment of calve pneumonia. Eighty-six per cent of 58 danofloxacin treated calves and sixty-six per cent of 50 oxytetracycline teated calves responded successfully to treatment for three days and the difference between treatment groups was highly significant. Danofloxacin was more efficacious than oxytetracycline in rapid and complete control of pyrexia and in resolution of clinical signs. The minimum inhibitory concentration of danofloxacin for Pasteurella hemolytica and Pasteurella multocida was equally 0.12~0.50 mcg/$m\ell$ while that of oxytetracycline for Pasteurella hemolytica and Pasteurella multocida was 2.0~4.0 and 4.0~16mcg/$m\ell$, respectively. During the treatment period side effect was not found in all animals of both treatment groups except some animals receiving oxytetracycline showed pain at the site of injection.
자기치유 마이크로캡슐을 혼합한 시멘트 모르타르의 초음파 활용 균열 치유특성에 관한 실험적 연구
최연왕 ( Choi Yun-wang ),김철규 ( Kim Cheol-kyu ),박준호 ( Park Jun-ho ),최홍준 ( Choi Hong-jun ),오성록 ( Oh Sung-rok ) 한국구조물진단유지관리공학회 2021 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.25 No.2
본 연구에서는 자기치유 마이크로캡슐의 치유성능을 평가하기 위하여 균열유도 시험편을 제조하였으며, 초음파를 활용하여 치유재령 경과에 따른 균열 치유특성을 평가하였다.
A Study on the Deep Hole Drilling for Refractory Metals
Sung Bo Sim(심성보),Chi Ok Kim(김치옥),Cheol Kyu Kim(김철규) 한국해양공학회 1999 韓國海洋工學會誌 Vol.13 No.1
오늘날 기계공업 현장에서 심공드릴가공은 광범위한 응용과 양호한 생산성으로 인하여 그 요구가 증가 되고 있다. 그러므로, 본 연구는 난삭재인 SKDll고합금공구강을 여러가지 절삭 조건하에서 BTA드릴가공 하여 얻은 실험결과(표면조도, 진직도, 진원도, 원통도, 구멍확대량, 등 )를 다루었으며 이들의 이론적 배경과 실험을 비교 분석하였다. 프레스금형 부품과 기계부품으로 사용되고 있는 SKDll고합금공구강은 기계가공이 힘든 난삭재료로서 그 어려움이 크므로 본 연구는 생산현장에 보다 나은 심공드릴가공결과와 관련 지식을 제공 할수 있다고 사료된다.
Living Concrete를 활용한 수직녹화시스템(V.G.S) 설계방안
최연왕 ( Choi Yun-wang ),오성록 ( Oh Sung-rok ),김철규 ( Kim Cheol-kyu ),남은준 ( Nam Eun-joon ),양능원 ( Yang Neung-won ) 한국구조물진단유지관리공학회 2021 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.25 No.2
기존 수직 및 벽면녹화 시스템 목적은 도시열섬저감 및 물순환 관점에서 환경적인 문제 해결 대안으로 제시되었다. 최근에는 미세먼지·CO<sub>2</sub> 저감에 효과적인 공기정화식물 및 선태식물을 활용한 다양한 기술이 개발되고 상용화하고 있다. 일반 건물의 수직면적은 수평면적에 비해 약 6배이상 넓으며, 고층의 경우 10~20배이상의 면적을 더 확보할 수 있어 수직녹화시스템을 활용하여 빌딩숲(Building Forest)을 조성하고 미세먼지 및 CO<sub>2</sub> 저감을 위해 활용할 수 있다. 이에 본 연구에서는 Living Concrete를 활용한 수직녹화시스템을 개발하고 설계방안을 제시하고자 한다.