비열등성 시험에서 위치 방법에 기초한 표본 수 결정

김지연,김동재,Kim, Jiyeon,Kim, Dongjae 한국데이터정보과학회 2013 한국데이터정보과학회지 Vol.24 No.6

임상시험에서 적당한 크기의 표본 수 결정은 통계적으로 유의한 연구결과의 도출과 연구수행의 효율적인 비용을 산출하기 위해서 중요한 사항 중의 하나이다. 기존의 비열등성 시험에서 표본 수 계산방법에는 t 검정법을 이용한 모수적 방법이 있고, Wilcoxon 순위합 검정을 이용하여 Wang 등 (2003)이 제안한 표본 수 계산방법을 Kim과 Kim (2007)이 비열등성 시험에 확장시켜 적용하여 제시한 비모수적 방법이 있다. 본 논문에서는 Orban과 Wolfe (1982)가 제안한 선형위치통계량의 검정법에 Kim (1994)이 계산한 검정력의 결과를 이용한 표본 수 계산 방법을 제안하고, 그에 따른 표본 수 계산결과를 기존에 제시된 표본 수 계산 결과와 비교하였다. 그 결과 기존의 방법들보다 본 논문에서 제안하는 방법으로 계산한 경우의 표본 수가 가장 작게 나왔다. 따라서 모집단에 대해서 구체적인 분포함수를 가정하기 힘든 경우 모수적 방법을 이용하게 되면 검정력이 떨어지거나 유의수준을 제어하지 못하는 문제점을 보완하고, 모수적 방법에 비해 표본 수가 크게 나와 시간이나 비용 면에서 효율적이지 않았던 Wilcoxon 순위합 검정을 이용한 방법의 단점을 보완할 수 있는 방법으로 본 논문에서 제시한 위치 (placement)를 이용한 표본 수 계산이 이용될 수 있다. In clinical research, sample size determination is one of the most important things. There are parametric method using t-test and non-parametric method suggested by Kim and Kim (2007) based on Wilcoxon's rank sum test for determining sample size in non-inferiority trials. In this paper, we propose sample size calculation method based on placements method suggested by Orban and Wolfe (1982) and using the power calculated by Kim (1994) in non-inferiority trials. We also compare proposed sample size with that using Kim and Kim (2007)'s formula and that of t-test for parametric methods. As the result, sample size calculated by proposed method based on placements is the smallest. Therefore, proposed method based on placements is better than parametric methods in case that it's hard to assume specific distribution function for population and also more efficient in terms of time and cost than method based on Wilcoxon's rank sum test.

높은 기저 난포 자극 호르몬 수치를 가지는 환자와 고령 환자의 체외수정시술을 위한 과배란 유도에서 GnRH antagonist 다회 투여법과 GnRH agonist 장기요법의 효용성에 대한 연구

김지연,김낙근,윤태기,차선희,김유신,원형재,조정현,차수경,정미경,최동희,Kim, JY,Kim, NK,Yoon, TK,Cha, SH,Kim, YS,Won, HJ,Cho, JH,Cha, SK,Chung, MK,Choi, DH 대한생식의학회 2005 Clinical and Experimental Reproductive Medicine Vol.32 No.4

Objectives: To compare the efficacy of GnRH antagonist multiple dose protocol (MDP) with that of GnRH agonist long protocol (LP) in controlled ovarian hyperstimulation for in vitro fertilization in patients with high basal FSH (follicle stimulating hormone) level or old age, a retrospective analysis was done. Methods: Two hundred ninety four infertile women (328 cycles) who were older than 41 years of age or had elevated basal FSH level (> 8.5 mIU/mL) were enrolled in this study. The patients had undergone IVF-ET after controlled ovarian hyperstimulation using GnRH antagonist multiple dose protocol (n=108, 118 cycles) or GnRH agonist long protocol (n=186, 210 cycles). The main outcome measurements were cycle cancellation rate, consumption of gonadotropins, the number of follicles recruited and total oocytes retrieved. The number of fertilized oocytes and transferred embryos, the clinical pregnancy rates, and the implantation rates were also reviewed. And enrolled patients were divided into three groups according to their age and basal FSH levels; Group A - those who were older than 41 years of age, Group B - those with elevated basal FSH level (> 8.5 mIU/mL) and Group C - those who were older than 41 years of age and with elevated basal FSH level (> 8.5 mIU/mL). Poor responders were classified as patients who had less than 4 retrieved oocytes, or those with $E_2$ level <500 pg/mL on the day of hCG injection or those who required more than 45 ampules of exogenous gonadotropin for stimulation. Results: The cancellation rate was lower in the GnRH antagonist group than in GnRH agonist group, but not statistically significant (6.8% vs. 9.5%, p=NS). The amount of used gonadotropins was significantly lower in GnRH antagonist group than in agonist group ($34.8{\pm}11.3$ ampules vs. $44.1{\pm}13.4$ ampules, p<0.001). The number of follicles > 14 mm in diameter was significantly higher in agonist group than in antagonist group ($6.7{\pm}4.6$ vs. $5.0{\pm}3.4$, p<0.01). But, there were no significant differences in clinical pregnancy rate (24.5% in antagonist group vs. 27.4% in agonist group, p=NS) and implantation rate (11.4% in antagonist group vs. 12.0% in agonist group, p=NS) between two groups. Mean number of retrieved oocytes was significantly higher in GnRH agonist LP group than in GnRH antagonist MDP group ($5.4{\pm}3.5$ vs. $6.6{\pm}5.0$, p<0.0001). But, the number of mature and fertilized oocytes, and the number of good quality (grade I and II) and transferred embryos were not different between two groups. In each group A, B, and C, the rate of poor response did not differ according to stimulation protocols. Conclusions: In conclusion, for infertile women expected poor ovarian response such as who are old age or has elevated basal FSH level, a protocol including a controlled ovarian hyperstimulation using GnRH antagonist appears at least as effective as that using a GnRH agonist, and may offer the advantage of reducing gonadotropin consumption and treatment period. However, much work remains to be done in optimizing the GnRH antagonist protocols and individualizing these to different cycle characteristics.

최대교두감합위 및 하악 전방운동 시의 교합접촉 및 교합유도 양상에 관한 분석

김지연,김강현,노관태,김형섭,우이형,배아란,Kim, Jiyeon,Kim, Kang-Hyun,Noh, Kwantae,Kim, Hyeong-Seob,Woo, Yi-Hyung,Pae, Ahran 대한치과보철학회 2013 대한치과보철학회지 Vol.51 No.3

연구 목적: 저작 및 하악 운동시 발생되는 치아접촉은 치열의 보존, 하악의 안정과 보철 수복과정에 있어서 중요하다. 이에 한국인의 20-30대 성인을 대상으로 최대교두감합위에서의 치아접촉점의 위치 및 교합유도양상과 교합유도치의 분포를 분석하여 알아보고자 한다. 연구 대상 및 방법: 29명의 성인을 대상으로 하악의 최대교두감합위에서의 치아접촉점의 위치와 분포 및 전방운동시 교합접촉양상을 shimstock foil (Whaledent, Langenau, Germany), T-Scan III (Tekscan Inc., Boston, MA, USA), polyvinylsiloxane registration material (Genie Bite, Sultan Healthcare, Hackensack, NJ, USA)을 이용하여 측정하였다. 측정시 자세는 직립위로 Frankfurt horizontal plane과 지면이 수평이 되도록 앉게 하였으며 접촉이 재현될 때까지 수 차례 반복한 후 3회씩 측정하였다. 최대교두감합위에서 세가지 방법 간의 통계적 유의성을 비교하기 Fisher's Exact Test (R-General Public License, ver. 2.14.1)를 이용하였고, 전방 운동시 Pearson's Test를 통해 통계 검증하였다(${\alpha}=.05$). 결과: 최대교두감합위에서의 치아 접촉 양상을 shimstock foil, T-Scan III, polyvinylsiloxane registration material로 측정시 전치부, 소구치부, 구치부 모두에서 접촉하는 경우가 대부분이었으며, shimstock 사용시 약51%의 최대교두감합위는 전치부 접촉에서 일어났다. Shimstock foil과 T-Scan III를 사용하여 전방운동 측정시 중절치의 접촉이 가장 많이 일어났다. 결론: 최대교두감합위에서 실제 모든 치아의 접촉이 이루어지지 않는 경우가 있었으며 따라서 구치부에서 전치부를 보호해 주고 있음을 확인할 수 있었다. 또한, 전방운동 시 전치부의 치아접촉은 과도한 구치부의 치아접촉을 방지해 전치부가 구치부를 보호해 주고 있었다. 따라서 교합 재구성 시에는 이러한 상호 보호 교합에 대한 고려가 필요하다. Purpose: The importance of occlusal contacts of the natural dentition for durability of teeth, mandibular stabilization, and restorative dentistry is well known. The purpose of this study is to analyze the occlusal contact and guidance pattern of Koreans by evaluating the static occlusion on maximal intercuspal position and measuring dynamic occlusion during straight protrusion. Materials and methods: The occlusal contacts at maximal interincisal position and the occlusal guidance pattern during straight protrusion of 29 subjects were recorded with shimstock foil (Whaledent, Langenau, Germany), T-Scan III (Tekscan Inc., Boston, MA, USA), polyvinylsiloxane registration material (Genie Bite, Sultan Healthcare, Hackensack, NJ, USA) and compared. Occlusal registration procedures were repeated 3 times. The position was fixed to an upright position and the head position was fixed with the Frankfurt horizontal plane paralleling the horizontal plane. Fisher's Exact Test (R-General Public License, ver. 2.14.1) and Pearson's Test were used to assess the significance level of the differences between the experimental groups (${\alpha}=.05$). Results: When using shimstock foil, T-Scan III system, and polyvinylsiloxane registration material, most of the patients showed contact on anterior, premolar, and molar teeth during maximal intercuspal position. Approximately 51% of maximal intercuspal position showed anterior contact using shimstock foil. When examining the protrusive movement using shimstock foil and T-Scan III system, guidance pattern with the central incisor was the most common. Conclusion: During maximal intercuspal position, there were cases in which not all of the teeth showed occlusal contact. During mandibular protrusive movements, one or more maxillary central incisors frequently joined in straight protrusion and the posterior teeth were disoccluded. Therefore, the anterior teeth protect the posterior teeth, and vice versa. Thus, mutually protected occlusion should be applied when reconstructing occlusion.

한국 현대시의 아이러니와 시적 내면의 심층화에 관한 연구

김지연(Kim Ji-Yeon) 한국문학회 2004 韓國文學論叢 Vol.38 No.-

The poetry has the power to leverage its literary meaning of the reality with the imagination. The literary meaning of the poetry can be interpreted and understood in different ways so that it contains a variety of meanings, especially when the meaning is exaggerated intentionally. Under this assumption, I have tried to re-interpret and analyze in depth poetries further based on the methodology of the irony. The study has approached self-identity, under the assumption that it is likely to be same as the reason of the being, to understand the inner thoughts of the identity. This study has interpreted and evaluated the works based on the loss of self-identity, investigation of the unconsciousness, and recovery of self-identity as well as its opposition. In a chapter of how to understand the loss of the self-identity and investigation of the unconsciousness, I used two poets <A cat with blue fur> by Seok-woo, Hwang and <A picture in the eye of a crow - The 15th> by Sang, Lee. With <A cat with blue fur>, I analyzed the poet in a way of the exodus of the body and the conflict of the consensus. With <A picture in the eye of a crow - The 15th>, I analyzed the poet in a way of the aggressive dissolution between the reality and the dream and the aspect of how to deal with the destructive remedy. In a chapter of how to understand recovery of self-identity and its opposition, I used two poets - <A butterfly and a Square> by Gyu-dong, Kim and <Enormous Roots> by Soo-young, Kim. With <A butterfly and a Square>, I analyzed the poet to a butterfly who aspires to fly. With <Enormous Roots>, I interpreted it to the status of lightness that roots it with the love. In conclusion, I believe that this study has contributed to re-interpreting and re-valuating Korean contemporary poetry based on the methodology of the irony.

VoIP 스팸 콜 탐지를 위한 음성신호의 DEVS 모델링 및 시뮬레이션

김지연,김형종,조영덕,김환국,원유재,김명주,Kim, Ji-Yeon,Kim, Hyung-Jong,Cho, Young-Duk,Kim, Hwan-Kuk,Won, Yoo-Jae,Kim, Myuhng-Joo 한국시뮬레이션학회 2007 한국시뮬레이션학회 논문지 Vol.16 No.3

VoIP 서비스 품질이 개선되고 많은 문제점들이 극복되면서 이에 대한 사용자들의 관심이 높아지고 있다. VoIP는 인스턴트 메시징 서비스 등 사용자들의 편익을 위한 서비스를 제공하고 있지만 비용 및 보안 문제는 사용자들의 이러한 서비스 사용을 주저하게 만들고 있다. 본 논문은 이와 같은 문제 중 하나인 VoIP 스팸 문제를 다루고자 한다. 스팸 콜에서의 음성 메시지 신호 패턴을 고려하여 정상 콜과 Noise가 포함된 정상 콜, 스팸 콜 이 세 가지 음성 모델을 설계하고, 논문에서 제시하는 음성 신호 정보량 기반의 스팸 탐지 알고리즘에 적용해 보았다. 각 모델의 모델링 및 시뮬레이션은 DEVS-$Java^{TM}$를 이용하였다. 본 연구는 스팸 콜 음성 신호를 탐지하기 위한 방법을 제시하고 이를 모델링 및 시뮬레이션 방법론을 통해 검증하는 것에 기여점을 둘 수 있다. As the VoIP service quality is getting better and many shortcomings are being overcome, users are getting interested in this service. Also, there are several additional features that provide a convenience to users such as presence service, instant messaging service and so on. But, as there are always two sides of rein, some security issues have users hesitate to make use of it. This paper deals with one of the issues, the VoIP spam problem. We took into account the signal pattern of voice message in spam call and we have constructed voice signal models of normal call, normal call with noise and spam call. Each voice signal case is inserted into our spam decision algorithm which detects the spam calls based on the amount of information in the call signal. We made use of the DEVS-$Java^{TM}$ for our modeling and simulation. The contribution of this work is in suggestion of a way to detect voice spam call signal and testing of the method using modeling and simulation methodology.

Two cases of late-onset cardiovascular toxicities after a single injection of local anesthetics during supraclavicular brachial plexus block - A report of two cases -

김지연,Park Beom Il,Heo Min Hee,Kim Kyoung Woo,Lee Sang-Il,Kim Kyung-Tae,Choe Won Joo,Park Jang Su,Kim Jun Hyun 대한마취통증의학회 2022 Anesthesia and pain medicine Vol.17 No.2

Background: Local anesthetics systemic toxicity (LAST) is a grave complication of regional anesthesia that usually occurs immediately after local anesthetics injection. Here, we report on rare late-onset toxicity cases after supraclavicular brachial plexus blocks.Case: Two patients underwent surgery for radius fractures. We used lidocaine 100 mg and ropivacaine 150 mg for blocking and infused dexmedetomidine for intraoperative sedation. The 63-year-old male patient’s blood pressure dropped to 87/60 mmHg after 3 h 15 min after blocking. Ventricular fibrillation occurred 10 min later. After five defibrillations, electrocardiography showed ventricular tachycardia that was normalized through one cardioversion. The 54-year-old female patient’s heart rate decreased to 35 beats/min 2 h 30 min after blocking. Her vital signs returned to normal after administering atropine, ephedrine, epinephrine, and lipid emulsion.Conclusions: Physicians should remember that LAST may occur long after local anesthetic injection and be aware of factors that may adversely affect the course of LAST.

‘청소년시’에 나타난 에코페미니즘 표현 양상 - 김선우의 청소년 시집을 중심으로 -

김지연 ( Kim Ji-yeon ) 배달말학회 2021 배달말 Vol.68 No.-

청소년 문학이 아동문학과 성인문학의 사이에 자리하기 시작한 이후, 청소년 문학의 하위 장르인 ‘청소년시’는 그 의미 영역을 확장하고 있다. 청소년 문학은 성인담론과 달리 청소년의 성장에 관심을 보이며 청소년의 세계 경험의 과정을 중시한다. 이 글에서는 김선우의 ‘청소년시’를 통해 청소년시의 서정성에 내포된 정치성을 살펴보고자 한다. 그의 서정성은 에코페미니즘 담론을 내포하고 있으며 구체적으로는 여성성과 남성성으로 대립하는 것이 아닌 상생의 의미를 담고 있다. 김선우 청소년시가 담고 있는 의미는 생명존중을 바탕으로 한 청소년의 자아 정체성 찾기와 모성성을 바탕으로 한 상생의 관계 맺기로 정리할 수 있다. 여성성과 남성성으로 나뉘어 대립하는 것이 아닌 한 개인이 다성성을 가지고 있다고 보고 남성중심적이었던 과거의 젠더 규범을 넘어 생명 존중과 자아존중으로 나아가야 함을 청소년의 목소리로 표현하고 있다. 그의 시는 ‘청소년시’의 서정성을 개인적인 서정을 넘어 정치적 서정성의 영역으로의 확장을 보여주고 있다. After youth literature began to take a place between children’s and adult literature, ‘Youth Poetry’, a sub-genre of youth literature, has expanded its meaning. Unlike adult discourse, youth literature presents interest in the growth of youth and emphasizes the process of youth's world experience. This study examined the politics reflected in the lyricism of youth poetry through ‘Adolescents poems’ by Sun-woo Kim. His lyricism reveals eco-feminist discourse, and specifically contains the coexistence of femininity and masculinity rather than their conflict. The significant meaning of Sun-woo Kim’s youth poetry is finding youth’s self-identity based on respect for life and establishing coexistence relationship based on maternity. The voices of youth express the need to go beyond the male-centered gender norms of the past and move toward respect for life and self-respect,considering that an individual has polysexuality rather than being divided into femininity and masculinity. His poetry presents the expansion of the lyricism of ‘Adolescents Poems’ into the realm of political lyricism beyond personal lyricism.

콘텐츠들 간의 유의어 태그매핑을 이용한 확장된 추천기법의 연구

김지연,김영창,정종진,Kim, Jiyeon,Kim, Youngchang,Jung, Jongjin 대한전기학회 2017 전기학회논문지 Vol.66 No.1

Recently recommendation methods need personalization and diversity as well as accuracy whereas the traditional researches have been mainly focused on the accuracy of recommendation in terms of quality. The diversity of recommendation is also important to people in terms of quantity in addition to quality since people's desire for content consumption have been stronger rapidly than past. In this paper, we pay attention to similarity of data gathered simultaneously among different types of contents. With this motivation, we propose an enhanced recommendation method using correlation analysis with considering data similarity between two types of contents which are movie and music. Specifically, we regard folksonomy tags for music as correlated data of genres for movie even though they are different attributes depend on their contents. That is, we make result of new recommendation movie items through mapping music folksonomy tags to movie genres in addition to the recommendation items from the typical collaborative filtering. We evaluate effectiveness of our method by experiments with real data set. As the result of experimentation, we found that the diversity of recommendation could be extended by considering data similarity between music contents and movie contents.

Bacillus circulans 유래 cellulolytic xylanase 유전자(bglBC2)의 염기서열 결정 및 분석

김지연,Kim, Ji-Yeon 한국미생물학회 2006 미생물학회지 Vol.42 No.1

The nucleotide sequence of the cloned cellulolytic xylanase gene (bglBC2) from B. circulans ATCC21367 was determined. bglBC2 consists of an 1,224 bp open reading frame (ORF) coding for a polypeptide of 407 amino acids with a deduced molecular weight of 45 kDa. The Shine-Dalgarno (SD) sequence (5'-AAAGGAG-3') was found 9 bp upstream of the initiation codon, ATG. A promoter region corresponding closely to the B. subtilis consensus sequence (-35: TTGACA,-10: TATAAT) was detected, the putative -35 and -10 sequences of which were TTTACA and TATACT, respectively. The deduced amino acid sequence of the cellulolytic xylanase showed 97% homology with that of the alkaline $endo-\beta-1,4-glucanase$ from B. circulans KSM-N257, 75% homology with that of the $endo-\beta-1,3-1,4-glucanase$ from B. circulans WL-12, and 45% homology with that of the $endo-\beta-1,4-glucanase$ (cellulase) from Bacillus sp. KSM-330. The bglBC2 sequence was deposited in Gen-Bank under the accession number AY269256. 클로닝된 Bacillus circulans ATCC21367 유래 cellulolytic xylanase 유전자(bglBC2)의 염기서열을 결정 분석하였다. 본 유전자는 1,224 bp의 407개 아미노산을 암호하는 open reading frame (ORF)으로 구성되어 있었으며 염기서열로부터 산출된 유전자의 분자량은 45 kDa으로 효소의 SDS-PAGE로부터 측정된 분자량과 일치하였다. ATG 개시 코돈의 9bp 위쪽에 Shine-Dalgarno (SD) 서열로 추정되는 5'-AAAGGAG-3' 서열이 확인되었고 그 상단에 promoter로 추정되는 -35 서열(TTTACA)과 -10 서열(TATACT)이 위치하고 있었으며, 이는 B. subtilis promoter consensus sequence와 유사하였다. 한편, 이 효소의 아미노산 서열은 이미 보고된 B. circulans KSM-N257의 alkaline $endo-\beta-1,4-glucanase$와는 97%, B. circulans WL-12의 $endo-\beta-1,3-1,4-glucanase$와는 75%, Bacillus sp. KSM-330의 $endo-\beta-1,4-glucanase$ (cellulase)와는 45%의 유사성을 나타내었다. 또한 bglBCS 염기서 열의 정보를 GenBank에 등록하였으며 등록번호는 Ar269256이다.

RFID를 활용한 안전 스쿨버스 시스템 설계

김지연,Kim, Ji-Yeon 한국정보통신학회 2022 한국정보통신학회논문지 Vol.26 No.11

As the use of school buses becomes more common, related laws are being enacted, such as making it mandatory for children to check school bus dropouts due to frequent accidents caused by the negligence of school bus drivers and their guardians. In this paper, we propose a safe school bus system that links efficient radio-frequency identification (RFID) and mobile APP in terms of energy utilization and cost. The school bus system uses RFID cards to check information on children boarding the school bus, and real-time SMS transmission allows parents to safely send their children to and from school. Instructors on the school bus can check their children's disembarkation information once more through APP, preventing various accidents that may occur to children left on the bus. Due to the automation of the school bus operation log, daycare center teachers can not only check the information on getting on and off, but also manage the information on the attendance and discharge of the students.