성인형 스틸씨 병에서 병발된 비인두암의 치료 및 문헌 고찰

김준영,김진동,이경빈,이원재,나건웅,박원일,박기철,김태규,지준호,Kim, Jun Young,Kim, Jin Dong,Lee, Kyung Bin,Lee, Won Jae,Na, Gun Wung,Park, Wonil,Park, Gi Cheol,Kim, Tae Gyu,Ji, Jun Ho The Korean Society for Head and Neck Oncology 2014 대한두경부 종양학회지 Vol.30 No.1

비인두암에서 시행되는 방사선 치료 이후에 구강건조증과 피부 변화는 흔하게 볼 수 있는 합병증 중 하나이다. 비인두암의 좋은 예후를 고려할 때, 그러한 치료와 관련된 독성들은 상대적으로 오랫동안 문제를 야기하며 삶의 질 저하를 불러온다. 특히 류마티스 관절염, 루푸스와 같은 결합조직 질환을 가진 환자들에게서 방사선 치료를 시행하였을 때, 빈번하게 심각한 독성이 관찰된다. 본 증례는 성인형 스틸씨 병에서 병발된 비인두암의 치료로 항암방사선 동시치료를 실시한 결과, 비교적 경미한 구강 건조, 점막염, 불면증 등의 합병증이 관찰되었으나, 완전 관해가 획득되었다. 이에 저자들은 과거에 보고된 적 없는 성인형 스틸씨 병에 병발한 비인두암의 치료 경험을 다른 결합조직질환들에서 방사선 치료의 문헌들과 함께 보고하는 바이다.

버섯재배 배지재료용 수입 농업부산물에서의 세균 조사 연구

김준영,김수산,김성환,Kim, Jun Young,Kim, Susan,Kim, Seong Hwan 한국미생물학회 2018 미생물학회지 Vol.54 No.4

국내 버섯 생산용 배지재료 용도로 수입되는 밀짚, 피트모스, 비트펄프, 면실피, 면실박 등 농업부산물에 대한 안전성 자료 구축이 시급히 요구되고 있다. 그러나 미생물에 대한 조사 연구는 미흡한 실정이다. 이에 따라 본 연구는 2년 동안 호주, 캐나다, 중국, 이집트, 독일, 인도, 우크라이나에서 수입한 농업 부산물인 밀짚, 피트모스, 면실박, 면실피, 비트펄프를 대상으로 인체, 식물, 버섯에 유해가능성 있는 세균의 존재 여부를 확인하기 위해 수행하였다. 조사된 수입된 농업부산물에는 $1.35{\times}10^2$에서 $8.34{\times}10^6CFU/g$ 농도 범위로 세균이 존재하였다. 세균을 분리하여 16S rDNA를 분석한 결과 총 19속 45종의 세균이 동정되었다. Basillus 속 세균이 우점으로 존재 하였고 그 다음으로 Paenibacillus 속 세균이 많이 존재하였다. 종 수준에서는 Firmicutes, Proteobacteria, Actinobacteria 그룹에 속하는 순으로 다양성이 존재하였다. 농업부산물 별로 볼 때는 밀짚과 피트모스에서 더 다양한 속의 세균들이 존재하였다. 이 중 인체 유해성이 보고된 세균은 5속 6종으로서 Enterobacter asburiae, Enterobacter ludwigii, Stenotrophomonas maltophilia, Pseudomonas monteilii, Bacillus anthracis, Cellulosimicrobium funkei가 존재하였다. 놀랍게도 인체병원균이면서 동시에 식물 병원균으로 보고된 Klebsiella pneumoniae subsp. pneumonia 그리고 식물병원균 Bacillus altitudinis가 존재하였다.또한 곤충 병원성의 Lysinibacillus sphaericus와 버섯 병원성의 Ochrobactrum pseudogrignonense가 존재하였다. 본 연구 결과는 국내에 수입되고 있는 버섯재배 배지용 농업부산물에 여러 종류의 잠재성 있는 병원성 세균이 존재함을 확인하였다. 이는 수입되고 있는 농업부산물이 버섯생산에 안전하게 사용되기 위해서는 위생 검사와 관리가 시급히 필요함을 시사한다. It is urgently required to construct safety data on agricultural by-products imported for use as medium materials for domestic mushroom production. However, research on microorganisms is insufficient. This study was conducted to investigate the presence of bacteria that have the possibility of harmful effects on human, plants and mushroom in wheat straw, peatmoss, cottonseed hull, cottonseed meal, and beet pulp imported from Australia, Canada, China, Egypt, Germany. Bacteria were found in the range of $1.35{\times}10^2$ to $8.34{\times}10^6CFU/g$. As a result of 16S rDNA sequence analysis, total of 19 genera and 45 species of bacteria were identified. Bacillus genus was dominant, followed by Paenibacillus genus. At the species level, diverse species was in the order of Firmicute, Proteobacteria and Actinobacteria. Regarding the agricultural by-products, straw and peat moss had more diverse bacteria than other agricultural by-products. Among the indentified bacteria, 6 species of 5 genera (Enterobacter asburiae, Enterobacter ludwigii, Stenotrophomonas maltophilia, Pseudomonas monteilii, Bacillus anthracis, and Cellulosimicrobium funkei) were present as potent harmful bacteria to human. Surprisingly, both the human and plant pathogenic Klebsiella pneumoniae subsp. pneumonia was present. Bacillus altitudinis was present as a plant pathogen. Lysinibacillus sphaericus, an insect pathogen, and Ochrobactrum pseudogrignonense, a mushroom pathogen, were also present. The results of this study confirmed that several kinds of pathogenic bacteria were present in the agricultural by-products for the mushroom cultivation medium imported into Korea. Our work suggests that hygiene inspection and management is urgently needed for imported agricultural by-products to be safely used for mushroom production.

폐 종양 FOG PET 영상의 다양한 추적자 역학 분석 방법 개발과 유용성 고찰

김준영,최용,최준영,이경한,김상은,최연성,김영진,김병태 ( Joon Young Kim,Yong Choi,Joon Young Choi,Sang Eun Kim,Yearn Seong Choe,Kyung Han Lee,Yong Jin Kim,Byung Tae Kim ) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.4

Purpose: The purpose of this study was to assess the diagnostic accuracy of various quantitation methods using F-18-fluorodeoxyglucose (FDG) in patients with malignant or benign lung lesion. Materials and Methods: 22 patients (13 malignant including 5 bronchoalverolar cell cancer; 9 benign lesions including 1 hamartoma and 8 active inflammation) were studied after overnight fasting. We performed dynamic PET imaging for 56 min after injection of 370 MBq (10 mCi) of FDG. Standardized uptake values normalized to patients body weight and plasma glucose concentration (SUVglu) were calculated. The uptake rate constant of FDG and glucose metabolic rate were quantified using Patlak graphical analysis (Kpat and Mrpat), three compartment-five parameter model (K5p, MR5p), and six parameter model taking into account heterogeneity of tumor tissue (K6p, MR6p), Areas under receiver operating charac-teristic curves (ROC) were calculated for each method. Results: There was no significant difference of rate constant or glucose metabolic rate measured by various quantitation methods between malignant and benign lesions. The area under ROC curve were 0.73 for SUVglu, 0.66 for Kpat, 0.77 for Mrpat, 0.71 for KSp, 0.73 for MRSp, 0.70 for K6p, and 0.78 for MR6p, No significant difference of area under the ROC curve between these rne- thods v;as observed except the area between Kpat vs. Mrpat (p<0.05). Conclusion: Quan- titative methods did not improve diagnostic accuracy in comparison with nonkinetic methods. However, the clinical utility of these methods needs to be evaluated further in patients with low pretest likelihood of active inflammation or bronchoalveolar cell carcinoma. (Korean J Nucl Med 1998;32:332-43)

설문조사를 통한 중대재해 처벌 법의 개선방향 제시

김준영,손기영,이지엽,Kim Junyoung,Son Kiyoung,Lee Jiyeop 한국건설안전학회 2023 한국건설안전학회 논문집 Vol.5 No.1

The Serious Disaster Punishment Act, which has been in effect since January 27, 2022, requires employers or management managers who neglect safety measures to be punished by imprisonment for more than one year in the event of a serious disaster. As this Act on the Punishment of Severe Disasters came into effect this year, it has received a lot of attention from society. According to experts, most of the opinions are that the bill was created focusing on increasing punishment for companies, contrary to the original purpose of the bill to reduce the safety accident rate. This study confirmed whether these contents were true through case studies, and if this continues, the conflict between companies and workers will intensify and the safety accident rate will not decrease. Therefore, this study does not unconditionally increase corporate punishment, but compares many situations through surveys and suggests a way for companies and workers to cooperate with the Critical Accident Punishment Act to reduce the safety accident rate.

한국의 자본스톡 , 자본코스트 및 투자함수 추정

김준영,구동현 ( Jun Young Kim,Dong Hyun Koo ) 한국경제학회 1992 經濟學硏究 Vol.40 No.2

버섯 재배용 배지 재료로 수입한 농업부산물에서 중금속, 잔류농약, 영양성분 조사

김준영,이근식,이찬중,김성환,Kim, Jun Young,Lee, Geun Sick,Lee, Chan Jung,Kim, Seong Hwan 한국환경농학회 2017 한국환경농학회지 Vol.36 No.3

BACKGROUND: For the food safety of cultivated mushroom, information on the safety of agricultural by-products imported as medium substrates for mushroom cultivation is urgently needed. Therefore, this study was performed to detect the presence of heavy metals, residual pesticides, and nutrient component in the imported medium substrates. METHODS AND RESULTS: Six kinds of medium substrates imported from nine countries from 2015 to 2017 were investigated. A mercury analyzer MA-2000 and an inductively coupled plasma spectrometer OPTIMA 7000DV were used to analyze mercury, lead, arsenic, copper, nickel and cadmium. All of these heavy metals were detected at lower level than heavy metal tolerance standard level of by-product fertilizer in Korea. When 246 kinds of residual pesticides were examined by GC and HPLC, imidacloprid, thiamethoxam and carbendazim were detected from Egyptian beet pulp, Indian cottonseed meal and cottonseed hull, respectively. The content of nutrient components (water, crude ash, crude fat, crude protein and crude fiber) varied among imported countries and the medium substrates. CONCLUSION:The presence of heavy metals and residual pesticides in imported medium substrates for mushroom cultivation was confirmed. For the safe production of mushroom, this study shows that imported medium materials for mushroom cultivation need to be managed through continuous monitoring.

순환신경망을 활용한 콘크리트궤도의 장기 침하 거동 예측

김준영,이수형,최영태,우상인,Kim, Joonyoung,Lee, Su-Hyung,Choi, Yeong-Tae,Woo, Sang Inn 한국지반공학회 2020 한국지반공학회논문집 Vol.36 No.3

콘크리트궤도는 고속, 고밀도의 운행선로에서도 차량의 주행안정성이 높고, 이용승객에게 좋은 승차감을 제공할 수 있으며, 궤도 보수 비용을 대폭 절감시킬 수 있는 장점을 가지고 있어 고속선을 중심으로 점차 적용 구간이 늘어나고 있다. 하지만, ◯◯고속철도 토공 구간의 노반 침하로 기인된 콘크리트궤도의 2차적 침하가 발생하는 사례가 빈번히 발생하고 있어, 이로 인한 철도 운행의 안정성 문제가 대두되고 있다. 허용 잔류침하량을 초과하는 콘크리트궤도에 대한 효율적인 유지보수 방안 수립을 위해서는 공용 기간 중 발생하는 콘크리트궤도의 장기 침하 거동을 합리적으로 예측하는 것이 필수적이다. 따라서, 본 연구에서는 다양한 인공지능 기술 중 순환신경망을 활용하여 콘크리트궤도의 장기 침하 거동을 예측하는 모델을 개발하였다. 또한 기존 모델의 침하 예측 결과와 비교를 통해 개발된 모델의 적용 가능성을 모색하였다. The railway concrete track has been increasingly adopted for high-speed train such as KTX due to its high running stability, improved ride quality for the passengers, and low maintenance cost. However, excessive settlement of the railway concrete track has been monitored at embankment sections of the ◯◯ High-speed Line, resulting in the concerns on the safety of railway operation. In order to establish an effective maintenance plan for the concrete track railway exceeding the allowable residual settlement, it is essential to reasonably predict their long-term settlement behavior during the public period. In this study, we developed a model for predicting the long-term settlement behavior of concrete track using recurrent neural network (RNN) and examined the applicability of the developed model.

인도에서 귀국한 가족에서 발생한 심한 고혈당 동반 소아 뎅기열 1례

김준영,김한울,Kim, Joon Young,Kim, Han Wool 대한소아감염학회 2020 Pediatric Infection and Vaccine Vol.27 No.2

Dengue fever (DF) is endemic throughout tropical and subtropical regions; however, it is not endemic in Korea. Imported infectious diseases should be suspected when encountering returned travelers with non-specific symptoms such as fever, rash, and headache. Persistent vomiting, abdominal pain, hemorrhagic tendency, hepatic enzyme abnormalities, and proteinuria are risk factors for the development of severe DF in a patient with DF. Severe hyperglycemia is also known to be related to poor prognosis in acute illness, and with certain underlying diseases that present with hyperglycemia, such as diabetes, it is related to the progression of severe DF. We report a DF case with severe hyperglycemia in an adolescent returning from India. Pediatric DF cases reported in Korea were also reviewed.

Observation of Papillary Thyroid Microcarcinoma Patient Treated with Acupuncture Alone

김준영,강지영,손창규,조정효,Kim, Junyoung,Kang, Jiyoung,Son, Changue,Cho, Junghyo Korean Academy of Traditional Oncology 2014 大韓癌韓醫學會誌 Vol.19 No.1

Objectives : Thyroid cancer is one of the most common and rapid increases of malignancy worldwide. It is the aim of the present a case of papillary thyroid microcarcinoma (PTMC) treated with acupuncture alone to derive further studies of the determination of treatment options for PTMC, such as surgery, acupuncture and observation alone, etc. Method : A 51-year-old woman with malignancy of thyroid nodule ($0.89{\times}0.59cm$) was referred to our hospital on January 2010. We applied to the acupuncture alone three times weekly by the patient's decision from January 2010 to November 2014. Blood tests were conducted three times during the treatment period and ultrasonography was performed every 6 months. Results : Both laboratory data and tumor size results showed no deteriorations as compared with those of initial examination. The patients has been survived in healthy state without any metastasis or disease progression on November, 2014. Conclusion : This case presents a possibility that acupuncture or observation alone can be provided as an option in the treatment means for patients with PTMC. Further study will need to study more longer follow-up and a large number of patients for PTMC using acupuncture or observation alone.

학술 1 - 안검내번에 대한 고찰과 그 치료법에 대한 접근법

김준영,Kim, Jun-Yeong 대한수의사회 2012 대한수의사회지 Vol.48 No.11