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원발성 및 전이성 간암환자에서 혈청 Adenosine Deaminase 활성도
김종숙(Chong Sook Kim),박실무(Sil Moo Park),송정길(Jung Guil song),이상재(Sang Jae lee),박일진(Ill Gin Park) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A This study was carried out of assess the serum activities of adenosine deaminase(ADA) which was a key enzyme in normal catabolic pathway for adenosine nucleotides, in patients with primary and metastatic liver cancer. Sera of 70 normal adults, metastatic liver cancer were 50 patients with primary liver cancer and 34 patients with analyzed with colorimetric method of Giusti for ADA activities. The results were obtained as follows; 1) In normal adults the activity of ADA was 15.40+-4.69 U/L 2) The mean value of ADA activity was 40.52+-12.15 U/L in patients with primary liver cancer and 36.73+-10.09 U/L in patients with metastatic liver cancer, there was no significant difference between two(p)0.05). But there was significant difference between normal and cancer patients(p<0.0l).3) In patients with primary liver cancer, correlation between ADA activity and liver function test was not significant(p70.05). 4) In patients with metastatic liver cancer, correlation between ADA activity and liver function test was not significant except SGPT(r=0.37, p<0.05)
Substance - P 가 흰쥐 위액분비에 (胃液分泌) 미치는 영향
김종숙(Chong Sook Kim),박실무(Sil Moo Park),박병국(Byung Goog Park),서승천(Seung Cheon Seo),김명식(Myung Sik Kim) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.2
N/A The present study was carried out to assess the effects of substance P on gastric secretion in rats. The following results were obtained. 1) The change of gastric juice between control and substance P group was not significant. 2) The greates:t increment of titratable acid output was obtained 30min. and the increasing rate of titratable acid output was ohtained 15 min. to 60 min. After administration of substance P.
Iodoacetamide 투여가 흰쥐 위액에 미치는 영향
김종숙(Chong Sook Kim),박실무(Sill Moo Park),김형락(Hyung Lak Kim),김봉경(Bong Kyung Kim),신명숙(Myung Sook Shin) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1
N/A The present study was carried out to investigate the effects of iodoacetamide on gastric acid secretion and dye binding mucoprotein in rats. The result were obtained as follows: 1) Iodoacetamide group was not noted significant difference in the volume of gastric juice compared with that of control group. 2) The pH was 6.2+-0.4 in iodoacetamide group and 4.7+-0.8 in control group. Its level vas ignificantly increased in iodoacetamide group (p<0.05). 3) The titratable gastric acid output in iodoacetamide group (5.7+-2.6 mEq/L) was significantly lower than control group (12.9+-5.1mEq/L) (p<0. 001). 4) The Alcian blue binding capacity of gastric juice was 51.6+-21.8 dye-binding mg/dl in iodoacetamide group and 39.7+-52.1 dye-binding mg/dl in control group, showing significantly increased in iodoacetamide group (p<0.05).
16 , 16 - Dimethyl prostaglandin E2 및 Urogastrone 투여가 흰쥐 위에 미치는 영향
김종숙(Chong Sook Kim),박실무(Sil Moo Park),한상희(Sang Hee Han) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1
N/A The effect of 16, 16-dimethyl prostaglandin E, and urogastrone on acute gastric mucosal lesions and DNA contents in the pylorus ligated rats with topical aspirin plus HCl were studied. 16, 16-dimethyl prostaglandin E, and urogastrone significantly reduced the lesion scores in stomach. Also, 16, 16-dimethyl prostaglandin E, and urogastrone significantly increased the DNA contents of oxyntic gland area of stomach, but decreased the DNA contents of antrum of stomach. We concluded that 16, 16-dimethyl prostaglandin E, and urogastrone have the cytoprotective effect on the gastric mucosa injured by topical aspirin plus HCl administration, and this was closely related with increase of DNA contents in stomach.
김종숙(Chong Sook Kim),박실무(Sill Moo Park),유병철(Byung Chul Yoo),안장훈(Jang Hoon Ahn) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.1
N/A We evaluated the effects of Ara-AMP in the 46 patients with biopsy proven chronic active hepatitis, who had HBsAg and HBeAg in serum for more than 6 months. 28 patients treated with Ara-AMP (1,000mg/day I.V. for 7 days followed by 500mg/day I.M. for 21 days) and 18 patients without treatment as control were followed for the mean period of 20 months (6-40 months) in regard to the serologic markers of HBV, biochemical liver function tests and side effects of Ara-AMP. The results were as following; 1) The rate of HBeAg clearance in the patients with Ara-AMP treatment (46%) was significantly higher than that of spontaneous HBeAg clearance in control patients (11%). None of the patients who cleared HBeAg became HBeAg positive during the follow-up period. 2) Serum AST and ALT levels of the patients who cleared HBeAg after Ara-AMP treatment decreased significantly after Ara-AMP treatment and kept the normal range persistently after the HBeAg clearance, whereas those of the patients who kept HBeAg positivity after Ara-AMP treat- ment decreased transiently after the treatment but returned to their pretreatment levels. In 2 patients with spontaneous clearance of HBeAg, acute exacerbation period with marked elevation of serum aminotransferase levels and bilirubin preceded the HBeAg clearances. 3) Side effects of the Ara-AMP treatment noted in 13 of the 28 treated patients (46%) included anorexia, nausea, indigestion and weakness, which were transient and mild. The above data suggested that Ara-AMP injection for 4 weeks would be the effective and safe treatment for HBeAg positive chronic active hepatitis.
Glucagon 이 흰쥐의 위 췌장 및 간의 DNA 함량에 미치는 영향
김종숙(Chong Sook Kim),박실무(Sill Moo Park),신명숙(Myung Sook Shin) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1
N/A The present study was undertaken to investigate the trophic effect of glucagon in rats. The DNA content of oxyntic gland, pancreas and liver were determined. The following results were obtained: 1) Glucagon stimulated the DNA synthesis in pancreas and liver of rats. 2) Glucagon stimulated the DNA synthesis in oxyntic gland of rats.