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Effect of Tween 20 on the Penetration of Ketoprofen through Excised Rat Skin
김정주,지상철,심창구,김종국,Kim, Jung-Ju,Chi, Sang-Cheol,Shim, Chang-Koo,Kim, Chong-Kook 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.2
The effect of Tween 20 on the penetration of ketoprofen in aqueous vehicles through excised rat skin has been evaluated. The addition of Tween 20, up to 2%, in water containing ketoprofen decreased the penetration of ketoprofen through the skin compared with the reference vehicle without this surfactant. However, the addition of Tween 20 in ketoprofen aqueous vehicle increased diffusion parameter significantly which was compensated with the lowered partition parameter.
탄광부 진폐증에서 혈장 Transforming Growth Factor-${\beta}_1$의 의의
김정주,라원연,홍애라,신표진,용석중,신계철,Kim, Chong-Ju,Lee, Won-Yeon,Hong, Ae-Ra,Shin, Pyo-Jin,Yong, Suk-Joong,Shin, Kye-Chul 대한결핵및호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.50 No.1
연구배경 : 탄광부 진폐증은 석탄 분진의 흡입에 의한 폐조직의 손상에 대하여 부적절하고 과도한 염증반응이 일어나 폐섬유화를 유발하여 발병하는 것으로 생각되어지고 있다. 이 반응에는 대식세포를 비롯한 많은 염증세포들과 그 세포들에서 분비되는 매개물질들이 중요한 역할을 한다. TGF-$\beta$는 특발성 폐섬유화증, 규폐증 및 석면증의 폐섬유화 과정에 관여한다고 알려져 있다. 그러나 비슷한 기전에 의해 폐 섬유화가 진행되는 것으로 생각되는 탄광부 진폐증에서는 TGF-$\beta$의 관여여부에 대한 보고가 거의 없다. 본 연구는 탄광부 진폐증 환자에서 혈청 TGF-${\beta}_1$을 측정하여 섬유화의 정도에 따른 그 활성도의 변화를 비교하여 탄광부 진폐증의 폐섬유화 과정에 TGF-${\beta}_1$이 관여하는지 알아 보고자 하였다. 방법 : 직업력과 방사선학적 소견 상 탄광부 진폐증으로 진단 된 환자 중 단순 탄광부 진폐증 20예와 복잡성 탄광부 진폐증 20예를 대상으로 하였다. 정상소견인 자 10명을 대조군으로 설정하였으며, 각 대상을 human TGF-${\beta}_1$ immunoassay kit (R&D system, Minneapolis, MN)을 이용하여 혈장 내 TGF-${\beta}_1$을 측정하였다. 결과 : 단순 탄광부 진폐증($0.64{\pm}0.17$ ng/mL)과 정상 대조군($0.63{\pm}0.18$ ng/mL)보다 복잡성 탄광부 진폐증 ($0.79{\pm}0.18$ ng/mL)의 혈중 TGF-${\beta}_1$의 농도가 의미 있게 높았다(p<0.05). 결론 : 탄광부 진폐증의 섬유화 진행 과정에 TGF-${\beta}_1$이 관여함을 알 수 있었다. 따라서 단순 탄광부 진폐증과 복잡성 탄광부 진폐증의 감별진단과 경과 예측인자로서 혈장 TGF-${\beta}_1$이 유용하리라 생각되며, TGF-${\beta}$의 생성을 억제한다면 탄광부 진폐증의 섬유화 진행을 저지함으로써 탄광부 진폐증의 치료에 있어 중요한 역할을 할 수 있을 것으로 기대된다. Background : Coal workers' pneumoconiosis is a fibrotic lung disease resulting from chronic inhalation of coal dust. The precise mechanism of lung fibrosis in coal workers' pneumoconiosis is uncertain. However, a relationship between the stimulation of fibroblast proliferation and collagen production by mediators released from in flammatory and resident lung cells is thought to be a major factor. The transforming growth factor-$\beta$(TGF-$\beta$), a multifunctional cytokine and growth factor, plays a key role in the scarring and fibrotic processes due to its ability to induce extracellular matrix proteins and modulate the growth and immune function of many cell types. To determine the involvement of TGF-$\beta$ in the development of lung fibrosis in coal workers' pneumoconiosis, the TGF-${\beta}_1$ level in plasma was measured in patients with coal workers' pneumoconiosis. Methods : Plasma was collected from 40 patients with coal workers' pneumoconiosis (20 with simple coal workers' pneumoconiosis and 20 with complicated coal workers' pneumoconiosis) and from 10 normal controls. The ELISA method was used to measure the plasma TGF-${\beta}_1$ concentration. Results : Compared to the control group ($0.63{\pm}01.8$ ng/mL), there was no significant difference in the plasma TGF-${\beta}_1$ level in patients with simple coal workers' pneumoconiosis ($0.64{\pm}0.17$ ng/mL) (p>0.05). However, in patients with complicated coal workers' pneumoconiosis the plasma TGF-${\beta}_1$ level ($0.79{\pm}0.18$ ng/mL) was significantly higher than in patients with simple coal workers' pneumoconiosis and the control group (p<0.05). Conclusion : The data suggests that TGF-${\beta}_1$ has some influence in the development of lung fibrosis in coal workers' pneumoconiosis.
면역저하가 없는 환자에서 Alcaligenes xylosoxidans에 의한 호흡기계 감염 2예
이주현 ( Ju Hyun Lee ),남동혁 ( Dong Hyuk Nam ),김도현 ( Do Hyun Kim ),김선혜 ( Sun Hye Kim ),김하나 ( Ha Na Kim ),한창훈 ( Chang Hun Han ),이선민 ( Sun Min Lee ),김정주 ( Chong Ju Kim ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.1
Alcaligenes xylosoxidans is a catalase and oxidase positive, motile, nonfermentative and gram-negative rod bacterium. A. xylosoxidans infection is a rare cause of pulmonary infection and little information concerning treatment is available. The majority of patients that develop A. xylosoxidans infection belong to a high-risk group due to an immunocompromised condition or due to pulmonary cystic fibrosis. We report two rare cases of immunocompentent patients that developed a pulmonary infection due to A. xylosoxidans. A 77-year-old man was admitted with a lung abscess. The patient denied having any prior medical illness. A culture of bronchial washing fluid showed the presence of A. xylosoxidans. Despite appropriate antibiotic treatment, the patient died from acute respiratory distress syndrome (ARDS). Another patient, a 61-year-old man without an underlying disease, was admitted with empyema. Under the condition of a closed thoracostomy, a high fever persisted and the empyema was also aggravated. A. xylosoxidans was detected from a culture of pleural fluid. Susceptible antibiotic treatment was provided and surgical intervention was performed. We report these cases with a review of the literature. (Tuberc Respir Dis 2008;64:33-38)
근치적 신절제술 후 7년만에 기관지내 전이로 발견된 신세포암
김도현 ( Do Hyun Kim ),김선혜 ( Sun Hye Kim ),김동환 ( Dong Hwan Kim ),나형중 ( Hyoung Jung Na ),이주현 ( Ju Hyun Lee ),이선민 ( Sun Min Lee ),김정주 ( Chong Ju Kim ),기정혜 ( Jeong Hae Kie ) 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.5
A distant metastasis from a renal cell carcinoma is quite common after a radical nephrectomy. For this reason, a5 year scheduled follow up is recommended. However, a distant metastasis 5 years after the resection is quite rare. We encountered an endobronchial metastasis from a renal cell carcinoma that was discovered 7 years after the radical nephrectomy, and did not present during the 5 year scheduled follow up regimen. We report this case with a review of the literatures. (Tuberc Respir Dis 2006; 61: 496-500)
BOOP 형태로 발현된 Epstein-Barr Virus 폐렴
나형중 ( Hyoung Jung Na ),김승업 ( Sueng Up Kim ),김도현 ( Do Hyun Kim ),남동혁 ( Dong Hyug Nam ),김정주 ( Chong Ju Kim ),이선민 ( Sun Min Lee ),기정혜 ( Jeong Hae Kie ),홍용국 ( Yong Kug Hong ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.1
In the average adult with a normal immune state, Epstein-Barr virus pneumonia is very rare, especially in the form of interstitial lung disease. According to recent studies, the Epstein-Barr virus is also associated with lymphocytic interstitial pneumonia, AIDS and Langerhans cell histiocytosis, but not with sarcoidosis. BOOP is caused by lung injury due to an infection or drug intoxication, and is related to connective tissue disease or bone marrow transplantation, but is sometimes idiopathic. We experienced a patient with symptoms and signs of interstitial lung disease, with confirmed BOOP and EBV ingection from an open lung biopsy and serologic examination, respectively Herein, this case is reported, with a review of the literature. (Tuberc Respir Dis 2007; 62: 51-55)
조성수 ( Sung Soo Cho ),김하나 ( Ha Na Kim ),김다함 ( Da Ham Kim ),한창훈 ( Chang Hoon Han ),이선민 ( Sun Min Lee ),기정혜 ( Jung Hye Ki ),김정주 ( Chong Ju Kim ) 대한내과학회 2009 대한내과학회지 Vol.77 No.6
AFOP은 임상적으로는 급성 또는 아급성으로 폐 손상의 악화 증세를 보이는 급성 간질성 폐렴의 한 형태이다. 임상양상은 미만성 폐포손상과 유사하나 기계환기의 필요성에 따라 다양한 예후가 보고되고 있다. 저자들은 최근 급성으로 진행하는 폐 손상에서 조직 검사상 AFOP가 확인된 예후가 좋지 않았던 1예와 아급성으로 진행하는 폐렴에서 조직 검사상 AFOP가 확인된 예후가 좋았던 1예를 거의 같은 시기에 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다. 결론적으로 적극적인 병리 조직학적 확진을 통하여 향후 더 많은 경험을 통한 연구가 필요할 것으로 생각된다. Acute fibrinous and organizing pneumonia (AFOP) is a histological pattern consisting of intra-alveolar fibrin in the form of fibrin "balls" and organizing pneumonia, without hyaline membranes or prominent eosinophil infiltration. Some reports suggest that the clinical course and pathological findings of AFOP are different from typical findings of bronchiolitis obliterans organizing pneumonia (BOOP) or eosinophilic pneumonia (EP), and its prognosis can be better or similar to that of diffuse alveolar damage (DAD). We report two cases of pathologically demonstrated AFOP experienced recently at our institute. One fatal case revealed a rapid development of respiratory failure and the need for mechanical ventilation. Another nonfatal case revealed subacute diffuse bilateral lung infiltration without the need for mechanical ventilation. Judging from our experience, the patient who required a mechanical ventilator had a poorer prognosis than the one who did not need a mechanical ventilator. (Korean J Med 77:764-770, 2009)
결절성경화증 남자 환자에서 동반된 폐의 다발성 미세결절폐세포증식증
남동혁 ( Dong Hyuk Nam ),최윤정 ( Yoon Jung Choi ),이주현 ( Ju Hyun Lee ),나형중 ( Hyoung Jung Na ),김동환 ( Dong Hwan Kim ),김정주 ( Chong Ju Kim ),이선민 ( Sun Min Lee ),홍용국 ( Yong Kug Hong ),한창훈 ( Chang Hoon Han ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.5
Tuberous sclerosis (TS) is an autosomal dominant disorder that is characterized by cutaneous lesions, seizures, mental retardation and hamartomas in various organs including the skin, kidney and brain. Pulmonary involvement is extremely rare, and occurs in approximately 0.1 to 1% of TS cases. Recent reports have indicated multiple micronodular pneumocyte hyperplasia (MMPH) as another rare form of pulmonary involvement of tuberous sclerosis. We report a case of a 35 year-old-male patient who had no pulmonary symptoms but showed multinodular pulmonary shadows on his chest CT scan. The patient was finally diagnosed with TS with MMPH of the lung. MMPH does not appear to have any malignant potential but the clinical significance of MMPH in TS patients is unknown. (Tuberc Respir Dis 2008;64:369-373)