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        반복 점진적 방법에 의한 2차원 단백질 분리 영상의 반점 정합

        김정자,김동욱,김남균,원용관,Kim, Jung-Ja,Hoang, Minh T.,Kim, Dong-Wook,Kim, Nam-Gyun,Won, Yong-Gwan 대한의용생체공학회 2007 의공학회지 Vol.28 No.5

        2 Dimensional Gel Electrophoresis(2DGE) is an essentialmethodology for analysis on the expression of various proteins. For example, information for the location, mass, expression, size and shape of the proteins obtained by 2DGE can be used for diagnosis, prognosis and biological progress by comparison of patients with the normal persons. Protein spot matching for this purpose is comparative analysis of protein expression pattern for the 2DGE images generated under different conditions. However, visual analysis of protein spots which are more than several hundreds included in a 2DGE image requires long time and heavy effort. Furthermore, geometrical distortion makes the spot matching for the same protein harder. In this paper, an iterative algorithm is introduced for more efficient spot matching. Proposed method is first performing global matching step, which reduces the geometrical difference between the landmarks and the spot to be matched. Thus, movement for a spot is defined by a weighted sum of the movement of the landmark spots. Weight for the summation is defined by the inverse of the distance from the spots to the landmarks. This movement is iteratively performed until the total sum of the difference between the corresponding landmarks is larger than a pre-selected value. Due to local distortion generally occurred in 2DGE images, there are many regions in whichmany spot pairs are miss-matched. In the second stage, the same spot matching algorithm is applied to such local regions with the additional landmarks for those regions. In other words, the same method is applied with the expanded landmark set to which additional landmarks are added. Our proposed algorithm for spot matching empirically proved reliable analysis of protein separation image by producing higher accuracy.

      • KCI등재
      • KCI등재후보

        신경근전기자극치료가 뇌졸중 환자의 연하장애에 미치는 효과

        김정자,이종원,Kim, Jeong Ja,Lee, Jong Won 대한물리치료과학회 2019 대한물리치료과학회지 Vol.26 No.2

        Background: The purpose of this study was to provide the basis for the treatment intervention by identifying the treatment effect when rehabilitation intervention is applied to patients with dysphagia due to stroke and by comparing the results of the treatment mediation according to the differences of the treatment methods and frequency. Design: Randomized Controlled Trial. Methods: 30 people diagnosed with dysphagia due to stroke were divided in accordance with the differences in treatment mediation techniques and treatment frequency- traditional swallowing rehabilitation coupled with neuromuscular electrical stimulation group and only neuromuscular electrical stimulation group/ 5 times per week group and 2 times per week group, and ten weeks of treatment intervention was performed. Paired t test was employed to show the efficacy of treatment intervention, Independent sample t test was used to compare the results according to difference and number of treatment intervention techniques. Results: There was a significant positive effect of treatment on traditional swallowing rehabilitation coupled with neuromuscular electrical stimulation group, only neuromuscular electrical stimulation group, 5 times per week group and 2 times per week group (p<0.05). There was no statistically significant difference in treatment effect between traditional swallowing rehabilitation coupled with neuromuscular electrical stimulation group and only neuromuscular electrical stimulation group (p<0.05). There was no statistically significant difference in treatment effect between 5 times per week group and 2 times per week group (p<0.05). Conclusion: There was no significant difference according to the technique or number of treatments of swallowing rehabilitation treatment interventions, but it was confirmed that rehabilitation intervention for dysphagia showed positive treatment effect.

      • KCI등재후보

        환자 프라이버시 보호행동 실천에 관한 연구 - 물리치료사와 작업치료사를 중심으로 -

        김정자,권은하,Kim, Jeong-Ja,Kweon, Eun-Ha 한국전자통신학회 2012 한국전자통신학회 논문지 Vol.7 No.2

        본 연구는 물리치료사와 작업치료사의 환자 프라이버시 보호행동 실천도를 알아보기 위해 시도되었다. 전국에 소재한 종합병원 및 재활치료 전문병원의 물리치료사와 작업치료사 297명을 대상으로 2012년 1월 2일부터 1월 13일까지 설문조사를 실시하였다. 연구결과 총 실천도 평균은 $3.54{\pm}.733$으로 나타났으며, 각 영역별 평균은 의사소통 영역 $3.62{\pm}.766$ 직접접촉 영역 $3.57{\pm}1.013$, 유지 관리 영역 $3.53{\pm}.780$ 순으로 나타났다. 일반적 특성 중 각 영역별로 분석한 결과 연령이 증가 할수록, 근무경력이 많을수록 실천도가 높았다. 환자 의료정보의 프라이버시는 100% 보호되어져야 하는 것이며, 실천도는 매우 잘 하고 있음의 수준(5)에 근접해야 할 것이나 환자의 기능 개선의 중추적 전문가인 치료사로서 의료정보 보호에 관한 관심이 적고 그 내용에 대해 거의 인지하지 못하는 것으로 나타났다. 이에 지속적인 홍보와 교육을 통하여 환자 프라이버시 보호에 대한 인식을 고취시고, 윤리의식을 확고하게 심어주는 마인드에 대한 제고가 필요하다. The present study was carried out with a view to examine the protective actions of physical and occupational therapists for patients's privacy. For this purpose, a survey was conducted with the questionnaires that were distributed to 297 physical and occupational therapists engaged in general hospitals as well as in rehabilitation clinics across the country from January 2 to 13, 2012. From the survey, it was made known that the overall extent of protective actions practiced by them was $3.54{\pm}.733$ in average. Divided by area, the average protective action in communication was $3.62{\pm}.776$, followed by $3.57{\pm}1.013$ in direct contact and $3.53{\pm}.780$ in maintenance and management, respectively. The analysis of general characteristics by each area showed that the older their age gets and the longer their career is, the more the protective action is practiced by them. Although they are well aware of the fact that the medical information of patients should be kept 100% secret and they practice it to almost excellent grade (5), the physical and occupational therapists, as key experts in charge of improving functions of patients, were found to have little concern for and little knowledge about contents of protecting medical information. It is thus required to perform public relation and instruction continuously to intensify their awareness of needs to protect patients' privacy and to implant ethical sense in this regard deep in their mind.

      • 단백질 구조 예측을 위한 서열 연관 규칙 탐사

        김정자,이도헌,백윤주,Kim, Jeong-Ja,Lee, Do-Heon,Baek, Yun-Ju 한국정보처리학회 2001 정보처리학회논문지D Vol.8 No.5

        바이오정보학(bioinformatic)은 생물학 분야 특히 분자 수준의 유전체 연구에서 발생하는 데이터를 저장, 관리, 분석하여 실험 프로젝트를 지원함은 물론, 기능 예측 및 조절에 대한 실험 설계를 가능하게 하는 제반 컴퓨터 기술을 의미한다. 유전체 연구의 다양한 접근 방식 중 단백체학(proteomics)는 유전체의 최종 산물인 단백질을 직접적으로 다룬다는 측면에서 그 효용성에 대해 많은 기대를 모으고 있다. 본 논문에서는 단백질의 기능을 결정하는 가장 중요한 요소 중 하나인 단백질의 구조를 예측하기 위한 데이터 마이닝 기법을 제안한다. 단백질의 일차 구조인 아미노산 서열에 타나나는 부서열간의 연관성이 해당 단백질의 이차 혹은 삼차 구조를 결정하는 중요한 단서임을 설명하고, 아미노산 부서열간의 연관성을 표현하기 위한 모델로서 서열 연관 규직을 정의한다. 서열 연관 규칙의 유용성을 평가하기 위한 지지도와 신뢰도를 새롭게 정의하고, 주어진 단백질 집단으로부터 유용한 서열 연관 규칙을 발견하기 위한 기법을 제안한다. 아울러, SWISS-PROT 단백질 데이터베이스로부터 입수한 단백질 서열 데이터를 이용하여 제안한 기법의 성능을 평가한다. Bioinformatics is a discipline to support biological experiment projects by storing, managing data arising from genome research. In can also lead the experimental design for genome function prediction and regulation. Among various approaches of the genome research, the proteomics have been drawing increasing attention since it deals with the final product of genomes, i.e., proteins, directly. This paper proposes a data mining technique to predict the structural characteristics of a given protein group, one of dominant factors of the functions of them. After explains associations among amino acid subsequences in the primary structures of proteins, which can provide important clues for determining secondary or tertiary structures of them, it defines a sequence association rule to represent the inter-subsequences. It also provides support and confidence measures, newly designed to evaluate the usefulness of sequence association rules, After is proposes a method to discover useful sequence association rules from a given protein group, it evaluates the performance of the proposed method with protein sequence data from the SWISS-PROT protein database.

      • KCI등재

        발살바 기법이 몸통 굴곡과 신전에 대한 저항운동에 미치는 영향

        김정자,윤혁진,장경만,이희선,이종원,Kim, Jeong-ja,Yoon, Hyuk-jin,Jang, Kyung-man,Lee, Hee-sun,Lee, Jong-won 대한물리치료과학회 2020 대한물리치료과학회지 Vol.27 No.3

        Background: The effect of the Valsalva maneuver applied in resistance exercise has shown contradictory results. This study aims to investigate the effect of the Valsalva maneuver on resistance exercise by examining the changes that occur by applying the Valsalva maneuver during trunk flexion and extension resistance exercise in healthy adults. Design: Randomized controlled trial. Methods: 34 healthy adults were conveniently recruited. According to the with or without Valsalva maneuver, the flexion and extension of the trunk were measured and evaluated. Results: Paired t test showed that there was a statistically significant difference in maximum torque of trunk flexion in the resistance exercise with Valsalva maneuver. However, there was no statistically significant difference in trunk extension (p<.05), in the total and average work of trunk flexion and extension (p<.05). Conclusion: The results of this study in which the difference in the amount of exercise according to the application of the Valsalva maneuver was not significant, show that the practice of the Valsalva maneuver, which has a risk of injury, should be avoided in rehabilitation exercises.

      • 복부비만 여성의 슬링을 결합한 플랭크 운동 효과

        김정자,강다현,양종화,장인선,조부연,홍창완,Kim, Jeong-Ja,Kang, Da-Hyeon,Yang, Jong-Hwa,Jang, In-Seon,Cho, Bu-Yeon,Hong, Chang-Wan 한국임상보건과학회 2019 한국임상보건과학회지 Vol.7 No.2

        Purpose. The study was conducted to find out the effects that women in their 20s with abdominal obesity can get from sling-based flanks. Methods. The study used In-Body to determine the weight and body fat rate of women in their 20s who were overweight at H University and used a tape measure to measure the circumference of the abdomen. Plank exercise using slings to reduce weight, body fat and abdominal circumference led to muscle stabilization and abdominal obesity reduction. The collected data were analyzed using the SPSS ver. 23.0 statistics program. Results. The results of the study showed statistically significant differences in the weight, body fat rate and abdominal circumference of the subjects before and after intervention. Conclusions. Steady abdominal muscles exercise help stabilize the abdomen, reduce abdominal body fat rate, and are effective in managing obesity.

      • KCI등재후보

        고령세대의 환경과 헬스 케어 시스템 주택에 관한 연구

        김정자,김진,Kim, Jeong-Ja,Kim, Jin 한국전자통신학회 2012 한국전자통신학회 논문지 Vol.7 No.4

        최근 우리나라는 65세 이상의 고령자들을 위한 헬스 케어에 기초를 둔 고령 친화적인 주택을 마련하는 데 초점이 맞추어 지고 있다. 본 연구에서는 국내의 법을 근거로 타당한 분석을 이용하여 보다 더 진보된 개선안을 마련하고자 하였다. 그리하여 헬스 케어 관련법과 고령자 주택의 두 가지로 구분하여 분석하였다. 하지만 의료법의 중요도를 변화시키는 것이 한계가 있어서 헬스 케어에 기초를 둔 개요와 고령화에 따른 문제들을 고찰하였다. 이러한 결과, 헬스 케어 시스템 주택을 만들기 위한 개선책과 여러 분야에 걸친 관련부처를 하나로 통일해 다가오는 고령 시대를 준비하고자 하였다. In the current legal system, establishing aging friendly house based on health-care for the senior people over 65 seems hard to be achieved. For these reasons, this study is intended to explore the improvements in the legal system using the comparative analysis in the domestic legal systems. The related legal system is divided into two sections - healthcare system house and senior house. It is very limited only th exchange the information with medical teams. Thus, we need to investigate th concept and all the matters of health-care on the basis of cases. From these results, we are aware of the necessity of the improvements of the health-care system, and suggest plans for these problems. That is to organize the legal system, and make a new law through revising the current specific identification.

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