$\alpha$-Methylpyridine유도체의 국지 선택적 리튬화 반응과 $Me_2RSiCl(R = Me, tBuCH_2(Me_3Si)CH)$을 이용한 반응생성물의 확인반응

김정균,박은미,손병영,Kim, Jeong Gyun,Park, Eun Mi,Son, Byeong Yeong 대한화학회 1994 대한화학회지 Vol.38 No.8

$\alpha$-Methylpyridine유도체1(a∼f)는 n-BuLi과의 반응에서 $\alpha$-methylenylpyridinium 염 3(a∼f)을 형성한다. 3(a∼f)와 $Me_3SiCl$ 및 $Me_2SiClCH(SiMe_3)CH_2tBu$반응에서 생성물 4(a∼f) 와 5(a∼f)을 형성한다. 화합물 4(a∼f)에 있는 규소원자와 결합된 methylene기의 수소원자는 화합물 4(a∼f)의 $CH_3$기 보다 n-BuLi과의 반응성이 큰 것으로 확인되었다. The metallation of $\alpha$-methylpyridine 1(a∼f) with n-BuLi produced $\alpha-methylenylpyridinium$ salt 3(a∼f) by elimination of butane. The trapping reactions of 3(a∼f) with $Me_3SiCl\;and\;Me_2SiClCH(SiMe_3)CH_2tBu$ produced only 4(a∼f) and 5(a∼f). The $\alpha$-hydrogen atom of silylated methylene group in 4(a∼f) is more reactive than unreacted $CH_3$ of 4(a∼f) itself and 1(a∼f) toward n-BuLi at low temperature in pentane medium.

심부 대염수층 CO₂ 격리 메커니즘에 관한 효율성 평가 모델 개발

김정균,이영수,이정환,Kim, Jung-Gyun,Lee, Young-Soo,Lee, Jeong-Hwan 한국가스학회 2012 한국가스학회지 Vol.16 No.6

$CO_2$ 감축은 최근 문제되고 있는 온실가스를 감축시킬 수 있는 직접적인 수단이 되고 있으며, 이러한 방법으로는 CCS 기술이 현실적인 대안기술로 부상하고 있다. 특히 전 세계적으로 널리 분포되어 있고 많은 양의 $CO_2$ 를 격리할 수 있는 심부 대염수층을 대상으로 활발한 연구가 진행 중이다. 이에 본 연구에서는 심부 대염수층에 대한 $CO_2$ 지중격리시 예비 타당성 평가 수행을 위하여 인공신경망을 이용한 효율성 평가 모델을 개발하였다. 모델 개발에 앞서 심부 대염수층을 대표할 수 있는 기본 모델을 선정하고 상용시뮬레이터 GEM을 활용하여 민감도 분석을 수행하였으며, 분석 결과를 바탕으로 심부 대염수층에 영향을 미치는 주요 인자 및 영향범위를 선정하였다. 인공신경망 학습을 위한 격리 시나리오 구성 결과 용해트랩과 잔류트랩에 의한 $CO_2$ 격리를 확인할 수 있었으며, 인공신경망 모델 자체 검증 결과 0.99이상의 높은 상관계수를 나타내어 심부 대염수층에서의 $CO_2$ 지중격리 효율성 평가에 활용 가능함을 확인하였다. The practical way to minimize the greenhouse gas is to reduce the emission of carbon dioxide. For this reason, CCS(Carbon Capture and Storage) technology, which could reduce carbon dioxide emission, has risen as a realistic alternative in recent years. In addition, the researcher is recently working into ways of applying CCS technologies with deep saline aquifer. In this study, the evaluation model on the feasibility of $CO_2$ sequestration in the deep saline aquifer using ANN(Artificial Neural Network) was developed. In order to develop the efficiency-evaluation model, basic model was created in the deep saline aquifer and sensitivity analysis was performed for the aquifer characteristics by utilizing the commercial simulator of GEM. Based on the sensitivity analysis, the factors and ranges affecting $CO_2$ sequestration in the deep saline aquifer were chosen. The result from ANN training scenario were confirmed $CO_2$ sequestration by solubility trapping and residual trapping mechanism. The result from ANN model evaluation indicated there is the increase of correlation coefficient up to 0.99. It has been confirmed that the developed model can be utilized in feasibility of $CO_2$ sequestration at deep saline aquifer.

N-(Alkyl-N'-nitrosocarbamoyl)-amino Acid Ester류의 合成 및 抗癌 作用 評價

김정균,박문태,신홍대,고영심,윤웅찬,유성호,문경호,김민숙,Kim, Jeong-Gyun,Park, Moon-Tae,Shin, Hong-Dae,Koh, Young-Sim,Yoon, Ung-Chan,Ryu, Sung-Ho,Moon, Kyung-Ho,Kim, Min-Sook 대한약학회 1984 약학회지 Vol.28 No.4

The derivatives of N-(alkylcarbamoyl) amino acid methyl ester, N-(2-chloroethylcarbamoyl)-glycine methyl ester (7a), -valine methyl ester (8a), -phenylalanine methyl ester (9a), N-(N'-methylcarbamoyl)-glycine methyl ester (7b), -valine methyl ester (8b), and-phenylalanine methyl ester (9b), were prepared by reacting the corresponding free amino acid methyl ester (glycine-, valine-, phenylalanine-methyl ester) with isocyanate (R-N=C=O${\cdot};R=Cl-CH_2-CH_2-or\; CH_3-)$. The prepared N-(alkylcarbamoyl) amino acid methyl esters (7,8,9) were treated with $NaNO_2$/98% HCOOH in order to obtain their nitrosoated products, N-(alkyl-N'-nitrosocarbmoyl)amino acid methyl ester. The compound (7,8,9) gave N-(2-chloroethyl-N'-nitrosocarbamoyl)-valine methyl ester (14a),-phenylalanine methyl ester (15a), N-(N'-alkyl-N'-nitrosocarbamoyl)-glycine methyl ester (13b),-valine methyl ester. (14b), and-phenylalanine methyl ester (15b) respectively under the nitrosoation. On the other hand, N-(2-chloroethylcarbamoyl) glycine methyl ester produced N-(2-chloroethylcarbamoyl)-N-nitrosoglycine methyl ester (13a). The inhibitory activity of the prepared N-(alkylcarbamoyl) amino acid methyl ester (7,8,9) and N-(alkyl-N'-nitrosocarbamoyl) amino acid methyl ester (13,14,15) towards the growth of L1210 murine leukemia cells were examined. Among them the compound (14a) and (15a) exhibit excellent activity having $ED_{50}\; to\;be\;1.5{\mu}g/ml\;and\;3.0{\mu}g/ml respectively.

'95 VERONA 농축산박람회를 돌아보고

김정균,Kim, Jeong-Gyun 대한양돈협회 1995 養豚 Vol.17 No.4

"VIV-EUROPE 94"를 참관하고

김정균,Kim, Jeong-Gyun 대한양돈협회 1995 養豚 Vol.17 No.1

DHA 함유 지질 추출소재로서 수산부산물의 검색

김정균,이응호,김진수,Kim, Jeong-Gyun,Lee, Eung-Ho,Kim, Jin-Soo 한국응용생명화학회 1997 Applied Biological Chemistry (Appl Biol Chem) Vol.43 No.2

수산부산물을 식품소재와 같이 효율적으로 이용하기 위한 일련의 기초 연구로서 DHA 함유 지질 추출소재로서 붕장어, 칼치의 내장 및 두부, 꽁치, 포클랜드산 및 뉴질랜드산 오징어의 내장 등과 같은 부산물에 대하여 검토하였다. 수산부산물의 건물당 지질함량은 $40.5{\sim}48.0%$이었고, 지질조성은 중성지질이 $92.1{\sim}99.0%$로 추출 소채에 관계없이 거의 대부분을 차지하였다. 중성지질은 트리글리세리드가 $50.0{\sim}69.9%$로 절반 이상을 차지하였고, 유리지방산이 $7.8{\sim}20.3%$, 스테롤류가 $3.5{\sim}13.9%$, 탄화수소가 $4.2{\sim}10.2%$ 및 디글리세리드가 $3.5{\sim}9.3%$를 차지하였으며, 모노글리세리드는 2% 내외 이었다. 수산부산물에서 추출한 총지질의 지방산조성 중 폴리엔산의 조성비는 포클랜드산 및 뉴질랜드산 오징어 내장유가 각각 41.0% 및 38.2%로 어류 부산물유의 $27.7{\sim}33.3%$에 비하여 높았다. DHA조성비는 뉴질랜드산 오징어 내장유가 21.1%로 가장 높았고, 다음으로 포클랜드산 오징어 내장유(16.3%), 갈치 부산물유(13.9%), 붕장어 부산물유(11.7%) 및 꽁치 부산물유(10.7%) 등의 순이었다. 총지질을 구성하는 주요 지방산은 지질 추출 소재인 부산물의 종류에 관계없이 16:0, 18:1n-9, 20:5n-3 및 22:6n-3 등이었다. As a part of basic investigation for utilizing by-products derived from marine food processing more effectively as a food source, lipid contents, fatty acid compositions and lipid compositions in viscera and head of conger eel and hair tail, viscera of mackerel pike, and squids caught off Newzealand and off Falkland island were determined. The lipid contents in marine by-products showed $40.5{\sim}48.0%$ on a dry weight basis and it consisted of $92.1{\sim}99.0%$ neutral lipid and $1.0{\sim}7.9%$ polar lipid such as phospholipid and glycolipid. The neutral lipids mainly consisted of triglyceride$(50.0{\sim}69.9%)$ and had free fatty acid, free sterol, esterified sterol and hydrocarbon, diglyceride, and monoglyceride in less quantity. Squid viscera oil showed higher content in polyenes such as 20:5 and 22:6 than by-product oil derived from fish processing. Viscera oil of squid caught off Newzealand(21.1%) was the highest on DHA composition, followed by that of squid caught off Falkland island(16.3%), hair tail by-product oil(13.9%), conger eel by-product oil(11.7%) and mackerel pike by-product oil(10.7%), in the order named. The major fatty acids in total lipid and neutral lipid of byproducts were generally 16:0, 18: 1n-9, 20:5n-3 and 22:6n-3.

Germyltriflate의 제조

김정균,박은미,손병영,Kim, Jeong Gyun,Park, Eun Mi,Son, Byeong Yeong 대한화학회 1994 대한화학회지 Vol.38 No.4

새만금방조제 축조에 따른 조류속 변화

김정균,송기일,최진규,Kim Jeong-Gyun,Song Ki-Il,Choi Jin-Kyu 한국관개배수위원회 2002 한국관개배수논문집 Vol.9 No.1

This study was carried out to investigate the changes of the tide velocity and direction during the construction of Saemangeum seadikes. Tide velocity and direction in the Saemangeum area were measured every year since the construction of Saemangeum seadi

VIV-ASIA 95를 돌아보고

김정균,Kim, Jeong-Gyun 대한양돈협회 1995 養豚 Vol.17 No.12

명태(Theragra chalcogramma) 및 다시마(Laminaria japonica) 부산물 유래 효소 가수분해물을 이용한 천연 풍미 소재의 제조

김정균 ( Jeong Gyun Kim ),노윤이 ( Yu Ni Noh ),박원혁 ( Kwon Hyun Park ),이지선 ( Ji Sun Lee ),김현정 ( Hyeon Jeong Kim ),김민지 ( Min Ji Kim ),윤무호 ( Moo Ho Yoon ),김진수 ( Jin Soo Kim ),허민수 ( Min Soo Heu ) 한국수산과학회 2012 한국수산과학회지 Vol.45 No.6

This study developed a natural seasoning (NS) and characterized its food components. Hydrolysate from Alaska Pollock Theragra chalcogramma heads and sea tangle Laminaria japonica byproduct were obtained by incubating them with Neutrase for 4 h. NS was prepared by mixing sorbitol 2%, salt 2%, ginger powder 0.04%, garlic powder 0.2%, onion powder 0.2% and inosine monophosphate (IMP) 0.1% based on concentrated hydrolysates from Alaska pollock head and sea tangle byproduct before vaccum f iltering. The proximate composition of NS was 82.7% moisture, 9.0% crude protein, and 5.1% ash. It had a higher crude protein content than commercial anchovy sauce (CS), it was lower in moisture and ash. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and angiotensin-I converting enzyme (ACE) inhibiting activity of NS were 90.1% and 88.9%, respectively, which were superior to those of CS. The free amino acid content and total taste value of NS were 1,626.0 mg/100 mL and 165.86, respectively, which were higher than those of CS. According to the results of taste value, the major free amino acids were glutamic acid and aspartic acid. In the sensory evaluation, the color and taste of NS were superior to those of CS. No difference in f ish odor between NS and CS was found.