사람의 골수 줄기 세포로부터의 골세포 분화 과정에서 BMP-2가 미치는 영향과 그에 따른 분화 유전자의 발현 비교 연구

김인숙,장옥련,조태형,이규백,박용두,노인섭,황순정,김명진,이종호,Kim, In-Sook,Zhang, Yu-Lian,Cho, Tae-Hyung,Lee, Kyu-Back,Park, Yong-Doo,Rho, In-Sub,Weber, F.,Hwang, Soon-Jung,Kim, Myung-Jin,Lee, Jong-Ho 대한악안면성형재건외과학회 2005 Maxillofacial Plastic Reconstructive Surgery Vol.27 No.1

It is commonly acknowledged that bone morphogenic protein (BMP-2) functions as a potential osteogenic inducer in bone formation. Recently, several papers reported that bone marrow-derived stem cell (BMSC) from human is not responsive to BMP-2 in comparison to high capacity of BMP-2 in the osteoinduction of stromal cell derived from bone marrow of rodent animals such as rat or mouse. In this study, we characterized BMSC derived from 11 years old donor for the responsiveness to rhBMP-2, dexamethasone (Dex) and 1,25-dihydroxyvitamin D (vitamin D), in order to analyze their function in the early osteogenesis. The effect of over mentioned agents was evaluated by means of assessing alkaline phosphatase (ALP) activity/staining, RT-PCR analysis and von Kossa staining. In addition, we analyzed the meaning of expressed several osteoblastic markers such as alkaline phosphatase, collagen typeI, osteopontin, bone sialoprotein and osteocalcin with relation to either differentiation or mineralization. Only in the presence of Dex, human BMSC could commit osteoblastic differentiation and matrix mineralization, and either BMP-2 or vitamin D treatment was not able to induce. But BMP-2 or Vitamin D showed potential synergy effect with Dex. ALP and bone sialoprotein were clearly expressed in response of Dex treatment compared to weak expression of osteopontin in early osteogenesis. Therefore, we expect that this study will contribute partly to elucidiating early osteogenesis mechanism in human, but variations among bone marrow donors must be considered through further study.

상부 위장관의 (胃腸管) 위내시경 (胃內視鏡) 검사 2470에 대한 고찰

김인숙,이원경,이충식,이은기,정을순,최용직 ( In Sook Kim,Won Kyung Lee,Choong Sik Lee,Eun Ki Lee,Eul Soon Chung,Yong Gik Choi ) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.2

The endoscopic findings were compared with the radiologic findings and the following results were obtained. 1) In the gastrofiberscopic findings, the main stomach diseases were gastritis, benign ulcer, stomach cancer in order of frequency, and duodenal ulcer, esophageal diseases k bezoars were also noted. In gastritis, chronic superficial gastritis was the most common with 47. 9%. 2) In normal group on gastrofiberscopy, the sex ratio was nearly same and the most fre- quent age group was 6th decade with the incidence of 28. 5%. In gastritis, male to female ratio also was same, and the most common age group was 5 th decade, In gastric ulcer, the sex ratio was 1. G:1 with male preponderance and in age distribution, 5 th was common, while stomach cancer heing 1.3:1 R 6 th decade was the most frequent occurrence. 3) In the advanced stomach cancer, endoscopic gross finding by Bormann's classification was as follows; type g (32.9%), type p (23.1po), type ]I (18.1%), type I (14. 0%). So called early cancer was 4. 5%. 4) In gastric ulcer, the site of lesion revealed that the antrum was the highest frequency (43. 3%), the next was angle (33. 3%), and the body (23. 7%) in order, while in gastric cancer, a e antrum was 40. 7%, the body was 32. 1% and the angle was 27. 2%, 5) In relationship between radiologic and endoscopic findings equality was noted in 79, 3% of gastritis, in 89. 5% of gastric ulcer and in 98. 7%of gastric cancer. 6) Of the total 2470 cases, 1303 cases were associated with other diseases, as follows; liver diseases(24. 7%), anemia(16. 2%), helminthiasis(14%), neurosis(6. S%), pulmonary tuberculosis (6. 7%), 6-U tractinfection (8. 2%), and so on.

지역 청년창업생태계 조성을 위한 대학의 지원방안 탐색: 서울시 사례를 중심으로

김인숙,양지희,Kim, In Sook,Yang, Ji Hee 한국벤처창업학회 2022 벤처창업연구 Vol.17 No.4

The purpose of this study was to analyze the perception and demand of local youth and to find ways to support universities in order to create an youth start-up ecosystem. To this end, 509 young people living in Seoul were analyzed to recognize and demand young people in the region for youth start-ups, and to support universities. The findings are as follows. First, as a result of analyzing young people's perception of youth start-ups in the region, the "Youth Start-up Program" was analyzed the highest in terms of the demand for regional programs by university. In addition, there was a high perception that the image of youth startups in the region was "challenging" and "good for changing times." Second, after analyzing the demand for support for youth start-ups in the region, it appeared in the order of mentoring, start-up education, and creation of start-up spaces. And it showed different needs for different ages. Third, the results were derived from analysis of the demand for university support for the creation of a regional youth start-up ecosystem, the criteria for selecting local youth start-up support organizations, and the period of participation in local youth start-up support. Based on the results of the above research, the implications and suggestions of university support for the creation of a community of youth start-up ecosystem are as follows. First of all, it is necessary to develop and operate sustainable symbiosis mentoring programs focusing on university's infrastructure and regional symbiosis. Second, it is necessary to develop and utilize step-by-step systematic microlearning content based on the needs analysis of prospective youth start-ups. Third, it is necessary to form an open youth start-up base space for local residents in universities and link it with the start-up process inside and outside universities. The results of this study are expected to be used as basic data for establishing policies for supporting youth start-ups and establishing and operating strategies for supporting youth start-ups at universities.

쥐의 골수로부터 추출한 줄기세포를 이용한 조골세포로의 분화 유도과정에서 나타난 문제점에 관한 분석 연구

김인숙,조태형,장옥련,이규백,박용두,노인섭,이종호,김명진,황순정,Kim, In-Sook,Cho, Tae-Hyung,Zhang, Yu-Lian,Lee, Kyu-Back,Park, Yong-Doo,Rho, In-Sub,Weber, F.,Lee, Jong-Ho,Kim, Myung-Jin,Hwang, Soon-Jung 대한악안면성형재건외과학회 2005 Maxillofacial Plastic Reconstructive Surgery Vol.27 No.1

This study was aimed to characterize osteogenic potential of rat bone marrow stromal cells (BMSC) isolated with standard flushing method and investigate the plasticity of transdifferentiation between osteoblastic and adipocytic lineage of cultured BMSC. Unlike aspiration method in human, rat bone marrow was extracted by means of irrigation with culture media that elevates the possibility of co-extraction of committed osteoprogenitor, or preosteoblast or other progenitor cells of several types present inside bone marrow. The cultured stromal cells showed high ALP activity which is representative marker of osteoblast without any treatment. Osteogenic inducers such as Dex and BMP-2 were examined for the evaluation of their effect on osteogenic and adipocytic differentiation of stromal cells, because they function as osteoinductive agent in stromal cells, but simultaneously induce adipogenic differentiation. Osteogenic differentiation was evaluated by measuring alkaline phosphatase activity or mRNA expression of osteoblast markers such as osteopontin, bone sialoprotein, collagen type I and CbfaI, and in vitro matrix mineralization by von Kossa staining. Oil red staining method was used to detect adipocyte and adipocytic marker, aP2 and $PPAR{\gamma}2$ expression was examined using RT-PCR. It can be supposed that irrigation procedure resulted in high portion of already differentiation-committed osteoprogenitor cell showing elevated ALP activity and strong mineralization only under the supplement of $100{\mu}M$ ascorbic 2-phosphate and 10mM ${\beta}$-glycerophosphate without any treatment of osteogenic inducers such as Dex and BMP-2. Dex and BMP-2 seemed to transdifferentiate osteoprogenitor cells having high ALP activity into adipocytes temporarily, but continuous treatment redifferentiated into osteoblast and developed in vitro matrix mineralization. This property must be considered either in tissue engineering for bone regeneration, or in research of characterization of osteogenic differentiation, with rat BMSC isolated by the standard irrigation method.

VMD전략을 위한 VMD, 공간구조, 행태간의 상호관계성 연구 - 패션 리테일 매장을 중심으로 -

김인숙(Kim, In-Sook),김영욱(Kim, Young-Ook) 대한건축학회 2020 대한건축학회논문집 Vol.36 No.12

VMD is a marketing strategy at the final stage that adjusts the level of visual product planning so that all corporate activities are visible in a physical space, and it requires quantitative and objective establishment. Unlike other channels of marketing communication, however, there is no objective criterion for controlling visual product planning when deciding in-store merchandising according to VMD. In order to establish a VMD strategy, it is important to fundamentally clarify the interrelationships of the properties of products and space, and responses of customers. Therefore, the purpose of this study is to determine the level of VMD strategy by verifying the efficiency of merchandise presentation(MP), an implementation method of image-centered and product-centered VMD through the interrelationship between spatial configuration and behavior. This study is consists of three subdivisions. First, the VMD strategy of the target fashion retail store is analyzed by dividing it into VP(visual presentation), PP(point of sale presentation), and IP(Item Presentation) based on MP. Second, the spatial configuration of the target fashion retail stores is analyzed based on MP. Third, the usage behavior of the target fashion retail space is analyzed based on MP. As these results, the correlation between VMD, spatial configuration, and usage behavior is analyzed. Only significant results based on correlation analysis and regression in identical products and periods in two fashion retail stores are analyzed, and space for recognized images(VP) and sales space(PP, IP) are compared for objectively and quantitatively. As a conclusion, the image recognition space(VP) is more strategically placed than the sales space(PP, IP). The sales space, however, is more attractive to the customers due to the impact on accessibility and visibility in actual utilization. This quantitative analysis can be the basis for the spatial planning of the VMD strategy of fashion retail stores. It will enable a retail shopping environment in line with changes in the market by presenting the basis for the efficiency of the VMD strategy in fashion retail.

전북지역 주부들의 외식행동과 음식물 쓰레기에 대한 의식 조사

김인숙,유현희,박선화,Kim, In-Sook,Yu, Hyeon-Hee,Park, Sun-Hwa 한국식생활문화학회 2000 韓國食生活文化學會誌 Vol.15 No.5

The purpose of this study was to investigate several aspects of eating out behavior especially in relation to food waste. The data were collected from 620 housewives in Jeonbuk area but, except for 134 case not eating out . The 66.9% of subjects ate eating out 1 to 2 times monthly. The younger in age, higher in education level and employed housewives, higher in monthly income have a more increase in eating out frequency. In the 50.8% of subjects food rest was rare when eating out. The higher in educational level and higher in monthly income have an inclination to more food waste. The 51.4% of subjects don't know [Good Menu System]. We housewives should order a planned and moderate food amount when eating out, and make an effort normally anywhere for the reduction of food waste, and then the wasted food and food rubbish will be reduced. Besides this, the restaurants should practice [Food Bank] & [Good Menu System] and the academic world should make further researches on this field. Moreover the government administration should enlighten the people and have a public information for the more reasonable food culture.

소년원생의 인성교육을 위한 차문화치료 프로그램 개발

김인숙,Kim, In-Sook 한국사물인터넷학회 2021 한국사물인터넷학회 논문지 Vol.7 No.4

본 연구는 소년원생들의 재비행 방지와 사회적응을 효과적으로 향상시키기 위하여 인성교육 차문화치료 프로그램을 개발하고자 한다. 사회적 개입을 통한 차문화치료 프로그램의 효과성을 검증하기 위하여 프로그램에 참여하기 전과 후 소년원생들의 자기효능감, 자기통제력, 대인관계 등의 사회적 특성 점수에 유의미한 차이가 나타났는지 분석하였다. B시 소재 소년원에서 수용생활을 하는 14세에서 17세 사이 소년원생들 10명을 연구대상의 실험집단으로 선정하였다. 소년원생 사회적 개입 인성교육을 위한 차문화치료 프로그램을 10회기 진행하였고, 그 결과 자기효능감은 사전 평균 2.37(SD 0.33), 사후 평균 2.49(SD 0.31)로 나타나 유의미한 차이를 보였으며(Z=-5.874, P=.000), 자기통제력은 사전 평균 2.06(SD 0.20), 사후 평균 2.16(SD 0.19)으로 나타나 유의미한 차이를 보였다(Z=-4.743, P=.001). 대인관계는 사전 평균 1.90(SD 0.32), 사후 평균 2.15(SD 0.21)로 나타나 유의미한 차이가 나는 것으로 확인되었다(Z=-5.892, P=.000). 이상의 결과들은 본 프로그램이 소년원생들의 자기효능감, 자기통제력, 대인관계 등의 사회적 특성 향상에 유의미한 효과가 있음을 보여주고 있다. 따라서 본 연구에서 개발된 소년원생 인성교육을 위한 차문화치료 프로그램은 향후 교정복지 현장뿐 아니라 다양한 유형의 청소년들을 위한 인성교육 프로그램으로 활용될 수 있을 것이다. The purpose of this study is to develop a personality education tea culture therapy program to effectively improve juvenile delinquency prevention and social adaptation. In order to verify the effectiveness of the tea culture therapy program through social intervention, we analyzed whether there were significant differences in the scores of social characteristics such as self-efficacy, self-control, and interpersonal relationships of juvenile detention students before and after participating in the program. Ten juvenile detention students between the ages of 14 and 17 who were accommodated to a juvenile detention center in B city were selected as the experimental group for the study. The tea culture therapy program was conducted 10 times as a social intervention personality education for juvenile delinquents, and as a result, self-efficacy was found to have a pre-mean of 2.37 (SD 0.33) and a post-mean of 2.49 (SD 0.31), showing a significant difference (Z=-5.874. P=.000), self-control showed a significant difference with the pre-mean 2.06 (SD 0.20) and the post-mean of 2.16 (SD 0.19) (Z=-4.743, P=.001). The interpersonal relationship was found to have a significant difference, with a pre-mean of 1.90 (SD 0.32) and a post-mean of 2.15 (SD 0.21) (Z=-5.892, P=.000). The above results show that this program has a significant effect on improving social characteristics such as self-efficacy, self-control, and interpersonal relationships among juvenile detention students. Therefore, the tea culture therapy program developed in this study for personality education for juveniles can be used as a personality education program for various types of adolescents as well as in the field of correctional welfare in the future.

차문화 융합 프로그램이 이용시설 노인의 의사소통 향상에 미치는 영향

김인숙,박선희,Kim, In Sook,Park, Sun Hee 한국사물인터넷학회 2020 한국사물인터넷학회 논문지 Vol.6 No.1

The purpose of this study was to examine the effect on improving communication by conducting a tea culture convergence program for elderly people using facilities. The subjects of this study consisted of a tea culture convergence program for 3 months, 60 minutes once a week for 7 people using the Elderly Day Care Center in the H-S S welfare center. Psychological and behavioral changes related to communication by sessions were compared by comparing elderly patients at each session of the Tea Culture Convergence Program.Tea culture convergence program was found to have a positive effect on behaviors and attitudes related to communication among the elderly in the facilities. As a result of analyzing pre- and post-action and attitudes, the Tea Culture Convergence Program brought positive changes in communication by acting as emotional and social support for the elderly. These findings suggest that the Tea Culture Convergence Program is a psychologically necessary program for the elderly in that it shows that the Tea Culture Convergence Program is an effective program that promotes communication among the elderly in the facilities. 본 연구는 이용시설노인들을 대상으로 차문화 융합 프로그램을 실시하여 의사소통 향상에 미치는 효과를 살펴보고자 하였다. 연구 대상은 H시 S복지관 내 노인주간보호센터를 이용하는 7명을 주 1회 60분씩 3개월 간 차문화 융합프로그램을 진행하였다. 차문화 융합 프로그램의 각 회기별 노인들이 차문화 융합 프로그램에 참여하는 연구대상자들에 대한 회기별 의사소통과 관련된 심리 및 행동 변화를 기록하여 비교하였다. 차문화 융합 프로그램이 이용시설 노인들의 의사소통과 관련된 행동 및 태도에 긍정적인 효과를 주는 것으로 나타났다. 사전과 사후의 행동 및 태도를 분석한 결과 차문화 융합 프로그램이 노인들에게 정서적, 사회적 지지의 역할을 함으로써 의사소통에 긍정적인 변화를 가져왔다. 이러한 연구 결과는 차문화 융합 프로그램이 이용시설 노인들의 의사소통을 증진시키는 효율적인 프로그램임을 보여 준다는 점에서 노인들에게 차문화 융합 프로그램은 심리사회적으로 꼭 필요한 프로그램이라는 점을 시사한다.

일개 도시지역 임신부의 영양섭취에 관한 조사연구 -간이식 영양조사법 이용-

김인숙,Kim, In-Sook 대한예방의학회 1983 Journal of Preventive Medicine and Public Health Vol.16 No.1

Aiming at the total 200 pregnant women including 150 ones registered with the Health Center of Chung Ku District and 50 ones registered with the Health Center of Mapo District, we have conducted a research study of the socio-medical characteristics, maternal child health, and the status of nutritional intake which has utilized the application of convenient method for the study of nutritional status, during the period of April 20 to May 25, 1983. And we have obtained the following conclusions: 1. Regarding age distribution, the pregnant women aged from 26 to 30 were most numerous, which was 54.0%. The percentage of women who experienced the first pregnancy was 12.0% and the percentage of those who experienced the second pregnancy was 37.0%, which was the highest. Regarding the weeks of pregnancy of the pregnant women, the first trimesterr was 11.5%, the second trimester 30.0%, and the third trimester 58.6%. 2. Regarding academic achievements, the pregnant women who graduated from middle schools reached 43.5%, which was the highest percentage. Regarding economic status, the pregnant women who owned their own houses were only 21.0%. And the pregnant women whose monthly income was from 300,000 won to 400,000 won were 40%, which was the most numerous. 5. The women above 15 years old who experienced the first menstruation were 84.0%. And those who experienced abortion were totally 54.4%. and 35.5% among those women experienced artificial abortion. 4. 70.5% of the pregnant women said that their health condition was excellent, 24.5% felt subjective complaints, and 5.0% specially received medical consultation for their diseases. 5. 82.0% received prenatal care, but 60.5% regularly received prenatal care. 68.0% received the education for nutrition and only 19.5% regularly received the education for nutrition. 6. Regarding the family composition, the families consisting of two generations were 47.0%, which was the most numerous. 97.5% of the preparation for meals was conducted by housewives. They said that they did not lack time for meal preparation. 7. 94.9% of the pregnant women said that they had eaten as in ordinary times during their pregnancy. 25.5% said that there were tabooed foods. Tabooed foods are chiefly pork, chicken, milk, and eggs. 68.0% don't drink milk during pregnancy, 32.5% take the intake of vitamins, and 20.5% take iron supplement. 8. The average amounts of the intake of protein, fat, and carbohydrate of a pregnant women are 49.3gm, 29.4gm, and 205.1gm respectively, which showed the phenomenon in which the amount of the intake of nutrition increased as the weeks of pregnancy increased. The average amount of the intake of salt was 14.2gm. 9. Regarding the hemoglobin value of all pregnant women, those whose hemoglobin value was less than 11.0gm were 66.5%, those whose hemoglobin value was 11 to 12 gm were 16.5%. and those whose hemoglobin value was above 12gm were 17.0%. The pregnant women whose hemoglobin value was less than 11.0gm in the first trimester of pregnancy, in the second trimester, and in the trimester were 81.8%, 62.8%, and 64.9% respectively. This shows that the phenomenon of anemia increased as the weeks of pregnancy increased 10. Regarding physical development of a pregnant woman during prenatal period, the height and weight were $156.7cm{\pm}14.1$ and $51.1kg{\pm}58$ respectively. When the standard increase of a prenatal weigt gain is set as 100%, the women over the range of 100% were 28.0% and the women under the range of 80% were 37.0%.

조선조 이상향(理想鄕)의 작품분석 연구

김인숙(Kim, In Sook) 한국전시산업융합연구원 2014 한국과학예술융합학회 Vol.17 No.-

동양의 이상향은 자연을 제재로 하여 전통 문학과 산수화에서 구체적으로 묘사되어 왔다. 특히 조선조는 유교의 이상 국가 건설을 의도적으로 지향한 이데올로기적 국가였으므로 이상향에 관한 문화적 구성으로서 시와 산수화가 지속적으로 생산됐다. 본고는 이와 같은 조선조의 이상향 전개를 작품분석을 통하여 조망하고자 한다. 우선 이상향을 구성하는 담론내용을 살피면 국초의 강력한 유교국가 지향에도 불구하고 당대의 이상향에는 고려조의 유 · 불 · 선이 절충된 개념들이 혼재되어 있었다. 본격적인 유교적 이상향은 중기 이후, 정치적 주체로 등장하는 사림의 산림적 이상향으로부터 이들이 경화사족화함에 따라 나타나는 성시산림적 이상향으로 나누어 전개됐으며 또한 조선조 후기 이후에는 신분제 해체에 의한 중인층의 부상에 따라 그 동안 억압되었던 현세구복적 이상향과 도가적 이상향이 나타난다. 본고에서는 이와 같은 조선조 이상향의 변화에 관하여 각각의 이상향을 표상한 작품 <몽유도원도>,<곡운구곡도>, <청풍계도>, <민화 소상팔경도>, <도원문진도>를 통하여 분석한다. 이와 같이 산수화의 형식으로 표상된 조선조 이상향의 장소성은 당대를 살았던 주체들이 그들이 살았던 사회에 대한 인식과 소망 등에서 비롯된 자연과 문화의 복합적 구성물로서 장소감을 넘어 장소정신으로 확장되면서 조선조의 이상향을 변화시켰다. The Asian utopia has been specifically described in traditional literature and landscape painting with a subject of nature. Especially since Cho-Sun dynasty was an ideological country intentionally directing to confucian country establishment, for the whole Cho-Sun dynasty period, poems and landscape paintings had been continuously produced as a literary composition regarding to utopia. This paper tries to take a view of utopia expansion of Cho-Sun dynasty through landscape painting work analysis. Firstly, when observing the discussion contents which consist utopia, there are notions compromised of Korea dynasty"s Yoo, Bul, Sun mingled in utopia of the time in spite of strong inclination to the confucian nation of early country establishment. The main confucian utopia had been expanded as being divided into Sung-Si-San-Lim utopia which appears according to Kyung-Hwa-Sa-Jok-Hwa from Sa-Lim"s San-Lim utopia appearing as a political subject after the middle period. Also after late Cho-Sun dynasty there appears double utopias, the upper class shows the taoistic utopia and the lower class shows basic utopia which had been oppressed for a while due to the rise of the people by hierarchial dismantlement. This paper analyses these kinds of changes of Cho-Sun dynasty utopia through works of 〈Mongyudowondo〉, 〈Gokungugokdo〉,〈Chungpungke〉, 〈Minhwa Sosangpalgyungdo〉, 〈Dowonmunjindo〉 which expressed each of the utopia. Sense of place of Cho-Sun dynasty utopia which expressed into a form of the landscape painting changed the Cho-Sun dynasty"s utopia as the main people living at the time expanded it to the place spirit beyond feelings of place as a composition of nature and culture which originated from the hope and perception about the society they were living in.