Candida Albicans 와 Carcinogen 의 경구투여에 의한 Mouse 의 위점막 변화

정정명(Jung Myung Jung),김을수(Eul Soo Kim),오형석(Hyung Seok Oh),최경해(Kyung Hae Choi),이부경(Boo Kyung Lee),설상영(Sang Yung Sul),최하진(Ha Jin Choi) 대한내과학회 1988 대한내과학회지 Vol.34 No.4

N/A 1) In the group of the subject mice administered with candida albicans only, all of 6 mice had an inflammatory change both in stomach antrum and body at the 1 month-interval check. At the 3 month interval check, an inflammation in stomach antrum occurred in all of 6 mice; however, in stomach body 5 mice had an inflammation and 1 mice a mocosal atrophy, At the 6 month-interval check, all of 8 mice had an inflammatory change in stomach antrum, while 4 of them got a mucosal atrophy in stomach body. 2) In the group of the mice with a carcinogen alone administered, 2 of 4 mice in the 6 month-group, and 5 of 8 mice in the 9 month-group revealed a mucosal dysplasia with no appearance of cancer. But the degree of dysplasia was one mouse in grade A and another one mouse in grade B, respectively, at the 6 month-interval check, while 2 mice in grade B, and 3 mice in grade C, respectively, at the 9 month-interval check. 3) In the group of mice administered both with carcinogen and candida albicans, 2 of 4 mice showed no cancer but mucosal dysplasia of grade B at the 6 month-interval check, while at the 9 month-interval check, 6 of 8 mice had a squamous cell cancer (especially 3 having been grossly examined) and the other two had mucosal dysplasia of grade C. 4) The findings in the liver tissue of the mice adminstered with the carcinogen for more than 8 months revealed a severe liver cell dysplasia with no evidence of hepatoma. 5) The results from this experimental study suggested that in case of provoking a stomach cancer due to a carcinogen administered in the mice, gastrointestinal infection of pathogenic organism such as candida does play a promoting role. However, whether a suggestion from this experimental study will be applicable to human beings as well or not will have to await a lot of further researches thereafter in the field, There have been reported many experimental researches on the oncogenic effects of various nitroso-compounds since Barnes and Magee, in 1956, concluded the acute hepatotoxicity and oncogenic action of dimethylnitrosamine in a number of experimental animals. Thereafter these nitroso-compounds have been assumed to be an environmental carcinogen in human beings as well as a potent carcinogen in animals. Much attention has been paid particulary on the relation of stomach cancer and nitrosamine since the nitrosamine synthesis in human gastric juice was known to be available. However. at present, it seems so hard to confirm nitrosamine as a vital factor of human cancer that far more information is demanded to identify it accurately. Recent reports, including ours, show a high frequency of candida albicans infection in gastrointestinal tract by various environmental factors. But the influence of candida multiplication on gastric ulcer or stomach cancer has scarcely been known. In this research we made a study of possible effects of candida infection on the gastric mucosa injury as well as on stomach cancer.

각종 간 질환에 있어서 HBV 표지들 ( Markers ) 의 변동에 관한 관찰

최하진(Ha Jin Choi),김동민(Dong Min Kim),오형석(Hyung Seok Oh),최경해(Kyung Hae Choi),김을수(Eul Soo Kim),정정명(Jung Myung Jung) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1

N/A In 17 cases of acute hepatitis, 20 cases of chronic active hepatitis, 4 cases of chronic persistent heptatitis, 36 cases of liver cirrhosis, and 26 cases of primary hepatocellular carcinoma who were admitted to the department of internal medicine, Inje medical college, Busan Paik Hospital, we examined the changing patterns of 5 HBV markers (i, e., HBsAg, anti-HBs, anti-HBc, HBeAg, anti-HBe) from January 1982 to May 1985. HBsAg and anti-HBs were examined for 10 months, and HBeAg and anti-Hbe for 8 months in cases of acute hepatitis. In chronic active hepatitis, HBsAg and anti-HBs, and HBeAg and anti-HBe were examined for 24 months, in chronic persistent hepatitis for 12 months, and in 7 cases of liver cirrhosis for 24 months. The serological profile of HBsAg(+)ve anti-HBc(+)ve HBeAg(+)ve was the most prevalent in acute hepatitis(76.5%). In chronic active hepatitis, the most prevalent profiles were HBsAg(+)ve anti-HBc(+)ve HBeAg(+)ve and HBsAg(+)ve anti-HBc(+)ve anti-HBe(+)ve (40% each), and the similar profiles as those of chronic active hepatitis were observed in liver cirrhosis, which were the most prevalent in liver cirrhosis (22.2% each). In primary hepatocellular carcinoma, the most prevalant profile was HBsAg(+)ve anti-HBc(+)ve anti-Hbe(+)ve (34.6%). With serial checks of HBV markers in 15 cases of acute hepatitis who exhibited positive HBsAg initially, 5 cases lost HBsAg, of which one case seroconverted to positive anti-HBs. Among 3 cases with positive HBsAg and HBeAg, one lost HBeAg 1.5 months later and other one 3 months later who regained the positivity for HBeAg 4.5 months later. There was no change of HBsAg and anti-HBs in 20 cases of chronic active hepatitis (17 cases with positive HBsAg, one case with negative HBsAg and anti-HBs, and two cases with positive anti-HBs) for 24 months. Among 8 cases of chronic active hepatitis with positive HBsAg and HBeAg, one case seroconverted to positive anti-HBe 2 months later and other one case lost HBeAg 3 months later (the annual rate of disappearance of HBeAg is 12.5% and that of seroconversion to anti-HBe is 6.3%). Between 2 cases of chronic persistent hepatitis with positive HBsAg and HBeAg, one case seroconverted to positive anti-HBs and anti-Hbe in 12 months. All of 4 cases of liver cirrhosis with positive HBsAg lost HBsAg, and only one of them seroconvert- ed to positive anti-HBs in 24 months. All of 3 cases of liver cirrhosis with positive anti-HBs lost anti-HBs during the same period. Among 4 cases of liver cirhosis with positive HBsAg, one case with positive HBeAg seroconverted to positive anti-HBe, other 2 cases with negative HBeAg and anti-HBe seroconverted to positive anti-Hbe and positive HBeAg respectively, and the other one with positive anti-HBe lost anti-HBe.

구연발표 : 간 질환들에 있어서 HBs 항원 및 HBs 항체 공존예에 관한 관찰

정정명(Jung Myung Chung),설상영(Sang Yong Seol),진기천(Chun Gi Jin),김을수(Eul Soo Kim),최하진(Ha Jin Choi),홍숙희(Sook Hee Hong) 대한소화기학회 1987 대한소화기학회 추계학술대회 Vol.1987 No.-

pH가 Bacillus Cereus의 Enterotoxin 생산에 미치는 영향

김을수,이시억,이언탁,이명수,오양효 인제대학교 1988 仁濟醫學 Vol.9 No.3

Bacillus cereus에 의한 식중독의 진단에는 원인균의 분리 동정은 물론 신속한 enterotoxin의 검출이 필수적인데 enterotoxin의 생산은 배지나 배양 조건에 영향을 많이 받는다. 본 실험에서는 CAYE-2배지에서 pH 8.5에서 가장 많은 양의 enterotoxin이 생산되었다. Cell-free culture filtrates of enterotoxin producing strain of Bacillus cereus biotype I were detected by RPLA test for the production of enterotoxin. The media used were CAYE-2, Biken No. 2 and BHI medium. The results obtained were as follows : 1) Among CAYE-2, Biken No. 2 and BHI medium, enterotoxin production was the highest in CAYE-2 medium. Enterotoxin production was appreciably diminished at or below pH 6.0 and at above pH 9.0 of the various test media. 2) B. cereus produced high levels of enterotoxin when grown in CAYE-2 medium pH initial pH at 85 and the 512-1014ng quantity of enterotoxin per ml can be detected by the RPLA method.

Phlegmon 성 위염 1 예

박경태,김을수,최영길,정정명,이부경,설상영,김기현 대한내과학회 1988 대한내과학회지 Vol.34 No.3

We had experienced a 34-year-old female patient with phlegmonous gastritis which was confirmed by radiologic studies and operation. Enterobacter aerogenes, E-Coli and Morganella morganii were cultured from the specimen of necrotic stomach tissue which was obtained by operation. The operation findings were revealed necrosis of total wall on the lower esophagus, stomach, duodenum and proximal portion of jejunum. The patient was rapidly deteriorated with downhill course and expired on 3rd hospital day.

남성 간경변증 환자에서의 여성형 유방 발현과 혈중 총단백에 대한 알부민 비율과의 관계

강창일,김을수,최경해 인제대학교 1987 仁濟醫學 Vol.8 No.3

남성 간경변증 환자 50명의 혈중 총단백에 대한 알부민의 비율이 44.06±9.49%인상태에선 그 중 여성형 유방을 동반한 22명의 혈중 총단백에 대한 알부민의 비율이 44.02±12.98%로 여성형 유방을 동반하지 않은 28명의 44.21±5.61%와 비교하여 별 의미있는 차이가 없어 간경변증 환자에서 여성형 유방의 출현은 간 기능의 정도와 직접적인 상관관계가 성립되지 않는 것으로 사료된다(P $gt;0.05). The ratio of serum albumin to total protein in 50 male liver cirrhosis was 44.06±9.49%. Among them 22 persons with gynecomastia have 44.00±12.98% albumin to protein ratio 42.21±5.61% of 28 non-gynecomastia group (P$gt;0.05). So it seems that there was no correlation between gynecomastia appearance and liver function in male liver cirrhosis. he ratio of serum albumin to total protein in 50 male liver cirrhosis was 44.06±9.49%. Among them 22 persons with gynecomastia have 44.00±12.98% albumin to protein ratio 42.21±5.61% of 28 non-gynecomastia group (P$gt;0.05). So it seems that there was no correlation between gynecomastia appearance and liver function in male liver cirrhosis.