노인 하지불안증후군에서의 인지기능 저하

김은수,윤인영,권국주,박혜연,이정석,한은경,김기웅,Kim, Eun Soo,Yoon, In-Young,Kweon, Kukju,Park, Hye Youn,Lee, Chung Suk,Han, Eun Kyoung,Kim, Ki Woong 대한수면의학회 2013 수면·정신생리 Vol.20 No.1

목 적: 하지불안증후군에서의 인지기능 저하는 흔히 동반되는 수면박탈, 불안, 우울 등에 의해 영향을 받는다. 본 연구의 목적은 투약 받지 않고 있는 한국 노인 인구에서 하지불안증후군과 인지기능 저하와의 관련성을 동반 증상의 영향을 배제하고 살펴보는 것이다. 방 법: 연구대상은 25명의 투약 받고 있지 않은 한국 노인 하지불안증후군 환자군과 나이, 성별, 교육연한에 따라 짝지은 50명의 대조군이다. 모든 연구대상에 대해 CERAD-K 신경심리평가, 중증인지감퇴평가 척도, 전두엽 기능 평가, 그리고 시계 그리기 검사(CLOX)를 포함한 광범위한 인지기능 평가를 시행하였다. 또한 수면의 질 평가를 위해 피츠버그 수면의 질 지수(Pittsburgh Sleep Quality Index, PSQI), 우울증의 평가를 위해 노인우울척도(Geriatric Depression Scale, GDS)를 사용하였다. 결 과: 환자군과 대조군 사이의 PSQI와 GDS 점수의 차이는 없었다. 구성 재인 검사에서 환자군이 대조군에 비해 더 낮은 점수를 보였으며(t=-2.384, p=0.02), 이를 제외한 모든 영역의 인지기능 평가에서 환자군과 대조군의 유의미한 차이는 관찰되지 않았다. 우울감이 있는 대상($GDS{\geq}10$)은 그렇지 않은 군에 비해 언어 유창성, 간이 정신상태 검사, 단어목록기억, 길 만들기 검사, 전두엽 기능 평가의 영역에서 유의한 인지기능 저하를 보였다. 수면의 질이 낮은 대상(PSQI>5)은 그렇지 않은 군에 비해 인지기능 평가의 전 영역에서 차이를 보이지 않았다. 결 론: 본 연구에서 하지불안증후군 환자군을 대조군과 비교한 결과 환자군은 불면과 우울의 영향을 배제하면 비교적 인지기능이 보존된 것으로 관찰되었다. 환자군에서 관찰되었던 시각 인지 영역의 저하는 하지불안증후군에서의 도파민 신경전달계의 장애와 연관하여 해석해 볼 수 있다. Objectives: Cognitive impairment in restless legs syndrome (RLS) patients can be affected by sleep deprivation, anxiety and depression, which are common in RLS. The objective of this study is to investigate relationship between cognitive impairment and RLS in the non-medicated Korean elderly with controlling for psychiatric conditions. Method: The study sample for this study comprised 25 non-medicated Korean elderly RLS patients and 50 age-, sex-, and education- matched controls. All subjects were evaluated with comprehensive cognitive function assessment tools- including the Korean version of Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K), severe cognitive impairment rating scale (SCIRS), frontal assessment battery (FAB), and clock drawing test (CLOX). Sleep quality and depression were also assessed with Pittsburgh sleep quality index (PSQI) and geriatric depression scale (GDS). Results: PSQI and GDS score showed no difference between RLS and control group. There was no significant difference between two groups in nearly all the cognitive function except in constructional recognition test, in which subjects with RLS showed lower performance than control group (t=-2.384, p=0.02). Subjects with depression ($GDS{\geq}10$) showed significant cognitive impairment compared to control in verbal fluency, Korean version of Mini Mental Status Examination in the CERAD-K (MMSE-KC), word list memory, trail making test, and frontal assessment battery (FAB). In contrast, no difference was observed between subjects who have low sleep quality (PSQI>5) and control group. Conclusions: At the exclusion of the impact of insomnia and depression, cognitive function was found to be relatively preserved in RLS patients compared to control. Impairment of visual recognition in RLS patients can be explained in terms of dopaminergic dysfunction in RLS.

소화관 폐색을 동반한 대장암 환자에서 중재적 치료의 역할

김은수,Eun Soo Kim 대한소화기암연구학회 2013 Journal of digestive cancer reports Vol.1 No.1

Incidence of colorectal cancer has been increasing in Korea probably due to the westernized life style. Although the technical development of colonoscopy and introduction of screening examination has led to the detection of early colorectal cancer, considerable patients still have clinical symptoms of colorectal obstruction. Most of these patients are old and they have advances stage of cancer or severe co-morbidities. In addition, the emergency operation under poor preparation state of colon can lead to serious mortality or complications. Since the introduction of colorectal stent, there have been a large number of studies for recent 10 years. It seems that the role of colorectal stent in the palliative indication or bridge to surgery has been recognized. A well designed, randomized prospective study with long term data is necessary to support the role of colorectal stent in the malignant colorectal obstruction.

유기용매중에서 Fe(Ⅲ), Mn(Ⅱ)과 p-aminoazobenzene 및 그 유도체와의 착물형성에 관한 연구

김은수,Eun Soo Kim 대한화학회 1988 대한화학회지 Vol.32 No.5

The complex formation of p-aminoazobenzene and its derivatives with Fe(III) and Mn(II) has been studied by UV and IR spectroscopy and conductometry. The effects of solvents, donor basicity, and other factors on the formation of these complexes have been examined. The vatio of metal to ligand for the complexes formed is 1 : 1, both in the solid state and in solution. The stability constants of Fe(III)-donor and Mn(II)-donor complexes are in the range of 10$^2$∼10$^4$ and 0.1∼1, respectively. The absorptivities are ~10$^4$ and ∼10$^3$ l/mol${\cdot}$cm respectively. Thermodynamic properties such as ${\Delta}H^{\circ}$, ${\Delta}G^{\circ}$ and ${\Delta}S^{\circ}$ are calculated from their stability constants utilizing Van't Hoff equation. Fe(Ⅲ) 및 Mn(Ⅱ)과 p-aminoazobenzene 및 그 유도체가 반응하여 형성된 착물들에 대하여 가시-자외선 및 적외선 분광광도법과 전기전도도방법을 이용하여 용매의 효과, donor의 염기도와 착물형성에 미치는 영향을 조사하였다. 그 결과 착물의 조성비, 안정도 상수 및 몰흡광계수를 구하여 van't Hoff식으로부터 ${\Delta}H^{\circ}$, ${\Delta}G^{\circ}$ 및 ${\Delta}S^{\circ}$를 계산하였으며 반응성과 등속도관계를 고려하여 반응속도와 평형조절인자를 알게 되었다.

양극성장애로 오인된 LGI1 자가면역성뇌염

김은수,이희준,전상원,조성준,Kim, Eun Soo,Lee, HeeJun,Jeon, Sang Won,Cho, Sung Joon 대한생물정신의학회 2020 생물정신의학 Vol.27 No.2

Leucine rich glioma inactivated (LGI1) encephalitis is an uncommon neurological disorder rarely encountered in clinical practice. However, it is a potentially fatal autoimmune syndrome that can decrease the level of consciousness, possibly progressing to coma. Additionally, unless diagnosed and promptly treated, it can cause permanent cognitive impairment. Since LGI1 encephalitis can initially present with psychiatric symptoms, there can be delays in reaching a proper diagnosis. This report describes a case of a 47-year-old woman with LGI1 antibodies-associated limbic encephalitis who initially presented with psychosis. Her blood tests were normal and no MRI and EEG abnormalities were found. Cerebrospinal fluid analysis was negative for other possible infectious causes. Three months after admission, she was found to be LGI1 antibody positive. LGI1 encephalitis should be suspected in patients with symptoms such as memory loss, confusion, seizures, and psychiatric symptoms. Prompt diagnosis and treatment of LGI1 encephalitis are warranted because prognosis becomes worse when such actions are delayed.

공급사슬망에서의 리스크 분류체계 연구

김은수,송병준,이종연,Kim, Eun-Soo,Song, Byung-Jun,Lee, Jong-Yun 한국정보처리학회 2012 정보처리학회논문지D Vol.19 No.3

본 연구는 화주와 물류업체의 협업을 통하여 급변하는 물류 환경에 유연하기 대응하기 위한 공급사슬망에서의 리스크 관리의 중요성과 리스크 분류체계를 제시하는데 있다. 이를 위하여 첫째, 공급사슬리스크와 관련된 기존연구를 고찰하여 18가지의 리스크 발생 원인별로 47개의 리스크요인을 파악하였다. 둘째, 파악된 리스크 요인을 토대로 기업 전문가 집단의 의견을 수렴하여 공급사슬망 관점에서 3개의 대분류와 10개의 중분류로 분류하였다. 셋째, 분류된 리스크에 대해 화주기업과 물류기업을 대상으로 설문 실시 후 확인적 요인분석, 집중타당성, 판별타당성 검증기법을 이용하여 공급사슬망 리스크 분류의 타탕도를 검증하였다. 마지막으로 검증결과를 바탕으로 시사점을 제시한다. The aim of this study is to present the importance of Risk Management and Risk Classification System in Supply Chain to cope with the rapidly changing distribution environment flexibly through the cooperation between a shipper and a distribution company. First of all, we considered existing studies related to the risks of Supply Chain Risk and analyzed 47 different risk factors by 18 kinds of risk causing factors. Second, we collected opinions of corporation specialist group based on the analyzed risk factors and then classified the risk factors into three categories and ten sub-categories. Third, we conducted a survey targeting shipping companies and distribution companies about classified risk and then verified the validity of Supply Chain Risk Classification using verification techniques such as Confirmatory Factor Analysis, Concentration Validity and Distinction Validity. Finally, we suggest some implications based on the verification results.

장대끈끈이주걱 분비모의 미세구조와 peroxidase 활성

김은수,오승은,유성철,Kim, Eun-Soo,Oh, Seung-Eun,Yu, Seong-Cheol 한국현미경학회 1998 Applied microscopy Vol.28 No.3

Glandular trichomes present on the leaf surface of Drosera capensis were examined using transmission electron microscopy. A large number of stalked glands exist on the adaxial surfaces of the leaf blade. The secretory head is composed of two layers of secretory cells, one layer of middle cells, and the inner tracheids. The secretory cells contain rough endoplasmic reticulum, mitochondria, plastids, Golgi apparatus, and vacuoles. The secretory cells show prominent cell wall ingrowth, and thick cuticle restricted on the subcuticular wall. Frequently, the cuticle has some pores, canal-like structures, showing electron -dense granules being penetrated through them. Ultrastructural localization using diaminobenzidine showed the electron-dense deposits in the vacuole. No peroxidase activity was seen in the cell wall and cytolasm. The activity of peroxidase (POX) isozymes in Drosera which isoelectric point (pI) is 3.6 and some anionic POX isozymes which pIs are laid between 3.6 and 4.6 were especially increased according to the development and the formation of glandular trichomes. Also, the activity of some POX isozymes which isoelectric points are laid between 4.6 and 5.1 were increased in the regions of leaves which has trichomes.

동일 색도 광원의 휘도 변화에 따른 색 순응 모델

김은수,장수옥,이성학,송규익,Kim Eun-Su,Jang Soo-Wook,Lee Sung-Hak,Sohng Kyu-lk 대한전자공학회 2005 電子工學會論文誌-SP (Signal processing) Vol.42 No.4

본 논문에서는 동일 광원에서 휘도 변화에 따른 색 순응 현상을 고려하여 원 피사체와 동일하게 보이는 대응색을 재현할 수 있는 색 순응 모델을 제안한다. 제안한 CAM$\Delta$Y는 저휘도 상태의 시험 색과 동일하게 보이는 고휘도의 상태의 대응색으로 변환하는 변환 행렬로 모델링하고, 제안 모델의 최적 계수 값들은 Breneman이 실험한 주위 휘도별 대응색 데이터들로부터 구한다. 제안한 색 순응 모델인 CAM$\Delta$Y에 의한 예측 대응색과 Breneman의 실험 데이터 간의 측색적 좌표 오차 $\Delta$u'v'를 비교해 본 결과, Breneman의 D55 광원의 세 가지 서로 다른 밝기에 대한 실험의 대응색과 제안한 모델에 의해 예측된 색과의 평균 측색적 좌표 에러 $\Delta$u'w'의 값이 0.004 정도로, 이는 제안 모델의 평균 측색적 좌표 오차가 인접한 (adjacent) 두 컬러 샘플간의 구별 색차 정도로 아주 작은 오차를 가짐으로 그 성능이 매우 좋음을 확인하였다. 또한 제안한 CAM$\Delta$Y를 이용하여 동일 광원의 밝기에 따른 동일한 백색으로 보이는 등백색 상관 색온도 곡선 (equal-whiteness CCT curve, EWC)을 제안한다. 제안한 둥백색 상관 색온도 곡선은 이제까지 TV 제조 업자들의 경험에 의해 결정된 디스플레이 장치의 기준 백색을 설정하는 정량적인 기준으로 사용될 수 있다 In this paper, we propose the chromatic adaptation models (CAM) for the variations of the luminance levels. A chromatic adaptation model, CAM$\Delta$Y , is proposed according to the change of luminance level under the same illuminants. The proposed model is obtained by the transform the test colors of the high luminance into the corresponding colors of the low luminance. In the proposed model, the optimal coefficients are obtained from the corresponding colors data of the Breneman's experiments. In the experimental results, we confined that the chromaticity errors, $\Delta$u'v', between the predicted colors by the proposed model and the corresponding colors of the Breneman's experiments are 0.004 in u'v' chromaticity coordinates. The prediction performance of the proposed model is excellent because this error is the threshold value that two adjacent color patches can be distinguished. Additionally, we also propose equal-whiteness CCT curves (EWCs) by CAM$\Delta$Y according to the luminance levels of the surround viewing conditions. And the proposed EWCs can be used as the theoretical standard which determines the reference white of the color display devices.

유도 저혈압하 양악 교정술 시 Nicardipine과 Remifentanil의 혈역학적 비교

김은수,황부영,김철홍,Kim, Eun-Soo,Hwang, Boo-Young,Kim, Cheul-Hong 대한치과마취과학회 2010 Journal of Dental Anesthesia and Pain Medicine Vol.10 No.2

Background: Controlled hypotension is used to reduce bleeding and improve surgical conditions during surgery. Nicardipine and remifentanil have been used to induce controlled hypotension in healthy patients. This study compared controllability of nicardipine and remifentanil on hemodynamic stability during controlled hypotension. Methods: Forty healthy patients scheduled for orthognathic two jaw surgery were randomly allocated to nicardipine (group N) and remifentanil (group R) group. After induction of anesthesia, group N (n = 20) was infused with nicardipine to induce hypotension and group R (n = 20) was infused with remifentanil. Mean arterial pressure (MAP) and heart rate (HR) were measured over 5 minute interval. Surgical field rating and blood loss were measured after surgery. Results: HR was lower in group R than group N. MAP was maintained at 50-60 mmHg during controlled hypotension but the fluctuation of blood pressure and HR were more frequent in group N than group R. There were no significant differences in the surgical field rating and blood loss between the groups. Conclusions: Nicardipine and remifentanil enabled controlled hypotension and provided good surgical conditions, but the fluctuation of hemodynamic parameters was more frequent in nicardipine group.

주위 시환경의 색도 변화에 따른 색 순응 모델

김은수,장수욱,이성학,송규익,Kim, Eun-Su,Jang, Soo-Wook,Lee, Sung-Hak,Sohng, Kyu-Ik 대한전자공학회 2005 電子工學會論文誌-SP (Signal processing) Vol.42 No.5

TV와 PC 모니터와 같은 컬러 디스플레이 장치 사용하는 실제 시환경은 표준 시환경과 상당히 다르다. 주위 시환경의 휘도와 색도의 변화에 따라 인간 시각계는 색 순응이 일어나게 되고, 사용자는 디스플레이 상에 재현된 측색적으로 동일한 색을 서로 다르게 느끼게 된다. 따라서 디스플레이에 재현된 색이 표준 시환경 하에서의 원래 색과 동일하게 재현하는 것이 중요하다. 본 논문에서는 동일한 휘도 조건에서 주위 조명광의 색도 변화에 따른 색 순응 모델을 제안한다. 제안한 색 순응 모델은 주위 시환경의 휘도 조건과 색도에 따라 시 세포의 L, M, 및 S 에 대한 감도의 이득을 모두 비선형 함수로 구한다. 그리고 제안한 색 순응 모델의 최적 이득 계수 값은 Breneman 색 순응 실험의 대응색 데이터들로부터 구한다. 제안한 색 순응 모델과 기존 모델들의 성능을 평가해 본 결과, 제안 방식의 색 순응 모델이 기존의 모델에 비해서 전 휘도 조건에서 매우 우수한 성능을 가짐을 확인하였다. 또한, 실제 시환경하에서 제안한 색 순응 모델을 이용하여 재현한 대응색이 표준 시환경 하에서의 원래의 색과 동일하게 보이는 것을 확인하였다. Real surround viewing conditions in watching the color display devices such as TV and PC monitor are quite different from the standard viewing conditions. Human visual system is adapted chromatically under the different viewing conditions in luminance levels and chromaticity of illuminants. Accordingly, the reproduced colors of the same chromaticity will appear as quite different color. Therefore, it is necessary that the displayed colors are reproduced to be appeared as the original colors in the standard viewing conditions. In this paper, we propose a chromatic adaptation model for the variations of the surround illuminants' chromaticity under the same luminance conditions. In proposed chromatic adaptation model, we calculate each gain of L, M, and S as nonlinear functions according to the chromaticity of the surround illuminants. And the optimal coefficients are obtained from the corresponding colors data of the Breneman's experiments. The proposed chromatic adaptation model is compared with the conventional chromatic adaptation models. In the experimental results, the proposed model has very good performance in the whole range of luminance levels. We also experimentally confirmed that the reproduced corresponding colors using the proposed chromatic adaptation are appeared as the original colors when the real surround viewing conditions are different from the standard viewing conditions.

Imidazole 염색에 의한 분비지질의 조직화학적 연구

김은수,Kim, Eun-Soo,Mahlberg, Paul G. 한국현미경학회 2000 Applied microscopy Vol.30 No.2

Lipophilic glandular trichomes form secretory vesicles that accumulate in a distended noncellular secretory cavity . Imidazole-buffered osmium tetroxide solution was used to visualize unsaturated lipids in glands of Cannabis sativa. This method of staining revealed two kinds of secretory vesicles in the cavity of glands. Some smaller and rounded vesicles in the secretory cavity and secretory cells were positively stained with the imidazole, and they appeared electron-dense. The other type of vesicles which have bigger sizes more or less were not reacted, however, they appeared transparent. A high contrast of the cuticles which cover the gland was also strongly reacted with that processing. Those result suggest that the dark vesicles in the cavity may contribute to enlarge the subcuticular wall and cuticle when contents of these vesicles are dispersed into wall.