간전이 위암환자의 치료 결과 및 예후

김은미,김세원,김상운,이경희,현명수,박원규,장재천,송선교,Kim, Eun-Mi,Kim, Se-Won,Kim, Sang-Woon,Lee, Kyung-Hee,Hyun, Myung-Soo,Park, Won-Kyu,Chang, Jae-Chun,Song, Sun-Kyo 대한위암학회 2006 대한위암학회지 Vol.6 No.4

목적: 간전이 위암환자들을 대상으로 치료 결과를 알아보고 생존 분석을 통해 예후를 확인하고자 하였다. 대상 및 방법: 1990년 3월부터 2006년 3월까지 영남대학교 영남의료원 내과 및 외과에 내원한 위암환자 중 간전이가 발견된 85예(동시성 62예, 이시성 23예)를 대상으로 후향적 연구를 시행하였다. 임상병리학적 인자와 위절제술, 간전이병소 절제술 및 항암화학요법 등 치료 관련 인자들에 대해 생존분석을 실시하였다. 결과: 간전이 위암환자들의 중앙생존기간은 11개월(동시성 11개월, 이시성 17개월)이었다. 동시성 간전이군의 경우 위절제율은 24.1%, 간전이병소 절제율은 16.1%였다. 간외 전이 동반율은 23.5%였고 생존기간에 차이가 있었다(P<0.05). 간전이 병소 절제 및 위절제군, 위절제군, 비절제군의 중앙생존기간은 각각 60개월 이상, 10개월 및 9개월이었다(Fig. 1, P<0.05). 이시성 간전이군의 경우 위암절제 후 무병생존기간의 중앙치는 8개월이었으며 초기병기와 간전이 빈도 사이에는 차이가 없었다. 동시성 간전이군에서는 단변량 분석 결과 간외 전이, 위절제술, 간전이 병소 절제술, 외과적 절제 형태 및 항암화학요법에 대한 반응이 유의하였고 다변량 분석 결과 간전이병소 절제술, 항암화학요법에 대한 반응 및 간외 전이가 독립적 예후인자였고, 이시성 간전이군에서는 간외 전이, 항암화학요법에 대한 반응 및 원발암 세포의 분화도가 유의하였고 간외 전이가 독립적 예후인자였다. 결론: 간전이 위암환자에서 예후는 간전이 병소의 절제, 원발 병소의 절제, 간외 전이 유무 및 항암화학요법에 대한 반응여부에 의해 결정되므로 치료에 있어 간외 전이가 없는 경우 보다 적극적인 절제 노력과 항암화학요법이 생존율 향상에 기여할 것으로 판단된다. Purpose: This study was conducted to evaluate the treatment outcomes and the prognosis for gastric cancer patients with hepatic metastasis. Materials and Methods: This retrospective study was based on the medical records of 85 gastric cancer patients with hepatic metastasis (62 synchronous and, 23 metachronous) who received chemotherapy with or without resectional therapy from March 1990 to March 2006. The survival rate was analyzed according to clinicopathologic factors and therapeutic factors, such as whether or not a gastrectomy, a hepatic resection, and/or chemotherapy had been performed. Results: The median survival of gastric cancer patients with hepatic metastasis was 11 months (synchronous: 11 months and metachronous: 17 months). The rates of gastrectomies and hepatic resections in the synchronous group were 24.1% and 16.1%, respectively A 23.5% prevalence of extra-hepatic metastasis was observed. The median survivals of patients who underwent a gastrectomy with a hepatic resection, a gastrectomy alone, and non-surgical treatment were 60, 18, and 9 months, respectively (P<0.05). The disease-free median survival of the metachronous group was 8 ($3{\sim}39$) months. There was no difference in initial pathologic stage and frequency of hepatic metastasis after the gastrectomy in the metachronous group. In the synchronous group, extra-hepatic metastasis, a gastrectomy as the operative procedure, a hepatic resection as the operative procedure and the response to chemotherapy were statistically significant in the univariate analysis, and a hepatic resection as the operative procedure, the response to chemotherapy, and extra-hepatic metastasis were independant prognostic factors identified by the multivariate analysis. In the metachronous group, extra-hepatic metastasis, the response to chemotherapy and differentiation were statistically significant in the univariate analysis, and extra-hepatic metastasis was an independent prognostic factor identified by the multivariate analysis. Conclusion: An aggressive surgical therapy and effective chemotherapy are necessary in the treatment of gastric cancer patients with hepatic metastasis. (J Korean Gastric Cancer Assoc 2006;6:237-243)

간호사가 인식한 이차 피해 경험이 삼차 피해 경험에 미치는 영향과 이차 피해 지지의 다중 매개효과

김은미,김순애,김지인,이주리,나선경,Kim, Eun-Mi,Kim, Sun-Aee,Kim, Ji-In,Lee, Ju-Ry,Na, Sun-Gyoung 한국의료질향상학회 2017 한국의료질향상학회지 Vol.23 No.2

Purpose: Nurse's second victim experiences could influence organizational negative work-related outcome. The purpose of this study was to investigate the casual relationship between nurses' second victim experience and third victim experience and multiple mediation effects of second victim supports. Methods: A cross-sectional, self-report survey (the Second Victim Experience and Support Tool) was conducted with 305 nurses working in a general hospital. Data were collected from October 20 to November 25, 2016 and analyzed using SPSS Win version 23.0. Results: The nurses' perceived second victim experience was $3.24{\pm}0.61$ and the third victim experience was $3.12{\pm}0.92$. Nurses' second victim experience was found to have a direct effect on increasing third victim experience and indirect effect of colleague support as mediator (p<.05). However, institutional support and supervisor support had not a partial and indirect effect on third victim experience. Conclusion:This study is one of the first to connect second victim experience to third victim experience in South Korea. This study broadens the understanding of the negative effects of a second victim experience influence third victim experience. When involvement in patient safety events, the important role of colleague support in limiting nurse's third victim experience have been acknowledged. This study reinforces the efforts health care leaders are making to develop interventional programs to colleague support their staff as they recover from adverse event involvement.

국내외 산업동향 - 국내식자재 산업동향과 식품안전관리시스템

김은미,Kim, Eun Mi 한국식품연구원 2013 食品技術 Vol.26 No.3

표고버섯의 미토콘드리아성 NADH 탈수소효소의 특성

김은미,민지영,민태진 ( Eun Mi Kim,Ji Young Min,Tae Jin Min ) 한국균학회 1998 韓國菌學會誌 Vol.26 No.1

Complete genome sequence of Neisseria sp. KEM232 isolated from a human smooth surface caries

김은미,성치남,Kim, Eun Mi,Seong, Chi Nam The Microbiological Society of Korea 2018 미생물학회지 Vol.54 No.1

Neisseria 속 균주 KEM232는 사람 평활면 치아우식 부위로부터 분리하였다. 균주 KEM232의 유전체는 G + C 비율이 58.5%, 2,369개의 유전자와 2,210개의 단백질 코딩 유전자, 108개의 위유전자, 51개의 RNA 유전자 그리고 한 개의 CRISPR array를 포함한 단일 원형 염색체로 구성되었으며 그 크기는 2,371,912 bp였다. 균주 KEM232의 최 근연종은 Neisseria baciliformis 로서 두 균주 사이의 16S rRNA 유전자 염기서열의 유사도는 96.8% 그리고 유전체의 평균 염기 동일성은 84%였다. We sequenced the genome of the Neisseria sp. KEM232 isolated from the smooth surface caries of human cavity of a 7-year old male in Republic of Korea by using the standard dilution plating technique. The genome comprises a single circular 2,371,912 bp chromosome with a G + C content of 58.5%, 2,210 protein-coding genes, 108 pseudo genes, 51 RNA genes, and one CRISPR array. Based on the 16S rRNA gene sequence similarity and average nucleotide identity, the strain KEM232 is most closely related to Neisseria baciliformis.

Rayon-mimetic 섬유의 분산염료에 의한 염색 및 견뢰도 특성

김은미,최재홍,Kim, Eun-Mi,Choi, Jae-Hong 한국섬유공학회 2008 한국섬유공학회지 Vol.45 No.4

The dyeing characteristics and fastness of rayon-mimetic (RMM) fiber were examined with some commercial disperse dyes compared to those of poly(ethylene terephthalate) fiber. Similar exhaustion yields were achieved at $120^{\circ}C$ to $130^{\circ}C$ which ranged from 90% to 99%. Critical adsorption range of disperse dyes on RMM fiber was lower than regular PET fiber about $10^{\circ}C$. Exhaustion was saturated at 2% owf dye concentration. Color fastness of RMM was similar to those of PET dyeings including fastness to wash, rubbing and light.

Kernel Relaxation과 동적 모멘트를 조합한 Support Vector Machine의 학습 성능 향상

김은미,이배호,Kim, Eun-Mi,Lee, Bae-Ho 한국정보처리학회 2002 정보처리학회논문지B Vol.9 No.6

This paper proposes learning performance improvement of support vector machine using the kernel relaxation and the dynamic momentum. The dynamic momentum is reflected to different momentum according to current state. While static momentum is equally influenced on the whole, the proposed dynamic momentum algorithm can control to the convergence rate and performance according to the change of the dynamic momentum by training. The proposed algorithm has been applied to the kernel relaxation as the new sequential learning method of support vector machine presented recently. The proposed algorithm has been applied to the SONAR data which is used to the standard classification problems for evaluating neural network. The simulation results of proposed algorithm have better the convergence rate and performance than those using kernel relaxation and static momentum, respectively. 본 논문에서는 커널완화법과 동적모멘트를 이용한 support vector machines의 학습성능 개선을 제안하였다. 제안된 학습 방법은 기존의 정적모멘트와는 달리 수렴 정도에 따라 현재의 학습에 과거의 학습 속성을 반영하는 동적모멘트 방법이다. 기존의 정적 상수로 정의된 모멘트가 전체 학습에 동등하게 영향을 주는 반면 제안된 동적모멘트를 이용한 학습방법은 학습 수행에 따라 동적으로 모멘트를 변경함으로써 수렴속도와 학습 성능을 효과적으로 제어할 수 있다. 제안된 학습법을 support vector machine의 새로운 순차 학습 방법인 커널완화법에 적용하였다. 신경망 분류기 표준 평가 데이터인 SONAR 데이터를 이용하여 실험한 곁과 동적모멘트를 이용한 방법이 수렴속도와 학습 성능면에서 기존의 커널완화법과 정적모멘트를 이용한 학습법에 비해 향상된 성능을 보이는 것을 확인하였다.

Si기판 위에 Ba_0.5Sr_0.5TiO₃ 산화물 에피 박막의 집적화 및 박막의 유전 특성에 관한 연구

김은미,문종하,이원재,김진혁,Kim, Eun-Mi,Moon, Jong-Ha,Lee, Won-Jae,Kim, Jin-Hyeok 한국세라믹학회 2006 한국세라믹학회지 Vol.43 No.6

Epitaxial $Ba_{0.5}Sr_{0.5}TiO_3$ (BSTO) thin films have been grown on TiN buffered Si (001) substrates by Pulsed Laser Deposition (PLD) method and the effects of substrate temperature and oxygen partial pressure during the deposition on their dielectric properties and crystallinity were investigated. The crystal orientation, epitaxy nature, and microstructure of oxide thin films were investigated using X-Ray Diffraction (XRD) and Transmission Electron Microscopy (TEM). Thin films were prepared with laser fluence of $4.2\;J/cm^2\;and\;3\;J/cm^2$, repetition rate of 8 Hz and 10 Hz, substrate temperatures of $700^{\circ}C$ and ranging from $350^{\circ}C\;to\;700^{\circ}C$ for TiN and oxide respectively. BSTO thin-films were grown on TiN-buffered Si substrates at various oxygen partial pressure ranging from $1{\times}10^{-4}$ torr to $1{\times}10^{-5}$ torr. The TiN buffer layer and BSTO thin films were grown with cube-on-cube epitaxial orientation relationship of $[110](001)_{BSTO}{\parallel}[110](001)_{TiN}{\parallel}[110](001)_{Si}$. The crystallinity of BSTO thin films was improved with increasing substrate temperature. C-axis lattice parameters of BSTO thin films, calculated from XRD ${\theta}-2{\theta}$ scans, decreased from 0.408 m to 0.404 nm and the dielectric constants of BSTO epitaxial thin films increased from 440 to 938 with increasing processing oxygen partial pressure.

각국의 식생활 교육.정책

김은미,Kim, Eun-Mi 한국식품연구원 2009 食品技術 Vol.22 No.3

공정거래정책 리포트 - 사건처리의 공정성 제고와 법 집행 강화를 위한 지침 개정 동향

김은미,Kim, Eun-Mi 한국공정경쟁연합회 2012 경쟁저널 Vol.- No.164