High - index 대수 미분방정식으로 모델링된 비선형 화학 공정의 구조적 제어성 평가

김윤식,윤인섭 ( Yoon Sik Kim,En Sup Yoon ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

Microwave Oven용 마그네트론의 전력제어에 관한 연구

김윤식,김종수,이성근,Kim Yoon-Sik,Kim Jong-Soo,Lee Sung-Gun 한국마린엔지니어링학회 2004 한국마린엔지니어링학회지 Vol.28 No.7

This paper describes a output power control of magnetron for microwave oven. Magnetron is used extensively in household microwave oven and industrial microwave heating devices it is operated by 3000[V]~5000[V] dc high voltage. Power supply for driving magnetron is consisted of a bridge rectifier. HB(half bridge) inverter, full wave rectifier and gate drive circuit. In proposed system. we confirm that line input power can be controlled extensively and linearly to 24.56[%] by change of duty ratio of inverter through a experiment.

병렬 컨버터에 의한 스위치모드 승압 정류기의 효율 개선

김윤식,김성환,오세진,이성근,전내석,Kim Yoon Sik,Kim Seong Hwan,Oh Sae Gin,Lee Sung Geun,Jeon Nae Sock 한국마린엔지니어링학회 2005 한국마린엔지니어링학회지 Vol.29 No.2

A new technique for improving the efficiency of single-Phase high-frequency switch-mode boost rectifiers is proposed. This rectifier includes an additional boost converter that parallels the main high-frequency switching device. The additional converter. which is controlled at lower frequencies. bypasses most of the current in the main switch and the high frequency switching loss is greatly reduced accordingly. The rectifier works cooperatively in high efficiency and as if it were a conventional rectifier with one switching device. The proposed scheme is verified by computer simulation using software PSIM.

만성치주염 환자에 대한 저용량 독시싸이클린의 임상적 효과

김윤식,백정원,김창성,최성호,김종관,Kim, Yoon-Sik,Paik, Jeong-Won,Kim, Chang-Sung,Choi, Seong-Ho,Kim, Chong-Kwan 대한치주과학회 2002 Journal of Periodontal & Implant Science Vol.32 No.2

Periodontal disease is a complex infectious disease caused by bacteria in the oral mucosa, which results in gingival inflammation, breakdown of periodontal tissues, bone resorption, and finally tooth loss. Mechanical plaque control methods-scaling and root planing are effective methods to stop the progression of such periodontal disease. It was reported that subantimicrobial dose of doxycycline(SDD) regimen could improve clinical conditions of periodontal tissues without causing the overgrowth of opportunistic organisms that was a typical antibiotic side effect. Therefore pharmacological therapy, used in conjunction with mechanical therapy could be considered a useful treatment modality in the treatment of chronic periodontal disease. In this study, 30 patients diagnosed as moderate to advanced chronic periodontitis were divided into 2 groups. In this double-blind, placebo-controlled study, the patients were administered 20mg doxycycline capsule or placebo capsule b.i.d. for 4months, after scaling and root planing. Clinical parameters-bleeding on probing, pocket depth and clinical attachment level were compared and evaluated between these groups at periods of first visit, 1 month, 2 months, 3 months, 4 months. The results were as follows ; 1. In case of moderate periodontitis, pocket depth showed significant reduction after treatment in both the control & experiment groups, when compared with the baseline values(p<0.01), but in case of advanced periodontitis, only the experiment group showed significant reduction after treatment when compared with the baseline values(p<0.05). Statistically significant reduction in pocket depth was observed in the experiment group compared to the control group(p<0.05). 2. In case of moderate periodontitis, clinical attachment level showed significant reduction after treatment in both the control & experiment groups, when compared with the baseline values(p<0.01), but in case of advanced periodontitis, only the experiment group showed significant reduction after treatment when compared with the baseline values(p<0.05). Statistically significant reduction in clinical attachment level was observed in the experiment group compared to the control group(p<0.05). 3. Bleeding on probing improved after treatment in both the groups. In case of moderate periodontitis, the experiment group showed statistically significant reduction of bleeding on probing when compared with the control group at 1 and 4 months after treatment(p<0.05). In case of advanced periodontitis, treatment resulted in statistically significant reduction of bleeding on probing in both the groups(p<0.05). These results indicate that the use of subantimicrobial dose of doxycycline is a useful supplement to mechanical treatment for periodontal patients in ameliorating the clinical parameters such as periodontal pocket, attachment level, and bleeding on probing.

임신 초기 임신양상에 따른 혈청 β-hCG의 결과 예측에 의한 희석배수 참고치 설정

김윤식,신장용,서영미,유신수,Kim, Yoon Sik,Shin, Jang Yong,Seo, Yeong Mi,Yoo, Shin Soo 대한임상검사과학회 2004 대한임상검사과학회지(KJCLS) Vol.36 No.2

This study was carried out to predict the value of serum ${\beta}$ subunit of humans chorionic gonadotropin(${\beta}$- hCG) in early pregnancy viability. This was performed among 85 women in vitro fertilization and embryo transfer(IVF-ET). The serum ${\beta}$-hCG levels were established for 30 normal singleton pregnancies, 10 twin and triplet pregnancies, 10 preclinical abortions, 10 clinical abortions, 20 biochemical abortions and 5 ectopic pregnancies. In comparison to normal singleton pregnancies, multiple pregnancies showed higher ${\beta}$-hCG. But clinical abortions, preclinical abortions and ectopic pregnancies showed lower ${\beta}$-hCG levels than singleton pregnancies. In conclusion, if we predict the value of serum ${\beta}$-hCG of variable early pregnancies and analyze it, we could predict the dilution protocol. Also, it can be useful in other ways.

H. pylori 감염 진단 시 ¹⁴C-요소호기검사의 임상적 유용성

김윤식,Kim, Yoon-Sik 대한임상검사과학회 2007 대한임상검사과학회지(KJCLS) Vol.39 No.3

Helicobacter pylori (H. pylori) infection is common in korea and high incidence at gastric ulcer and duodenal ulcer. $^{14}C-urea$ breath test ($^{14}C-UBT$) is regarded as a highly reliable and non-invasive method for the diagnosis of H. pylori infection. The purpose of this study was to evaluate the diagnositc performance of a new and rapid $^{14}C-UBT$, which was equipped with Geiger-Muller counter and compared the results with those obtained by gastroduodenoscopic biopsies (GBx). One hundred sixty-eight patients (M : F = 118 : 50) underwent $^{14}C-UBT$, rapid urease test (CLO test), and GBx. The results of $^{14}C-UBT$ were classified as positive (>50 cpm), borderline (25<p<50 cpm), or negative (<25 cpm) and CLO tests were classified as positive or negative according to color change. The results of GBx on giemsa stain were distribution of H. pylori by the Wyatt method. We compared $^{14}C-UBT$ or CLO test results with GBx as a glod standard. In the assessment of the presence of H. pylori infection, the $^{14}C-UBT$ global performance yielded positive predictive value, negative predictive value and accuracy of 93.3% and 83.3%, respectively. However, the CLO test had performance yielded positive predictive value, negative predictive value and accuracy of 76.9%, 50.0%, respectively. In this study $^{14}C-UBT$ is a highly accurate, simple and non-invasive method or the diagnosis of follow up H. pylori infection.

마르크스주의의 관점에서 본 기후변화에 대한 일 고찰

김윤식(Yoon Sik Kim) 경상대학교 사회과학연구소 2016 사회과학연구 Vol.34 No.-

This paper is a comparative analysis of papers on climate change in the Marxist camp centered on Marx and Engels" "A View of Nature". The left gruop of the Progressive camp argues that Marxism is lacking in "ecological sensitivity", or would be cautious about generalizations and "class contradiction reductionism". However, it can be seen that Marx"s "economics, philosophy and capitalism" and Engels" "MEGA" refer to "human beings and nature" as interactions. Therefore, it is concretely stated through the root cause of capitalist environmental destruction and the mode of production between man and nature, and Bellamy Foster is moving the theory and practice into action with Engels" standpoint. Therefore, the mechanism of the interaction between the laws of motion of capitalism and the mode of production and production relations is to examine the consciousness of the problem of climate change in Engels" "A view of Nature".

H. pylori 감염 진단 시 14C-요소호기검사의 a임상적 유용성

김윤식 ( Yoon Sik Kim ) 대한임상검사과학회 2007 대한임상검사과학회지(KJCLS) Vol.39 No.3

Helicobacter pylori (H. pylori) infection is common in korea and high incidence at gastric ulcer and duodenal ulcer. 14C-urea breath test (14C-UBT) is regarded as a highly reliable and non-invasive method for the diagnosis of H. pylori infection. The purpose of this study was to evaluate the diagnositc performance of a new and rapid 14C-UBT, which was equipped with Geiger-Muller counter and compared the results with those obtained by gastroduodenoscopic biopsies (GBx). One hundred sixty-eight patients (M : F = 118 : 50) underwent 14C-UBT, rapid urease test (CLO test), and GBx. The results of 14C-UBT were classified as positive (>50 cpm), borderline (25<p<50 cpm), or negative (<25 cpm) and CLO tests were classified as positive or negative according to color change. The results of GBx on giemsa stain were distribution of H. pylori by the Wyatt method. We compared 14C-UBT or CLO test results with GBx as a glod standard. In the assessment of the presence of H. pylori infection, the 14C-UBT global performance yielded positive predictive value, negative predictive value and accuracy of 93.3% and 83.3%, respectively. However, the CLO test had performance yielded positive predictive value, negative predictive value and accuracy of 76.9%, 50.0%, respectively. In this study 14C-UBT is a highly accurate, simple and non-invasive method or the diagnosis of follow up H. pylori infection.

원저 : 혈액과 양수, 조직등에서 삼염색체 20의 핵형분석 고찰

김윤식 ( Yoon Sik Kim ) 대한임상병리사협회 2007 임상혈액검사학회 발표자료집 Vol.9 No.1

Trisomy 20 is the most common autosome mosaicim diagnosed from genetic amniotic fluid and placental tissue(or CVS). Only rarely 100% trisomy 20 was identified of cells culture from the amnion and placental tissue. But not in fetal tissue and blood cell culture. Complete trisomy 20 is not viable. Outcome of prenatally detected trisomy 20 mosaicism is normal phenotype in 90-95 % of cases. Abnormal phenotype has been in 5-10% of the reported cases of trisomy 20 detected on amniocentesis. Abnormal outcomes found include unexplained fetal demise, intrauterine growth restriction(IUGR) and multiple congenital anomalies. It remains a dilemma in diagnosis and counselling. There are many case reports from abroad on trisomy 20, some of which involve long-term follow-up and outcome, but it IS hard to find out such reports in Korea. We report on a domestic case of trisomy 20 which we observed in amniotic fluid and placental tissue cultures. but trisomy 20 has never been detected in cord blood, fetal blood and fetal tissue cultures.

정상 자궁근조직과 자궁근종조직에서 FSTL1 유전자 클로닝 및 발현양상

김윤식 ( Yoon Sik Kim ),김재성 ( Jae Sung Kim ),천영일 ( Yong Ri Qian ),이미홍 ( Mei Hong Li ),김지은 ( Ji Eun Kim ),천예영 ( Yea Young Chun ),기광수 ( Kwang Soo Kee ),전홍성 ( Hong Sung Cheon ),김성준 ( Sung Jun Kim ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.6

목적 : 정상자궁근조직과 자궁근종조직사이에서 다르게 발현되는 유전자 클로닝 및 발현양상을 비교ㆍ분석을 위한 실험을 실시하고자 한다. 연구 방법 : 광주기독병원 산부인과에서 2002년 9월부터 2003년 9월까지 자궁적출술, 근종절제술, 제왕절개술을 받은 25명의 환자의 정상자궁근조직과 자궁근종조직에서 total RNA를 분리하였다. Differential display PCR에서 분리된 유전자를 클로링하여 유전자염기서열분석을 하였으며, PCR을 이용하여 자궁근종조직과 정상자궁근조직사이에서 유전자 발현비의 양상을 비교ㆍ분석하였다. 유의치 검증은 paired t test을 이용하여 p<0.05로 하였다. 결과 : Differential display PCR에 의해 분절된 유전자는 FSTL1으로 자궁근종조직과 정상자궁근조직에서 FSTL1의 발현비의 양상을 보면, 생식연령기 여성에서는 정상자궁근조직 및 인접 정상자궁근조직에서 자궁근종조직보다 유의하게 )p<0.05) 높게 나타났으며, 이에 반하여 폐경연령기 여성에게서는 자궁근종조직에서 유의하게 (p<0.05) 높게 나타났으며, 인접 정상자궁근조직에서는 유의한 차이는 없었다. 자궁근종 축소 호르몬치료군에서 1.4-1.6배 유의하게 (p<0.05) 높았고, 폐경기 증상완화 비치료군에서 1.6-2.0배 유의하게 (p<0.05) 높았다. 결론 : FSTL1의 작용기전은 확실하지 밝히지 못했지만, 자궁근종조직과 정상자궁근조직의 발현양상을 비교ㆍ분석해 볼 때 자궁근종에서의 FSTL1은 estrogen에 의해 직ㆍ간접적으로 조절되는 자궁근종성장억제인자일 것으로 사료된다. Objective : To study the influence and cloning of differentially expressed genes in human female normal myometrium and uterine leiomyoma tissue. Methods : In this experiment, human uterus tissues (n=25) were taken for total RNa isolation by using Trizol reagent. Differential display was performed by using GeneFishing^TM DEG Kit and processed to cDNA sequencing and gene cloning for Follistatin-like 1 (FSTL1). Data were analyzed with the image Master VDS software and statistical significance was defined as p<0.05 by paired t test results. Results : FSTL1 mRNA expression level was significantly higher 9p<0.05) in normal and adjacent normal myometrium tissues than uterine leiomyoma tissue of women int the reproductive age. Whereas in the menopausal age, FSTL1 mRNA expression level was significantly higher (p<0.05) in uterine leiomyoma than normal myometrium. There was no significant differences between uterine leiomyoma and adjacent normal myometrium. Conclusion : Although the mechanisms of FSTL1 gene were uncertain, FSTL1 seemed to play an important role in the growth of uterine leiomyoma, it also might be related to the regulation of uterine leiomyoma growth inhibiting factors by modulating Follistatin related protein gene (FLRG) system.