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김유겸(Yoo Kyum Kim),이정신(Jung Shin Lee),김원동(Won Dong Kim),김기용(Key Yong Kim) 한국의학교육학회 1995 Korean journal of medical education Vol.6 No.2
It has pointed out that there are problems in the traditional medical education in Korea. First of all, basic science and clinical education were not integrated so that students can not develop abilit ies to incorporate scientific concepts and principles into solving clinical problems. In order to improve medical education, new educational program was developed in College of Medicine, University of Ulsan, which started medical education in 1990. Among the many types of new medical educational system, the program from the University of Calgary, which was thought to be more applicable to educational environment in Korea, was adopted. The new program comprises principles of (1) integrated teaching, (2) patient-oriented, (3) problem-oriented, (4) student-oriented, (5) adoption of core and elective course and (6) self learning. During the first two year period, integrated curriculum of eleven system courses(musculoskeletal, hematology oncology, immunology and infection, gastroenterology, endocrinology, reproductive, nephrology, cardiology, pulmonology and neuroscience), introductory course, continuity course, elective course, clinical skills, independent study and integrative course were proceeded. Students have spent the last two years in clinical clerkships, including 4 months of elective course. Students evaluated the integrated curriculum as being satisfactory for clinical education, but not enough for basic science education.
AIDS 환자에서 CD4+ T 세포수 감소에 따른 CMV 감염
조영걸,김유겸,오원일,조군제,Cho, Young-Keol,Kim, Yoo-Kyum,Oh, Won-Il,Cho, Goon-Jae 대한미생물학회 1998 Journal of Bacteriology and Virology Vol.28 No.4
Cytomegalovirus is the most common cause of life-threatening viral infection in HIV-infected patients. This study was done prospectively to investigate the incidence of CMV infection according to the decrease of CD4+ T cell count (CD4+) in Korean AIDS patients. Thirty-nine HIV-infected patients diagnosed before 1994 were followed for regular immunological monitoring. We have used urine shell vial method for the CMV detection from 1994 and have also checked clinical findings. Positive urine culture rate definitely depended on the CD4+ as follows; 45%, 22%, 17%, 11% and 0%, CD4+ <50, 50-100, 100-200, 200-500 and >500, respectively. Except culture positive 2 patients with CD4+ of $200{\sim}300/{\mu}l$, all eight culture positive patients with CD4+ less than $200/{\mu}l$ showed CMV related diseases on or before urine culture. But, we could not get a positive culture for a late AIDS patient with vision loss. With ganciclovir therapy, all culture results were at least negative just after or on late of first 14 days-ganciclovir infusion-course. These data suggest that the incidence of CMV disease in Korean AIDS patients is very high, and early diagnosis and treatment for CMV diseases is required for the prevention of life threatening results.
비 AIDS 면역 결핍 환자들에서 발생한 주폐포자충 폐렴의 예후인자
박완 ( Wann Park ),김유겸 ( Yoo Kyum Kim ),이진성 ( Jin Seong Lee ),안종준 ( Jong Jun Ahn ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),김우성 ( Woo Sung Kim ),김동순 ( Dong Soo 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.4
중합 효소 연쇄 반응을 이용한 Salmonella typhi 편모 항원 j 변이체의 검출
송재훈(Jae Hoon Song),김유겸(Yoo Kyum Kim),배직현(Chik Hyun Pai) 대한내과학회 1992 대한내과학회지 Vol.43 No.2
N/A Background: Most species of Salmonella have the phenomenon of phase variation of flagellar antigens, the alternation between expression of two flagellin genes, at loci called H1 (fli C) and H2 (flj B). Salmonella typhi, the etiologic agent of typhoid fever, typically has only a phase-1 flagellar antigen, H,-d, but some isolates, found only in Indonesia, have antigenj (H1-j) instead as a phase-1 antigen. H,-j antigen consists of 1269bp sequence resulting from the deletion of 261bp from the total 1530bp of the H1-d antigen and could be detected by polymerase chain reaction (PCR). The ex5ct prevalence of H1-j strain in other parts of the world and its clinical significance ere still open questions. Methods: To investigate the presence of H1-j strains among Korean isolates of S. typhi, we performed PCR for 46isolates from Asan Medical Center, Seoul, Korea. A 1530-bp fragment of H., d antigen was amplifed with specific primers and was analyzed by 1.5% agarose gel electrophoresis. H1-j antigen, if present, could be identifed as a 1269-bp fragment in this PCR- electrophoresis. Results; Of the 46 isolates examined, only one was found to possess the 1269-bp H,-j antigen. Other 45 isolates showed the 1530 bp fragments of H1-d antigen. The isolate with H1-j antigen was cultured from a Korean-Indonesian who was symptomatic in Indonesia when he left for Korea. Conclusions: These results suggest that there are no H1-j strains S. tyPhi among those endemic in Korea. This study will be extended to the larger scale including more S. typhi isolates in Korea.