만성 발목 관절 외측 불안정성의 진단에서 스트레스 방사선검사의 유용성

김용민,조병기,김동수,최의성,손현철,박경진,김동환,Kim, Yong-Min,Cho, Byung-Ki,Kim, Dong-Soo,Choi, Eui-Sung,Shon, Hyun-Chul,Park, Kyoung-Jin,Kim, Dong-Hwan 대한정형외과스포츠의학회 2011 대한정형외과스포츠의학회지 Vol.10 No.1

목적: 만성 발목 관절 외측 불안정성 환자에 대한 기계적 불안정성의 평가에서 스트레스 방사선검사의 진단적 유용성을 알아보고자 하였다. 대상 및 방법: 본원에서 변형 Brostrom 술식을 시행받은 환자들 중 수술 소견상 외측 측부인대(전 거비 인대)의 완전 파열이 확인되었던 42예를 대상으로 하였다. 대조군으로는 발목 관절 손상의 과거력이 없고 이학적 검사상 불안정성 소견을 보이지 않는 정상 한국인 성인 총 60명(120예)을 모집하였다. Telos 기구를 이용한 전방 전위 및 내반 스트레스 검사를 시행한 뒤, 거골 경사각과 거골 전방전위 정도를 계측하였다. 대조군에서 얻어진 정상범위를 기준으로 스트레스 방사선검사의 민감도, 특이도, 양성 예측도, 음성 예측도를 분석하였다. 결과: 스트레스 방사선검사 상 정상 한국인 성인에서의 거골 경사각은 평균 $4.2{\pm}2.1$도, 거골 전방전위는 평균 $3.9{\pm}1.9$ mm로 계측되었다. 95% 신뢰한계 분석을 이용한 정상 범위의 설정시 거골 경사각의 정상 범위는 8.3도 이하, 거골 전방전위는 7.6 mm 이하로 분석되었다. 이 수치를 기준값으로 하는 경우 발목 관절 스트레스 방사선검사 상 거골 경사각의 민감도는 57%, 특이도는 97%, 양성 예측도는 89%, 음성 예측도는 86% 였고, 거골 전방전위의 민감도는 69%, 특이도는 97%, 양성 예측도는 91%, 음성 예측도는 90% 였다. 결론: 만성 발목 관절 외측 불안정성 환자에 대한 기계적 불안정성의 평가에서 스트레스 방사선검사는 비교적 우수한 특이도 및 양성, 음성 예측도를 보였으나 민감도는 낮아, 유용하지만 정확성은 떨어지는 검사법인 것으로 분석되었다. 기계적 불안정성이 발목 관절 스트레스 방사선검사 상 실제보다 덜 반영된다고 생각되며, 스트레스 방사선검사 소견만으로 발목 관절 외측 불안정성을 배제해서는 안 될 것으로 생각한다. Purpose: This study was performed to evaluate the diagnostic usefulness of ankle stress radiograph for evaluation of chronic lateral ankle instability. Materials and Methods: Among patients undergoing the modified-Brostrom procedure, 42 cases with complete rupture of the anterior talofibular ligament were enrolled in this study. Sixty Korean adults (120 cases) were recruited as the control group. Radiologic measurement of talar tilt and anterior talar translation was performed through stress radiographs using Telos device. We obtained the normal range of Korean adults, and used as a standard value for judgment of mechanical instability. We analyzed the sensitivity, specificity, positive and negative prediction value of ankle stress radiograph. Results: On ankle stress radiograph, normal range of talar tilt angle and anterior talar translation was below $8.3^{\circ}$, below 7.6mm. Talar tilt angle on varus stress radiograph showed 57% of sensitivity, 97% of specificity, 89% of positive and 86% of negative prediction value. Anterior talar translation on anterior drawer stress radiograph showed 69% of sensitivity, 97% of specificity, 91% of positive and 90% of negative prediction value. Conclusion: Ankle stress radiograph had a good specificity, positive and negative prediction value for the evaluation of mechanical instability. However it underestimated the mechanical instability of ankle joint. It must be remembered that normal stress radiograph does not exclude ankle instability.

순서기반 비정상행위 탐지 센서의 임계치 결정 방법

김용민,김민수,김홍근,노봉남,Kim, Yong-Min,Kim, Min-Su,Kim, Hong-Geun,No, Bong-Nam 한국정보처리학회 2001 정보처리학회논문지 C : 정보통신,정보보안 Vol.8 No.5

본 논문은 SOM과 HMM을 이용하여 시스템 호출 수준에서 순서기반의 비정상행위 탐지 센서를 구현하였다. 그리고, 시스템 호출에서 중요한 정보가 무엇이고 임계값은 어떻게 설정해야하는 지를 분석하였다. 본 논문에서 사용한 SOM의 새로운 필터링 규칙과 축약 규칙은 HMM의 입력 크기를 줄일 수 있었다. 이러한 축약은 HMM기반 비정상행위 탐지의 실시간 처리능력을 보장해 준다. 또한, 비정상행위 수라는 개념을 도입하여 HMM의 탐지결과에 대한 민감성을 둔화시켜서, 사용자가 탐지결과를 쉽게 이해하고 false-positive를 줄이는 효과가 있었다. 그리고, 능동적으로 threshold 값을 조정하여 시스템 상황에 따라 탐지센서가 적응할 수 있도록 하였다. In this paper, we implement sequence-based anomaly detection sensor using SOM and HMM, and analyze what is important information in system call and how a threshold is decided. The new filtering and reduction rules of SOM reduces the input size of HMM. This gives real-time processing to HMM-based anomaly detection sensor. Also, we introduced an anomaly count into the sensor. Due to lessened sensibility, a user easily understand easily the detection information and false-positive was decreased. And the active coordination of the threshold value makes the detection sensor adapt according to the system condition.

Anti-Inflammatory Effects of Tongbi-san(通痺散) Extract on RAW264.7 Macrophages

김용민,김희택,김이화,Kim, Yong-Min,Kim, Hee-Taek,Kim, Ee-Hwa The Society of Korean Medicine Ophthalmology 2016 한방안이비인후피부과학회지 Vol.29 No.4

Objectives : This study is to investigate the anti-inflammatory and anti-oxidant effects of Tongbi-san extract (TS) on RAW264.7 macrophages using by cell cytotoxicity, Nitric Oxide (NO) and Prostaglandin $E_2$ ($PGE_2$) production and 1,1-diphenyl-2-picryl ghdrazyl (DPPH) free radical scavenging capability. Methods : Cell cytotoxicity was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The production of NO was measured by Griess assay. The production of $PGE_2$ was measured by immunoassay. And the anti-oxidant activity was measured by the DPPH method. Results : TS did not increased significantly compared to the TS untreated group in the cell cytotoxicity. TS inhibited NO and $PGE_2$ production in lipopolysaccharide-stimulated RAW 264.7 cells. TS had the DPPH free radical scavenging capability. Conclusion : The anti-inflammtory and anti-oxidant effects of TS may be use for a treatment of anti-inflammatory diseases.

백내장 수술 후 각막 지각의 변화와 각막신경 회복의 비교

김용민,김선웅,김태임,김응권,서경률,Yong Min Kim,Sun Woong Kim,Tae Im Kim,Eung Kwon Kim,Kyung Ryul Seo 대한안과학회 2007 대한안과학회지 Vol.48 No.1

Purpose: To compare corneal sensitivity and recovery of corneal innervations after a temporal clear corneal incision in cataract surgery. Methods: We measured changes to corneal sensitivity using Cochet-Bonnet esthesiometer in 25 eyes of 20 patients and analyzed corneal nerve density with confocal microscopy in 20 eyes of 20 patients who had undergone cataract surgery. The parameters were measured before, and at 1 week, 1 month, and 3 months after cataract surgery. Results: The mean preoperative corneal sensitivity was 56.40±3.39 mm at the temporal corneal incision site, and there was a significantly decreased sensitivity of 29.80±2.69 mm and 42.40±4.36 mm postoperatively at 1 week and 1 month, respectively. Nonetheless, by three months, corneal sensitivity had returned to 56.00±2.89 mm and was not significantly different from measurements prior to the cataract surgery. The mean preoperative subbasal nerve density was 5296±1642 ?m/mm2. After cataract surgery, the subbasal nerve density was significantly reduced to 4113±1421, 3555±1448, 4198±1239 ?m/mm2 at 1 week, 1 month, and 3 months, respectively. Conclusions: Corneal sensitivity after cataract surgery returned to near preoperative levels within 3 months before complete restoration of normal corneal innervations. Therefore, regeneration of subbasal nerve fibers (, as determined by confocal microscopy,) requires more time than the return of corneal sensation after cataract surgery.

불포화 풍화토 사면의 모관흡수력 분포에 대한 지반조건과 강우강도의 영향

김용민,이광우,김정환,Kim, Yong Min,Lee, Kwang Woo,Kim, Jung Hwan 대한토목학회 2013 대한토목학회논문집 Vol.33 No.3

본 연구에서는 강우 침투에 의한 사면의 모관흡수력 분포특성을 분석하기 위하여 수리학적-역학적 특성을 고려한 동시연계해석을 수행하였다. 이를 위해, 국내 3가지 지역에서 채취한 풍화토를 대상으로 함수특성곡선(SWCC)을 산정하였으며, 이를 토대로 지반조건, 강우특성, 사면경사에 따른 모관흡수력의 변화를 관측하였다. 그 결과, 강우강도가 증가함에 따라 사면내의 모관흡수력은 급격히 감소하는 경향이 나타났으며, 사면 경사에는 큰 영향을 받지 않는 것으로 나타났다. 또한 강우강도보다 포화투수계수가 작은 지반은 표층에서 포화가 쉽게 일어나는 것을 확인하였으며, 다층으로 존재하는 경우에도 사면표층 지반의 수리학적 특성이 모관흡수력 분포에 큰 영향을 주는 것으로 나타났다. The monolithically coupled finite element analysis for a deformable unsaturated soil slope is performed to investigate matric suction distribution on a soil slope subjected to rainfall infiltration, which can consider the hydraulic-mechanical characteristics for the analysis. The soil-water characteristic curves (SWCC) are experimentally determined to estimate three types of hydraulic properties of domestic areas. Based on the physical properties, the distribution of matric suction is investigated by considering the major factors, such as soil conditions, rainfall intensities, and slope angles. It is found from the results of this study that the matric suction rapidly decreases with an increase in rainfall intensity, regardless a slope angle. The slope surface is more easily saturated when its saturated hydraulic conductivity is smaller than rainfall intensity, and for the case of multi-layered soil slope, hydraulic characteristics of slope surface has a significant influence on matric suction distribution.

당뇨황반부종의 치료에서 유리체 절제술의 효과와 유리체강 내 트리암시놀론 주입술과의 비교

김용민,김성수,이성철,권오웅,고형준,Yong Min Kim,Sung Soo Kim,Sung Chul Lee,Oh Woong Kwon,Hyung Jun Koh 대한안과학회 2006 대한안과학회지 Vol.47 No.7

Purpose: The purpose of this study is to evaluate the benefit of pars plana vitrectomy (PPV) and removal of the internal limiting membrane (ILM) in diabetic macular edema, and to compare the effects of PPV and removal of ILM with intravitreal triamcinolone acetonide injection. Methods: Fifteen eyes of 14 patients on whom PPV and removal of the ILM (group A) were performed and 14 eyes of 14 patients who received single intravitreal triamcinolone acetonide injection (group B) for diabetic macular edema over six months were included in this study. The main outcome measures were macular thickness, as measured by optical coherence tomography and visual acuity at 1, 3, and 6 months postoperatively. Results: The mean preoperative visual acuity was 0.06±0.05 and macular thickness 516.01±120.29 ?m in group A. At 1 month postoperatively, this group showed no significant improvement of visual acuity. However, there was significant improvement at 3 and 6 months postoperatively. Macular thickness also decreased significantly at 1, 3, and 6 months postoperatively. In group B, the mean preoperative visual acuity was 0.10±0.08 and macular thickness was 548.82±116.44 ?m. At 1 and 3 months postoperatively, significant improvement of visual acuity was noted in this group. However, there was no significant difference at 6 months postoperatively. Macular thickness also decreased significantly at 1, 3, and 6 month postoperatively. Between two groups, visual acuity and macular thickness improved in Group B at 1 month postoperatively but at 6 months, visual acuity improved in Group A and there was no significant difference of macular thickness between the two groups. Conclusions: PPV and removal of the ILM are good therapeutic options for diabetic macular edema to improve visual acuity and macular thickness. These also offer more long term efficacy than intravitreal tiamcinolone acetonide injection.

가스저장탱크 제조업의 보건관리 사례

김용민,Kim, Yong-Min 대한산업보건협회 2007 산업보건 Vol.230 No.-

회양목 부위별 추출물의 효능평가

김용민,김명기,Kim, Yong-Min,Kim, Myong-Ki 중소기업융합학회 2020 융합정보논문지 Vol.10 No.11

This study was conducted to confirm the component and efficacy evaluation of Buxus Koreana by different part. Leaf, stem, root, and fruit were extracted with 70% ethanol, and the contents of polyphenols and flavonoids were analyzed, and the efficacy against anti-inflammatory, moisturizing and wrinkles were confirmed. The contents of polyphenols and flavonoids of B. Koreana were the highest in fruit extracts at 77.32 and 51.91 mg/g, respectively. As a result of confirming the NO production inhibitory effect, the root extracts showed an inhibitory effect of 29.6%, and iNOS significantly decreased as the concentration of the extracts increased compared to the LPS treatment group. As a result of checking the mRNA expression level of MMP1, it was found to be effective in the root and stem extracts. Through the efficacy evaluation of B. Koreana the possibility of use as a cosmetic material was confirmed. 본 연구는 회양목의 부위별 성분과 효능평가를 확인하기 위해 수행되었다. 잎, 줄기, 뿌리, 열매를 70% 에탄올로 추출하여 폴리페놀과 플라보노이드의 함량을 분석하였으며 항염, 보습 및 주름에 대한 효능을 확인하였다. 회양목의 부위별 폴리페놀과 플라보노이드 함량은 열매 추출물에서 각각 77.32, 51.91 mg/g으로 가장 높게 나타났다. NO 생성 억제 효과를 확인한 결과, 뿌리 추출물에서 29.6%의 저해 효과를 나타냈으며, iNOS는 LPS 처리군과 비교하였을 때 추출물의 농도가 증가함에 따라 유의적으로 감소하였다. MMP1의 mRNA 발현 수준을 확인한 결과, 뿌리와 줄기에서 효과가 있는 것으로 나타났다. 회양목에 대한 효능평가를 통해 화장품 소재로서 활용 가능성을 확인하였다.

진행된 무지 강직증에서 생체흡수성 압박나사를 이용한 원위 중족골의 배측 쐐기 절골술

김용민,조병기,김동수,최의성,손현철,박경진,박지강,최승명,Kim, Yong-Min,Cho, Byung-Ki,Kim, Dong-Soo,Choi, Eui-Sung,Shon, Hyun-Chul,Park, Kyoung-Jin,Park, Ji-Kang,Choi, Seung-Myung 대한족부족관절학회 2012 대한족부족관절학회지 Vol.16 No.1

Purpose: This study was performed retrospectively to evaluate clinical outcomes of distal metatarsal osteotomy using bio-compression screw as the joint preservation method for advanced hallux rigidus. Materials and Methods: Eleven cases were followed up for more than 1 year after distal metatarsal dorsal wedge osteotomy for advanced hallux rigidus. The clinical evaluation was performed according to the American Orthopaedic Foot and Ankle Society (AOFAS) score and patient's satisfaction score. The range of motion, and the period to return to running exercise, tip-toeing gait, squatting, walking down the stairs were evaluated. As the radiographic evaluation, the interval of $1^{st}$ MTP (metatarsophalangeal) joint space and the period to union were measured. Results: The AOFAS hallux score had improved significantly from preoperative average 50.7 points to 87.6 points at the last follow-up (p=0.005). The subjective satisfaction score was average 90.6 points. There were no case of subsequent fusion or additional operation, and no complication associated with bio-compression screw. The period to return to running exercise, tip-toeing gait, squatting, walking down the stairs were average of 24.8 weeks, 20.4 weeks, 16.8 weeks, 18.5 weeks respectively. Dorsiflexion of $1^{st}$ MTP joint had improved significantly from preoperative average $17.5^{\circ}$ to $44^{\circ}$ (p<0.001). All cases achieved union of osteotomy site, and the period to union was average 10.4 weeks. The interval of $1^{st}$ MTP joint space had improved significantly from preoperative average 1.2 mm to 3.5 mm (p=0.014). Conclusion: Distal metatarsal osteotomy using bio-compression screw seems to be one of effective treatment methods for advanced hallux rigidus, because of restoration of the first MTP joint motion, and reliable pain relief, and needlessness of hardware removal.

기업이 바라는 공학교육 내용 - 기업 연구소의 입장에서 -

김용민,Kim Yong-Min 한국공학교육학회 1997 Ingenium(人材니움) Vol.4 No.4