Nocardia SP . 에 의한 Δ4 - 3 - Ketosteroid 류의 산화

김옥희,이상섭 ( Ok Hee Kim,Sang Sup Lee ) 생화학분자생물학회 1974 BMB Reports Vol.7 No.1

Rationalizing of conformational or structural modification effect on 9α-hydroxylation of 17-ketosteroids which have Δ⁴-3-keto-system was attempted. When 6-methylandrost-4-ene-3,17-dione was incubated with Nocardia opaca, the rate of 9 a-hydroxylation was much slower than that of androst-4-ene-3,17-dione. In contrast, 9 a-hydroxylation of 6α-methylandrost-4-ene-3, 17-dione was faster than that of 6 ~-isomer. In addition to these two compounds, 19-norandrost-4-ene3,17-dione and 6,19-oxidoandrost-4-ene-3,17-dione were also compared with androst-4-ene-3,17-dione, and it was found that the rate of 9α-hydroxylation and B-ring rupturing of androst-4-ene-3,17-dione was fastest among tested steroids.

교합 유도 형태에 따른 저작근 활성도에 관한 연구

김옥희,계기성,Kim, Ok-Hee,Kay, Kee-Sung 대한치과보철학회 1989 대한치과보철학회지 Vol.27 No.2

The purpose of this study was to investigate the muscle activity of the group function occlusion and the changed canine guided occlusion using EM2. In this study, 13 subjects with group function occlusion and without temporomandibular disorders were selected, each subject was changed to the canine guided occlusion by forming the lingual ramps in the upper canines with light curing composite resin. The muscle activities of the anterior temporal and masseter muscle were recorded in the group function occlusion and immediately, one week, and two weeks after changing to the canine guided occlusion under the condition of maximum voluntary clenching in centric occlusion, lateral excursion, and during gum chewing. The results were as follows: 1. In case of maximum voluntary clenching in centric occlusion, the muscle activities of the anterior temporal and masseter muscle of working and balancing side didn't show any difference immediately after changing to the canine guided occlusion, one week after changing to the canine guided occlusion, one week after changing to it the muscle activities of the anterior temporal masseter muscle of working and balancing side were increased significantly, and two weeks after changing to it the muscle activities of the masseter muscle were increased significantly in comparison with the group function occlusion. 2. In case of maximum voluntary clenching in lateral excursion, the muscle activities of the anterior temporal and masseter muscle of working and balancing side were reduced significantly immediately after changing to the canine guided occlusion, one week after changing to it the muscle activities of the anterior temporal muscle of balancing side and of the anterior temporal and masseter muscle of working side were reduced significantly, and 2 weeks after changing to it the muscle activities of the anterior temporal and masseter muscle of working side were reduced significantly in comparison with the .group function occlusion. 3. During gum chewing, the muscle activities of the anterior temporal and masseter muscle of working and balancing side didn't show any difference immediately after changing to the canine guided occlusion, one week after changing to it the muscle activities of the masseter muscle of working and balancing side were increased significantly, and two weeks after changing to it only the muscle activities of masseter muscle of working side were increased significantly.

Nocardia Sp.에 의한 ${\Delta}^4$-3-Ketosteroid 류의 산화

김옥희,이상섭,Kim, Ok-Hee,Lee, Sang-Sup 생화학분자생물학회 1974 한국생화학회지 Vol.7 No.1

Steroid의 핵구조(ring structure)가 $9{\alpha}$-hydroxylation에 미치는 영향을 검토하기 위하여 $6{\beta}$-methylandrost-4-ene-3, 17-dione, $6{\alpha}$-methylandrost-4-ene-3, 17-dione, 19-norandrost-4-ene-3, 17-dione, androst-4-ene-3, 17-dione과 6, 19-oxidoandrost-4-ene-3, 17-dione 등 ${\Delta}^4$-keto-system을 갖고 있는 steroid를 Nocardia opaca 배양액중에 첨가하여 주고 $9{\alpha}$-hydroxylation 되는 과정을 살폈다. ${\Delta}^4$-keto-system에 $6{\beta}$-methyl group이 존재하면 현저히 hydroxylation의 속도가 느린 것을 발견하였다. Rationalizing of conformational or structural modification effect on $9{\alpha}$-hydroxylation of 17-ketosteroids which have ${\Delta}^4$-3-keto-system was attempted. When $6{\beta}$-methylandrost-4-ene-3, 17-dione was incubated with Nocardia opaca. the rate of $9{\alpha}$-hydroxylation was much slower than that of androst-4-ene-3, 17-dione. In contrast, $9{\alpha}$-hydroxylation of $6{\alpha}$-methylandrost-4-ene-3, 17-dione was faster than that of $6{\beta}$-isomer. In addition to these two compounds, 19-norandrost-4-ene-3, 17-dione and 6.19-oxidoandrost-4-ene-3, 17-dione were also compared with androst-4-ene-3, 17-dione, and it was found that the rate of $9{\alpha}$-hydroxylation and B-ring rupturing of androst-4-ene-3, 17-dione was fastest among tested steroids.

쑥뜸치료가 암환자의 심박변이도에 미치는 영향

김옥희,최정은,윤정원,유화승,Kim, Ok-Hee,Choi, Jung-Eun,Yoon, Jeung-Won,Yoo, Hwa-Seung 대한암한의학회 2011 大韓癌韓醫學會誌 Vol.16 No.1

Objective : The study aims to investigate the effect of moxibustion treatments on autonomic nervous system function of cancer patients through the evaluation of heart rate variability (HRV) biofeedback testing. Materials and Methods : Six cancer patients from inpatient care unit of Dunsan Oriental Hospital, Daejeon University were given three moxibustion treatment sessions every other day over one week period on five Oriental Medicine meridian points CV4, CV6, CV12, KD1, and PC8. HRV biofeedback was conducted before and after each treatment sessions. Three areas of analyses were done from the test conducted; Time Domain Analysis, Frequency Domain Analysis and Autonomic Nervous System (ANS) balance analysis. Results : Time Domain Analysis has shown increased Standard Deviation of all Normal R-R Intervals (SDNN), and decreased Mean Heart Rate and Physical Stress Index (PSI) levels, with statistical significance (P<0.05). In Frequency Domain Analysis, series of moxa treatments have increased Total Power (TP), Very Low Frequency Oscillation Power (VLF), High Frequency Oscillation Power (HF), normalized HF values while decreasing Low Frequency Oscillation Power (LF), normalized LF and LF/HF ratio with statistical significance (P<0.05). The values of ANS activity, ANS balance, Stress resistance, Stress index, have also shown significant changes. For cardiac stability stroke volume power (SP) and Blood Vessel Tension (BVT) were followed, which were both increased after treatment. All changes were statistically significant (P<0.05). Conclusion : The results have shown a positive correlation between the moxibustion treatments and autonomic nervous system responses on cancer patients through the HRV biofeedback testing. This study suggests possible application of moxibustion treatments for managing ANS functions of cancer patients, although additional studies with larger population are necessary to confirm the data.

생강성분 6-Paradol의 세포 독성 및 병리학적 연구

김옥희,유은숙,정인경,이상섭,Kim, Ok-Hee,Yoo, Eun-Sook,Jung, In-Kyung,Lee, Sang-Sup 한국환경성돌연변이발암원학회 1998 한국환경성돌연변이·발암원학회지 Vol.18 No.1

It is previously reported that 6-paradol can induce prolonged analgesia in experimental animals. In order to investigate the mutagenicity of 6-paradol, Ames Samonella/microsome plate assay was carried out with Salmonella typhimurium strains, TA 98, TA 100, TA 1535 and TA 1538, 6-Paradol was nonmutagenic in Salmonella typhimurium with and without rat liver microsomal activation. The rec assay with Bacillus substilis strains H 17 $rec^+$ and M 45 $rec^+$ was carried out ot test 6-paradol and other compounds (1-3 mg/disc) for DNA damaging activity, 6-Paradol was also nonmutagenic in DNA damaging activity. The relative size of the inhibition zone for 6-paradol was smaller than that of capsaicin. We have also determined the pathological effects of this compound on the various tissues of rats after administrating(i.p.) with increasing doses of 4, 8, 12, 16 mg/kg at 2 hour intervals and found no significant changes in terms of histology.

커뮤니티댄스 실행 모델 생태감성 무용 구조 연구

김옥희 ( Ok Hee Kim ) 한국무용교육학회 2012 韓國舞踊敎育學會誌 Vol.23 No.2

Ecological sensitivity based community dance has been an practical attempt to build up an alternative that seeks to recover and yearn human being`s innate naturalness and beauty through emotional education teaching how to feel nature-friendly life. In other word, ecological sensitivity based movement is both the process of changing the perspective about our lives through rediscovering emotion about body and a body movement that can perform the genuine communication with our body. This is an activity that experiences both nature and art, which is also a program that respects emotion that activates a variety of human senses through natural images, thereby making us get to know our unique emotion. Ecological sensitivity based body movement program is divided into body self-realization, sympathy, emotion expression and communication segments. Ecological sensitivity based body movement program is centered around community dance which encourages the handicapped and disabled to overcome their limited life condition through rediscovery of innate emotion by communication with natural life.

진로만다라 과제학습이 대학생의 진로정체감과 진로준비행동에 미치는 영향

김옥희(Kim Ok-Hee),이근희(Lee Geun-Hee) 국민대학교 교육연구소 2006 교육논총 Vol.26 No.1

  본 연구의 목적은 만다라를 활용한 진로(진로만다라)과제학습이 진로정체감과 진로준비행동에 미치는 영향에 대해서 알아보는 것이다. 만다라는 깨달음의 성취란 의미로 하나의 원형으로서의 상징을 표현하는 문화적 의미나 치유적이고 교육적인 의미를 가지고 있다. 만다라에 생애발달적 접근으로서의 다양한 진로와 관련된 주제를 주고 그리도록 했다. 연구대상은 교육심리과목을 듣는 대학생으로 실험집단 39명, 통제집단 43명이다. 사전검사를 실시해 동질집단임을 확인하였고 처치 후 사후검사를 실시해 t검증을 하였다. 그 결과 진로정체감에는 유의한 차이가 보이지 않았다. 하위척도 중 안정성, 독특성, 자기주장, 자기존재의식에서는 유의미한 차이를 보이지 않았지만 목표지향성에서만 p<.0l수준에서 유의미한 차이를 보였다. 목표지 향성은 장래에 꼭 하고 싶은 분야, 장래의 인생에 대한 방향 설정, 졸업 후의 진로 결정과 적성 등에 대한 문항 등으로 되어 있다. 진로만다라 과제학습이 자신의 목표를 설정하고 나아갈 방향에 대해서 생각해 볼 수 있는 확신을 갖게 해 주었음을 의미한다고 볼 수 있다.<BR>  진로준비행동에는 p<. 001에서 유의미하게 나타났다. 진로준비행동은 자신의 진로와 관련한 인지나 태도치원이 아닌 실제적이고 구체적인 행위의 치원을 말하는 것이다. 따라서 진로만다라 과제학습이 진로를 준비하기 위한 실제적인 행동을 하도록 동기를 부여하거나 도움을 주는데 효과적임을 알 수 있다.<BR>  진로정체감은 진로준비행동과 상관이 있는 것으로 나타났다. 진로정체감의 하위요인들도 모두 진로준비 행동과 상관이 높은 것으로 나타났다. 이는 정체감이 높을수록 진로준비행동을 잘 하고 있다고 보여진다. 따라서 대학생들이 자신의 진로에 대해서 내면적으로 갚은 탐색을 해 볼 수 있는 다양한 프로그램의 개발과 보급이 필요하다. 또 성별, 연령별, 기간별, 학과별에 따른 진로만다라 과제학습에 대한 추후연구가 필요하다.   The purpose of this study was intended to investigate the effect of career(career mandala) task learning on college students" career identity and preparation activities. The college students were given the subject related to diverse careers as an approach to mandala of lifelong development and asked to draw it. The subjects taking a course in educational psychology comprised 39 college students in the experimental group and 43 college students in the control group. It was confirmed that they were the homogeneous group by conducting the pre-test and the t-test was conducted through the post-test after treatment. As a result, it was found that there was no difference in career identity between both groups. It was found that there was no significant difference in such sub-scales as stability, peculiarity, self-assertiveness, self-existence consciousness but that there was a significant difference in goal-orientedness alone at the level of p<.01. Goal-orientedness comprises the items on the field to want to do in the future, the setting of a direction for their future life, decision on post-graduation career and aptitude, and the like. It can be thought that this study has its significance in that career experience learning activity convinced college students to think about the direction to set and go towards their goal.<BR>  It was found that there was a significant difference in career preparation activity between groups at the level of P<.001. career preparation behavior refers to the dimension of physical and concrete conduct, not that of recognition or attitude related to their career. It can be found that career mandala task learning is effective in motivating and helping college students to actually prepare for their career.<BR>  It was found that career identity correlated with career preparation behavior. And it was shown that the sub-factors of career identity all were highly correlated to career preparation behavior, which indicates that the level of higher career identity leads to better career preparation behavior.<BR>  Accordingly, it is necessary to develop and disseminate diverse programs for enabling college students to make a profound inner exploration of their career. And it is thought that subsequent research will be conducted on career mandala task learning by sex, by age, by period and by department.

전기 베이비부머의 노화 인식과 성공적 노화 준비에 관한 연구 -저소득 무배우자 남성을 중심으로-

김옥희 ( Ok Hee Kim ),서연희 ( Yeon Hee Seo ) 한국가족복지학회 2015 한국가족복지학 Vol.20 No.1

This study conducted qualitative research using Colaizzi``s analytical method with a phenomenological approach to understand deeply and concretely non-mate males in low-income groups’ awareness of their aging and their preparation for successful aging. After the data from in-depth interviews with eight non-mate males in low-income groups among former baby boomers was analyzed, the results of this study were deducted with 16 constituted meanings and 6 categorized themes as the essential structure of the experiences. The results of this study are as follows. First, the participants recognized aging as “black hole like poverty”, “adaptation/avoidance about aging”, “realizing the importance of their family” and “becoming a new person in the workplace.” Second, the participants recognized unprepared old age as “Miserable old age without having money”, “Feeling desolate of the unemployment in old age” , and they prepared for their successful aging by health care and Settling their single life, working continually and having a religion like a crutch of life.

요보호아동의 정보화 실태 분석

김옥희(Kim Ok-Hee) 가정과삶의질학회 2002 가정과삶의질연구 Vol.20 No.5

일자리사업 참여노인의 정신건강에 영향을 미치는 요인 연구: 성별 및 한 일 간 비교

김옥희 ( Ok Hee Kim ) 한국사회복지정책학회 2011 사회복지정책 Vol.38 No.4

본 연구는 일자리사업 참여노인의 정신건강에 영향을 미치는 요인에 관한 연구이다. 특히 영향요인에 관하여 성별 및 한국과 일본 양 국가를 비교 분석하였다. 이러한 연구 결과에 근거하여 참여노인의 정신건강 향상을 위한 노인일자리 정책적, 실천적 제언을 제시하였다. 한국의 경우 서울과 부산지역 일자리사업 참여노인을 편의표집한 후 설문조사를 실시하였는데, 회수한 995부중 894부를 통계 분석하였다. 일본은 동경도(東京都)와 대판(大阪) 등의 실버인재센터 회원들을 대상으로 우편조사를 실시하였는데, 회수한 1038부중 831부를 최종적으로 통계분석하였다. 자료 분석은 SPSS 14.0 for Window를 사용하여 이루어졌다. 본 연구 결과는 다음과 같다. 첫째, 일본 일자리사업 참여노인의 정신건강(48.51)은 한국(43.15)보다 더 좋은 것으로 나타났고, 한국과 일본 남성노인의 정신건강이 여성노인보다 각각 더 좋은 것으로 나타났다. 둘째, 한국의 경우, 남성노인은 신체건강과 일자리사업 만족도가, 여성노인은 연령, 신체건강, 일자리유형 중 공익형, 교육형, 복지형과 시장형이, 그리고 참여기간이 각각 정신건강에 정적인영향을 미치는 것으로 나타났다. 일본의 경우, 남성노인은 신체적 건강과 사업만족도가, 여성노인은 신체건강, 일자리유형 중 관리감독형이 각각 정신건강에 정적인 영향을 미치는 것으로 나타났다. 정책적, 실천적 제언으로 지속적이고 안정적인 노인 일자리의 제공, 지역사회 중심 민간주도형 자주적, 자발적 노인일자리사업으로의 전환, 노인일자리사업의 사회적 기업으로의 전환, 그리고 관련 성별 분리 통계자료의 구축, 성별 영향 평가와 성인지적 예산 편성을 통한 성인지적 노인 일자리정책의 수립, 수행과 평가를 제시하였다. This study was aimed to analyze the influence that the Senior Employment Promotion Project has on the mental health of the participants, and to analyze effects of factors on the mental health of the participants by comparing the gender and Korea-Japan. 995 questionnaires in Seoul, Busan, Korea were collected out of which 948 were used for the research. And 1038 questionnaires in Tokyo, Osaka, Japan were collected out of which 831 were used for the research. The results of this study are summarized as follows: First, the mental health of the participants of the Senior Employment Promotion Project in Japan were higher than the mental health of the participants in Korea. The mental health of male were higher than the mental health of female in Korea and Japan. Second, In case of male in Korea, the Multi Regression analysis found that the important variables in determining the mental health of participants were health condition and job satisfaction. In case of female in Korea, the Multi Regression analysis found that the important variables in determining the mental health of participants were age, health condition, job period, public benefit type, educational type, welfare type and market type among job type. In case of male in Japan, the Multi Regression analysis found that the important variables in determining the mental health of participants were health condition and job satisfaction. In case of female in Japan, the Multi Regression analysis found that the important variables in determining the mental health of participants were health condition and control/inspection type among job type.