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Kim Oh Whan(金吾煥) 대한구강악안면외과학회 1975 대한구강악안면외과학회지 Vol.1 No.1
The author has treated a true trigeminal neulagia patient, so-called Tic Douloureux, in 56 years old korean house-wife. This Tic Douloureux has been originated from her left inferior alveolar nerve. Under local anesthesia with 2% Lidocaine HCL containing 1:50,000 Epinephrine solution, the alveolar nerve avulsion has been performed from mental foramen to mandibular foramen. The patient has satisfied the operation results because she has been free from the neuralgic pain. The avulsed nerve was 6.5cm. in length.
오환용(Whan Young Oh),고승오(Seung O Ko),신효근(Hyo Keun Shin),김오환(Oh Whan Kim) 대한구강악안면외과학회 1996 대한구강악안면외과학회지 Vol.22 No.3
The effective way of control cancers currently relies on early case finding and treatment but the best way is more fundamental prevention through inhibition of many stages of carcinogenesis. Since many cancers are related to environmental and life style factors, recently chemoprevention through micronutrients, nonnutrient plant substances, synthetic nutrient derivatives, and synthetic chemicals have been attracted interest of cancer researcher. Almost 40clinical chemoprevention trials are now in progress around world among which γcarotene and 13cis retinoic acid were proven to be effetive in many cancers including colon, lung, breast, skin, cervix and head and neck cancer. The main purpose of this study is to get a basic data for the development of chemopreventive agents in Korean Herbs. It has been reported that Ganoderma has a hypotensive effect through the inhibition of angiotensin converting enzyme, antiallergic and antiasthmatic effect through the inhibition of histamin release from the mast cells, in addition to an inhibitory effect of lipid peroxidation, and a potenting effect of the immune system. Attempts were made to see the anticancer effect of Ganoderma extracted with hot water a common preparative method in most herb medicine, employing human cancer cell lines such as K562 derived from erythroleukemia, Raji from lymphoma and Molt4 from blastogenic tumors. Apart from those tumor cell suspinsions derived from hematopoietic cells, the anticancer effect of Ganoderma was also investigated with other human solid tumors of liver, lung, kidney and stomach cancers. The anticancer effect of Ganodrma of three different preparations, that is, a naturally grown one, a cultivated one and a molded one during malstorage, was also compared. The results obtained from this study were as follows. 1. Inhibitory effect of cancer cell growth by Ganoderma in 5different human solid tumor cell lines such as KHOS/MP, SDK, HeLa, A549, HepG2 was 6-28% showing highest effect in HeLa and lowest effect in HepG2 among tested. 2. Native Ganoderma showed 7-28%, inhibitory effect of cancer cell growth in 5different human solid tumor cell lines tested, and cultivated Ganoderma showed 6-28%, indicating that native and cultivated one do not reveal the difference on the cancer cell inhibitory effect. Mal-stored Ganoderma with fungal contanimation showed only 0-12%, half value of cancer cell inhibitory effect. 3. On the contrary to the solid human cancer cell lines, cancer cell suspensions like K562 derived from chronic myelogenous leukemia showed 72% Molt4 derived from acute lymphoblastic leukemia showed 71%, and Raji derived from Burkitt lymphoma showed 58%, indicating that Ganoderma has more anticancer effect on cancer cell suspensions derived from hematopoietic system than solid tumors tested in this study. 4. In the dosage dependent study of Ganoderma together with 5-fluorouracil(5 FU) as referenfe drug, HeLa cell was most effective showing 30% of cancer cell cytotoxicity at the 1mg/ml, while 5FU showed 47% of cancer cell cytotoxicity at the same concentration. Above results revealed Ganoderma was more effective to the cancer cell suspensions derived from hematopoietic system than solid tumors. And cancer cell cytotoxicity is not almost different both in native and cultivated Ganoderma.
Macrophage Inflammatory Protein $1{\alpha}$가 T세포성장 및 CD4, CD8 발현에 미치는 영향
최종선,김오환,Choi, Jong-Sun,Kim, Oh-Whan 대한악안면성형재건외과학회 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.1
Macrophage inflammatory protein $(MIP)-1{\alpha}$ is a cytokine which produces wide range of bioactivities such as proinflammatory, immunomodulatory, and hematopoietic modulatory actions. To determine whether $MIP-1{\alpha}$ acts as a negative regulator on the functions of lymphocyte, $[^3H]$-thymidine incorporation test and flow cytometric analysis were performed by using human tonsil T cell, human peripheral blood T cell, and murine cytolytic T lymphocyte (CTL) line CTLL-2, The results were as follow. 1. When human tonsil T lymphocytes were stimulated with anti-CD3 monoclonal antibody (mAb), rate of T cell proliferation was about four times increased. 200ng/ml of $MIP-1{\alpha}$ inhibited anti-CD3 mAb-mediated T cell growth as much as 60% (P<0.05). 2. The suppression of human peripheral T cell proliferation produced by $MIP-1{\alpha}$ was dramatic, but variable among T cells derived from different individuals $(40%{\sim}90%)$. 3. $MIP-1{\alpha}$inhibited the proliferation of murine CTL line CTLL-2 as much as 75%(P<0.001). 4. When the $MIP-1{\alpha}$ was added to human peripheral T cell, cell proporation of $CD4^+$ helper T cell and $CD8^+$ CTL were not noticeably affected. The expression level of CD4, not of Cd8, however, was down regulated by $MIP-1{\alpha}$ treatment $(27%{\sim}82%)$.
Huh Hong Yell(許洪烈),Cho Sang Ki(趙相紀),Yun Cheri Hee(尹哲熙),Jin Woo Jeong(陳宇政),Shin Hyo Keun(辛曉根),Kim Oh Whan(金晤煥) 대한구강악안면외과학회 1986 대한구강악안면외과학회지 Vol.12 No.1
We had treated 63 cases with cleft lip and palate which visited Department of Oral & Maxillofacial surgery, college of Dentistry, Chon Buk National University from May 1981 to April 1986. In total 63 cases, male patients were 41 cases (65.1%) and female patients were 22 cases (34.9%) Cleft lip and palate patients were 31 cases (49.2%) cleft palate patients were 14 cases (22.2%) and cleft lip patients were 18 cases (28.6%) We performed cheiloplasty by means of Millard s method, LeMesurier s method, Veau s method, Tennison s method and Bauer s method, palatorrhaphy by means of Von Langenbeck method and V-Y retroposition procedure.