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혈액 투석막에 따른 말초 혈액 단핵세포의 Interleukin 1 , Iterleukin 6 , Tumor necrosis Factor 생산능에 관한 연구
김영훈(Yeong Hoon Kim),임대건(Dae Geon Lim),조현대(Hyun Dae Cho),김양욱(Yang Wook Kim),박원도(Won Do Park),안재형(Jae Hyung Ahn),이태원(Tae Won Lee),임천규(Chun Gyoo Ihm),김명재(Myung Jae Kim) 대한내과학회 1997 대한내과학회지 Vol.52 No.6
N/A Objectives: In order to evaluate the role of these cytokines in biological response induced by blood interaction with hemodialysis membranes. Methodes: We have investigated the IL-1, TNF and IL-6 concentrations in the supernatant of 24-hours cultured peripheral blood mononuclear cells (PBMC) without(spontaneous group) or with broken cuprophan or P1VMA membranes in 9 chronic hemodialyzed patients and 8 healthy controls. The blood samples were drawn before dialysis using following criteria: (a) in last dialytic treatment with PMMA membranes(HDEl), (b) after two weeks of dialytic treatment wih cuprophan membranes(HDE2), Results: In the both of patient group(HDE1 and HDE2) and controls production of IL-l, TNF and IL-6 of PBMC stimulated with cuprophan or PMMA membrane particles was increased compared to those of spontaneous group. IL-1 production of HDE1 stimulated PMMA(99.31±30.15fmol/ml) was significantly higher compared to that of cuprophan(48.43±11.29fmol/ml), TNF production of HDE2 with cuprophan(114.86±38.5lfmoVml) was significantly high compared to that of spontaneous group(52.42±29.94fmol/ml). IL-6 production of HDE2(646.70±103.84fmol/ml) was significantly high compared to that of spontaneous group(385.88±87.03fmoVml). Comparing cytokine production of PBMC, there was a significant correlation between IL-1 and IL-6(r=0.78), IL- 1 and TNF(r=0.78) and TNF and IL-6(r=0,76). Conclusion: Our results show that the interaction of cuprophan or PMMA membranes with blood increase the production of IL-1, TNF and IL-6. We suggest that in patients undergoing routine hemodialysis PBMC are primed by exposure to chronic stimulation.
특집-만성 콩팥병, 적극적 치료가 필요하다 ; 만성 콩팥병 단계에 따른 치료의 최신 경향
김영훈 ( Yeong Hoon Kim ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5
Chronic kidney disease (CKD) is a major public health problem. It is estimated that 400-600 million adults worldwide have CKD. Furthermore, more than 5% of the adult population has some form of kidney damage. CKD is not an isolated disease, but is strongly linked to other health problems, such as diabetes and cardiovascular diseases (CVD), with high blood pressure as the main indicating risk factor. For example, every year millions die prematurely of CKD-linked CVD alone. However, adverse outcomes of CKD can be prevented through early detection and treatment. Earlier stages of the disease can be detected through routine laboratory measurements. Therefore, a clinical action plan should be developed for each patient, based on the stage of disease. The basic principle of treatment for CKD is to prevent the further deterioration of renal function and to minimize complications, including cardiovascular events. For this purpose, treatment should include specific therapy based on the underlying disease; an evaluation of comorbid conditions; a method of slowing the loss of renal function; the prevention and treatment of CVD as well as complications associated with decreased renal function; and replacement treatment for renal function, using dialysis and transplantation, if signs and symptoms of uremia are present. (Korean J Med 76:521-527, 2009)
신성골이영양증의 지표로써 혈청 Osteocalcin 의 유용성
김영훈(Yeong Hoon Kim),최병길(Byung Kil Choi),이태원(Tae Won Lee),임천규(Chun Gyoo Ihm),김명재(Myung Jae Kim) 대한내과학회 1988 대한내과학회지 Vol.34 No.4
N/A Osteocalcin, the vitamin K dependent protein synthesized by osteoblast, has been shown to be a specific and sensitive marker of bone turnover in various metabolic bone disorders. We measured the serum osteocalcin concentration with the purpose of determining the usefulness of serum osteocalcin in diagnosis and follow up of the therapeutic response in patients with renal osteadystrophy before and after 1 month of renal transplantation. The results were as follows; 1) The level of serum osteocalcin in normal Korean was 4.4±1.0ng (4.5±1.1ng/ml in male, 4.4±1.0ng/ml in female). 2) The level of serum osteocalcin in patients with renal osteodystrophy was 25.4±8.5ng/ml which was significantly elevated compared with that of normal controls. (P<0.005). 3) After one month of kidney transplantation, serum level of osteocalcin was significantly decreased compared with that of pretransplantation. (3.6±2.6ng/ml vs 27.9±13.9ng/ml, P<0.005). 4) The level of serum osteocalcin correlated with those of alkaline phosphatase (r=0.62, P<0.025) and PTH (r=0.69, P<0.01). 5) The level of serum osteocalcin showed the trend of increase with the decrease of renal function but with no statistical significance. (P<0.1). In conclusion, serum osteocalcin may be used as a marker to evaluate the state and therapeutic response of renal osteodystrophy in patients with end stage renal disease.
김영훈(Kim Young-Hoon),김기남(Kim Ki-nam),장현목(Jang Hyun-mog),박영일(Park Yeong-il) 한국철도학회 2004 한국철도학회 학술발표대회논문집 Vol.- No.-
In this thesis, the impact analysis for the shunting procedure using the dynamic buffer characteristics of the coupler was developed. In this study, each car was modeled as one dimensional element by using the equivalent system. After the impact, the slip exists only between wheel and rail in the braked trainset. For this analysis the analysis code named the POTAS-MSM (Power Transmission Analysis Software- Multi Slip Mechanism) which was developed for the numerical analysis of dynamic system is developed. The validation of this analysis was proven by comparing the numerical results with the results of world-famous S company which is located in Europe.