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인진이 간성상세포의 섬유화 억제에 미치는 영향에 대한 연구
김영철,이장훈,우홍정,Kim, Young-Chul,Lee, Jang-Hoon,Woo, Hong-Jung 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.4
Object : This study was performed to investigate the anti-fibrogenic effect of Artemisiae Capillaris Herba(ACH) on cultured rat hepatic stellate cells. Methods : Hepatic Stellate Cells were obtained from a 350gm Sprague-Dawley rat by tissue perfusion system, and the cells for the study were selected after 3 passages of culture on non-coated plastic culture dishes which enable the cells to activate, thus producing collagens in the cell media. Cells were treated with various concentrations of Artemisia Capillaris Herba(ACH) extract powder for 24 or 48 hours. After the treatment, Soluble collagen, procollagen levels and the mRNA of the procollagen type I C were measured by using assay kit and RT-PCR method. Results : Procollagen production by the hepatic stellate cells decreased after the treatment in a time-dependent dose-dependent manner. The mRNA expression decreased consistently with the volume of the secreted procollagen which indicates the herb hat inhibitory effect on fibrogenesis of the liver by regulating one of the fibrosis associated genes in transcription. Conclusion : These results suggest that ACH is beneficial in the treatment of cirrhotic patients as well as for the patients with chronic hepatitis.
신체형 장애(Somatoform disorder)의 개념, 평가, 감별진단
김영철,Kim, Young-Chul 한국정신신체의학회 1996 정신신체의학 Vol.4 No.2
Somatoform disorders are a group of syndromes in which patients focus on and complain of physical symptoms when there is no demonstrable underlying organic pathology or when complaints are in excess of what is expected. The author reviewed concept, sociocultural etiology, differential diagnosis and methods of evaluation of somatoform disorder. The symptoms of Korean culture-specific somatizing cluster, so called Wha-Byung, are discussed.
유한요소해석을 이용한 압축 하중을 받는 오픈 홀 복합재 시편의 점진적 손상 및 파손 분석
김영철,주근수,장홍규,김진봉,강민규,이우경,김지훈,Young Cheol Kim,Geunsu Joo,Hong-Kyu Jang,Jinbong Kim,Min-Gyu Kang,Woo-Kyoung Lee,Ji Hoon Kim 한국복합재료학회 2023 Composites research Vol.36 No.5
In this paper, a Progressive Damage and Failure Analysis (PDFA) modeling method was developed using ABAQUS/EXPLICIT to predict in-plane damage and delamination for Open-Hole Compression (OHC) testing. The proposed PDFA model was constructed based on Hashin criteria and cohesive behavior. The strength and stiffness of OHC specimens with three types of stacking sequences [(45/-45/0<sub>2</sub>)<sub>3</sub>]<sub>s</sub> , [(45/0/-45/90)<sub>3</sub>]<sub>s</sub> and [45/-45/0/45/-45/90/(45/-45)<sub>2</sub>]<sub>s</sub> were compared to comprehensively evaluate the validity of the Finite Element(FE) model of PDFA. The strength and stiffness of the OHC specimens were predicted relatively well, with less than a percentage error 10.0 %. For the numerical simulation case for each layup, the damage initiation/evolution of OHC specimens were evaluated for delamination and tension/compression matrix damage before and after failure.
김영철,Kim, Young-Chul 대한생물정신의학회 2000 생물정신의학 Vol.7 No.1
외상성 뇌손상으로 외상 후 스트레스 장애, 범불안장애, 공황장애, 강박장애, 공포장애 등의 불안장애가 비교적 흔히 발생할 수 있다. 그러나 빈발하는 불안장애인데 비해 의사들로부터 적절하게 관심을 받지도 못했으며 치료받지도 못하였다. 외상성 뇌손상 후 불안장애는 뇌손상 자체에 의해, 뇌손상과 기능상실에 대한 환자 또는 간호인의 반응에 의해 증상이 발생하기도 하고 지속되기도 한다. 의사는 이들 환자들을 진단하고 치료하기 위해서는 우선 뇌손상의 기전과 양상에 대해 지식이 있어야 하며, 불안증상을 호소하는 외상성 뇌손상 환자를 이해하고 수용하고 지지해주는 태도를 취해야 하며, 불안증상이 뇌손상에 의한 것인지 통상적인 불안 증상인지 확인해야 한다. 이들 뇌손상 환자들은 약물의 부작용에 아주 취약하기 때문에 약물치료시에는 약물의 작용기전은 말할 것도 없고 부작용에 대해 잘 알고 있어야 한다. Traumatic brain injury(TBI) is generally considered to be a risk factor for psychiatric disorders, especially depression and anxiety disorder. Despite the anxiety disorders are frequent sequelae after traumatic brain injury, the patients have not been payed medical attention and treated by doctors properly. The factors of precipitating and sustaining the anxiety disorders after TBI are brain injury itself, and the patient's or caregiver's response to the disability after TBI. To diagnose and treat them effectively, the knowledge about the mechanisms of and symptoms after TBI have to be needed. Psychiatrist should be a supportive and good listener to the patients who are complaining anxiety symptoms and differentiate whether the psychiatric symptoms are due to TBI or not. Because the TBI patients are very sensitive to drug side effects, doctors have to be familiar with the side effects as well as the mechanisms of action of the common psychotropics.
동적 버퍼관리 방식의 Dynamic GSMP V3의 구조와 하드웨어 구현
김영철,이태원,김광옥,Kim, Young-Chul,Lee, Tae-Won,Kim, Kwang-Ok 대한전자공학회 2001 電子工學會論文誌-TC (Telecommunications) Vol.38 No.8
In this paper, the architecture of Dynamic GSMP V3(General Switch Management Protocol Version 3), an open interface protocol with resource management functions for efficient IP service on ATM over MPLS, is proposed and implemented in hardware. And we compare and analyze the proposed GSMP with the GSMP under standardization process in terms of CLR (Cell Loss Rate). We design the Slave block of the Dynamic GSMP V3 using SAM-SUNG SoG $0.5{\mu}m$ process, which performs functions for switch connection control in the ATM Switch. In order to compare difference performanaces between the proposed method and the conventional one, we conducts simulations using the minimum buffer search algorithm with random cell generation. The exponential results show that the proposed method leads to performance enhancement in CLR. 본 논문에서는 ATM 기반 MPLS 망에서 효율적으로 IP 서비스를 전송하기 위한 동적 버퍼관리 방식의 Dynamic GSMP V3(General Management Protocol Version 3)를 구현하였으며, 하드웨어 모델링 구조를 제안하였다. 또한 현재 표준화중인 GSMP와 동적 버퍼관리 방식을 수용한 GSMP를 셀 손실률 측면에서 비교 분석하였다. ATM 스위치 상에 연결 제어의 성능 향상을 위해 스위치에서 연결설정 및 제어를 수행하는 Dynamic GSMP V3의 Slave 블록을 산성 SoG $0.5{\mu}m$ 공정으로 설계하였다. 기존의 방식과 제안한 방식의 성능 평가를 위해 확률 랜덤 변수에 의해 발생된 셀과 최소 버퍼 알고리즘을 이용하여 모의 실험을 하였으며, 이때 셀 손실률이 향상되었음을 알 수 있었다.
홍차추출물 함유 누드팩의 Hairless 마우스 피부주름 형성 억제효과
김영철,박은예,김상남,유용기,박미순,이귀영,이석준,장병수,Kim, Young-Chul,Park, Eun-Ye,Kim, Sang-Nam,Yoo, Yong-Gi,Park, Mi-Soon,Lee, Gui-Yeong,Lee, Suk-Jun,Chang, Byung-Soo 한국현미경학회 2011 Applied microscopy Vol.41 No.2
The aim of this study was to evaluate the inhibitory effect of nude pack containing black tea water extract (NPBT) on skin wrinkle formation in hairless mice. Skin wrinkles were induced by UVB irradiation to the backs of hairless mice for 5 weeks. And at the same time, NPBT was applied topically. Wrinkle formation, histological changes, expression of matrix metalloproteinase-3 (MMP-3) and protein activities of MMP-2 and MMP-9 were observed or analyzed. Wrinkles for the control group were formed as a pattern of deep furrows and thick crests. Whereas wrinkles for the NPBT treated group were formed as a pattern of shallow furrows and thin crests, and their wrinkle areas were significantly (p<0.001) lower than the control group. Collagen fibers were arranged irregularly and sparse in density and some elastic fibers were degenerated in the control group, while they were almost intact in the NPBT treated group. MMP-3 mRNA expression in the control group was significantly (p<0.001) higher than the normal group, and that of NPBT treated group was significantly (p<0.001) lower than the control group. The NPBT treated group showed remarkably lower protein activities of MMP-2 and MMP-9 than the control group. NPBT could have a considerable inhibitory effect on skin wrinkle formation in hairless mice. 홍차함유 누드팩의 피부주름 형성 억제효과를 알아보기 위해 SKH-1 hairless 마우스 등 부위에 UVB를 5주간 조사하여 주름을 유발시키고 이와 병행하여 홍차함유 누드팩을 도포한 실험에서 다음과 같은 결과를 얻었다. (1) 육안적인 피부주름 양상 비교에서, 대조군은 정상군에 비해 주름 능선의 두께가 굵고 간격이 넓으며 주름이 깊게 형성된 반면, retinoic acid를 도포한 양성대조군과 홍차함유 누드팩 도포군은 대조군에 비해 상대적으로 주름 능선의 두께가 얇고 간격이 좁은 양상을 띠었으며 주름 총넓이 수치가 유의하게(p<0.001) 낮았다. (2) 피부의 조직학적 관찰에서, 대조군은 정상군에 비해 진피층내 교원섬유의 배열이 불규칙하고 양이 많이 줄어들었으며 변성된 탄력섬유가 군데군데 엉겨 있는 탄력섬유증이 관찰된 반면, 양성대조군과 홍차함유 누드팩 도포군은 대조군에 비해 상대적으로 교원섬유의 배열이 규칙적이고 밀도가 조밀하며 변성된 탄력섬유의 양이 줄어 있었다. (3) 피부조직의 MMP-3 mRNA 발현량 측정 결과, 정상군에 비해 대조군은 유의하게(p<0.001) 높았으며 양성대조군과 홍차함유 누드팩 도포군은 대조군에 비해 유의하게(p<0.001) 낮았다. MMP-2와 MMP-9 단백질 활성 측정 결과, 대조군은 정상군에 비해 현저하게 높은 반면, 양성대조군과 홍차함유 누드팩 도포군은 대조군보다 현저하게 낮게 나타났다. 본 연구를 통하여, 홍차함유 누드팩 도포군은 hairless 마우스에서 세포외 기질단백질의 분해 억제와 피부주름 형성 억제효과를 보였음을 확인하였다.
항공기 결항과 연쇄 교통사고를 야기한 연안안개 사례 연구
김영철,Kim, Young Chul 한국항공운항학회 2017 한국항공운항학회지 Vol.25 No.1
A heavy foggy event accompanying with complex coastal fog was investigated in this study. This heavy foggy event occurred on FEB 11, 2015. Due to reduced visibility with this foggy event induced more than 100times serial traffic accidents over the Young-jong highway, and Flights from 04:30 AM to 10:00 AM were cancelled on Inchon International Airport. This heavy foggy event was occurred in synoptic and mesoscale environments but dense coastal fog were combined with a combination of sea fog, steam fog, and radiation fog. This kind of coastal fog can predicted by accurate analysis of the direction of the air flow, sea surface temperature(SST), and 925hPa isotherms from numerical weather prediction charts and real time analysis charts.
키틴분해세균의 현장 대량 배양방법을 이용한 효과적인 식물병의 생물적 방제 전략
김영철,강범용,김용환,박서기,Kim, Young-Cheol,Kang, Beom Ryong,Kim, Yong Hwan,Park, Seur Kee 한국식물병리학회 2017 식물병연구 Vol.23 No.1
유기농 및 지속 가능한 농산물에 대한 최근의 전 세계적인 수요는 농가 현장에서 사용 가능한 생물 농약의 개발 및 활용에 대한 요구가 증대되고 있다. 그러나 대부분의 생물학적 방제 방법은 실제 현장 조건에서 식물병 방제 스펙트럼이 제한적이고 효능이 높지 않다. 본 연구팀은 키틴분해 미생물과 키틴을 활용하여 적은 비용으로 방제효과가 우수한 키틴 기반 제형을 개발했다. 이 제형은 포장 조건에서 다양한 식물병을 성공적으로 방제하였다. 본 리뷰에서는 성공적인 포장 연구와 관련하여 이 제형에 함유되어 있는 키틴분해미생물들의 생태학적 측면과 생물적 방제 기작에 대해 기술하였다. 또한 현장에서 키틴분해미생물의 현장 대량 배양과 효과적인 생물학적 방제 방법을 사용하여 농민 친화적인 수단으로 확대 할 수 있는 생물적 방제 방법과 전략의 가능성에 대해 논의했다. Recent worldwide demand for organic and sustainable agriculture products is driving the development of formulations of biopesticides effective in the field. Biopesticides have the benefit of environmentally-friendly qualities. However, biocontrol approaches largely have been ineffective in controlling plant pests in field conditions. Previously, we developed a cost-effective biocontrol formulation containing chitin and chitinase-producing biocontrol bacteria with field efficacy. This formulated product has successfully suppressed various plant diseases in the field conditions. In this review, we focus on ecological aspects and the potential mechanisms underpinning the success of chitinase-producing bacteria. In addition, we discuss the possibility on-site cultivation of the formulated products to further strengthen the approach as being farmer friendly and successful.
'연줄'인가, '연결'인가?: 인적 네트워크의 노동시장 효과 분석
김영철,KIM, Young Chul 한국개발연구원 2012 韓國 開發 硏究 Vol.34 No.3
본 논문은 한국노동패널(KLIPS) 자료를 활용하여 국내 노동시장에서의 인적 네트워크 활용의 효과성을 검증하고 임금근로자 개인의 구직 네트워크 가치를 추정하였다. 흔히 인적 네트워크를 활용한 이직을 '연줄' 혹은 '정실인사'라고 하여 부정적으로 보는 견해가 많으나, 본 연구는 인적 네트워크가 이직자와 구인자 사이의 정보전달기능을 수행함으로써 사회 전반의 일자리 매치(job match)의 적합성을 증대시키는 긍정적 기능을 수행하고 있음을 입증하고 있다. Propensity Score Matching 방법론을 활용하여 검증한 결과, 자발적 이직자들의 이직을 네트워크형 이직과 비네트워크형 이직으로 구분하여 보았을 때, 네트워크형 이직만이 교육수준 및 기술수준의 적합도를 각기 (100점 만점에서) 2.13점과 2.52점 개선시키는 것으로 확인되었으며, 이러한 적합도의 개선은 월 4.074만원(2010년 기준)의 임금상승효과로도 재확인되었다. 덧붙여, 이를 활용하여 임금근로자 개인의 구직 네트워크의 가치를 추정해 보면, 구직 네트워크의 생애 금전적 가치는 1,872.0만원으로 집계되었으며, 여기에 주관적 만족도에 대한 보상측면까지 고려하면, 만족도 1점의 현금가치를 n만원으로 환산할 때, 대략 (1,872.0+758.2n)만원에 이르는 것으로 집계되었다. This paper analyzes the effectiveness of social networks in finding jobs and estimates the value of job search network using the Korean Laber and Income Panel Study (KLIPS) dataset and utilizing the Difference-in-Difference Propensity Score Matching (PSM) methodology (Heckman et al., 1997). While the wide use of social networks in the Korean labor market is often perceived as 'nepotism,' this study confirms that social networks, by serving as an effective information transmitter between job search and recruitment, make a significant contribution to improving the adequacy of job matching in the domestic labor market. In order to verify the effectiveness of using social networks for getting jobs, this study looks into the cases of labor turnover using social networks and also not using it. In the aspect of individual satisfaction improvement relating to workplace and job duties, both cases of turnover turn out to experience an increased satisfaction by 2~3 points (on a 100-score scale). Meanwhile, as for the educational and technical adequacy improvement, no positive effects are found in the case of turnover without social networks, whereas the educational and technical adequacy improvement turns out to increase by 2.13 and 2.52 points, respectively, in the case of turnover using social networks. The effect of income increase through turnover using social networks registered 40,074 Korean won per month (as of 2010), which can be considered as the result from the improved educational and technical adequacy. Of all things being considered, the value of job search network per wage worker in the Korean society is estimated to be 18.72 million won in terms of life-cycle wage improvement, and 758.2 scores in terms of the improvement of working life satisfaction. Provided that the cash value of satisfaction score 1 is equivalent to 'n' times 10,000 won, the aggregate value of job search network is estimated to be 18.72+7.582n million won, which means the total amount of costs that a wage worker in the Korean society willingly pays to maintain and manage job networks for lifetime.
A New Algorithm for the Estimation of Variable Time Delay of Discrete Systems
김영철,정찬수,양흥석,Kim, Young-Chol,Chung, Chan-Soo,Yang, Heung-Suk The Institute of Electronics and Information Engin 1987 전자공학회논문지 Vol.24 No.1
A new on-line estimation algorithm for a time varying time delay is proposed. This algorithm is based on the concept of minimization of prediction error. As only the parameters directly related to the poles and zeros of the process are estimated in the algorithm, persistently exciting condition for the convergence of parameters can be less restrictive. Under some assumptions which is necessary in adaptive control, it is shown that this algorithm estimates time varying time delay accurately. In view of computational burden, this algorithm needs far less amount of calculations than other methods. The larger the time delay is, the more effective this algorithm is . Computer simulation shows good properties of the algorithm. This algorithm can be used effectively in adaptive control of large dead time processes.