문어 자숙액의 전자선 조사에 의한 생리활성 개선

김연주(Yeon-Joo Kim),김현주(Hyun-Joo Kim),최종일(Jong-il Choi),김재훈(Jae-Hun Kim),전병수(Byung-soo Chun),안동현(Dong-Hyun Ahn),권중호(Joong-Ho Kwon),김영지(Yeung-Ji Kim),변명우(Myung-Woo Byun),이주운(Ju-Woon Lee) 한국식품영양과학회 2008 한국식품영양과학회지 Vol.37 No.9

수산 가공 부산물을 천연 기능성 소재로 개발하기 위한 기초 자료를 마련하고자 문어 자숙액 에탄올 추출물을 전자선 조사하여 이에 대한 항산화, 항고혈압 및 미백효과를 평가하였고, 이와 더불어 대조군(0 kGy)의 생리활성과 비교하였다. 전자선 조사 문어 자숙액 에탄올 추출물의 색도를 측정한 결과 감마선 조사와는 달리 조사선량이 증가함에 따라 색상이 변화되었음을 확인하였다. DPPH 라디칼 소거능은 전자선 조사선량의 증가에 따라 유의적으로 증가하였으며, 이러한 소거능의 증가는 단백질의 항산화력의 증가가 원인인 것으로 판단되었다. ACE 및 tyrosinase 저해 활성 측정결과 조사선량이 증가함에 따라 각 활성이 증가하였다. 따라서 수산가공 폐자원인 자숙액이 전자선 조사에 의하여 생리활성이 개선된 기능성식품 소재로 활용될 수 있으며, 또한 전자선 조사의 산업적인 활용이 더욱 활발할 것으로 기대한다. Effect of electron beam irradiation on various physiological property changes of the ethanol extract from the cooking drips of Enteroctopus dofleini was investigated. The Hunter's color values of extract were increased with increasing irradiation doses. The radical scavenging activity of the extract was increased depending on the irradiation dose. The inhibitory activities against tyrosinase and angiotensin Ⅰ converting enzyme were also increased with irradiation dose. It was also shown that the contents of proteins and polyphenols were increased by the irradiation. It was reasoned that the antioxidant activities were increased by proteins modified by the irradiation.

장기기증에 대한 대학생들의 지식수준과 태도

박휘향,김연주,김진희,박미현,김연경,김연빈,김윤서,김지안,민지현,배성철,김진아,안성아,김은희,Park, Hwi-Hyang,Kim, Yeon-Joo,Kim, Jin-Hui,Park, Mi-Hyeon,Kim, Yeon-Gyeong,Kim, Yeon-Bin,Kim, Yoon-Seo,Kim, Ji-An,Min, Ji-Hyeon,Bae, Seong-Cheol,Kim 한국임상보건과학회 2015 한국임상보건과학회지 Vol.3 No.1

Purpose. The purpose of this study was to investigate level of knowledge and attitude about organ donation in university and provide basic information on correct education and promotion. Method. The sample is consisted of 90 the students related to health and 90 general college students ; total 180 students in J city. The questionnaires were used to obtain the results. Data was collected from November 6th to 8th, 2013. For data analysis, the SPSS for window 12.0 K program was utilized to get descriptive statistics including the percentage, average, standard deviation and t-test. Results. Comparing the results between a series of health students and general college students, a series of health students showed high level of more knowledge and more positive attitude about organ donation than general college students. A series of health showed significant correlation but general college didn't show significant correlation. Conclusion. To educate correct knowledge draw positive attitude about organ donation is needed to improve the level of Knowledge and Attitude about organ donation.

이동수단과 보행환경에 따른 보행자의 안전감 분석 - 대학 캠퍼스 보행환경을 중심으로

김연주(Kim, Yeon-Joo),황성주(Hwang, Sungjoo) 대한건축학회 2021 대한건축학회 학술발표대회 논문집 Vol.41 No.2

The purpose of this study is to analyze pedestrian feelings of safety. In this study, the district was designated as the Ewha Womans University campus, then factors affecting pedestrian feeling of safety were analyzed with a focus on a means of transportation and the walking environment. In addition, by comparing this result with objective pedestrian environment type, a plan for improving pedestrian safety for each area was suggested. The analysis result showed that the pedestrian’s feeling of safety is very closely related to the traffic and walking environment. Therefore, this study aims to contribute to the improvement of pedestrian safety by analyzing how two factors affect pedestrian safety.

공공디자인 진흥계획 안에서의 디자인 가이드라인에 대한 고찰

김연주 ( Yeon-joo Kim ),이수연 ( Su-yeon Lee ) 중앙대학교 예술문화연구원 2022 예술문화융합연구 Vol.16 No.-

As the Act on the Promotion of Public Design was enacted in 2016, domestic public design is proposing a new public design paradigm starting with the first comprehensive plan for public design promotion established by the Ministry of Culture, Sports and Tourism in 2018. However, the existing design guidelines are design guidelines presented in the basic plan for urban design and public design before the establishment of the first comprehensive plan for public design promotion. This is inconsistent with the current public design promotion plan as guidelines are presented as construction and design criteria rather than design perspective by applying guidelines such as national construction standards, directives, and regulations of central ministries. Therefore, this study began with the aim of deriving the direction that the design guidelines of the public design promotion plan to be established by each local government in the future based on the first comprehensive plan for public design promotion. In order to examine the trend of design guidelines from the perspective of public design, this study first reviewed the institutional definition of public design and guidelines proposed by domestic law, and compared and analyzed the current status of design guidelines and classification system for each local government. Therefore, in this study, based on the analysis of the change in the composition system of design guidelines following the establishment of the first comprehensive plan for public design promotion, it was found that guidelines were gradually established in consideration of the characteristics of local governments. As a result of this study, the guidelines of the public design promotion plan are expected to have a direction to guide the entire process to the design stage of consultation, deliberation, construction, supervision, maintenance, and management.

商代 東夷 열국과 문화

김연주(Kim, Yeon-Joo) 고조선단군학회 2012 고조선단군학 Vol.26 No.-

In Korea, studies on Dong-Yi in the era of Shang dynasty until now were mainly focused on whether Shang" racial origin was Dong-Yi or not. However, Dong-Yi had a lot of influence on Shang civilization. I studied Dong-Yi in the Shang dynasty, focusing their own history and culture. Recent academic circles are trying to incorporate Dong-Yi"s history and culture into China, asserting that Dong-Yi is one of the branches of Chinese race. I payed special attention to their interpretations of archeological remains lest the facts be distorted by records. After analyzing historical records, oracle bone inscriptions, bronze inscriptions and archeological remains, I arranged Dong-Yi’s four cultural peculiarities. First, They were culturally advanced. Second, their stock-farming and agriculture were developed. Third, they accepted culture of Shang civilization actively. Forth, they also had the custom of sacrificing human beings and burying the living with the dead. Dong-Yi seemed to be a potential rival of Shang on account of their fertile land and their advanced culture. Therefore, Shang dynasty conquered Dong-Yi dozens of times. Shang let shamans curse Dong-Yi and performed special ceremonies like 望’ to suppress Dong-Yi" religious power, before attacking ‘Dong-Yi’. It is reasonable to assume that Shan sacrificed Dong-Yi before and after attacking them. I presume that Dong-Yi’s kneeling upon their knees was not their own custom. Shang dynasty celebrated their triumph over Dong-Yi considerably. They not only desired for winning the war by sacrificing Dong-yi, but also sacrificed Dong-Yi after war as a symbol of Shang’s authority. Shang wanted Dong-Yi to bend their knees to them. I presume the name-Dong-Yi- reflects Shang’s mentality.

Immunohistochemical Study to Evaluate the Prognostic Significance of Four Biomolecular Markers in Radiotherapy of Nasopharyngeal Carcinoma

김연주(Yeon-Joo Kim)ㆍ이승희(Seung Hee Lee)ㆍ우홍균(Hong-Gyun Wu)ㆍ고현정(Heounjeong Go)ㆍ전윤경(Yoon Kyung Jeon) 대한방사선종양학회 2010 Radiation Oncology Journal Vol.28 No.2

목 적: 방사선 치료를 받은 코인두암 환자의 치료 전 조직을 면역조직화학염색하여 생체분자적 예후인자를 찾고자하였다.대상 및 방법: 1998년부터 2006년까지 방사선 치료를 받은 코인두암환자는 68명이었다. 이중 38명의 환자에서 면 역조직화학염색을 위한 파라핀 블록을 찾을 수 있었다. 전체 환자 중 31명은 미분화암종이었고, 7명은 편평세포암종이었다. 전체 환자의 84%가 2002 American Joint Committee on Cancer Stage III or IV 환자였다. 전체 환자의파라핀 블록을 이용하여 Met, COX-2, epidermal growth factor receptor (EGFR), nm23-H1에 대해 면역조직화학염색을 시행하였다.결 과: 전체 환자의 중앙 추적 기간은 30개월이었고 생존 환자의 중앙 추적 기간은 39개월이었다. 높은(≥50%)Met 발현을 보인 환자들의 5년 생존율은 48%, 낮은 Met 발현을 보인 환자들의 5년 생존율은 84%로 이는 통계적으로 유의한 차이를 보였다(p=0.02). Met 발현 정도는 다변량 분석에서도 유의한 인자로 분석되었다(p=0.01). Met발현은 종양의 병기, 성별, 나이, 항암제나 방사선 치료에 대한 반응 정도와 상관관계를 보이지 않았다. Met 발현정도는 COX-2 발현과 중등도의 상관관계를 보였으나(Pearson coefficient 0.496, p<0.01), COX-2 발현은 전체생존율에 영향을 미치지 않았다. 본 연구에서는 nm23-H1이나 EGFR의 발현은 예후인자가 아닌 것으로 분석되었다.결 론: 방사선치료를 받은 코인두암에서, 높은(≥ 50%) Met 발현은 전체생존율에 영향을 미치는 독립적인 예후인자일 가능성이 있다. Purpose: We performed an immunohistochemical study with pre-treatment biopsy specimens to evaluate the prognostic significance of four biomolecular markers which can be used as a predictive assay for radiotherapy (RT) treatment of nasopharyngeal carcinoma (NPC). Materials and Methods: From January 1998 through December 2006, 68 patients were histologically diagnosed as non-metastatic NPC and treated by RT. Only 38 patients had the paraffin block for the immunohistochemical study. Thirty-one patients had undifferentiated carcinoma and 7 patients had squamous cell carcinoma. Thirtytwo patients (84%) had advanced stage NPC (2002 AJCC Stage III∼IV). Immunohistochemical staining was performed for Met, COX-2, nm23-H1, and epidermal growth factor receptor (EGFR) expression using routine methods. Results: The median follow-up time was 30 months (range, 11 to 83 months) for all patients, and 39 months (range, 19 to 83 months) for surviving patients. The 5-year overall survival (OS) rate of the patients with high Met extent (≥50%) was significantly lower than that of the patients with low Met extent (48% vs. 84%, p=0.02). In addition, Met extent was also a significant prognostic factor in multivariate analysis (p=0.01). No correlation was observed between Met extent and T stage, N stage, stage group, gender, age, and the response to chemotherapy or RT. Met extent showed moderate correlation with COX-2 expression (Pearson coefficient 0.496, p<0.01), but COX-2 expression did not affect OS. Neither nm23-H1 or EGFR expression was a prognostic factor for OS in this study. Conclusion: High Met extent (≥50%) might be an independent prognostic factor that predicts poor OS in NPC treated with RT.

신사(‘神思)’를 통해 본 ‘수물부형(隨物賦形)’ 서화(書畵)창작론의 초월성 연구

김연주 ( Kim Yeon-joo ) 동양철학연구회 2016 東洋哲學硏究 Vol.87 No.-

본 연구는 蘇軾(1037-1101)의 예술창작론 중에서 ‘隨物賦形’ 書畵창작론을 ‘神思’의 초월적 성격으로 고찰하고자 한다. 그는 詩·書·畵의 창작이론 뿐만 아니라 그 각각의 예술풍격도 동일하게 보는 예술적 관점을 형성하여, 예술이론이나 창작에 있어서 각 장르의 특수성과 보편성을 긴밀하게 관련시키고 있는데, 특히 그의 ‘隨物賦形’論이 文藝와 書?예술세계를 포괄하는 장르 초월적 창작이론으로 역할을 하였다. 劉?에 의해 체계화된 ‘神思’는 내적 충실에 의한 노닒이 중시되며, ‘神用象通’하는 경지의 구성과 창작 및 감상단계에까지 영향을 미치는 개념 으로서 이는 곧 예술적 상상력으로서 간주된다. 예술적 상상력으로서 神思는 초월적 形을 구현하도록 하며, 다양한 관점의 초월성을 종합하고 융합하여 표현하는 최고의 예술경지를 창출하도록 이끈다. 蘇軾의 예술이론과 그 실천으로서의 창작에서 보이는 ‘隨物賦形’의 초월성은 무엇보다도 다양한 각도로 접근하는 열린 사유로부터 가능했다. 그가 가진 儒·佛·道및 이들의 융합사상, 다양한 장르를 섭렵하고 활용하는 유연성 넘치는 예술언어의 운용, 특히 초월성 강한 그의 ‘禪的意’는 항상 ‘新意’의 예술적 발현으로 구현되었다. ‘禪意’와 ‘新意’는 그의 예술적 내용을 추동하는 인식론적 힘이었으며 예술적 상상력으로서 神思의 작용을 통해 다양한 詩·詞·書·畵의 예술언어로 구현되었다. 따라서 ‘神思’를 통해 본 ‘隨物賦形’ 書畵創作論은 사물의 실제 객관 형상을 따르면서도 주관의 경계를 포괄한 형성적이면서도 불확정적 意境을 창출하며 역동적으로 관계한다. 士人畵와 寫意畵를 제출했던 蘇軾의 書畵藝術에는 ‘神思’를 통한 창조적 과정으로 드러난 초월적 예술언어의 내적 표출로서의 ‘形’이 감상자에게도 끊임없이 새롭게 형성되며 변화하는 意境을 제공한다. This study is to research ‘Shapes created by according to anything encountered(隨類賦形)’ by Sushi(蘇軾, 1037-1101) in calligraphy and painting creation theory through the viewpoint of transcendence of ‘ShenSi(神思)’. He had formed the artistic viewpoint regarding each art such as poem, calligraphy and painting is related with the universality and particularity, not only the creation theory but also the artistic style. ‘ShenSi’ systematized by Liuxie(劉?) has focused on enjoying by inner faithfulness, and it is the concept that influences on formating, creating and appreciating stage in creative work of art. ‘ShenSi’ is regarded as an artistic imagination enables artists to realize transcendental forms and lead to attain completeness of artistic achievement by synthesizing, fusing and expressing the transcendences of various viewpoints. Transcendences of ‘Shapes created by according to anything encountered’ in Sushi`s artistic theory and creation were possible from the open mind accessed from various angles. His profound knowledge with Confucianism, Buddhism, and Taoism, their fused ideology, and the operation of the flexible artistic languages that ranges over various fields, especially his ‘the meaning of zen meditation(禪意)’ with strong transcendence has been always realized into artistic expression of ‘new meaning(新意)’. ‘The meaning of zen meditation’ and ‘new meaning’ were his epistemic drives in art creation which was realized into various artistic languages of poet, writing, painting and calligraphy by acting ShenSi as an artistic imagination. Therefore, Sushi`s art theory about ‘Shapes created by according to anything encountered’ considered through ‘ShenSi’ communicates dynamically by imitating objective forms of nature things and creating the formative and undefined mind boundary embracing subjectivity. Sushi`s art works have showed internal expressions of transcendental artistic language revealing as creative process through ‘ShenSi’.

텍스트 마이닝을 활용한 고등학교 영어 교과서 어휘 목록 개선방안에 대한 제안

김연주 ( Kim Yeon-joo ),이건수 ( Lee Gun-soo ) 대한언어학회 2016 언어학 Vol.24 No.4

The purpose of this study is to propose a way of revising high school English textbooks. We extracted 300 engineering and IT-related vocabularies from American math & science textbooks and English newspapers to be reflected on the textbook revision. The proposed revision including the extracted words is deemed highly necessary in the current hi-tech age as Korea has emerged as an IT power nation. The IPA method was used for a survey to find out whether college students feel the necessity of the early ESP instruction. The 300 words were selected through POS tagging and frequency analyses after basic lexical items were removed by stop-word lists by utilizing text mining techniques. It is expected that such a revision would greatly facilitate students` understanding of engineering fields and enhance their ESP communication skills at the college level if the newly revised English textbooks could be used for high school English education prior to college.

유송(劉宋) 종병(宗炳)의 「화산수서(畵山水序)」 : 도(道)의 체현(體現)으로서 초기산수화(初期山水畵) 연구

김연주 ( Kim Yeon-joo ) 호남사학회(구 전남사학회) 2016 역사학연구 Vol.64 No.-

宗炳(375-443)의 「畵山水序」는 그의「明佛論」에서 보이는 佛家의 思想을 기반으로 儒ㆍ道家와 이를 포함하는 玄學을 융합하고 山水畵에 적용시켜 체계적이고도 철학적으로 기술한 현존하는 最古의 山水畵 이론서이자, 중국회화사에 실질적으로 가장 큰 영향을 미친 山水畵論이다. 「畵山水序」는 최초로 山水自然美에 주목하고 山水의 아름다움을 `道`의 드러남으로 설명하는 복합적 관점의 玄學的 회화이론이라는데 그 의의가 있다. 宗炳은 聖人들이 道를 대하는 방식과 함께 山水를 그 객관대상으로 드러냄으로써, 自然을 道가 아름답게 드러나는 것으로 구체화시키고 창작이나 감상의 심미적 대상으로 삼았다. 본질적이며 형이상학적이고 철학적인 道는 宗炳에 의해 구체적 山水를 통해 山水畵에도 구현되는 것으로 이론화되었고, 이로써 예술의 진지함과 심미성을 담보할 수 있었다. 「畵山水序」에서 가장 먼저 제출된 `澄懷味象`은 심미적 태도를 견지하고 있으나 상당히 이지적인 면이 다분한데, 宗炳은 이를 `臥遊`와 `暢神`의 개념을 통해 직접적이고 즉각적인 심미적 快와 연결시켰다. 이는 교화적이고 권계적인 내용을 담은 인물화 효능론으로부터 산수화 개화기에 그 창작 목적을 심미적으로 전환시키는 실제적 발상이었다. 宗炳은 山水畵의 본질이 단지 山水외관의 재현으로서의 모방으로 그려지는 것이 아니라 감성을 초월하는 초월적 감성과 무한한 정신을 체현해야 한다고 주장하며, 정신의 해방을 느낄 수 있는 `오묘한 묘사(妙寫)`를 주장하고 있는 것이다. 宗炳에게 있어서 山水畵는 山水의 정신(神)이자, 이치(理)이자, 道를 즉물적으로 표현하는 것이었으며, 그 진정한 가치는 이를 드러내는 사실적 묘사에 중점을 둔 것이 아니라 이를 體現함에 있어서 산수화를 창작하고 감상하는 방법과 그 목적을 觀道와 體道에 두었다. 예술은 감성적 직관력과 풍부한 상상력에 의해 그 경계를 확장시킨다. 그가 山水를 통해 道를 풍부하게 체험하도록 한 것은 `味象`, `臥遊` 및 `暢神`의 예술·심미적 가치를 인지하고 있었기 때문이다. Hua shan-shui hsu(畵山水序) of Tsung Ping(宗炳, 375-443) is not only the oldest existing theoretical book of landscape painting by fusing the Confucianism and Taoism based on the thought of Buddhism appeared in his Ming Fo lun(明佛論) and the Pedagogism including this and applying these in the landscape painting, but also the theory of landscape painting having the biggest effect on the Chinese painting history substantially. There is the meaning that the Hua shan-shui hsu is to take note on the natural beauty of natural landscape for the first time and the painting theory of complex point of view explaining the beauty of landscape as the exposure of Tao. Tsung Ping materialized that the nature is the exposure of Tao beautifully by revealing the natural landscape as the object with the method that saints dealt with the Tao and considered as the aesthetic object of creation or appreciation. The essential, metaphysical and philosophical Tao have been theorized as it is realized in the landscape painting through the concrete natural landscape by Tsung Ping. Moreover, the seriousness and aesthetic impression of art could be secured. It is full of the intelligent side even though `chunghuai weixiang(澄懷味象)` submitted earliest in Hua shan-shui hsu sticks to the aesthetic attitude, Tsung Ping connected this with the direct and intermediate aesthetic pleasure through the concept of `woyou(臥遊, strolling while lying)` and `changshen(暢神, rejoice the spirit)`. This was the practical idea converting the creative purpose aesthetically at the time of early landscape painting from the theory of efficacy of figure painting containing the edifying and admonishing content. Tsung Ping insisted that the essence of landscape painting was not painted as the imitation as the representation of landscape appearance only the transcendental sensitivity transcending the sensitivity and infinite spirit should be embodied. In addition, he assertes `a absrtus description(妙寫)` which is capable of feeling the liberation of spirit.

레트 증후군의 MECP2 유전자 돌연변이와 다형성

김연주 ( Yeon Joo Kim ),이동형 ( Dong Hyung Lee ),김철민 ( Cheol Min Kim ),최욱환 ( Ook Hwan Choi ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.4