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중등도-중증의 한국인 건선 환자에서 Ustekinumab 장기 투여에 따른 효과 및 안전성 연구
김연아 ( Yeona Kim ),배경남 ( Kyung-nam Bae ),손진화 ( Jin-hwa Son ),신기혁 ( Kihyuk Shin ),김훈수 ( Hoonsoo Kim ),고현창 ( Hyun-chang Ko ),김문범 ( Moon-bum Kim ),신봉석 ( Bong Seok Shin ),김병수 ( Byungsoo Kim ) 대한피부과학회 2022 대한피부과학회지 Vol.60 No.3
Background: Ustekinumab is a humanized monoclonal antibody targeting interleukin (IL)-12 and IL-23. Although popular, data on its long-term efficacy and safety in Korean patients with psoriasis are limited. Objective: To evaluate the long-term efficacy and safety of ustekinumab in Korean patients with psoriasis. Methods: A retrospective study in patients with moderate-to-severe psoriasis who had been treated with ustekinumab for at least 5 years was conducted. The sex, age, body mass index, medical records, previous psoriasis therapy, psoriasis area and severity index (PASI) scores, and adverse events were evaluated. Results: Twenty-five patients (median age 47.00 years) had been treated with ustekinumab for 5 years. The mean duration of psoriasis was 19.12±8.45 years, and the treatment duration with ustekinumab was 285.12±8.48 weeks. The baseline PASI was 17.52±7.38. PASI75 was achieved in 84% of the patients at week 28, and 96% of the patients maintained PASI75 during the 5-year follow-up period. Furthermore, 56% of patients reached PASI90 at 28 weeks, and 48% of patients maintained PASI90 for 5 years. No unexpected adverse events other than herpes zoster, herpes simplex, or elevated liver enzymes were reported. Conclusion: Ustekinumab demonstrated long-lasting efficacy with an acceptable safety profile in Korean patients with moderate-to-severe psoriasis. (Korean J Dermatol 2022;60(3):151∼158)
김연아 ( Yeona Kim ),하대룡 ( Dae-lyong Ha ),손진화 ( Jin-hwa Son ),신기혁 ( Kihyuk Shin ),이정수 ( Jungsoo Lee ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-chang Ko ),김병수 ( Byung Soo Kim ),김문범 ( Moon-bum Kim ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.9
A poroma is a benign adnexal neoplasm originating from the sweat gland duct. It usually presents clinically as a soft erythematous or flesh-colored papule, plaque, or nodule on the palms and soles. In most cases, poromas manifest as a solitary lesion, but rarely, multiple lesions have been reported and are defined as poromatosis. Although the pathogenesis is unclear, poromatosis is known to be associated with actinic damage, human papillomavirus infection, radiation therapy, or polychemotherapy. Herein, we describe a 53-year-old woman who had multiple erythematous papules on her feet for a year. She had a medical history of acute lymphoblastic leukemia and had undergone polychemotherapy with stem cell transplantation. To our knowledge, poromatosis related to chemotherapy is a rare entity, and our case could be attributed to the theory that using polychemotherapy can induce poromatosis. (Korean J Dermatol 2020;58(9):617∼619)
김연아 ( Yeona Kim ),하대룡 ( Dae-lyong Ha ),손진화 ( Jin-hwa Son ),신기혁 ( Kihyuk Shin ),이정수 ( Jungsoo Lee ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-chang Ko ),김병수 ( Byung Soo Kim ),김문범 ( Moon-bum Kim ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.9
Background: Tumoral calcinosis is characterized by the deposition of calcific masses around major joints, and it often causes significant impairment of joint function. Dermatologists sometimes encounter patients with a subcutaneous hard mass around the joint. However, there are few studies about tumoral calcinosis in the dermatologic literature, especially in Korea. Objective: The aim of this study was to determine the clinical characteristics of tumoral calcinosis. Methods: We reviewed the clinical photographs, medical records, and biopsy specimens of 11 cases of tumoral calcinosis seen at our clinic in 10 years. Results: All 11 patients were female, and the mean age at onset was 58.5 years. The mean duration of the disease was 7.1 years. Most patients (9, 81.8%) presented with an asymptomatic subcutaneous hard mass around the iliac crest. None of the patients had a family history, or abnormal serum calcium, phosphorus, and parathyroid hormone levels. All patients underwent surgery for treatment. Conclusion: Tumoral calcinosis can occur sporadically without metabolic disease. Therefore, careful history taking and biochemical work-up involving the metabolism of calcium and phosphorus should be performed. If there is no peculiarityon examination, the lesion is cured by resection. Although the sample size of this study is small, it can be inferred that the characteristics of tumoral calcinosis in Korea can be described by its predominant sex preponderance and location, that is, the female sex and the iliac crest, respectively. (Korean J Dermatol 2020;58(9):596∼600)
아이돌보미 사업 아동학대사례관리 전담인력의 현황 및 개선방안
김경은(Kim, Kyoung-Eun),임정하(Lim, JungHa),김리진(Kim, Leejin),김주현(Kim, Joo Hyun),김연아(Kim, Youn-A),이아연(Lee, Ayeon) 한국인간발달학회 2021 人間發達硏究 Vol.28 No.4
본 연구는 안전한 아이돌봄서비스에 대한 요구도가 높아지고 아이돌보미에 대한 모니터링 강화 필요성이 증가함에 따라 2020년 신설된 아이돌봄 아동학대사례관리 전담인력의 현황 및 개선점을 살펴보고자 하였다. 이를 위해 전국 건강가정․다문화가족지원센터에 재직 중인 아동학대사례관리 전담인력 106명, 서비스제공기관 책임자 88명, 광역모니터링단 10명으로부터 설문조사 자료를 수집하였다. 아이돌봄 아동학대사례관리 전담인력의 일반적 배경, 업무 현황을 알아보기 위해 빈도와 백분율, 평균, 표준편차를 산출하였고, 전담인력의 업무에 대한 인식차이를 알아보기 위해 일원변량분석과 반복측정변량분석을 실시하였다. 연구결과, 전담인력의 학력, 전공, 자격증, 이전 경력은 다양하였고, 이들은 자신의 업무 중 아동학대 의심가정 사례관리 업무를 가장 중요하게 생각하였으나 이 업무에 대한 이해도는 가장 낮은 것으로 나타났다. 아이돌봄 아동학대사례관리 전담인력의 업무 실행 상황을 살펴본 결과, 아이돌보미 채용 시 인․적성 검사 및 인성교육 실시 업무 외의 주요업무 실행에서 어려움을 경험하고 있는 것으로 나타났다. 아이돌봄 아동학대사례관리 전담인력의 효율적 업무 수행을 위한 지원 방안에 대한 의견을 살펴본 결과, 아동학대 의심가정 사례관리 업무 수행을 위해 사례관리 전담인력 역량강화 교육이 필요한 것으로 나타났다. 본 연구의 결과는 아이돌보미 아동학대사례관리 전담인력의 업무 효율성과 전문성을 높이는데 기초자료로 활용될 것으로 기대된다. This study examines the perception, present status, and improvement points for the task of the case manager of child abuse prevention, which was newly established in 2020 as the demand for safe child-care support services and the need to reinforce monitoring for child-care providers indcreased. A questionnaire survey was conducted with 106 case managers of child abuse prevention working at the health family support center and healthy family and multicultural centers, 88 persons in charge of service providing institutions, and 10 members of the regional monitoring group across the nation. For data analyses, descriptive statistics and ANOVA were conducted. The results are as follows. First, educational background, majors, qualifications, and previous experience of the case managers of child abuse prevention varied and they considered ‘the case management for families with suspected child abuse’ to be the most important among their tasks, with that being said they showed the lowest level of understanding in that task. Second, the case managers were experiencing difficulties in performing major tasks other than ‘personality and aptitude tests and personality education when hiring child-care providers’. Third, it was found that the case managers need capacity-building training to perform their ‘case management tasks for families suspected of child abuse’. The findings in this study are expected to be used as basic data to improve the efficiency and expertise in the task of the case manager of child abuse prevention.