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김승환,김성민,오정탁,한석주,최승훈,Kim, Seung-Hwan,Kim, Seong-Min,Oh, Jung-Tak,Han, Seok-Joo,Choi, Seung-Hoon 대한소아외과학회 2006 소아외과 Vol.12 No.2
Central venous catheter (CVC) for long-term venous access is indispensable for various reasons including hyperalimentation, frequent blood sampling, frequent IV drug use in pediatric patients. We report clinical experience of surgical neonates in whom CVC was inserted primarily via great saphenous vein into suprarenal inferior vena cava. From March 2004 to March 2006, we performed CVC insertion via saphenous vein - contralateral side to main wound - into suprarenal inferior vena cava in surgeries of neonates. 2.7Fr or 4.2Fr, single lumen, tunneled Broviac catheters (Bard Access system, Inc, Salt Lake City, Utah) were used. Skin exit site of tunneled catheter was located in ipsilateral flank area just below edge lower rib. At the end of the procedure, location of the catheter tip was confirmed by plain radiography of abdomen. We retrospectively reviewed the admission records of the patients including nursing staff charts. Nine (50.0 %) patients were male and nine (50.0%) were female. Median gestational age was 38 weeks (range, 29-42 weeks) and median birth weight was 3,105 gm (range, 1,040-3,720 gm). Median age at catheter insertion was 38.5 days (range, 1-236 days). The purpose of CVC insertion was short-and long-term hyperalimentation in nine (50.0 %) patients. CVC insertion was performed in operation room under general anesthesia in sixteen (88.9 %) patients (in these cases, CVC insertion was performed just prior to concurrent operation) and neonatal intensive care unit (NICU) under local anesthesia with adequate sedation in two (11.2%). During the admission period (total catheter-indwelling time: 553 days), CVC functioned well without any significant side effects. Transient swelling of the ipsilateral leg (n=1, 5.6 %) and transient migration of catheter tip (n=1, 5.6 %) were noted, which did not affect function of the indwelled CVC. Mean catheter-indwelling time was 30.7days (range, 3-72 days). All catheters were removed electively except two mortality case. Complications, such as thrombosis, infection, kinking or extravasation of drugs, were not observed in our study period. Tunneled trans-great saphenous vein inferior vena cava catheters are not only comparable to cervical CVCs in terms of function and complication rates, but also very beneficial in selected patients, especially those in whom cervical approach is technically impossible or contraindicated.
목탄분말 시용이 고추의 생육 및 토양미생물상 변화에 미치는 영향
김승환 ( Kim Seung-hwan ),이상민 ( Lee Sang-min ),이윤정 ( Lee Yoon-jeong ),김한명 ( Kim Han-myung ),손석용 ( Son Seok-yong ),송범헌 ( Song Beom-hun ) 한국유기농업학회 2003 韓國有機農業學會誌 Vol.11 No.3
It was investigated the possibility to use charcoal powder as beneficial soil conditioner, which used frequently in environmentally friendly agricultural farming system. For this purpose, the effects of charcoal powder on the growth of red pepper and chemical and microbiological properties of soil were also determined. The application of charcoal powder resulted in no significant differences of pH and EC in the soil compared to those of control. However, small particle size of charcoal powder increased yield of red pepper while large charcoal powder resulted in decrease of root growth of red pepper. Furthermore, the application of charcoal powder resulted in changes of soil microflora relating to plant growth stage. The number of the nitrogen fixing bacteria and fungi increased at the early growth stage, while phosphate releasing fungi in the soil increased at the late stage of growth by charcoal powder application. These beneficial effect of charcoal powder on the soil microbial properties was larger by the use of smaller particle size of charcoal powder. Therefore, it indicated that the small size of charcoal powder might be more influential on the red pepper yield and soil microbial properties may be due to large capacity of nutrients uptake for the plant and microorganisms. Additionally the optimal application amount of charcoal powder for the red pepper could be suggested as much as 300㎏ 10a<sup>-1</sup> for the both purposes of improvement of crop yield and retardation of the nutrients accumulation by excess charcoal application.
김승환 ( Kim Seung-hwan ),최두회 ( Choi Doo-hoi ),이상민 ( Lee Sang-min ),남재작 ( Nam Jae-jak ),김한명 ( Kim Han-myung ),손석용 ( Son Suk-yeong ),송범헌 ( Song Beom-hun ) 한국유기농업학회 2003 韓國有機農業學會誌 Vol.11 No.2
The chemical properties of oak tree wood vinegar and the effect of wood vinegar on the tomato seedling were investigated to apply wood vinegar efficiently to the organic - and natural farming system. On the basis of the results from chemical properties of the oak tree wood vinegar, mineral nutrient contents of wood vinegar was low. Therefore, wood vinegar could not be a suitable nutrient source for the plant growth at 500~1000 times dilution level, which commonly used in the farming, if only wood vinegar is supplied for the nutrient source for the plant growth. The application of wood vinegar increased root growth up the 500 times dilution level while decreased shoot growth. Furthermore, the anion concentrations such as nitrate and phosphate of the plant were decreased by the application of wood vinegar while cation concentrations such as K, Ca, and Mg were increased. Phenolic compounds of wood vinegar such as chlorogenic acid and ferulic acid enhanced the root growth. Interestingly the application of ferulic acid increased both root and shoot growth at the level of 10<sup>-4</sup>M concentration. It indicated that the effect of wood vinegar on the production of healthy plant seedling may be due to the beneficial root growth by phenolic compounds such as chlorogenic acid and/or ferulic acid of the wood vinegar. However, the effect of the wood vinegar on the plant growth could be influenced by synergism or antagonism of different phenolic compounds in wood vinegar used. In addition, drench in the soil of wood vinegar may be more beneficial compared to foliar application for the improvement of root activity and plant growth.
한승기(Seung Kee Han),임태규(Tae Gyu Yim),박선희(Seon Hee Park),김승환(Seunghwan Kim),김승환(Seunghwan Kim),유창수(Chang Su Ryu) 한국정보과학회 1996 정보과학회논문지(B) Vol.23 No.11
이 논문에서는, 신경계가 정보를 인지하는 방식으로 이해되고 있는 동기화(synchronization)와 반동기화(desynchronizaton)를 함께 줄 수 있는 새로운 모형계를 제시한다. 일반적으로, 전기적결합(electric coupling)을 하고 있는 신경모형계에서는 신경세포(neuron) 들 사이에 동기화가 일어나는 것으로 알려져 왔으나, 우리는 반동기화를 줄 수 있는 새로운 방법을 발견했다. 이 현상은 같은모임쌍갈림(homoclinic bifurcation)으로 부터 생기는 주기운동에서 일어나며, 간단히 위상모델(phase model)로 설명될 수 있다. 또한 여러 개의 신경세포가 결합되었을 때, 신경세포들 사이에 반위상으로 인한 새로운 종류의 발작(bursting)이 일어남을 알았다. 이러한 결합된 신경모형계의 집단적 거동을 분석하기 위해서 계를 축소된 3차원 위상공간으로 재구성했다. 이 축소된 위상공간에 대한 분석으로 부터, 이 신경모형계가 외부자극의 세기에 따라 주기배가에 의한 혼돈거동(chaotic behavior)을 보임을 알 수 있었다. 이 결과로 부터, 외부자극의 세기와 같은 양들을 사용해서 결합된 신경계의 거동을 예측할 수 있음을 보였다. In this paper, we propose a new mechanism for generating synchronization and desynchronization of neurons, which is believed to play an important role in the information processing in the biological neural network. When the neurons are electrically coupled, it is usually expected that they will be synchronizing. But, counter-intuitively, it has been turned out found that they are desynchronizing. This can be explained in terms of phase model analysis of oscillatory behavior which occurs through a homoclinic bifurcation. As a collective behavior for a coupled system with many neurons, we have found that a new kind of bursting behavior arises because of the dephasing of neurons. To analyze the collective behavior, we have replotted the attractor in 3-dimensional mean phase space and have found that there is a period-doubling route to chaos as decrease the strength of the external stimulus. Through this result, we have found that it is possible to predict the behavior of a coupled neuronal system for a given external stimulus.
코사인 유사도를 이용한 원자력발전소 운전원 커뮤니케이션 품질 평가 프레임워크
김승환(Seung-Hwan Kim),박진균(Jin-Kyun Park),한상용(Sang-Yong Han) 한국컴퓨터정보학회 2010 韓國컴퓨터情報學會論文誌 Vol.15 No.9
커뮤니케이션은 다양한 산업 분야에서 심각한 문제를 야기하는 주요 원인 중에 하나로 여기 지고 있다. 이런 이유로 인간 공학의 한 분야로서 커뮤니케이션에 대한 광범위한 연구가 진행되어왔다. 대형화 및 고도화된 산업 시스템의 안전성을 유지하기 위하여 운전원들의 양질의 커뮤니케이션 품질을 유지하는 것이 중요한 것으로 간주되고 있다. 비상 및 비정상 상황 등의 위급 상황 하에서의 운전원의 커뮤니케이션 품질은 상황 대처 성능을 결정짓는 주요 요인이라 할 수 있다. 양질의 커뮤니케이션은 대화자간의 대화 내용을 상호간에 올바르게 이해 및 숙지한 것이라고 규정할 때, 이는 대화 메시지의 충실도 및 유사도 등을 기반으로 판단할 수 있을 것이다. 본 연구에서는 이러한 필요성에 따라, 원자력발전소 주제어실 운전원들이 비상 및 비정상 상황 하에서의 대응 운전 직무를 수행하기 위해 발생하는 대화 내용의 유사성을 코사인 유사도를 이용하여 측정함으로써, 운전원 커뮤니케이션 품질을 평가할 수 있는 프레임워크를 제안하였다. 모의 훈련 실습에 대해 각 실습조별 수행도 정량 평가 결과와 본 시스템을 이용한 실습조 대화 품질 평가 결과를 비교한 결과 커뮤니케이션 품질이 좋은 실습조가 직무 수행도 평가에서도 높은 점수를 취득하고 있음을 확인하였다. Communication problems have been regarded as one of the biggest causes in trouble in many industries. This led to extensive research on communication as a part of human error analysis. The results of existing researches have revealed that maintaining a good quality of communication is essential to secure the safety of a large and complex process system. In this paper, we suggested a method to measure the quality of communication during off-normal situation in main control room of nuclear power plants. It evaluates the cosine similarity that is a measure of sentence similarity between two operators by finding the cosine of the angle between them. To check the applicability of the method to evaluate communication quality, we compared the result of communication quality analysis with the result of operation performance that was performed by operators under simulated environment.
Song-Yi Han(한송이),Cho-Yi Jin(진초이),Kisang Kwon(권기상),Eun Young Yun(윤은영),Tae Won Goo(구태원),Seung-Whan Kim(김승환),Jong-Soon Choi(최종순),Kweon Yu(유권),O-Yu Kwon(권오유) 한국생명과학회 2011 생명과학회지 Vol.21 No.6
인간형 재조합단백질 각질세포 성장인자를 안정적으로 생산하는 누에 배양 세포(Bm5-hKGF cell)을 만들었다, 이 세포에서 분비되어 배지에 포함된 양은 15-20 ng/㎖ 정도였다. Bm5-hKGF cell에 누에의 PDI를 함께 발현시키면 세포외 분비량이 2배 증가하였다. Wound healing migration assay 결과 누에세포에서 생산된 인간형 재조합단백질 각질세포 성장인자는 세포생장을 촉진하는 활성을 가지고 있었다. 본 실험의 결과는 누에배양세포를 사용하여 저비용으로 양질의 인간형 재조합단백질을 대량생산 할 수 있는 것을 기대한다. Using silkworm Bombyx mori Bm5 cells, we established a stable cell line expressing the human keratinocyte growth factor (hKGF), named by the Bm5-hKGF cell, in which the protein hKGF is synthesized in the cell and secreted in the cell culture supernatant (CCS) at approximately 15-20 ng/㎖. When the Bm5-hKGF cell was co-expressed with B. mori protein disulfide isomerase (bPDI) cDNA, its secretion increased by about two times the original amount. Through wound healing migration assay, it was demonstrated that the secreted hKGF included in the CCS has a very powerful biological activity of keratinocyte proliferation. We expect to produce useful human recombinant proteins from silkworm cultured cells in large quantities at low prices.