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냉과 간헐적 압박이 실험적 지연발생 근육통에 미치는 영향
김승준,김용남,이근희,이인실,김병조,배성수,Kim, Seung-Joon,Kim, Yong-Nam,Lee, Keun-Heui,Lee, In-Sil,Kim, Byung-Jo,Bae, Sung-Soo 대한물리치료학회 2001 대한물리치료학회지 Vol.13 No.3
Delayed onset muscle soreness (DOMS) was the sensation of discomfort and stiffness in the muscle, often after taking part in unaccustomed physical activity. No universally accepted treatment exist. The aim of this study was to examine the influence of cryotherapy and intermittent compression on the delayed onset muscle soreness. Flexion elbow joint position and extension(Universal Goniometer). pain(Muscle Soreness Rating Scale) and mechanical pain threshold(Algometer) were measured before 30minutes DOMS was induced.The data were analyzed by measure of Mann-Whitney test and Kruskal-Wallis test. The result were as follow; 1. There were no significantly differences between groups or over time in relation to range of motion. 2. Muscle Soreness Rating was significantly high in cryotherapy and intermittent compression at 48, 72 hours after DOMS was induced(p<.05). 3. Mechanical pain threshold begin to increased at 24 hours and significantly in cryotherapy and intermittent compression groups at 48, 72 hours after DOMS was induced(p>.05). 4. A negative Correlation between muscle soreness rating scale and mechanical Pain threshold graphs at 24, 48, and 72 hours after exercise indicated in cryotherapy and intermittent compression groups.
IP-10에 의한 기도상피세포에서의 TNF-α 유도 MUC5AC발현 억제: 특발성폐섬유증 환자의 적은 객담과의 연관성
김승준 ( Seung Joon Kim ),강춘미 ( Chun Mi Kang ),유문빈 ( Moon Bin You ),윤형규 ( Hyung Kyu Yoon ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),문화식 ( Hwa Sik Moon ),박성학 ( Sung Hak Park ),송정섭 ( Jeong Sup Song 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.5
연구배경: 특발성폐섬유증 환자의 전형적인 증상은 운동호흡곤란과 마른기침으로, 객담이 적은 원인에 대해서 아직까지 잘 알려져 있지 않다. Interferon-γ inducible protein-10 (IP-10)은 여러 호흡기질환과 관련되는데 폐 내로 염증을 유입시키는데 중요한 역할을 한다. 본 연구는 특발성폐섬유증 환자에서 객담이 적은 기전으로 IP-10이 연관성이 있는지에 대해 연구하였다. 방법: 특발성폐섬유증 환자를 대상으로 기관지폐포세척액에서 IP-10의 농도를 ELISA로 측정하였다. IP-10이 기도 점액소 발현에 미치는 영향을 간접적으로 알아보기 위해 NCI-H292 세포(점막표피모양 암종 세포주)에서 IP-10을 전처치한 이후 tumor necrosis factor-α (TNF-α)로 자극하여 발현정도를 측정하였다. 이때 점액소 발현과 관련되는 기전으로 epidermal growth factor receptor-mitogen activated protein kinase (EGFR-MAPK)의 신호전달 경로를 알아 보았다. 결과: IP-10의 기관지폐포세척액내 농도는 특발성폐섬유증 환자가 건강 대조군에 비해 유의하게 높았다. IP-10의 전처치는 NCI-H292 세포에서 TNF-α 유도 MUC5AC 점액소 발현을 감소시켰는데 이 때 EGFR-MAPK 신호전달 경로의 차단과 관련되었다. 결론: 특발성폐섬유증 환자의 적은 객담은 IP-10의 발현증가와 일부 관련 가능성이 있으며, 이때 IP-10의 작용은 MUC5AC 점액소 유전자 발현에 필요한 EGFR-MAPK 신호전달 경로의 차단과 관련될 것으로 생각한다. (Tuberc Respir Dis 2008;64:347-355) Background: IPF is characterized by chronic, fibrosing inflammatory lung disease of unknown etiology. Typical symptoms of IPF are exertional dyspnea with nonproductive cough. Why patients with typical IPF have dry cough rather than productive cough, is unknown. IP-10 plays an important regulatory role in leukocyte trafficking into the lung. The present study investigated the effect of IP-10 in the pathogenesis of dry cough rather than productive cough in IPF patients. Methods: IP-10 concentration was measured by ELISA from BALF of IPF patients. To evaluate the role of IP-10 in mucin expression, the expression of the MUC5AC mucin gene was measured in NCI-H292 cells, a human pulmonary mucoepidermoid carcinoma cell line, after stimulation by TNF-α with or without IP-10 pretreatment. EGFR-MAPK expression was also examined as a possible mechanism. Results: IP-10 levels were significantly higher in the BALF of IPF patients compared to healthy controls. IP-10 pretreatment reduced TNF-α induced MUC5AC mucin expression by inhibiting the EGFR-MAPK signal transduction pathway in NCI-H292 cells. Conclusion: These findings suggest that little mucus production in IPF patients might be attributable to IP-10 overproduction, which inhibits the EGFR-MAPK signal transduction pathway required for MUC5AC mucin gene expression.
수술로 절제된 비소세포폐암 조직에서 예후인자로서 VEGF와 bFGF 발현의 의의
김승준 ( Seung Joon Kim ),이정미 ( Jung Mi Lee ),김진숙 ( Jin Sook Kim ),강지영 ( Ji Young Kang ),이상학 ( Sang Hak Lee ),김석찬 ( Seok Chan Kim ),이숙영 ( Sook Young Lee ),김치홍 ( Chi Hong Kim ),안중현 ( Joong Hyun Ahn ),권순석 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.3
연구배경: 혈관신생은 종양의 성장과 유지 및 전이에 필수적이며 따라서 종양조직은 혈관신생을 위해 많은 종류의 혈관형성 촉진인자들을 생성하고 있다. VEGF와 bFGF는 혈관신생과 관련되는 물질로 본 연구에서는 폐암환자에서 조직 내 VEGF와 bFGF의 발현에 대해 알아보고자 하였다. 방법: 조직학적으로 샘암종 또는 편평상피세포암종으로 진단받고 완치의 목적으로 수술을 시행 받은 35명의 폐암환자 조직에서 VEGF 및 bFGF의 농도를 ELISA 방법으로 측정하였으며 이에 대한 임상적 양상을 후향적으로 분석하였다. 결과: VEGF 및 bFGF의 농도는 종양조직이 대조조직보다 유의하게 높았으며 T2+T3의 종양조직이 T1의 종양 조직보다 유의하게 VEGF의 농도가 높았다. 림프절 전이가 있었던 경우가 없었던 경우보다 종양조직에서 VEGF의 농도가 증가한 경향을 보였다(p=0.06). 하지만 VEGF 및 bFGF의 농도는 환자의 병기 및 생존율에 통계적으로 유의한 차이를 보이지 않았다. 결론: VEGF 및 bFGF 모두 종양조직에서 증가하였으나 VEGF만이 종양크기, 림프절 전이 등의 임상양상과 연관성을 보여주었다. 하지만 각각의 VEGF 및 bFGF의 종양조직 내 농도는 예후와 관련되지는 않았다. Background: Tumor angiogenesis plays an important role in tumor growth, maintenance and metastatic potential. Tumor tissue produces many types of angiogenic growth factors. Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) have both been implicated to have roles in tumor angiogenesis. In this study, the expression of tissue VEGF and bFGF from non-small cell lung cancer (NSCLC) patients were analyzed. Methods: We retrospectively investigated 35 patients with a histologically confirmed adenocarcinoma or squamous cell carcinoma of the lung, where the primary curative approach was surgery. An ELISA was employed to determine the expression of VEGF and bFGF in extracts prepared from 35 frozen tissue samples taken from the cancer patients. Results: VEGF and bFGF concentrations were significantly increased in lung cancer tissue as compared with control (non-cancerous) tissue. The VEGF concentration was significantly increased in T2 and T3 cancers as compared with T1 cancer. Expression of VEGF was increased in node-positive lung cancer tissue as compared with node-negative lung cancer tissue (p=0.06). VEGF and bFGF expression were not directly related to the stage of lung cancer and patient survival. Conclusion: Expression of VEGF and bFGF were increased in lung cancer tissue, and the expression of VEGF concentration in lung cancer tissue was more likely related with tumor size and the presence of a lymph node metastasis than the expression of bFGF. However, in this study, expression of both VEGF and bFGF in tissue were not associated with patient prognosis. (Tuberc Respir Dis 2008;64:200-205)
만성 폐쇄성 폐질환 환자에서 Tiotropium 1일 1회, 1회 18㎍ 요법과 Ipratropium 1일 4회, 1회 40㎍ 요법의 치료효과 및 안전성 비교
김승준 ( Seung Joon Kim ),김명숙 ( Myung Sook Kim ),이상학 ( Sang Haak Lee ),김영균 ( Young Kyoon Kim ),문화식 ( Hwa Sik Moon ),박성학 ( Sung Hak Park ),이상엽 ( Sang Yeub Lee ),인광호 ( Kwang Ho In ),이창률 ( Chang Youl Lee ) 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.5
김명훈,김승준,박용근,김석찬,이숙영,김영균,김관형,문화식,송정섭,박성학,Kim, Myung-Hoon,Kim, Seung-Joon,Park, Yong-Keun,Kim, Seok-Chan,Lee, Sook-Young,Kim, Young-Kyoon,Kim, Kwan-Hyoung,Moon, Hwa-Sik,Song, Jeong-Sup,Park, Sung-Hak 대한결핵및호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.49 No.5
연구배경 : Cytokine은 주요한 염증 매개 물질로서 질환에 따라 다른 양상을 보일 수 있어, 흉수를 일으키는 다양한 원인 질환의 감별에 이용되어 왔다. 이 중에서 악성 흉수, 결핵성 흉수, 부폐렴 삼출액 및 농흉에서 INF-${\gamma}$, IL-2R, IL-6, IL-1를 동사에 측정하여 비교한 연구는 많지 않아 본 연구를 시행하게 되었다. 방법 : 흉수를 주소로 내원한 환자 중에서 흉수 천자로 삼출액이 확인된 환자들을 대상으로 흉수를 채취하여, ELISA kit를 이용하여 INF-${\gamma}$, IL-2R, IL-6, IL-10 농도를 측정하였다. 결과 : 악성 흉수, 결핵성 흉수, 부폐렴 삼출액 및 농흉에서 흉수 내의 cytokine의 순서대로, INF-${\gamma}$는 $16.7{\pm}50$, $295.5{\pm}585.5$, $10.0{\pm}0$ pg/ml, IL-2R은 $3247.4{\pm}1713.3$, $7423.5{\pm}3752.8$, $3790.2{\pm}3201.1$ pg/ml, IL-6는 $600{\pm}12.8$, $556.4{\pm}161.7$, $514.4{\pm}224.8$ pg/ml, IL-10은 $28.2{\pm}55.5$, $11.3{\pm}11.7$, $98.4{\pm}141.7$ pg/ml로 각각 측정되어, 결핵성 흉수가 다른 원인의 흉수에 비해 IL-2R 농도가 의 있게 높았으며, IFN-${\gamma}$ 농도도 높은 경향을 나타내었으며, 부폐렴 삼출액에서는 IL-10농도가 다른 원인의 흉수에 비해 의미있게 높았다. 결론 : 결론적으로 흉수 내의 IL-2R농도 측정은 결핵성 흉수와 다른 원인의 흉수를 감별하는데 어느 정도 도움이 될 것으로 사료되며, IL-10 측정은 부폐렴 삼출액과 다른 원인의 흉수를 감별하는데 어느 정도 도움을 줄 것으로 생각된다. Background : Cytokines are chemical mediators that control and modulate many inflammatory processes. They work in different fashions in a variety of diseases. Discriminating between malignant effusion, tuberculous effusion, and parapneumonic effusion are crucial from the clinical view-point in Korea. In the current study, interferon-gamma (IFN-${\gamma}$), soluble interleukin-2 receptor (IL-2R), interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured for this purpose. Methods : Pleural fluids from patients with malignant disease, tuberculosis, parapneumonic effusion and lung empysema were collected and gauged using commercial ELISA kits. Results : 34 patients were enrolled in this study. Among these 15 cases were malignant effusions, 12 were tuberculosis pleurisy and 7 were parapneumonic effusion and lung empyema. The levels of cytokines measured in this study were as follows, in order of frequency, malignant effusion, tuberculous effusion, parapneumonic effusion and lung empyema. The levels of INF-${\gamma}$ were higher in tuberculous effusion than in malignant or parapneumonic effusion ($295.5{\pm}585.5$ vs. $16.7{\pm}50$ vs. $10.0{\pm}0$ pg/ml, p>0.05). The levels of IL-2R were higher in tuberculous effusion than in malignant or parapneumoruc effusion ($7423.5{\pm}3752.8$ vs. $3247.4{\pm}1713.3$ vs. $3790.2{\pm}3201.1$ pg/ml, p<0.05). No significant differences were found in the levels of IL-6 between the groups ($600{\pm}12.8$ pg/ml in malignant effusion, $556.4{\pm}161.7$ pg/ml in tuberculous effusion, $514.4{\pm}224.8$ pg/ml in parapneumoruc effusion). IL-10 levels were higher in parapneumoruc effusion than in malignant or tuberculous effusions ($98.4{\pm}141.7$ vs. $28.2{\pm}55.5$ vs. $11.3{\pm}11.7$ pg/ml, p<0.05). Conclusion : These results suggest that the measurement of IL-2R levels in pleural fluids may be a useful means of differentiating between tuberculous effusion and pleural effusions of other origins, and that the measurement of IL-10 levels in pleural fluids may be useful to differentiate between parapneumonic effusion and pleural effusions of other origins.
증 례 : EGFR 돌연변이와 ALK 재배열 공존하는 폐선암 환자 1예
김민아 ( Min Ah Kim ),강진형 ( Jin Hyoung Kang ),김인호 ( In Ho Kim ),김태정 ( Tae Jung Kim ),김승준 ( Seung Joon Kim ),성숙환 ( Sook Whan Sung ),허솔미 ( Sol Mi Huo ) 대한내과학회 2016 대한내과학회지 Vol.90 No.1
A 58 year-old woman was diagnosed with lung adenocarcinoma (cT3N1M0). We detected a point mutation in epidermal growth factor receptor (EGFR) exon 21 (L858R) and an echinoderm microtubule-associated protein-like 4- anaplastic lymphoma kinase (ALK) rearrangement. The patient was treated with preoperative neoadjuvant chemotherapy and underwent a left lower lobectomy with mediastinal lymph node dissection. However, we could not detect any mutation in EGFR or the ALK rearrangement from the tumor tissue removed. Then, 70 days after completion of adjuvant chemotherapy, she visited our outpatient clinic with diminished visual accuracy and tinnitus. A single brain metastatic lesion was seen on brain magnetic resonance imaging. She underwent surgical removal of the brain mass, which showed a mutation of EGFR, exon 21, but no ALK rearrangement. We report this unusual case of lung adenocarcinoma with a coexisting EGFR mutation and ALK rearrangement, and identify gene alterations before chemotherapy, after chemotherapy, and at recurrence. (Korean J Med 2016;90:72-77)
주무열,김승준,박승규,정연우,배성수,Ju Mu-Yeol,Kim Seung-Joon,Park Seung-Kyu,Jung Yeon-Woo,Bae Sung-Soo 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.4
Orthopaedic manual therapy(OMT) includes knowledge in arthokinematic, biological, behavioral, biomechanical, patholology, anatomy, and clinical science. it allows proper approach to patient evaluation and program development and relieves joint and soft tissue lesions. The OMT has sports injurys, traumatic, developmental, and neuromusculoskeletal disorders of acute and chronic states, and prevention of dysfunction as well as the development, improvement, restoration, or maintenance of joint and muscular mobility, stability, relaxation, strenth, endurance, balance, and functional skills. The purpose of this article has to define and clarify the change and development of basic concepts of orthopaedic manual therapy. OMT is ancient in origin. The book of ' Manipulation Past and Present ' contains pictures recording various types of joint mobilization by Hippocrates. Recently, there are many kinds of manual therapeutic maneuvers to assess and relieve joint and soft tissue lesions developed by James Cyriax, John McM Mennell, Brian R Mullign, Robin McKenzie, Freddy Kaltenborn, Geoffrey Maitland, and Ola Grimsby.