성인의 턱관절장애 자각증상에 영향을 미치는 요인

김수경,김소라,김현경,박지수,이유진,조민서,정은서,Kim, Soo-Kyung,Kim, So-Ra,Kim, Hyun-Kyung,Park, Ji-Su,Lee, Yu-Jin,Cho, Min-Seo,Jung, Eun-Seo 한국치위생학회 2017 한국치위생학회지 Vol.17 No.4

Objectives: The purpose of this study is to identify the perceived symptoms of oral and temporomandibular joint disorders in adults and to analyze the factors affecting subjective symptoms of temporomandibular joint disorders. Methods: 249 adults over 20 years old who had subjective symptoms of temporomandibular joint disorders were surveyed and analyzed. Independent t-test and ANOVA test were used to examine the relationship between oral habits and temporomandibular joint disorder according to general characteristics. $Scheff{\acute{e}}$ test was used for post-hoc analysis. Multiple regression analysis was conducted to examine the factors affecting oral habits and temporomandibular joint disorder. Results: First, the factors affecting oral and habitual behaviors were married (p<0.05) and monthly income between 1 million~1.9 million won (p<0.001), higher temporomandibular joint disorder (p<0.01) And the degree of habit was increased. Second, the factors affecting temporomandibular joint disorder were increased in occupation (p<0.05) and the degree of oral habit (p<0.01). Conclusions: In conclusion, it was confirmed that oral habit influences temporomandibular joint disorder. Especially, it is suggested that prevention and promotion of temporomandibular joint disorder are needed to recognize the removal of oral habits.

Peroxidase 고생산 식물세포주의 선발

김수경,곽상수,정경희,민성란,박일현,유장렬 ( Soo Kyung Kim,Sang Soo Kwak,Kyung Hee Jung,Sung Ran Min,Il Hyun Park,Jang R. Liu ) 생화학분자생물학회 1994 BMB Reports Vol.27 No.2

To establish an efficient system for peroxidase (POD) production by plant cell culture, we investigated the POD activity in 41 cell lines derived from 26 plant species using pyrogallol as substrate. A cell line from sweet potato (Ipomoea batatos cv. White Star) shoot meristem explants cultured on LS medium supplemented with 1 ㎎/ℓ 2,4-D showed the highest activity: 3,500 U/g cell dry wt, about 15 folds higher than that of intact roots of horseradish plants. Furthermore, a cell tine SP-47 having a high growth rate and POD yield was selected by a small cell-aggregate method, of which productivity was about 1.5 times higher than the original cell line in cell suspention culture. A hairy root culture obtained from sweet potato leaf tissue following infection with Agrobacterium rhizogenes strain 15834 also produced a high level of POD: 1,400 U/g dry wt. POD isoenzyme of the cell line and hairy roots of sweet potato showed the same patterns as those of the intacts roots. However, they were prominently different from those of intact roots of horseradish. One major isoenzyme of POD in SP-47 and hairy root covered about 90% of total POD. Due to its high productivity and dominant major isoenzyme, the cell culture system of sweet potato established in this study seems to be suitable for the mass production of POD.

사립대학 구조개혁의 경제적 접근 방안 연구

김수경,문보은,Kim. Soo-Kyung,Moon. Bo-Eun 한국교육재정경제학회 2015 敎育財政 經濟硏究 Vol.24 No.1

이 연구의 목표는 인구학적, 경제적 접근을 통한 대학 구조개편 모형을 제 시하는데 있다. 이 연구의 방법은 크게 세 가지로 첫째, 인구학적 통계를 활용 한 대학입학자 추정, 둘째, 일반초월대수 비용함수모형을 이용한 대학특성별 규모의 경제성 분석, 셋째, 자료포락분석 CCR 모형을 통한 대학 전공계열의 효율성 분석이다. 이 연구의 결과는 크게 세 가지다. 첫째, 우리나라 대학입학 예정자 수는 평 균 대학진학률 70.9%가 유지된다고 가정할 때, 2016년 16,915명 감소 경향성을 시작으로, 2017년 23,789명, 2018년 14,575명, 2020년 56,441명이 각각 감소하여 2015~2020년까지 총 97,147명이 감축되는 것으로 추정되었다. 둘째, 대학 특성 별 규모의 경제성 분석 결과, 대학이 현재 교육의 질을 유지한다는 가정 하에, 수도권 소재 대규모 대학, 중규모 대학, 소규모 대학과 비수도권 소재 대규모 대학, 소규모 대학은 과대 규모를 보유하고 있으며, 규모의 경제성을 제고하기 위해서는 현재 대학 규모에서 7.9%~21.7%의 감축을 해야 하는 것으로 나타났 다. 다만, 비수도권 중규모 대학은 오히려 과소한 규모로 현재 규모 보다 10.9% 규모를 증대할 때 규모의 경제성을 갖는 것으로 분석되었다. 이러한 경 제성 규모는 앞에서 추정된 2015년~2020년의 대학입학 예정자 수 감소 규모와 유사한 수준이다. 셋째, 규모의 비경제성을 갖는 대학 유형 중 수도권 대규모, 비수도권 대규모 대학의 전공계열별 효율성을 분석한 결과, 규모의 경제성을 갖추기 위해서는 수도권 대규모 대학의 자연과학･예체능･공학계열에서 총 31,912명 감축이 필요하며, 비수도권 대규모 대학에서는 인문사회･자연과학･ 예체능･공학계열에서 총 38,775명 감축이 필요한 것으로 분석되었다. 사립대학의 구조조정을 경제적으로 접근하는 이 연구는 학령인구를 감안하 여 대학운영의 효율성을 가장 높일 수 있는 경제적 규모를 도출함과 동시에 사립대학 간 특성화를 실현할 수 있는 전공계열 효율성 분석 접근을 시도함으 로써 정부와 사립대학의 당면과제인 사립대학 구조개혁을 실현하는데 경제적 이고 전략적인 가이드라인을 제공한다는데 연구의 의의를 두고 있다. The purpose of this study is to provide a structural reform model for universities through economic and demographic approaches. For the study, the size of university application is estimated with demographic variation reflected; the economic scale of universities by their specialization is analysed; and the efficiency of college majors is compared and analyzed. Based on the finding, the strategic economic scale for universities by specialization is presented as a systematic restructuring model for universities to enhance their competitiveness. The results of the study are as follow. Firstly, it is estimated that if the average admission rate is maintained at 70.9%, the number of students admitted to college is going to start to decrease by 16,915 in 2016, 23,789 in 2017, 14,575 in 2018, and 56,441 in 2020, and the number will be added up to 97,147 in total between 2015 and 2020. Secondly, the result of the economic analysis of universities by specialization shows that if universities keeps the quality of the current education, it will be more economical for universities, except medium-sized ones located in non-capital regions, to reduce the size. The finding indicates that the size of university should be reduced by 7.9% ~ 21.7% to improve its competitiveness. Lastly, in order to obtain economies of scale, it is necessary to cut down total 31,912 of students in natural science, art, physical education and engineering in large-scale universities in metropolitan areas and to reduce total 38,775 of students in humanities, natural science, art, physical education and engineering in non-metropolitan areas.

Effects of Neuroleptics on the Opioid Receptor Binding in the Mouse Striatum

김수경,이성룡,박창교,Kim, Soo-Kyung,Lee, Seong-Ryong,Park, Chang-Gyo The Korean Society of Pharmacology 1994 대한약리학잡지 Vol.30 No.3

Our purpose was to gain insight into a possible modulatory role for ${\mu},\;{\delta},\;and\;{\kappa}$ opioid receptors by neuroleptics (chlorpromazine, thioridazine, haloperidol, sulpiride, and pimozide) in chronic morphine 5 mg/kg and 20 mg/kg treated mouse striatum. We attempted quantitative receptor assays using highly specific radioligands, $[^3H]\;DAGO\;([D-Ala^2,\;N-Mephe^4,\;Glycol^5]\;enkephalin)$, $[^3H]DPDPE\;([D-Pen^2,\;D-Pen^5]\;enkephalin)$ and $[^3H]\;DPN(diprenorphine)$ to measure the binding affinity in the experimental groups. The decrease of $[^3H]DAGO$ binding was potentiated by sulpiride and pimozide in the chronic morphine treatment (5 mg/kg and 20 mg/kg). The decrease of $[^3H]DPDPE$ binding was inhibited by chlorpromazine, thioridazine, haloperidol, sulpiride, and pimozide in chronic morphine treatment (5 mg/kg and 20 mg/kg). The decrease of $[^3H]\;DPN$ binding was significantly inhibited by chlorpromazine, thioridazine, sulpiride, and pimozide in chronic morphine 20 mg/kg treatment. $[^3H]\;DPN$ binding on the neuroleptics was antagonized by naloxone pretreatment in chronic morphine 20 mg/kg treatment. These findings suggest that neuroleptics influence opposing tonically active on the ${\delta},\;and\;{\kappa}$ opioid receptor compared with ${\mu}$ opioid receptor in the chronic morphine treated mouse striatum. 이 연구에서는 선조체에서 opioid 신경계와 dopamine 신경계의 상호 관계를 알아보기 위해서 morphine을 5m/kg, 20 mg/kg로 10일간 복강내 투여한 후 chlorpromazine, thioridazine, haloperidol, sulpiride, pimozide를 투여하였다. Opioid ${\mu},\;{\delta},\;{\kappa}$ 수용체의 binding의 변화를 관찰하고자 $[^3H]\;DAGO$, $[^3H]\;DPDPE$, 및 $[^3H]\;DPN$ binding assay를 하였으며, 그 결과 morphine (20 mg/kg) 장기 투여된 실험군에서 $[^3H]\;DAGO$, $[^3H]\;DPDPE$, 및 $[^3H]\;DPN$ 결합이 감소되었다. Morphine 20 mg/kg 장기 투여군에 chlorpromazine, thioridazine 주사시에는 morphine 5mg/kg 투여군에 비하여 $[^3H]\;DAGO$ 결합의 감소와, $[^3H]\;DPDPE$, 및 $[^3H]\;DPN$ 결합의 증가를 나타내었고, haloperidol 주사군은 $[^3H]\;DAGO$, $[^3H]\;DPN$ 결합의 감소, 및 $[^3H]\;DPDPE$ 결합의 증가를 나타내었다. Sulpiride, pimozide 주사군은 morphine 5 m/kg 투여군에 비하여 20m/kg 투여군에서 $[^3H]\;DAGO$, $[^3H]\;DPDPE$, 및 $[^3H]\;DPN$ 결합의 증가를 나타내었다. 이상의 결과로 보아 각 약물간의 opioid 결합에 대한 차이점은 있었으나, morphine 5mg/kg 투여군보다 20m/kg 투여군에서 $[^3H]\;DPDPE$ 및 $[^3H]\;DPN$의 결합이 증가의 경향을 보임으로써, 다량의 morphine을 투여했을 때 ${\mu}\;opioid$ 수용체에 비하여 ${\delta}와 ${\kappa}\;opioid$ 수용체가 더 활성화되는 것을 알 수 있었다.

턱관절 장애 자각증상 및 관련요인

김수경,김연주,남정민,박정선,심미연,윤세진,정은서,Kim, Soo-Kyung,Kim, Yeon-Ju,Nam, Jung-Min,Park, Jeong-Sun,Sim, Mi-Yeon,Yun, Se-Jin,Jung, Eun-Seo 한국치위생학회 2017 한국치위생학회지 Vol.17 No.4

Objectives: This study aims to prove that stress directly or indirectly affects the jaw joint disorders and provide basic data for developing oral health promotion program. Methods: The study was conducted by distributing a questionnaire survey to more than 350 people from December 30, 2016 to January 7, 2017. Among them, 336 copies were collected and 314 copies were utilized eventually, except Section 314, for the final analysis. Regression analysis was performed to investigate the factors affecting temporomandibular joint disorders. Results: As a result, academic achievement and stress were found to affect the temporomandibular joint disorders. The higher the level of education and stress, the higher the subjective symptoms of jaw joint disorder. Conclusions: Because stress affects temporomandibular joint disorders, it is necessary to find out the cause of stress not only for professional treatment but also for solution of temporomandibular disorder. Thus, stress level must be conisdred as influential factors in developing a jaw joint disease prevention program.

환경부(環境部) "폐금속자원(廢金屬資源) 재활용(再活用) 대책(對策)"의 주요(主要) 내용(內容)

김수경,Kim, Soo-Kyung 한국자원리싸이클링학회 2010 資源 리싸이클링 Vol.19 No.4

금속광물자원은 특정한 소수국가에 편재되어 있어 공급제한, 고가판매 등 자원의 무기화 전략이 확산되고 있으며 국제 금속가격이 급등하고 수급이 불안한 가운데 95% 이상의 금속을 수입하고 있는 우리나라로서는 지속적으로 발생량이 증가하고 있는 폐금속자원에 대한 재활용 대책이 수립되어야 한다. 이를 위해 환경부에서는 국내 금속 자급률을 제고하고 국가경쟁력 강화 및 녹색성장 달성을 견인하는 동력으로 재활용 산업을 육성하기 위해 범정부 차원의 종합대책을 추진하게 되었으며, 지난 '09년 9월 22일(화) 국무회의에서 지식경제부 등 관계부처(기획재정부교육과학기술부국방부지식경제부국토해양부) 합동으로 "폐금속자원 재활용 대책(일명 "숨은 금속자원 찾기 프로젝트")"을 수립하고 확정발표하였다. 본 대책은 10년 계획의 장기적인 종합대책으로서 1단계와 2단계로 구분한 후, 단계별 정책목표를 설정하여 추진함으로써 '20년까지 재활용 기술 및 산업의 선진화, 폐금속 재활용율 75% 달성, 무역역조 연간 12.5억불 이상 개선을 목표로 하고 있다. Countries which have a lot of metal resources are weaponizing metal resources such as supply limitation, high price sale. It's necessary for us to establish the countermeasure for recycling of used metal resources on a government basis. Ministry of Environment has established and announced the project for finding and reuse the hidden metal resources as pan-government department pass the Cabinet meeting at September 22, 2009. This countermeasure, 10 years project, is classified into 2 steps. Aim of this project is advance of the recycling technology and industry, achievement of recycling rate, 75%, improvement in adverse balance of trade, 1.25 billion US$.

The Changes of Cyclic AMP Content by Opiates in Chronic Haloperidol Treated Mouse Striatum

김수경,Kim, Soo-Kyung The Korean Society of Pharmacology 1994 대한약리학잡지 Vol.30 No.1

Opioid수용체는 adenylate cyclase의 활성을 억제하므로써 cyclic AMP의 양을 감소시킨다. 본 연구에서는 striatum에서 dopamine과 opioid 신경전달계의 상호관계를 알아보고자 haloperidol(750ug/kg)을 10일간 복강내 투여하여 dopaminergic pathway를 차단시킨후 mouse striatum에서 선택적 opioid ${\mu},\;{\gamma}\;{\kappa}$ 수용체 agonist들에 의해 축적되는 cAMP양을 측정하여 본 결과, haloperidol단독투여에 의해서 cAMP는 유의한 증가를 나타내었으며, haloperidol 장기투여된 mouse striatum 에서 morphine(20mg/kg), DAGO(5Oug/kg), DPDPE(50ug/kg), U5O,488H (500ug/kg)투여에 의해서 haloperidol에 의한 cAMP 증가는 억제되었으며, 정상 mouse에 투여된 morphine, DAGO, DPDPE, U5O,488H에 비해서는 DAGO, DPDPE 투여군에서 증가를 나타내었다. Haloperidol장기투여로 인한 morphine, DAGO, DPDPE, U5O,488H의 영향은 naloxone에 의해서 morphine과 U5O, 488H투여군에서 길항되었으며 정상 mouse에 투여된 morphine, DAGO, DPDPE, U5O,488H에 의한 cAMP의 감소는 naloxone에 의하여 모든 실험군에서 길항되었다. 이상의 결과로 보아 dopaminergic denervation시 mouse striatum에서 ${\mu},\;{\gamma},\;{\kappa}$효현제에 의하여 축적되는 cAMP양은 ${\kappa}$수용체 효현제인 U5O,488H에서 가장 현저한 감소를 보여 각 수용체의 활성화정도는 변화되며, 그중에서 ${\kappa}$수용체는 그 기능이 가장 보존되고 있음을 알 수 있었다. Cyclic adenosine 3'5'-monophosphate (cyclic AMP) has been frequently accepted as an intracellular messenger for receptor-mediated action of opioids. In this experiment, it was designed to determine the interaction of dopaminergic and opioidergic system in the mouse striatum in normal and chronic haloperidol treated groups. Haloperidol 750ug/kg I.P. for 10 days was performed for dopamine denervation. The morphine, DAGO, DPDPE, and U5O,488H inhibited the increase of haloperidol-induced cyclic AMP content in chronic haloperidol treated mouse striatum. The inhibition of DAGO and DPDPE showed significant increase compared to normal mouse striatum. Naloxone showed antagonistic effect on the morphine and U5O,488H in chronic haloperidol treated group, and showed antagonistic effect on morphine, DAGO, DPDPE, and U5O, 488H in normal mouse striatum. These findings support that there is a functional interrelationship of dopaminergic and opioidergic pathway in the striatum. This result provides an evidence that following destruction of striatal dopaminergic neuron, there are some changes of cAMP content on the ${\mu},\;{\gamma},\;and\;{\kappa}$ opioid receptor, but the ${\kappa}$ opioid receptor still has its function.

가미쌍화탕과 양의공진단 투여로 호전된 양하지 속 상연축 환자 1례

김수경,여서원,이현중,이동혁,두경희,조승연,박성욱,고창남,박정미,Kim, Soo-Kyung,Lu, Hsu-Yuan,Lee, Hyun-Joong,Lee, Dong-Hyuk,Doo, Kyeong-Hee,Cho, Seung-Yeon,Park, Seong-Uk,Ko, Chang-Nam,Park, Jung-Mi 대한중풍순환신경학회 2014 대한중풍.순환신경학회지 Vol.15 No.1

■ Objectives This clinical study is to report the effect of Korean medicine on patient with chronic benign fasciculation syndrome on a both legs. ■ Methods A patient who suffered from involuntary fasciculation of Quadricepts femoris and Gastrocnemius was treated with herbal medicine Gami SSanghwa-Tang and Yang Eui Gongjin-dan, acupuncture and moxibustion. Degree of fasciculation and general condition was measured. ■ Results After taking Gami Ssanghwa-Tang and Yang Eui Gongjin-Dan, degree of fasciculation have reduced and patient's general condition improved. ■ Conclusion This clinical case study showed the effect of Korean medicine on symptom of fasciculation.

국내 수도권 중·노년층의 한방건강증진행위 예측모형

김수경,최형욱,우원홍,Kim, Soo-Kyung,Choi, Hyung-Wook,Woo, Won-Hong 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.2

Objective : This study was a covariance structural analysis to identify korean medicine health promotion behavior by the general characteristics of the subjects and build a predictive model and theoretical framework based on Pender's health promotion model(1996) and related literature reviews. Method : A hypothetical model was consisted of 8 theoretical variables and 27 measured variables. Related variables included Individual Characteristics and Experience, Behavior-specific cognitions and affect and Behavioral outcome. The data was collected from 802 middle and old-aged people living in Seoul and Gyeong gi province through structured questionnaires by face to face interviews between February and March, 2014. SAS ver. 9.1 and AMOS 18.0 programs were used for the data analysis. Results : Difference in the verification of Korean medicine health promotion behavior by the general characteristics, Older people who are male, with higher economic status, no chronic disease or with diabetes, no smoking, no drinking, with more exercise showed significantly higher scores, but education level has no difference. 15 paths were statistically significant among 16 paths on the direct effect, 6 paths were statistically significant among 9 paths on the indirect effect in the hypothetical model. The greatest impact variable on Korean medicine health promotion behavior was perceived self-esteem. Also, the findings showed that the higher perceived social support, perceived health status, previous Korean medicine health promotion behavior, community environment, perceived benefit and the lower perceived barrier had a significant effect on Korean medicine health promotion behavior. Conclusion : This research model has an empirical validity as the variables of this study verified their effects and significances. Therefore, the understanding of Korean medicine health promotion behavior can be increased and the utilization will be higher when seeking a comprehensive health promotion plan. Also, a strategy can be utilized the strategy for Korean medicine health promotion behavior.

오류 데이터로부터의 데이터 품질 메트릭의 정립

김수경(Soo-Kyung Kim),최병주(Byoungju Choi) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.2Ⅰ

소프트웨어 제품의 품질을 보증하는 일은 매우 중요하며, 국제 표준인 ISO/IEC 9126은 소프트웨어 품질 특성 및 측정 메트릭 표준을 제공하고 있다. 이때 ISO/IEC 9126에서는 소프트웨어를 프로그램, 절차, 규칙 및 관련문서로 한정하고 있기 때문에 데이터의 품질에는 적용할 수 없다. 본 논문에서는 데이터 품질 평가 및 제어를 위하여 오류 데이터 형태를 분류하고, 이를 기반으로 데이터 품질 특성을 추출한다. 추출된 데이터 품질 특성을 측정하기 위해, 오류 데이터를 품질 속성으로 하는 데이터 품질 메트릭을 제안한다. 본 논문에서 제시하는 데이터 품질 메트릭은 지식 공학(knowledge engineering) 시스템이 최종 사용자에게 제공하는 데이터나 지식의 품질 측정 및 제어에 기준이 된다.