수순(水醇)추출법으로 조제된 오공 약침액의 생리활성 효과

김성철,서근영,이성원,박성주,김재효,안성훈,황성연,Kim, Sung-Chul,Seo, Geun-Young,Lee, Sung-Won,Park, Sung-Joo,Kim, Jae-Hyo,Ahn, Seong-Hun,Hwang, Sung-Yeoun 대한약침학회 2010 Journal of pharmacopuncture Vol.13 No.3

Reactive Oxygen Species(ROS) are continuously produced at a high rate as a by-product of aerobic metabolism. Since tissue damage by free radical increases with age, the reactive oxygen species(ROS) such as hydrogen peroxide($H_2O_2$), nitric oxide(NO). Several lines of evidence provided that ROS appears to cause to develop aging-related various diseases such as cancer, arthritis, cardiovascular disease. Our reserch objective was to examine the in vitro biological activity of Scolopendrid Pharmacopuncture, including the total poly-phenol content, DPPH radical scavenging, ABTS radical scavenging, Superoxide dismutase(SOD)-like activity, Nitrite scavenging ability. The total poly-phenol contents of Scolopendrid Pharmacopuncture was 35.859mg/L. Elctron donation ability on DPPH was 36.82%. The 2,2'-azinobis-3-ehtlbezothiazoline-6-sulfonic acid radical decolorization (ABTS) was 84.7%. The superoxide dismutase (SOD)-like activities of Scolopendrid Pharmacopuncture was 44.33%. The nitrite scavenging effects were pH dependent, and were highest at pH 1.5(45.2%) and lowest at pH 6.0(11.3%). We conclude that Scolopendrid Pharmacopuncture may be useful as potential sources of antioxidant.

알콜과 각막상피절삭기를 이용한 각막 상피층 분리 및 창상치유 정도 비교

김성철,김웅재,정성근,Sung Chul Kim,Wung Jae Kim,Sung Kun Chung 대한안과학회 2006 대한안과학회지 Vol.47 No.8

Purpose: Laser epithelial keratomileusis (LASEK) is a refractive surgery technique in which the cornea is covered with the epithelial flap after keratectomy. However, there have been reports of tissue damage by the alcohol utilized in this procedure while preparing the epithelial flap, which has led to novel methods. One of these is the mechanical designing of the epithelial flap named epipolis laser assisted in situ keratomileusis (Epi-LASIK). This study evaluates the histologic features and wound healing process of the corneal flap using Epi-Tome, which is the epithelial cutter of the newly introduced Epi-Lasik. Methods: Twenty-four eyes of 12 dogs were devided into two groups. In one group (n=12), 20% alcohol was used and, in the other group (n=12), Epi-Tome (Gebauer, Germany) was used to make a corneal flap. The size change of a fluorescein-stained epithelial defect was followed postoperatively at 6, 12, 24, and 36 hours. Results: The maximum decrease in defect size were observed at 0 to 6 hours in the Epi-Tome group, and from 6 to 12 hours in the alcohol group; the value were 10.01±5.32 mm2 and 9.23±4.75 mm2 respectively. Histologic review revealed that there was less tissue damage and smoother cut edge in the Epi-Tome group compared to the alcohol group, and the adhesion between stroma and epithelium was faster in the Epi-Tome group. Conclusions: Mechanically detached corneal flaps had favorable chances of survival such that re-epithelialization occurred early in the postoperative phase. A few epithelial fragments at a corneal section plane prevent corneal opacification and minimize inflammatory reaction, thus reducing postoperative pain.

초오 약침 개발을 위한 백서 독성 연구 및 생리활성에 대한 연구

김성철,안성훈,김성하,이상관,송봉근,Kim, Sung-Chul,Ahn, Seong-Hun,Kim, Sung-Ha,Lee, Sang-Kwan,Song, Bong-Keun 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.1

Objective : We investigate toxicity of Aconiti ciliare tuber and antioxidant activity of Aconiti ciliare tuber Pharmacopuncture to develop safe Aconiti ciliare tuber Pharmacopuncture and find out the effect. Methods : In order to investigate toxicity of Aconiti ciliare tuberm, we administered Aconiti ciliare tuberm orally to rats and examined the survival rate, comparing with the survival rate of rats administered by Radix aconitum simmered with Semen Glycine and Radix Glycyrrhizae. We examined the in vitro biological activity of Aconiti ciliare tuber Pharmacopuncture, including the total polyphenol content, and ABTS radical scavenging. Results and Conclusions : The $LD_{50}$ of Radix aconitum simmered with Semen Glycine and Radix Glycyrrhizae was 9.0g/kg, on the other hand, the $LD_{50}$ of Aconiti ciliare tuberm was more than 15g/kg. The total polyphenol contents of Aconiti ciliare tuberm Pharmacopuncture was 2.31mg/L. The 2,2'-azinobis-3-ehtlbezothiazoline-6-sulfonic acid radical decolorization (ABTS) was 10.26%. We conclude that Aconiti ciliare tuberm is not highly toxic, Aconiti ciliare tuber Pharmacopuncture has a little antioxidant effect.

X선영상증배관의 상대변환계수 측정에 관한 검토

김성철,신성일,이선숙,허준,김성수,Kim, Sung-Chul,Shin, Sung-Ill,Lee, Sun-Sook,Huh, Joon,Kim, Sung-Soo 대한방사선기술학회 1997 방사선기술과학 Vol.20 No.2

For the Evaluation of X-ray image intensifier, we measured radiation dose at input of I. I., brightness and fluorescence at output of I. I. by using X-ray exposure meter, optometer and fluorescence meter for the relative conversion factor. Especially, by using fluorescence meter, we could easily get relative conversion factor without having regulated machine by JIS. Since using, the quality of image intensifier is going down. Consequently, it needs continuous quality maintenance.

하나의 GRIN Rod Lens를 이용한 효율적 병렬 광연결

김성철,이욱,이병호,정지채,Kim, Sung-Chul,Lee, Wook,Lee, Byoung-Ho,Jeong, Ji-Chai 대한전자공학회 1997 電子工學會論文誌, D Vol.d34 No.1

We proved the feasibiltiy of a parallel optical interconnection technique using single GRIN (graded-index) rod lens as an intermediate coupling device, which increases the working distance and makes packaging easy. The proposed technique shows relatively less dependency on misalignments. In this paper, for convensience of experiments, we applied this method to 4-channel coupling between two fiber arrays, and compared it with butt-coupling and the method of using ball lens. The comparison shows the feasibility of adopting the proposed method to the parallel interconnection between a laser diode array and an optical fiber array.

침감(鍼感) 및 침향(鍼響)에 대한 문헌적(文獻的) 고찰(考察)

김성철,Kim, Sung-chul 대한침구의학회 2001 대한침구의학회지 Vol.18 No.3

Objective : To study needling sensation and the flow of the needling sensation the ancient and the present literatures were reviewed. Results : 1. The needling sensation was getting the Qi and a normal reaction of acupuncture. 2. The flow of the needling sensation was promoted the Qi and normalized the flow of the Qi 3. The needling sensation of a patient expressed soreness, distension, heaviness, numbness, tingling, flushing, fervor, chill, itching, and so forth. 4. The needling sensation of a patient expressed simple or complex syndrome. 5. The needling sensation of a doctor expressed objectively more than the needling sensation of a patient in the hand feeling of a doctor. 6. The doctor was compared good needling sensation and bad needling sensation. 7. The needling sensation and the flow of the needling sensation were processed continuously. 8. The needling sensation and the flow of the needling sensation were connected with a nervous system and expressed variously in the anatomical structure and hand acupuncture tenchnique.

생혈액분석을 통한 저용량 He-Ne 레이저 유침치료에 관한 임상적 연구

김성철,Kim, sung-chul 대한침구의학회 2001 대한침구의학회지 Vol.18 No.3

Objective : The purpose of this study was to investigate the effect of Intravascular Laser Irradiation of Blood(ILIB) by the live blood analysis. Methods : We had analysed the changing forms of the live blood samples with Ultra Darkfield Microscope before and after Intravascular Laser Irradiation of Blood. Results and Conclusion : 1. Nomal Erythrocytes were increased significantly after ILIB by the live blood analysis. 2. Poikilocytes were decreased significantly after ILIB by the live blood analysis. 3. Target Cells were decreased significantly after ILIB by the live blood analysis. 4. Somatid was improved significantly after ILIB by the live blood analysis. 5. Erythrocyte Aggregtion was improved significantly after ILIB by the live blood analysis.

저용량(低容量) He-Ne 레이저침의 혈락적용(血絡適用) 연구(硏究)

김성철,조은희,나창수,Kim Sung-Chul,Cho Eun-Hee,Na Chang-Su 경락경혈학회 2003 Korean Journal of Acupuncture Vol.20 No.3

Objective : The purpose of this study was to investigate the significance of the Oriental medical treatment using He-Ne laser with low energy intravascular Laser Irradiation of Blood(ILIB) through the superficial venules. Methods : The investigation of details connected with the superficial venules in the literature is performed. The investigation of details connected with the pricking blood techniques through the superficial venules in the literature is performed. The classification of the pricking blood techniques through the superficial venules by the blood-letting puncture methods in the literature is performed. The arrangement of domestic clinical treatises on the effectiveness of medical treatment using He-Ne laser with low energy ILIB through the superficial venules is performed. The consideration on the methodology for the improvement of the clinical effectiveness of He-Ne laser with low energy ILIB through superficial venules is performed. Results and Conclusions : The superficial venules are small arteries, veins and capillaries in the superficial region of the human body. In the pricking blood techniques, there are the blood-letting puncture using the implement of acupuncture to the Jing points, Extra points and superficial blood vessels and the acupuncture using the Hirudo. The methods of the blood-letting puncture are classified into the venous blood-letting puncture, the pricking , the picking out white fiber-like substances from the subcutaneous tissue, the cluster needling, the scattered needling, the blood-letting puncture of the tready collateral branch of the large channel and the blood-letting puncture of skin. The He-Ne laser with low energy ILIB through the superficial venules belongs to the Oriental medical treatment as the method of the blood-letting puncture in the vein of cubital fossa. The He-Ne laser with low energy ILIB has an effect on hyperfibrinogenemia, hyperlipidemia, speech and motor dysfunction in the case of cerebral infarction, headache, dizziness, pain and numbness. It is considered that fundamental research on the biological change of the human body, the experimental animal and the unicellular animal, and research on the effectiveness and the safety, and the development of He-Ne laser with low energy ILIB of an effective wavelength range are necessary.

수직 직근의 단계적 부분 건절제술을 통한 상사시 치료

김성철,임혜빈,AlbertWBiglan,Sung-Chul Kim,Hye-Bin Yim,Albert W Biglan 대한안과학회 2005 대한안과학회지 Vol.46 No.4

Purpose: To evaluate the effectiveness of graded (adjustable intraoperatively) partial vertical rectus muscle tenotomy at the insertion in correcting small degrees of hypertropia. Methods: All patients with best corrected visual acuity of better than 6/30 in both eyes who had undergone only partial tenotomy of vertical rectus muscle(s) over a 30-month period were included. Improvement was evaluated 6 weeks postoperatively as the change in alignment in prism diopters (PD) in primary gaze and in the field of action of the affected rectus muscle(s). Binocular function was evaluated by Titmus stereoacuity and the Worth 4-light tests. Results: All 24 patients who met the inclusion criteria had diplopia preoperatively, and this had resolved in 17 (71%) postoperatively (P<0.005). Prisms were used by 6 preoperatively vs. 2 postoperatively (P<0.05). The average vertical deviation in primary gaze decreased from 8 PD to 2 PD (P<0.005). In the field of action of the treated rectus muscle, hypertropia decreased from an average of 8 PD to 3 PD (P<0.005). For the available pre- and post-operative assessments, stereoacuity improved after 10 of the 18 (56%) procedures and Worth 4-light testing showed improvement or maintenance of fusion after 13 of 19 procedures (68%). Conclusions: Graded vertical rectus partial tenotomy can effectively reduce small degrees of hypertropia and associated diplopia, improve binocular function, and reduce or eliminate the need for prism correction.

신용등급전이행렬의 경험적 베이지안 추정과 비교

김성철,박지연,Kim, Sung-Chul,Park, Ji-Yeon 한국통계학회 2009 응용통계연구 Vol.22 No.3

신용전이행렬을 추정함에 있어서 국내의 등급전이자료의 축적이 부족한 점을 극복하기 위하여 외국의 신용평가기관(무디스)의 전이행렬자료와 국내의 신용등급 부여자료를 이용하여 경험적 베이지안 추정방법에 의한 전이행렬을 도출하고, 이 전이행렬을 다른 전이행렬과 비교해보기 위하여 전이행렬의 동적인 요소를 평균전이확률의 개념으로 표시할 수 있는 특성척도를 개발하여 신용전이행렬의 시계열 특성과 통계적 특성을 비교한다. 시계열자료의 척도는 베이지안 추정행렬이 안정적임을 보여주는 반면 국내 행렬은 시간적으로 변화의 폭이 크고 무디스나 베이지안 행렬보다 상대적으로 인접전이의 비율이 높게 나타났다. 붓스트랩 검정을 통하여 세 가지 추정방법이 통계적으로 유의한 차이가 있음을 보이고 베이지안 행렬이 무디스 자료보다는 국내자료에 더 많은 영향을 받았음을 유추할 수 있다. 신용등급 전이에 따른 포트폴리오의 가치변화를 고려하는 몬테칼로 시뮬레이션을 통하여 신용 VaR를 구하여 비교하였다. 국내 전이행렬의 경우에 평균은 가장 크고 신용위험도 가장 큰 값을 보였다. 시뮬레이션에서도 베이지안 추정에 의한 결과가 국내자료에 의한 결과와 더 가깝다는 것을 알 수 있다. In order to overcome the lack of Korean credit rating migration data, we consider an empirical Bayes procedure to estimate credit rating migration matrices. We derive the posterior probabilities of Korean credit rating transitions by utilizing the Moody's rating migration data and the credit rating assignments from Korean rating agency as prior information and likelihood, respectively. Metrics based upon the average transition probability are developed to characterize the migration matrices and compare our Bayesian migration matrices with some given matrices. Time series data for the metrics show that our Bayesian matrices are stable, while the matrices based on Korean data have large variation in time. The bootstrap tests demonstrate that the results from the three estimation methods are significantly different and the Bayesian matrices are more affected by Korean data than the Moody's data. Finally, Monte Carlo simulations for computing the values of a portfolio and its credit VaRs are performed to compare these migration matrices.