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      • KCI등재
      • SCIESCOPUSKCI등재

        운동이상형 소화불량증을 호소하는 당뇨병 환자에서 주석산 시사프리드의 효과

        김선명(Sun Myung Kim),추교영(Kyo Young Choo),최명규(Myung Gyu Choi),진일(Jin Il Kim),방춘상(Choon Sang Bhang),한석원(Sok Won Han),병욱(Byung Wook Kim),최황(Hwang Choi),성수(Sung Soo Kim),이동수(Dong Soo Lee),최규용(Kyu Yong Ch 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.1

        N/A evaluated the effects of cisapride tartrate on gastrointestinal symptoms and gastric emptying times in diabetic patients with dysmotility like dyspeptic symptoms. Methods: Cisapride was administered before each meal in 61 patients for 4 weeks. The intensity of gastrointestinal symptoms before and after cisapride administration was scored from 0 to 4, in the order of increasing severity of symptoms. In addition, a gastric emptying test was performed. Results: A significant reduction in the total intensity score of symptoms was observed during the first two weeks, from 8.5±2.1 to 4.0±3.0 (p<0.05), and a further reduction was noted during the next two weeks, to 2.8±2.8 (p<0.05). Good to excellent improvement was obtained in 70.4% of the patients, but the improvement in symptoms was not related to age, duration of diabetes, glucose, Hb A1c, neuropathy, or retinopathy. Treatment with cisapride induced a significant regression of symptoms and a significant improvement of delayed gastric emptying from 104.0± 31.7 minutes to 79.5±17.1 (p<0.05). However, there was a lack of association between the changes in gastric emptying times and improvements in symptoms(r2=0.00186). Only 3 patients complained of loose stool, nausea, or dizziness. Conclusions: Cisapride was effective in improving dysmotility like dyspeptic symptoms in diabetic patients without serious side effects. (Korean Journal of Gastrointestinal Motility 2001;7:56-64)

      • KCI등재

        마이크로 유전알고리즘을 이용한 등분포 하중을 받는 립ㄷ형강 보의 단면 최적설계

        김선명(Kim Sun-Myung),이재홍(Lee Jae-Hong) 대한건축학회 2003 大韓建築學會論文集 : 構造系 Vol.19 No.7

        An important advantage of cold-formed steel is the great flexibility of cross-sectional profiles and sizes available to structural steel designers. However, this flexibility makes the selection of the most economical section difficult for a particular situation. In this study, Micro Genetic Algorithm(μ-GA) is used to find an optimum cross section of cold-formed lipped channel beams under uniformly distributed load considering all structural constraints such as moments, deflection, shear, web crippling, and flange curling. The efficiency of μ-GA has been proved through many problems, especially the problem with 3∼5 design variables. The design curves are generated for optimum values of the thickness, the flange flat-width-to-thickness ratio and lip flat-width-to-thickness ratio for unbraced beams. The optimum design curves presented in this paper can be a valuable guide to structural engineers.

      • 튜브형 GFRP 교량 바닥판의 웨브 좌굴성능 실험

        김선명 ( Kim Sun-myung ),이영호 ( Lee Young-ho ),박기태 ( Park Ki-tae ),황윤국 ( Hwang Yoon-koog ) 한국구조물진단유지관리공학회 2004 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.8 No.1

        The experimental study for web buckling capacity of FRP bridge decks proposed by KICT in 2003 is performed in this paper. Four kinds of test are conducted with the shape of specimen and loading type as variables and five specimens for each test are made. Furthermore, analytic research using commercial package ABAQUS with a 4-node shell element is carried to estimate web buckling capacity and its behavior The web buckling was verified to major cause of failure as a result of tests and bonding failure at adhesive section of web and compression failure at joint of flange and web are main cause of failure of the FRP specimens. The buckling stability of FRP specimens is superior as a whole. Especially, the 2-cells FRP specimen under uniformly distributed loading near most with actual behavior, whose web buckling safety rate is 5.0 and is safe very much from buckling.

      • KCI등재

        산악 터널시공에 따른 주변 지하수위 변화에 대한 수리 및 수문학적 해석

        김선명,Kim, Sun-Myung 한국터널지하공간학회 2011 한국터널지하공간학회논문집 Vol.13 No.2

        산악터널이 건설되는 지역에 있는 우물이나 작은 하천들은 흔히 주민들의 일상생활용수원으로 사용되고 있다. 이때 터널이 굴착됨에 따라 우물의 수위 저하와 같은 문제들이 발생할 수 있다. 따라서 본 연구에서는 설계단계에서 터널 주위의 지하수에 대한 부정적인 영향을 경감시키기 위해 MODFOLOW와 같은 수치모델링 기법을 사용하여 터널내 지하수 유입량과 지하수위 저하 지역에 대한 평가를 실시하였다. 또한 수문학적인 방법에 의해서 터널주변 지역의 지하수의 용수량을 평가하였다. It is not uncommon that private wells and small streams are used for daily life in the regions where mountain tunnels are located. Then serious social problems such as well water level fall, being attributable to tunnel excavation can occur. In the design stage, firstly we evaluated that the quantity of leakage water into tunnels. And groundwater drawdown area was simulated using numerical modeling such as MODFLOW to reduce adverse effects on life environment around tunnel. In addition we also used hydrological method to evaluate the groundwater change of tunnel area.

      • PET/CT 2D와 3D 영상 획득에서 방사능 집적에 따른 방사능 농도의 평가

        선명,홍건철,이혁,,최춘기,석재동,Park, Sun-Myung,Hong, Gun-Chul,Lee, Hyuk,Kim, Ki,Choi, Choon-Ki,Seok, Jae-Dong 대한핵의학기술학회 2010 핵의학 기술 Vol.14 No.1

        양전자 방출 단층촬영은 세포의 생화학적 변화에 따른 방사성의약품의 집적 정도를 영상화함으로서 암을 조기에 진단할 수 있는 검사방법으로 알려져 있다. 이러한 집적 정도는 여러 가지 원인에 따라 발생될 수 있는 것으로 $^{18}F$-FDG 주사량, 종양의 크기, 혈중 포도당 농도 등이 있다. 본 연구에서는 집적방사능과 2D와 3D 영상 획득이 방사능 농도(kBq/mL)에 미치는 영향에 대하여 평가하고자 한다. GE Discovery STe 16 PET/CT에서 1994 NEMA PET phantom을 이용하였으며, 배후방사능과 열소의 방사능 농도비가 1:2, 1:4, 1:8, 1:10, 1:20, 1:30 표준이 되도록 하여 2D와 3D로 영상을 획득하였다. 재구성 방법으로 2D와 3D 모두에서 반복연산법으로 반복횟수 2회, 부분집합 20을 적용하였다. 그리고 CT 감쇠보정법과 획득 시간은 10분으로 설정하였다. 또한 영상분석은 열소의 중심과 배후방사능에 동일한 관심영역을 설정 한 후 각 부분의 방사능 농도를 측정하여 비교 분석하였다. 설정된 관심영역의 배후방사능과 열소의 방사능 농도 비는 2D에서 1:1.93, 1:3.86, 1:7.79, 1:8.04, 1:18.72, 1:26.90, 3D는 1:1.95, 1:3.71, 1:7.10, 1:7.49, 1:15.10, 1:23.24 값을 얻었다. 또한 표준 방사능 농도비를 기준으로 한 백분율 차이(% Difference)는 2D에서 3.50%, 3.47%, 8.12%, 8.02%, 10.58%, 11.06%로 최소 3.47%에서 최대 11.06% 차이가 있고 3D는 3.66%, 4.80%, 8.38%, 23.92%, 23.86%, 22.69%로 최소 3.66%에서 최대 23.92%까지의 차이를 나타냈다. 방사능 농도가 증가할수록 실제 집적된 방사능 농도의 차이가 커짐을 알 수 있으며, 2D가 3D보다 평균 약 10.6% 높게 집적되어 방사능 농도 변화에 영향을 적게 받는 것으로 나타났다. 따라서 임상환자의 추적 검사에서 영상 획득 방법을 변화할 시 정확한 정량 평가를 위해서 이점을 고려하여 적용하여야 한다. Purpose: There has been recent interest in the radioactivity uptake and image acquisition of radioactivity concentration. The degree of uptake is strongly affected by many factors containing $^{18}F$-FDG injection volume, tumor size and the density of blood glucose. Therefore, we investigated how radioactivity uptake in target influences 2D or 3D image analysis and elucidate radioactivity concentration that mediate this effect. This study will show the relationship between the radioactivity uptake and 2D,3D image acquisition on radioactivity concentration. Materials and Methods: We got image with 2D and 3D using 1994 NEMA PET phantom and GE Discovery(GE, U.S.A) STe 16 PET/CT setting the ratio of background and hot sphere's radioactivity concentration as being a standard of 1:2, 1:4, 1:8, 1:10, 1:20, and 1:30 respectively. And we set 10 minutes for CT attenuation correction and acquisition time. For the reconstruction method, we applied iteration method with twice of the iterative and twenty times subset to both 2D and 3D respectively. For analyzing the images, We set the same ROI at the center of hot sphere and the background radioactivity. We measured the radioactivity count of each part of hot sphere and background, and it was comparative analyzed. Results: The ratio of hot sphere's radioactivity density and the background radioactivity with setting ROI was 1:1.93, 1:3.86, 1:7.79, 1:8.04, 1:18.72, and 1:26.90 in 2D, and 1:1.95, 1:3.71, 1:7.10, 1:7.49, 1:15.10, and 1:23.24 in 3D. The differences of percentage were 3.50%, 3.47%, 8.12%, 8.02%, 10.58%, and 11.06% in 2D, the minimum differentiation was 3.47%, and the maximum one was 11.06%. In 3D, the difference of percentage was 3.66%, 4.80%, 8.38%, 23.92%, 23.86%, and 22.69%. Conclusion: The difference of accumulated concentrations is significantly increased following enhancement of radioactivity concentration. The change of radioactivity density in 2D image is affected by less than 3D. For those reasons, when patient is examined as follow up scan with changing the acquisition mode, scan should be conducted considering those things may affect to the quantitative analysis result and take into account these differences at reading.

      • KCI등재

        Back Analysis of Field Measurements Around the Tunnel with the Application of Genetic Algorithms

        김선명,윤지선,전덕찬,윤상길,Kim Sun-Myung,Yoon Ji-Sun,Jun Duk-Chan,Yoon Sang-Gil Korean Geotechnical Society 2004 한국지반공학회논문집 Vol.20 No.7

        In this study, the back analysis program was developed by applying the genetic algorithm, one of artificial intelligence fields, to the direct method. The optimization process which has influence on the efficiency of the direct method was modulated with genetic algorithm. On conditions that the displacement computed by forward analysis for a certain rock mass model was the same as the displacement measured at the tunnel section, back analysis was executed to verify the validity of the program. Usefulness of the program was confirmed by comparing relative errors calculated by back analysis, which is carried out under the same rock mass conditions as analysis model of Gens et at (1987), one of back analysis case in the past. We estimated the total displacement occurring by tunnelling with the crown settlement and convergence measured at the working faces in three tunnel sites of Kyungbu Express railway. Those data measured at the working face are used for back analysis as the input data after confidence test. As the results of the back analysis, we comprehended the tendency of tunnel behaviors with comparing the respective deformation characteristics obtained by the measurement at the working face and by back analysis. Also the usefulness and applicability of the back analysis program developed in this study were verified. 본 논문에서는 역해석 방법 중 직접법의 성능에 큰 영향을 미치는 최적화 과정을 인공지능의 한 기법인 유전자알고리즘을 이용하여 역해석 프로그램을 구성하였다. 유전자 알고리즘 및 역해석 기법의 효용성을 검증하기 위하여 과거 역해석 연구 사례 중의 하나인 Gens et al(1987)과 동일한 암반조건을 가진 모델에 대한 역해석을 실시하여 그 결과를 비교${\cdot}$검토하였다. 경부고속철도 터널 현장의 내공변위 및 천단침하에 대한 계측자료로부터 최종 내공변위의 예측함수를 결정하는 방법으로 터널의 총 변위를 분석하였다. 이를 역해석에 필요한 입력자료로 활용하여 역해석을 실시하고 터널 주변 암반의 거동을 반영할 수 있는 지반의 특성치를 구하였다. 각 현장 시험에서 얻어진 지반의 특성치와 비교한 결과 본 연구에서 적용된 유전자 알고리즘을 이용한 역해석 방법이 유의한 수준의 결과를 도출하고 있다는 사실을 확인하였다.

      • KCI등재

        안성 청룡사삼층석탑의 풍화훼손도 진단과 보존처리

        선명,이명성,조영훈,이찬희,전성원,주옥,선덕,Lee, Sun-Myung,Lee, Myeong-Seong,Jo, Young-Hoon,Lee, Chan-Hee,Jeon, Seong-Won,Kim, Ju-Ok,Kim, Sun-Duk 대한자원환경지질학회 2007 자원환경지질 Vol.40 No.5

        Rock materials of the three-storied stone pagoda in the Cheongryongsa temple in Korea are mainly composed of gneissose two-mica granite and fine-grained granite. This stone pagoda shows structural instability due to cracks and breaking-out of the stones. The surface properties of the stone is highly degraded by various inorganic pollutants and epilithic biospecies. Therefore, this study carried out comprehensive deterioration diagnosis by non-destructive methods, and some conservation treatments base on the diagnosis were carried out to reduce weathering progress. As the treatments, the biospecies and lichen that covering on the stone surfaces were removed by dry and wet cleaning, and degraded concrete applied to the pagoda for restoration in the past was removed and repaired with epoxy resin. Oxidized iron plates inserted between the rock properties were also substituted titanium stainless steels. After all processes are completed, we sprayed consolidant on the rock surface. Finally, the ground of the stone pagoda was rearranged using small rock aggregates, and the fence was established for control of artificial deterioration by visitors and environmental maintenance. 안성 청룡사삼층석탑의 구성암석은 대부분 편마상 복운모 화강암과 세립질 화강암으로 이루어져 있다. 이 석탑은 거의 전면에 걸쳐 나타나는 부재의 균열과 결실이 탑의 구조안정성을 위협한다. 또한 표면의 무기오염물과 다양한 서식형태를 갖는 생물침해는 석재표면의 손상을 가중시키고 있다. 따라서 이 연구에서는 석탑에 대한 종합적인 비파괴훼손도 진단을 수행하고 이를 근거로 풍화를 저감시키기 위해 최소한의 보존처리를 수행하였다. 보존처리에서는 석탑의 전면에 걸쳐 자생하는 지의류 및 생물오염물을 건식 및 습식 세정하였으며, 과거 이 석탑의 보수에 사용되었던 노화된 콘크리트를 제거하고 합성수지를 이용하여 복원하였다. 부재사이에 삽입된 부식된 철편은 티타늄 강철 합금으로 교체하였으며, 모든 공정이 완료된 후에 석질 강화처리를 실시하였다. 또한 석탑의 지반과 주위환경을 보강하고 정비하였으며 관람객에 의한 손상을 제어하기 위한 보호시설을 설치하였다.

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